Research Topics
Genomes and Genes | Kimiyoshi IchidaSummaryAffiliation: Jikei University School of Medicine Country: Japan Publications
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Publications
Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type IIK Ichida
Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8461, Japan
Biochem Biophys Res Commun 282:1194-200. 2001..These results indicate that a functional defect of the HMCS gene is responsible for classical xanthinuria type II, and that HMCS protein functions to provide a sulfur atom for the molybdenum cofactor of XDH and AO...- A Turkish case with molybdenum cofactor deficiencyK Ichida
Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan
Nucleosides Nucleotides Nucleic Acids 25:1087-91. 2006..The insertion is located in the loop connecting the fifth beta strand to the sixth alpha helices of the TIM barrel structure. This arginine insertion would induce the conformation change and the lack of the activity... - Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretionKimiyoshi Ichida
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
J Am Soc Nephrol 15:164-73. 2004..The findings indicate that SLC22A12 was responsible for most renal hypouricemia and that URAT1 is the primary reabsorptive urate transporter, targeted by pyrazinamide, benzbromarone, and probenecid in vivo... - [Usefulness of combination treatment using allopurinol and benzbromarone for gout and hyperuricemia accompanying renal dysfunction: kinetic analysis of oxypurinol]Iwao Ohno
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Nihon Jinzo Gakkai Shi 50:506-12. 2008.... - Urate transport via human PAH transporter hOAT1 and its gene structureKimiyoshi Ichida
Department of Internal Medicine, Jikei University School of Medicine, Kyorin University School of Medicine, Tokyo, Japan
Kidney Int 63:143-55. 2003..Whether urate is transported by the PAH transporter in humans remains unclear. Familial juvenile gouty nephropathy (FJGN) is thought to develop as a result of an abnormality in the urate transporter... - Sevelamer decreases serum uric acid concentration through adsorption of uric acid in maintenance hemodialysis patientsIwao Ohno
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
Intern Med 48:415-20. 2009..In this study we verify the urate-lowering effect of sevelamer in Japan in which the hemodialysis environment is different from that of western countries, and we also clarify the urate-lowering mechanism of sevelamer... - [Urate transport in human kidney]Hiroaki Kimura
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Nippon Rinsho 61:119-23. 2003 - Function and localization of urate transporter 1 in mouse kidneyMakoto Hosoyamada
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
J Am Soc Nephrol 15:261-8. 2004..RST mRNA and protein levels were higher in male kidneys than female. RST transported urate similar to hURAT1 and, therefore, appears to be mURAT1-the mouse homologue of hURAT1... - Effect of fenofibrate on uric acid metabolism and urate transporter 1Daijiro Uetake
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
Intern Med 49:89-94. 2010..To examine the effects of fenofibrate, an antilipotropic drug, on uric acid metabolism in healthy male subjects and on urate transporter 1 (URAT1)... - [Hereditary xanthinuria and molybdenum cofactor deficiency]Kimiyoshi Ichida
Division of Kidney and Hypertension, Jikei University School of Medicine
Nippon Rinsho 61:377-82. 2003 - [Primary underproductive hypouricemia]Kimiyoshi Ichida
Division of Kidney and Hypertension, Jikei University School of Medicine
Nippon Rinsho 61:364-7. 2003 - Frequency of gouty arthritis in patients with end-stage renal disease in JapanIwao Ohno
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
Intern Med 44:706-9. 2005.... - Production and characterization of transgenic mice harboring mutant human UMOD geneYuichi Takiue
Department of Pharmacotherapeutics, Kyoritsu University of Pharmacy, Tokyo, Japan
Nucleosides Nucleotides Nucleic Acids 27:596-600. 2008..Moreover, the creatinine clearance was not different between wildtype and transgenic animals. Consequently, the onset of the disease was not observed in transgenic mice until 24 weeks of age... - [Hyperuricemic nephropathy: Pathogenesis, pathophysiology, and therapy]Kimiyoshi Ichida
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Nippon Rinsho 64:438-41. 2006 - Increased expression of SLC2A9 decreases urate excretion from the kidneyToru Kimura
Department of Pharmacology and Toxicology, School of Medicine, Kyorin University, Tokyo, Japan
Nucleosides Nucleotides Nucleic Acids 30:1295-301. 2011..Our results suggest that hyperfunctioning URATv1 in the kidney can lead to increased urate reabsorption and may contribute to the development of hyperuricemia... - Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in manTatsuo Hosoya
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Nucleosides Nucleotides Nucleic Acids 30:1001-10. 2011..In this symposium, the interaction between various specialties formed an excellent basis for translational research between these specialties but also from the bench to the clinic... - Relationship between hyperuricemia and body fat distributionMiho Hikita
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
Intern Med 46:1353-8. 2007..We investigated the relationship between serum uric acid (SUA) and body fat area, serum lipid level, insulin resistance, and metabolic syndrome in Japanese men... 
Decreased extra-renal urate excretion is a common cause of hyperuricemiaKimiyoshi Ichida
1 Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachiouji, Tokyo 192 0392, Japan 2 Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 19 18 Shinbashi, Minato ku, Tokyo 105 8471, Japan 3
Nat Commun 3:764. 2012....- Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandinsHiroaki Kimura
Division of Nephrology and Hypertension, Department of Internal Medicine, Jikeikai University School of Medicine, Tokyo, Japan
J Pharmacol Exp Ther 301:293-8. 2002.... - Concentration-dependent inhibitory effect of irbesartan on renal uric acid transportersMakiko Nakamura
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
J Pharmacol Sci 114:115-8. 2010..The inhibitory effects of irbesartan exceeded those of losartan and other ARBs, and the results suggest that irbesartan can reduce serum uric acid level... - Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrateYuichiro Yamaguchi
Department of Biochemistry and Molecular Biology, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
J Biochem 141:513-24. 2007..Unlike wild-type XOR, the mutants were not subject to time-dependent inhibition by allopurinol... - [Xanthine dehydrogenase (xanthine oxidase)]Kimiyoshi Ichida
Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Nippon Rinsho 61:98-102. 2003 - Altered D: -methionine kinetics in rats with renal impairmentHiroshi Hasegawa
Department of Pathophysiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192 0392, Japan
Amino Acids 40:1205-11. 2011..The elimination behavior of D: -[²H₃]methionine observed in rats demonstrated that kidney was the principal organ responsible for chiral inversion of D: -methionine... - Familial juvenile gouty nephropathy: exclusion of 16p12 from the candidate locusIwao Ohno
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Nephron 92:573-5. 2002..We analyzed the localization of the responsible gene for FJGN concerning the chromosomal region of 16p12 using parametric linkage analysis in our FJGN... - Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in JapaneseK Ichida
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
Clin Genet 74:243-51. 2008..Thus, this mutation found in Japanese patients was originally brought by immigrant(s) from the continent and thereafter expanded in the Japanese population either by founder effects or by genetic drift (or both)... - Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuriaFaysal Gok
Department of Pediatric Nephrology, Gulhane Military Medical School, Ankara, Turkey
Nephrol Dial Transplant 18:2278-83. 2003..This raises the point that individuals with a heterozygous XDH mutation may also present with renal stones... - Molecular identification of a renal urate anion exchanger that regulates blood urate levelsAtsushi Enomoto
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
Nature 417:447-52. 2002..Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution... - Successful living-related kidney transplantation in hereditary renal hypouricaemiaIzumi Yamamoto
Nephrol Dial Transplant 21:2041. 2006 - [Molecular mechanism in biological transport in the kidney: Urate transporter URAT1]Makoto Hosoyamada
Department of Pharmacotherapeutics, Kyoritsu University of Pharmacy
Nippon Rinsho 64:176-9. 2006 - [Hypouricemia]Kimiyoshi Ichida
Nippon Naika Gakkai Zasshi 95:894-8. 2006 - Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humansNaohiko Anzai
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181 8611 Tokyo, Japan
J Biol Chem 283:26834-8. 2008.... - Human uric acid transporter 1 gene analysis in familial renal hypo-uricemia associated with exercise-induced acute renal failureYasufumi Ohtsuka
Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan
Pediatr Int 49:235-7. 2007 - [New antihyperuricemic medicine: febuxostat, Puricase, etc]Kimiyoshi Ichida
Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences
Nihon Rinsho 66:759-65. 2008..Polyethylene glycol (PEG) conjugation with recombinant uricase sufficiently reduces the immunogenicity to permit repeated dosing and the clinical trials are ongoing for patients with treatment-failure gout and hyperuricemia... - Molybdenum cofactor deficiency: clinical features in a Turkish patientHuseyin Per
Erciyes University Medical Faculty, Department of Pediatric Neurology, Talas Kayseri, Turkey
Brain Dev 29:365-8. 2007..We reported here an infant with MoCD who presented with hypoxic ischaemic encephalopathy and identified a novel mutation, c.130C>T in cDNA of the MOCS2 gene from the infant...