Jun Araya

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
  2. ncbi Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
  3. ncbi Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
  4. ncbi Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
  5. ncbi Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
  6. ncbi Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011
  7. ncbi Epithelial cell fate following lung injury
    Kazuyoshi Kuwano
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Expert Rev Respir Med 2:573-82. 2008

Collaborators

  • Kazuyoshi Kuwano
  • Hiromichi Hara
  • Takanori Numata
  • Jun Kojima
  • Katsutoshi Nakayama
  • Toshiaki Morikawa
  • Makoto Kawaishi
  • Makoto Odaka
  • Satoko Fujii
  • Naoki Takasaka
  • Jun Hirano
  • Yoko Yumino
  • Shunsuke Minagawa
  • Takeo Ishikawa
  • Hiroshi Hano
  • Keisuke Saito
  • Kenichiro Shimizu
  • Stephen L Nishimura
  • Chikako Tsurushige
  • Toru Miyazaki
  • Saburo Ito
  • Noriki Kamiya
  • Yumi Kaneko
  • Satoko Arai
  • Kenji Kobayashi
  • Satoko Nojiri

Detail Information

Publications7

  1. ncbi Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
    ..Therapies that act upstream or downstream of TGF-beta activation have the therapeutic potential to treat all fibrogenic responses in the lung...
  2. ncbi Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
    ....
  3. ncbi Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
    ..Concomitant loss of enzymatic activity regulating energy homeostasis may lead to the acceleration of bronchial epithelial cell senescence, which is implicated in the pathogenesis of COPD...
  4. ncbi Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
    ..Accordingly, we attempt to determine if AIM is expressed in AM and whether AIM is involved in the regulation of apoptosis in the setting of cigarette smoke extract (CSE) exposure...
  5. ncbi Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
    ..These results indicate the significance of TLR3-mediated dsRNA-induced apoptosis in the pathogenesis of apoptosis-driven lung disease and provide evidence for a novel protective role of insulin...
  6. ncbi Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011
    ..These findings suggest that accelerated epithelial senescence plays a role in IPF pathogenesis through perpetuating abnormal epithelial-mesenchymal interactions, which can be antagonized by SIRT6...
  7. ncbi Epithelial cell fate following lung injury
    Kazuyoshi Kuwano
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Expert Rev Respir Med 2:573-82. 2008
    ..Further understanding of mechanisms of cell death and its regulation may lead to the development of effective treatments against lung injury...