Takahiro Kimura

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. doi request reprint Expression of ERG oncoprotein is associated with a less aggressive tumor phenotype in Japanese prostate cancer patients
    Takahiro Kimura
    Department of Urology, Path Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 62:742-8. 2012
  2. pmc Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors
    Hiroshi Matsumoto
    Magee Womens Research Institute, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    BMC Gastroenterol 10:44. 2010
  3. doi request reprint A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient
    Takahiro Kimura
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Prostate 69:1660-7. 2009
  4. ncbi request reprint The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas
    T Kimura
    Department of Urology, Institute of DNA Medicine, Jikei University, School of Medicine, Tokyo, Japan
    Cancer 92:2555-61. 2001
  5. pmc Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer
    Hidetoshi Kuruma
    Department of Urology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Am J Pathol 174:2044-50. 2009
  6. doi request reprint Upfront transection and subsequent ligation of the dorsal vein complex during laparoscopic radical prostatectomy
    Hiroshi Sasaki
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Int J Urol 17:960-1. 2010
  7. ncbi request reprint Replication of prostate cancer risk loci in a Japanese case-control association study
    Hiroki Yamada
    Department of Urology, Jikei University School ofMedicine, Tokyo, Japan
    J Natl Cancer Inst 101:1330-6. 2009
  8. doi request reprint Patterns of failure and influence of potential prognostic factors after surgery in transitional cell carcinoma of the upper urinary tract
    Tatsuya Shimomura
    Department of Urology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Int J Clin Oncol 14:213-8. 2009
  9. ncbi request reprint Mid-term outcome of permanent prostate iodine-125 brachytherapy in Japanese patients
    Takahiro Kimura
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Int J Urol 21:473-8. 2014
  10. doi request reprint Immunohistochemical ETS-related gene detection in a Japanese prostate cancer cohort: diagnostic use in Japanese prostate cancer patients
    Bungo Furusato
    Departments of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 61:409-14. 2011

Detail Information

Publications23

  1. doi request reprint Expression of ERG oncoprotein is associated with a less aggressive tumor phenotype in Japanese prostate cancer patients
    Takahiro Kimura
    Department of Urology, Path Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 62:742-8. 2012
    ..ERG expression was associated with a less aggressive tumor phenotype, and its biological significance needs to be further investigated...
  2. pmc Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors
    Hiroshi Matsumoto
    Magee Womens Research Institute, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    BMC Gastroenterol 10:44. 2010
    ....
  3. doi request reprint A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient
    Takahiro Kimura
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Prostate 69:1660-7. 2009
    ....
  4. ncbi request reprint The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas
    T Kimura
    Department of Urology, Institute of DNA Medicine, Jikei University, School of Medicine, Tokyo, Japan
    Cancer 92:2555-61. 2001
    ..In view of these findings, the authors investigated the incidence of TD mutations in the FGFR3 gene in a large series of bladder carcinomas to clarify their role in the progression of bladder carcinoma...
  5. pmc Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer
    Hidetoshi Kuruma
    Department of Urology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Am J Pathol 174:2044-50. 2009
    ..As SND1 mRNA was overexpressed in cancer cells, the growth of these cells was suppressed following SND1 knockdown in vitro, thus representing a promising prostate cancer biomarker and therapeutic target...
  6. doi request reprint Upfront transection and subsequent ligation of the dorsal vein complex during laparoscopic radical prostatectomy
    Hiroshi Sasaki
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Int J Urol 17:960-1. 2010
    ..A stitch in a Z-shaped fashion is then applied to the entire transected stump of the DVC. This procedure is simple and easily performed, even by those with limited experience. Here we provide an overview of our current technique...
  7. ncbi request reprint Replication of prostate cancer risk loci in a Japanese case-control association study
    Hiroki Yamada
    Department of Urology, Jikei University School ofMedicine, Tokyo, Japan
    J Natl Cancer Inst 101:1330-6. 2009
    ..The effect of these risk variants and their cumulative effect in other populations are unknown...
  8. doi request reprint Patterns of failure and influence of potential prognostic factors after surgery in transitional cell carcinoma of the upper urinary tract
    Tatsuya Shimomura
    Department of Urology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Int J Clin Oncol 14:213-8. 2009
    ..We investigated the long-term outcome of upper urinary tract transitional cell carcinoma (TCC) after surgery...
  9. ncbi request reprint Mid-term outcome of permanent prostate iodine-125 brachytherapy in Japanese patients
    Takahiro Kimura
    Department of Urology, Jikei University School of Medicine, Tokyo, Japan
    Int J Urol 21:473-8. 2014
    ..To analyze mid-term oncological outcomes of low-dose rate brachytherapy in Japanese patients...
  10. doi request reprint Immunohistochemical ETS-related gene detection in a Japanese prostate cancer cohort: diagnostic use in Japanese prostate cancer patients
    Bungo Furusato
    Departments of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 61:409-14. 2011
    ....
  11. doi request reprint Lateral view dissection of the prostato-urethral junction to reduce positive apical margin in laparoscopic radical prostatectomy
    Hiroshi Sasaki
    Department of Urology, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Int J Urol 16:664-9. 2009
    ..To assess the impact of lateral view apical dissection in laparoscopic radical prostatectomy (LRP) on the reduction of positive surgical margin rates and recovery of postoperative continence...
  12. ncbi request reprint [Clinical study of laparoscopic adrenalectomy for adrenal pheochromocytoma]
    Nozomu Furuta
    Department of Urology, Jikei University, School of Medicine
    Hinyokika Kiyo 55:245-8. 2009
    ....
  13. pmc Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer
    Katri A Leinonen
    Authors Affiliations Institute of Biomedical Technology and Institute of Signal Processing, Prostate Cancer Research Center, BioMediTech, Department of Urology, School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland Departments of Pathology and Urology, Jikei University School of Medicine, Minato ku, Tokyo Department of Urology, Toho University Sakura Medical Center, Sakura, Chiba, Japan Departments of Pathology and Urology, Johns Hopkins University, Baltimore, Maryland and Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 22:2333-44. 2013
    ..We assessed the association of ERG expression with AR, PTEN, SPINK1, Ki-67, and EZH2 expression levels, deletion, and mutations of chromosomal region 3p14 and TP53, and clinicopathologic variables...
  14. ncbi request reprint [New biomarkers for the prostate cancer]
    Gen Ishii
    Department Urology, School of Medicine, Jikei University
    Nihon Rinsho 70:828-32. 2012
    ..Moreover, we introduced our proteomic-based findings in our search for new prostate cancer biomarkers...
  15. ncbi request reprint [Prostate histopathology of NIH category IV prostatitis detected by sextant prostate needle biopsy from the patients with high prostatic specific antigen]
    Tatsuya Shimomura
    Department of Urology, Jikei University, School of Medicine
    Kansenshogaku Zasshi 77:611-7. 2003
    ..However, we should pay attention to the presence of prostate cancer, because a small number of the patients were diagnosed as prostate cancer, later...
  16. ncbi request reprint [Retrospective analysis of uroepithelial malignancies detected in the renal pelvis and ureter over the past decade at the Jikei University Hospital]
    Isao Ikemoto
    Department of Urology, Jikei University School of Medicine
    Hinyokika Kiyo 49:451-6. 2003
    ..We conclude that the cancer grade and stage still have classical predictive value, but that the presence of symptoms at the time of diagnosis is also an important prognostic factor...
  17. ncbi request reprint Antitumor immunity against bladder cancer induced by ex vivo expression of CD40 ligand gene using retrovirus vector
    Takahiro Kimura
    Department of Urology, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, Japan
    Cancer Gene Ther 10:833-9. 2003
    ..These data demonstrated that the antitumor immunity induced by CD40L was effective in the vaccination model and suggested that immunogene therapy using CD40L may be a new strategy of systemic therapy against bladder cancer...
  18. ncbi request reprint [A case of complete self-mutilation of penis]
    Masayuki Tomita
    Department of Urology, Jikei University School of Medicine
    Hinyokika Kiyo 48:247-9. 2002
    ..The patient was treated by a psychiatrist under a diagnosis of alcoholic dementia. To our knowledge, this is the 24th case of self-mutilation of the penis reported in the Japanese literature...
  19. ncbi request reprint Extracorporeal shock wave treatment for Peyronie's disease using EDAP LT-02; preliminary results
    Hiroshi Kiyota
    Department of Urology, Jikei University, School of Medicine, Tokyo, Japan
    Int J Urol 9:110-3. 2002
  20. doi request reprint Neonatal gene transfer using lentiviral vector for murine Pompe disease: long-term expression and glycogen reduction
    S O Kyosen
    Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Gene Ther 17:521-30. 2010
    ..Therefore, we show that LV-mediated delivery system was effective in correcting the biochemical abnormalities and that this gene transfer system might be suitable for further studies on delivering GAA to Pompe disease mouse models...
  21. doi request reprint Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
    ..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...
  22. pmc Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer
    T Kato
    Department of Surgery II, School of Medicine, Tokyo Women s Medical University, 8 1 Kawadacho, Shinjuku ku, Tokyo 162 8666, Japan
    Br J Cancer 97:1277-86. 2007
    ..04, P=0.01, respectively). The present study shows that MVD contributes to the Japanese-British disparity in breast cancer. However, the MVD variability did not explain the survival differences between Japanese and British patients...
  23. ncbi request reprint Point-mutations related to the loss of batrachotoxin binding abolish the grayanotoxin effect in Na(+) channel isoforms
    H Ishii
    Department of Physiology, School of Medicine, Hiroshima University, Hiroshima, 734 8551, Japan
    Jpn J Physiol 49:457-61. 1999
    ..All the mutants lost their sensitivity to GTX. This finding indicates that GTX may share a binding site with BTX in transmembrane segment I-S6 of two different Na(+) channel isoforms, micro1 and RH1...