Jun Araya

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. doi request reprint Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
  2. pmc Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    Satoko Fujii
    Division of Respiratory Diseases Department of Internal Medicine Jikei University School of Medicine Tokyo, Japan
    Oncoimmunology 1:630-641. 2012
  3. doi request reprint Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
  4. doi request reprint Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    Naoki Takasaka
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 192:958-68. 2014
  5. doi request reprint Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
  6. doi request reprint Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Japan
    Am J Physiol Lung Cell Mol Physiol 305:L737-46. 2013
  7. pmc Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
  8. doi request reprint Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
  9. pmc Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011
  10. ncbi request reprint Epithelial cell fate following lung injury
    Kazuyoshi Kuwano
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Expert Rev Respir Med 2:573-82. 2008

Collaborators

  • Kazuyoshi Kuwano
  • Hiromichi Hara
  • Makoto Odaka
  • Jun Kojima
  • Shunsuke Minagawa
  • Takanori Numata
  • Naoki Takasaka
  • Satoko Fujii
  • Makoto Kawaishi
  • Toshiaki Morikawa
  • Yoko Yumino
  • Katsutoshi Nakayama
  • Jun Hirano
  • Stephen L Nishimura
  • Saburo Ito
  • Hiroshi Wakui
  • Yumi Kaneko
  • Yutaka Yoshii
  • Noriki Kamiya
  • Chikako Tsurushige
  • Kenichiro Shimizu
  • Yusuke Kurita
  • Kenji Kobayashi
  • Takeo Ishikawa
  • Stephen Nishimura
  • Satoko Nojiri

Detail Information

Publications11

  1. doi request reprint Fibrogenic reactions in lung disease
    Jun Araya
    Division of Respiratory Disease, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Annu Rev Pathol 5:77-98. 2010
    ..Therapies that act upstream or downstream of TGF-beta activation have the therapeutic potential to treat all fibrogenic responses in the lung...
  2. pmc Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    Satoko Fujii
    Division of Respiratory Diseases Department of Internal Medicine Jikei University School of Medicine Tokyo, Japan
    Oncoimmunology 1:630-641. 2012
    ....
  3. doi request reprint Insufficient autophagy in idiopathic pulmonary fibrosis
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 304:L56-69. 2013
    ....
  4. doi request reprint Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
    Naoki Takasaka
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 192:958-68. 2014
    ..These results suggest that SIRT6 is involved in CSE-induced HBEC senescence via autophagy regulation, which can be attributed to attenuation of IGF-Akt-mTOR signaling. ..
  5. doi request reprint Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Am J Respir Cell Mol Biol 46:306-12. 2012
    ..Concomitant loss of enzymatic activity regulating energy homeostasis may lead to the acceleration of bronchial epithelial cell senescence, which is implicated in the pathogenesis of COPD...
  6. doi request reprint Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
    Hiromichi Hara
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Japan
    Am J Physiol Lung Cell Mol Physiol 305:L737-46. 2013
    ..CSE-induced mitochondrial fragmentation is involved in cellular senescence through the mechanism of mitochondrial ROS production. Hence, disruption of mitochondrial dynamics may be a part of the pathogenic sequence of COPD development...
  7. pmc Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
    Jun Kojima
    Department of Internal Medicine, Division of Respiratory Diseases, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Respir Res 14:30. 2013
    ..Accordingly, we attempt to determine if AIM is expressed in AM and whether AIM is involved in the regulation of apoptosis in the setting of cigarette smoke extract (CSE) exposure...
  8. doi request reprint Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
    ..These results indicate the significance of TLR3-mediated dsRNA-induced apoptosis in the pathogenesis of apoptosis-driven lung disease and provide evidence for a novel protective role of insulin...
  9. pmc Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    Shunsuke Minagawa
    Division of Respiratory Diseases, Dept of Internal Medicine, Jikei Univ School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L391-401. 2011
    ..These findings suggest that accelerated epithelial senescence plays a role in IPF pathogenesis through perpetuating abnormal epithelial-mesenchymal interactions, which can be antagonized by SIRT6...
  10. ncbi request reprint Epithelial cell fate following lung injury
    Kazuyoshi Kuwano
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Expert Rev Respir Med 2:573-82. 2008
    ..Further understanding of mechanisms of cell death and its regulation may lead to the development of effective treatments against lung injury...
  11. ncbi request reprint Autophagy in the pathogenesis of pulmonary disease
    Jun Araya
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Japan
    Intern Med 52:2295-303. 2013
    ..We herein review recent findings regarding the role of autophagy in cellular processes and cell fates and summarize the role that autophagy appears to play in the pathogenesis of pulmonary diseases. ..