Toshifumi Ohkusa

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial
    Toshifumi Ohkusa
    Department of Gastroenterology and Hepatology, Jikei University, Tokyo, Japan
    Am J Gastroenterol 105:1820-9. 2010
  2. ncbi Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis
    Toshifumi Ohkusa
    Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Chiba 277 8567, Japan
    J Med Microbiol 58:535-45. 2009
  3. ncbi Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 40:1334-42. 2005
  4. ncbi Colonic mucosal lesions associated with low-dose aspirin: a case control study
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 46:810-7. 2011
  5. ncbi Regulation of tumor immunity by tumor/dendritic cell fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Dev Immunol 2010:516768. 2010
  6. ncbi Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistency
    Taro Osada
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 16:192-7. 2010
  7. ncbi Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis
    Taro Osada
    Department of Gastroenterology, Jutendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S262-7. 2008
  8. ncbi Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Biomed Biotechnol 2011:910836. 2011
  9. ncbi Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid-dependent cases
    Toshiki Uehara
    Department of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S62-6. 2010
  10. ncbi Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Immunol 135:384-400. 2010

Detail Information

Publications36

  1. ncbi Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial
    Toshifumi Ohkusa
    Department of Gastroenterology and Hepatology, Jikei University, Tokyo, Japan
    Am J Gastroenterol 105:1820-9. 2010
    ..Fusobacterium varium may contribute to ulcerative colitis (UC). We conducted a double-blind placebo-controlled multicenter trial to determine whether antibiotic combination therapy induces and/or maintains remission of active UC...
  2. ncbi Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis
    Toshifumi Ohkusa
    Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Chiba 277 8567, Japan
    J Med Microbiol 58:535-45. 2009
    ..Certain commensal bacteria can invade colonic epithelial cells, activating early intracellular signalling systems to trigger host inflammatory reactions...
  3. ncbi Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 40:1334-42. 2005
    ..Our goal was to assess whether an antibiotic combination therapy against F. varium is effective for induction and maintenance of remission of UC...
  4. ncbi Colonic mucosal lesions associated with low-dose aspirin: a case control study
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 46:810-7. 2011
    ..Recently, there has been a substantial increase in prescriptions for LDA. We analyzed the risk of colonic mucosal lesions associated with the long-term use of LDA...
  5. ncbi Regulation of tumor immunity by tumor/dendritic cell fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Dev Immunol 2010:516768. 2010
    ..This paper reviews tumor immune escape and current strategies employed in the field of tumor/DC fusions vaccine aimed at enhancing activation of TAAs-specific cytotoxic T cells in tumor microenvironment...
  6. ncbi Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistency
    Taro Osada
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 16:192-7. 2010
    ..This study evaluated inter- and intraobserver agreement in the assessment of ulcerative colitis (UC) activity using 4 established indices and a newly designed Modified 6-point Activity Index...
  7. ncbi Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis
    Taro Osada
    Department of Gastroenterology, Jutendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 23:S262-7. 2008
    ..In the present study we assessed the relationship between endoscopic and histological findings, clinical symptoms, and laboratory data...
  8. ncbi Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Biomed Biotechnol 2011:910836. 2011
    ..In this review, we will discuss immunologic monitoring of cellular responses for the evaluation of cancer vaccines including fusions of DC and whole tumor cell...
  9. ncbi Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid-dependent cases
    Toshiki Uehara
    Department of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S62-6. 2010
    ..Herein, we assessed whether antibiotic combination therapy is effective for active UC, including cases with steroid refractory or dependent disease...
  10. ncbi Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Immunol 135:384-400. 2010
    ..However, fusions from patients with metastatic pancreatic cancer induced increased expression levels of TGF-beta1 in CD4+ CD25high T cells and low levels of CTLs with decreased IFN-gamma production...
  11. ncbi Current immunotherapeutic approaches in pancreatic cancer
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Dev Immunol 2011:267539. 2011
    ..We offer our perspective on how to increase the clinical efficacy of immunotherapies for pancreatic cancer...
  12. ncbi Increased esophageal sensitivity to acid and saline in patients with nonerosive gastro-esophageal reflux disease
    Akihito Nagahara
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Clin Gastroenterol 40:891-5. 2006
    ..To investigate the features of nonerosive reflux disease (NERD)...
  13. ncbi Endoscopic, histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: comparison between responder and non-responder cases
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Digestion 68:57-62. 2003
    ..CONCLUSION: Persistent high gastrin levels were found in the non-responder cases with gastric hyperplastic polyps...
  14. ncbi Colonic mucosal lesions associated with long-term or short-term administration of nonsteroidal anti-inflammatory drugs
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Colorectal Dis 12:1113-21. 2010
    ..We assessed the risk of developing colonic mucosal lesions according to the duration of exposure to NSAIDs: short-term and/or long-term use...
  15. ncbi Cancer immunotherapy by fusions of dendritic cells and tumor cells
    Shigeo Koido
    Department of Internal Medicine, The Jikei University, Tokyo, Japan
    Immunotherapy 1:49-62. 2009
    ..This review deals with recent progress in the immunotherapy of cancer with fusions of DCs and tumor cells...
  16. ncbi Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Biomed Biotechnol 2010:752381. 2010
    ..We will discuss perspectives for future development of DCs/tumor fusions for CTL induction...
  17. ncbi Double-balloon endoscopy for treatment of long-term abdominal discomfort due to small bowel penetration by an eel bone
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Med Sci Monit 14:CS107-9. 2008
    ..Penetration of the GI tract by a fish bone was treated by laparotomy. DBE is a useful procedure for removal of a foreign body from the small bowel...
  18. ncbi Obstructing small bowel bezoars due to an agar diet: diagnosis using double balloon enteroscopy
    Taro Osada
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Intern Med 47:617-20. 2008
    ..The bezoars were elastic hard, crystallized objects. These bezoars were considered to have formed from highly-concentrated, dissolvable agar...
  19. ncbi Helicobacter pylori is a fragile bacteria when stored at low and ultra-low temperatures
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University School of Medicine, Division of Animal Center, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 19:200-4. 2004
    ..3 for E. coli and 9.1 +/- 0.4, 8.7 +/- 0.6, 8.6 +/- 0.5, and 8.8 +/- 0.3 for B. distasonis. CONCLUSIONS: Helicobacter pylori is a fragile bacteria for storage at low and ultra-low temperatures in comparison with other intestinal bacteria...
  20. ncbi Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study
    Mashu Aizawa
    Department of Gastroenterology and Hepatology, Kashiwa Hospital, Kashiwa, Japan
    Intern Med 49:1067-72. 2010
    ..The aim of this study was to investigate the outcome of overlap/switch to adefovir dipivoxil (ADV) monotherapy for chronic hepatitis B (CHB) patients with lamivudine (LAM)-resistant HBV, who responded to LAM plus ADV combination therapy...
  21. ncbi [Diagnosis of Helicobacter pylori infection: comparison with gold standard]
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 56:1007-13. 2008
    ..pylori infection. This review provides a general overview of the diagnostic methods and tests the characteristics (sensitivity and specificity) for H. pylori infection...
  22. ncbi Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis
    Daisuke Asaoka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Gastroenterol 40:781-90. 2005
    ..The aim of this study was to investigate the distribution and expression pattern of tight-junction proteins in the esophageal mucosa of control rats and rats with reflux esophagitis...
  23. ncbi Highly active antiretroviral therapy improved persistent lamivudine-resistant viremia in acute hepatitis B virus genotype Ae infection with coinfection of human immunodeficiency virus
    Mashu Aizawa
    Department of Gastroenterology and Hepatology, Kashiwa Hospital, Tokyo, Japan
    Hepatol Res 40:229-35. 2010
    ....
  24. ncbi Location of early colorectal cancers at fold-top may reduce the risk of lymph node metastasis
    Wensheng Pan
    Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
    Dis Colon Rectum 49:579-87. 2006
    ..Clinically, these results provide evidence of a new indicator of endoscopic mucosal resection for early colorectal cancers at the fold-top...
  25. ncbi Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis
    Yo Aoyagi
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 52:729-34. 2010
    ..We attempted to demonstrate whether the functional imbalance between TLRs and PPARγ could lead to the onset and some polymorphisms of those genes could contribute to susceptibility to IBD...
  26. ncbi Identification of bacteria from blood in febrile patients with ulcerative colitis by terminal restriction fragment length polymorphism profile analysis of 16S rRNA gene
    Akira Harada
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 43:423-30. 2008
    ..The aim of this study was to detect bacteremia in febrile patients with ulcerative colitis (UC) using a new molecular approach...
  27. ncbi Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 17:849-53. 2002
    ..varium and ulcerative colitis...
  28. ncbi N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease
    Kan Uchiyama
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Kashiwa Hospital, Chiba, Japan
    Inflamm Bowel Dis 16:1696-707. 2010
    ..We investigated the influence of diet therapy involving the use of an "n-3 PUFA food exchange table" (n-3DP) on the fatty acid composition of the erythrocyte membranes of IBD patients and its remission-maintaining effects...
  29. ncbi Cancer vaccine by fusions of dendritic and cancer cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 277 8567, Japan shigeo
    Clin Dev Immunol 2009:657369. 2009
    ..This review summarizes recent advances in concepts and techniques that are providing new impulses to DCs/tumor fusions-based cancer vaccination...
  30. ncbi Improvement of reflux symptoms 3 years after cure of Helicobacter pylori infection: a case-controlled study in the Japanese population
    Hiroto Miwa
    Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan
    Helicobacter 7:219-24. 2002
    ..However, a significantly greater number of case group patients than control subjects gained weight. CONCLUSION: Reflux symptoms as well as general well-being were significantly improved after cure of H. pylori infection...
  31. ncbi High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients
    Makoto Umeda
    Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontol 74:129-34. 2003
    ..The purpose of this study was to use nested polymerase chain reaction (PCR) to clarify whether the oral cavity acts as a reservoir for H. pylori...
  32. ncbi Four-week pegylated interferon alpha-2a monotherapy for chronic hepatitis C with genotype 2 and low viral load: a pilot, randomized study
    Akihito Tsubota
    Institute of Clinical Medicine and Research, Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba 277 8567, Japan
    World J Gastroenterol 14:7220-4. 2008
    ..To assess the efficacy and advantages of 4-wk pegylated interferon alpha-2a (peg-IFN-alpha 2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response (SVR)...
  33. ncbi Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells
    Toshiaki Sakurazawa
    First Department of Internal Medicine, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    J Gastroenterol 40:600-9. 2005
    ..This cytotoxicity may contribute to the pathogenesis of colonic ulcers...
  34. ncbi Antibacterial and antimycobacterial treatment for inflammatory bowel disease
    Toshifumi Ohkusa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 20:340-51. 2005
    ..Recently, treatments have focused on Gram-negative anaerobes and mycobacteria. The present paper briefly reviews antimicrobial and antimycobacterial treatments in inflammatory bowel disease...
  35. ncbi Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication: a multicenter study of 4940 patients
    Hiroto Miwa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Helicobacter 9:9-16. 2004
    ..CONCLUSIONS: Curative treatment of H. pylori infection is useful in preventing ulcer recurrence. Gastric ulcer is more likely to relapse than duodenal ulcer. Recurrent ulcer tended to recur at the site of the original ulcers...
  36. ncbi In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells
    Shigeo Koido
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Transl Med 6:51. 2008
    ..In this study, generation of cytotoxic T lymphocytes (CTL) and regulatory T cells (Treg) by fusions of dendritic cells (DCs) and HCC cells was examined...