K Sudo

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells
    K Sudo
    Department of Laboratory Medicine, Jikei University, Daisan Hospital, Komae City, Japan
    Biochem Biophys Res Commun 240:372-5. 1997
  2. ncbi request reprint A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes
    K Sudo
    Department of Laboratory Medicine, Jikei University, Daisan Hospital, Komae City, Tokyo, Japan
    Clin Biochem 32:137-41. 1999
  3. ncbi request reprint Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 91:163-8. 1993
  4. ncbi request reprint Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene
    H J Han
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 73:137-9. 1996
  5. ncbi request reprint Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae
    S Nakatsuru
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Biochem Biophys Res Commun 202:82-7. 1994
  6. ncbi request reprint Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 88:34-8. 1991
  7. ncbi request reprint Analysis of a genetic mutation in an electrophoretic variant of the human lactate dehydrogenase-B(H) subunit
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 91:423-6. 1993
  8. ncbi request reprint Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Biochem Biophys Res Commun 180:1083-90. 1991
  9. ncbi request reprint Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Clin Chem 40:665-8. 1994
  10. ncbi request reprint Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant
    K Sudo
    Department of Laboratory Medicine, Jikei University School of Medicine, Daisan Hospital, Komae, Japan
    Hum Genet 89:158-62. 1992

Detail Information

Publications28

  1. ncbi request reprint Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells
    K Sudo
    Department of Laboratory Medicine, Jikei University, Daisan Hospital, Komae City, Japan
    Biochem Biophys Res Commun 240:372-5. 1997
    ..These results showed this amino acid substitution of BCHE, Leu330 to Ile, really caused the abnormal DN and FN. We conclude that the BCHE L330I mutation is a fluoride-resistant gene, a Japanese type fluoride-resistant gene...
  2. ncbi request reprint A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes
    K Sudo
    Department of Laboratory Medicine, Jikei University, Daisan Hospital, Komae City, Tokyo, Japan
    Clin Biochem 32:137-41. 1999
    ..LD activity in serum from this patient was extremely low, similar to complete LD-H deficiency, and also that in erythrocytes was low...
  3. ncbi request reprint Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 91:163-8. 1993
    ..These amino acid replacements may cause conformational changes in neighboring residues; this probably affects the active site arrangement and results in the loss of enzyme activity...
  4. ncbi request reprint Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene
    H J Han
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 73:137-9. 1996
    ..This gene was expressed ubiquitously in all human tissues examined. By fluorescence in situ hybridization we mapped RABL to chromosome band 17q21.2...
  5. ncbi request reprint Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae
    S Nakatsuru
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Biochem Biophys Res Commun 202:82-7. 1994
    ..Each of these sequence homologues, including Saccharomyces cerevisiae CDC10, contains the GTP-binding motif. Northern blot analyses indicated that the hCDC10 gene is expressed ubiquitously in normal tissues...
  6. ncbi request reprint Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 88:34-8. 1991
    ..Thus, all four known affected families in Japan have been shown to carry the same mutant gene, which may have been derived from a single mutational event...
  7. ncbi request reprint Analysis of a genetic mutation in an electrophoretic variant of the human lactate dehydrogenase-B(H) subunit
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Hum Genet 91:423-6. 1993
    ..The change may cause the heat instability and affect the net charge of the variant subunit, resulting in an electrophoretic LDH-B subunit variant of the fast type...
  8. ncbi request reprint Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Biochem Biophys Res Commun 180:1083-90. 1991
    ..The DCP technique using the polyacrylamide gradient gel and silver staining method seems likely to be useful for the rapid screening of mutations and for further genotype detection...
  9. ncbi request reprint Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes
    M Maekawa
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Japan
    Clin Chem 40:665-8. 1994
    ..This missense mutation was also observed in the patient's son, and genotypes of mother and son were consistent with their biochemical phenotypes, as evaluated by LD isoenzyme analysis...
  10. ncbi request reprint Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant
    K Sudo
    Department of Laboratory Medicine, Jikei University School of Medicine, Daisan Hospital, Komae, Japan
    Hum Genet 89:158-62. 1992
    ..The change may affect the arrangement of the cofactor binding site and result in the loss of enzyme activity. The experimental observations are consistent with computer graphics analyses...
  11. ncbi request reprint Fifty sequenced-tagged sites on human chromosome 11
    T Miwa
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 17:211-4. 1993
    ..These STSs can serve as new reagents for investigating human DNA in somatic cell hybrids and for isolating yeast artificial chromosomes to anchor large DNA contigs and fine-scale physical maps of chromosome 11...
  12. ncbi request reprint Isolation and mapping of the human beta-signal sequence receptor gene (SSR2)
    K Chinen
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 70:215-7. 1995
    ..Northern blot analysis revealed its ubiquitous expression in all organs examined. We also localized the human beta-signal sequence receptor gene (SSR2) to chromosome bands 1q21-->q23 by fluorescence in situ hybridization...
  13. ncbi request reprint Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2
    K Sudo
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 71:385-8. 1995
    ..Furthermore, we have localized the human EIF4A2 to chromosome 18p11.2 by fluorescent in situ hybridization...
  14. ncbi request reprint Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2
    K Koyama
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 21:460-1. 1994
  15. ncbi request reprint Genetic mutations of butyrylcholine esterase identified from phenotypic abnormalities in Japan
    M Maekawa
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Clin Chem 43:924-9. 1997
    ..They also showed a higher frequency (47% as allele frequency) of the K-variant than the general population (17.5%). Finally, we confirmed low serum BCHE activity in 10 of 23 individuals heterozygous for silent genes...
  16. ncbi request reprint TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus
    F Fukamauchi
    Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10, Kandasurugadai, Chiyoda ku, Tokyo, 101 0062, Japan
    Biochem Biophys Res Commun 281:220-6. 2001
    ..We suspect that the subtle changes in neural plasticity induced by TAG-1 deficiency during development cause the selective vulnerability of specific brain regions and the epileptogenicity in TAG-1 (-/-) mice...
  17. ncbi request reprint Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication
    S Nakatsuru
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 68:226-30. 1995
    ..Analysis by Northern blotting revealed that the human MCM2 gene is expressed ubiquitously in normal tissues. Furthermore, we localized this gene to chromosomal bands 7q21.3-->q22.1 by fluorescence in situ hybridization...
  18. ncbi request reprint 2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library
    K Sudo
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 24:276-9. 1994
    ..6% showed no homology to any genes or DNA sequences in the public database. These data and reagents will be useful for future investigations of gene expression during prenatal development of human lung...
  19. ncbi request reprint Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants
    N Ishida
    Department of Physiological Chemistry, The Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo, 113 8613, Japan
    J Biochem 126:1107-17. 1999
    ..Our results demonstrate the importance of the transmembrane core region of the UDP-galactose transporter protein...
  20. ncbi request reprint Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit
    K Sudo
    Department of Laboratory Medicine, Jikei University School of Medicine, Daisan Hospital, Komae, Japan
    Biochem Int 27:1051-7. 1992
    ..In addition, four synonymous substitutions with no amino-acid replacements were found at codons 51, 119, 163 and 175 in the LDH-A gene from the patient...
  21. ncbi request reprint Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2)
    S Ikegawa
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 71:182-6. 1995
    ..We have mapped this novel gene to chromosomes 11q13.5 by fluorescent in situ hybridization (FISH) using a cosmid clone containing the entire coding sequence and the 3' non-coding sequence...
  22. ncbi request reprint Assignment of the human ribosomal protein S25 gene (RPS25) to chromosome 11q23.3 by sequence analysis of the marker D11S456
    T Imai
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 20:142-3. 1994
  23. ncbi request reprint Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification
    K Koyama
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Genomics 26:245-53. 1995
    ..The expressed-sequence tags isolated here will be useful resources for a transcriptional map of chromosome 8 and for isolation of new genes...
  24. ncbi request reprint Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA
    S Shimada
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 163:5367-73. 1999
    ..These results demonstrate that dIgA is mainly transported by pIgR on the epithelial cells of intestine and hepatocytes, but a small quantity of IgA may be secreted via other pathways...
  25. ncbi request reprint Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death
    T Kawakami
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 71:41-3. 1995
    ..The gene represented by PDCD2 was expressed in all human tissues examined. We assigned the PDCD2 locus to chromosomal band 6q27 by fluorescence in situ hybridization (FISH)...
  26. ncbi request reprint Substitution of lysine for arginine in the N-terminal 217th amino acid residue of the H gamma II of Staphylococcal gamma-hemolysin lowers the activity of the toxin
    K Sudo
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 59:1786-9. 1995
    ..The H gamma II(P83) showed about 50% of the hemolytic activity of normal H gamma II in the presence of LukF...
  27. ncbi request reprint Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency
    M Maekawa
    Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biochem Biophys Res Commun 168:677-82. 1990
    ..Am J Hum Genet 39:232-238, 1986). In addition, three synonymous (silent) substitutions, A to C, T to C, and G to A, were observed at codons 115, 160 and 172, respectively, in this LDH-A mutant gene...
  28. ncbi request reprint A missense mutation found in human lactate dehydrogenase-B (H) variant gene
    K Sudo
    Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biochem Biophys Res Commun 168:672-6. 1990
    ..This mutation results in an amino-acid replacement of a conserved arginine by histidine at the residue "173," which is involved in an anion-binding site at the P-axis of LDH subunits...