Kimiyoshi Ichida

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II
    K Ichida
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8461, Japan
    Biochem Biophys Res Commun 282:1194-200. 2001
  2. ncbi request reprint A Turkish case with molybdenum cofactor deficiency
    K Ichida
    Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 25:1087-91. 2006
  3. ncbi request reprint Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:164-73. 2004
  4. ncbi request reprint [Usefulness of combination treatment using allopurinol and benzbromarone for gout and hyperuricemia accompanying renal dysfunction: kinetic analysis of oxypurinol]
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 50:506-12. 2008
  5. ncbi request reprint Urate transport via human PAH transporter hOAT1 and its gene structure
    Kimiyoshi Ichida
    Department of Internal Medicine, Jikei University School of Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 63:143-55. 2003
  6. ncbi request reprint Sevelamer decreases serum uric acid concentration through adsorption of uric acid in maintenance hemodialysis patients
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 48:415-20. 2009
  7. ncbi request reprint [Urate transport in human kidney]
    Hiroaki Kimura
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
    Nihon Rinsho 61:119-23. 2003
  8. ncbi request reprint Function and localization of urate transporter 1 in mouse kidney
    Makoto Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:261-8. 2004
  9. ncbi request reprint Effect of fenofibrate on uric acid metabolism and urate transporter 1
    Daijiro Uetake
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 49:89-94. 2010
  10. ncbi request reprint [Hereditary xanthinuria and molybdenum cofactor deficiency]
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Jikei University School of Medicine
    Nihon Rinsho 61:377-82. 2003

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II
    K Ichida
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8461, Japan
    Biochem Biophys Res Commun 282:1194-200. 2001
    ..These results indicate that a functional defect of the HMCS gene is responsible for classical xanthinuria type II, and that HMCS protein functions to provide a sulfur atom for the molybdenum cofactor of XDH and AO...
  2. ncbi request reprint A Turkish case with molybdenum cofactor deficiency
    K Ichida
    Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 25:1087-91. 2006
    ..The insertion is located in the loop connecting the fifth beta strand to the sixth alpha helices of the TIM barrel structure. This arginine insertion would induce the conformation change and the lack of the activity...
  3. ncbi request reprint Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:164-73. 2004
    ..The findings indicate that SLC22A12 was responsible for most renal hypouricemia and that URAT1 is the primary reabsorptive urate transporter, targeted by pyrazinamide, benzbromarone, and probenecid in vivo...
  4. ncbi request reprint [Usefulness of combination treatment using allopurinol and benzbromarone for gout and hyperuricemia accompanying renal dysfunction: kinetic analysis of oxypurinol]
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 50:506-12. 2008
    ....
  5. ncbi request reprint Urate transport via human PAH transporter hOAT1 and its gene structure
    Kimiyoshi Ichida
    Department of Internal Medicine, Jikei University School of Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Kidney Int 63:143-55. 2003
    ..Whether urate is transported by the PAH transporter in humans remains unclear. Familial juvenile gouty nephropathy (FJGN) is thought to develop as a result of an abnormality in the urate transporter...
  6. ncbi request reprint Sevelamer decreases serum uric acid concentration through adsorption of uric acid in maintenance hemodialysis patients
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 48:415-20. 2009
    ..In this study we verify the urate-lowering effect of sevelamer in Japan in which the hemodialysis environment is different from that of western countries, and we also clarify the urate-lowering mechanism of sevelamer...
  7. ncbi request reprint [Urate transport in human kidney]
    Hiroaki Kimura
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
    Nihon Rinsho 61:119-23. 2003
  8. ncbi request reprint Function and localization of urate transporter 1 in mouse kidney
    Makoto Hosoyamada
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:261-8. 2004
    ..RST mRNA and protein levels were higher in male kidneys than female. RST transported urate similar to hURAT1 and, therefore, appears to be mURAT1-the mouse homologue of hURAT1...
  9. ncbi request reprint Effect of fenofibrate on uric acid metabolism and urate transporter 1
    Daijiro Uetake
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 49:89-94. 2010
    ..To examine the effects of fenofibrate, an antilipotropic drug, on uric acid metabolism in healthy male subjects and on urate transporter 1 (URAT1)...
  10. ncbi request reprint [Hereditary xanthinuria and molybdenum cofactor deficiency]
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Jikei University School of Medicine
    Nihon Rinsho 61:377-82. 2003
  11. ncbi request reprint [Primary underproductive hypouricemia]
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Jikei University School of Medicine
    Nihon Rinsho 61:364-7. 2003
  12. ncbi request reprint Frequency of gouty arthritis in patients with end-stage renal disease in Japan
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 44:706-9. 2005
    ..The purpose of this study was to investigate gouty arthritis in Japanese patients with end-stage renal disease (ESRD)...
  13. doi request reprint Production and characterization of transgenic mice harboring mutant human UMOD gene
    Yuichi Takiue
    Department of Pharmacotherapeutics, Kyoritsu University of Pharmacy, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 27:596-600. 2008
    ..Moreover, the creatinine clearance was not different between wildtype and transgenic animals. Consequently, the onset of the disease was not observed in transgenic mice until 24 weeks of age...
  14. ncbi request reprint [Hyperuricemic nephropathy: Pathogenesis, pathophysiology, and therapy]
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
    Nihon Rinsho 64:438-41. 2006
  15. doi request reprint Increased expression of SLC2A9 decreases urate excretion from the kidney
    Toru Kimura
    Department of Pharmacology and Toxicology, School of Medicine, Kyorin University, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 30:1295-301. 2011
    ..Our results suggest that hyperfunctioning URATv1 in the kidney can lead to increased urate reabsorption and may contribute to the development of hyperuricemia...
  16. doi request reprint Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in man
    Tatsuo Hosoya
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 30:1001-10. 2011
    ..In this symposium, the interaction between various specialties formed an excellent basis for translational research between these specialties but also from the bench to the clinic...
  17. ncbi request reprint Relationship between hyperuricemia and body fat distribution
    Miho Hikita
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 46:1353-8. 2007
    ..We investigated the relationship between serum uric acid (SUA) and body fat area, serum lipid level, insulin resistance, and metabolic syndrome in Japanese men...
  18. pmc Decreased extra-renal urate excretion is a common cause of hyperuricemia
    Kimiyoshi Ichida
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachiouji, Tokyo 192 0392, Japan
    Nat Commun 3:764. 2012
    ....
  19. ncbi request reprint Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
    Hiroaki Kimura
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikeikai University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 301:293-8. 2002
    ....
  20. ncbi request reprint Concentration-dependent inhibitory effect of irbesartan on renal uric acid transporters
    Makiko Nakamura
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    J Pharmacol Sci 114:115-8. 2010
    ..The inhibitory effects of irbesartan exceeded those of losartan and other ARBs, and the results suggest that irbesartan can reduce serum uric acid level...
  21. ncbi request reprint Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
    Yuichiro Yamaguchi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
    J Biochem 141:513-24. 2007
    ..Unlike wild-type XOR, the mutants were not subject to time-dependent inhibition by allopurinol...
  22. ncbi request reprint [Xanthine dehydrogenase (xanthine oxidase)]
    Kimiyoshi Ichida
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
    Nihon Rinsho 61:98-102. 2003
  23. doi request reprint Altered D: -methionine kinetics in rats with renal impairment
    Hiroshi Hasegawa
    Department of Pathophysiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192 0392, Japan
    Amino Acids 40:1205-11. 2011
    ..The elimination behavior of D: -[²H₃]methionine observed in rats demonstrated that kidney was the principal organ responsible for chiral inversion of D: -methionine...
  24. ncbi request reprint Familial juvenile gouty nephropathy: exclusion of 16p12 from the candidate locus
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephron 92:573-5. 2002
    ..We analyzed the localization of the responsible gene for FJGN concerning the chromosomal region of 16p12 using parametric linkage analysis in our FJGN...
  25. doi request reprint Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese
    K Ichida
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Clin Genet 74:243-51. 2008
    ..Thus, this mutation found in Japanese patients was originally brought by immigrant(s) from the continent and thereafter expanded in the Japanese population either by founder effects or by genetic drift (or both)...
  26. ncbi request reprint Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria
    Faysal Gok
    Department of Pediatric Nephrology, Gulhane Military Medical School, Ankara, Turkey
    Nephrol Dial Transplant 18:2278-83. 2003
    ..Both types present mainly with renal stones and lead to renal failure in some cases. We studied the molecular basis of xanthinuria in a Turkish family with two affected siblings...
  27. ncbi request reprint Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution...
  28. ncbi request reprint Successful living-related kidney transplantation in hereditary renal hypouricaemia
    Izumi Yamamoto
    Nephrol Dial Transplant 21:2041. 2006
  29. ncbi request reprint [Molecular mechanism in biological transport in the kidney: Urate transporter URAT1]
    Makoto Hosoyamada
    Department of Pharmacotherapeutics, Kyoritsu University of Pharmacy
    Nihon Rinsho 64:176-9. 2006
  30. ncbi request reprint [Hypouricemia]
    Kimiyoshi Ichida
    Nihon Naika Gakkai Zasshi 95:894-8. 2006
  31. doi request reprint Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181 8611 Tokyo, Japan
    J Biol Chem 283:26834-8. 2008
    ....
  32. ncbi request reprint Human uric acid transporter 1 gene analysis in familial renal hypo-uricemia associated with exercise-induced acute renal failure
    Yasufumi Ohtsuka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan
    Pediatr Int 49:235-7. 2007
  33. ncbi request reprint [New antihyperuricemic medicine: febuxostat, Puricase, etc]
    Kimiyoshi Ichida
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences
    Nihon Rinsho 66:759-65. 2008
    ..Polyethylene glycol (PEG) conjugation with recombinant uricase sufficiently reduces the immunogenicity to permit repeated dosing and the clinical trials are ongoing for patients with treatment-failure gout and hyperuricemia...
  34. ncbi request reprint Molybdenum cofactor deficiency: clinical features in a Turkish patient
    Huseyin Per
    Erciyes University Medical Faculty, Department of Pediatric Neurology, Talas Kayseri, Turkey
    Brain Dev 29:365-8. 2007
    ..We reported here an infant with MoCD who presented with hypoxic ischaemic encephalopathy and identified a novel mutation, c.130C>T in cDNA of the MOCS2 gene from the infant...