T Yada

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
  2. pmc Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus
    Yuko Maejima
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 3:1092-7. 2011
  3. pmc Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
    Yuko Maejima
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    Aging (Albany NY) 3:1169-77. 2011
  4. pmc Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity
    Yusaku Iwasaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    PLoS ONE 8:e67198. 2013
  5. ncbi request reprint Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Pharm Des 19:6960-5. 2013
  6. ncbi request reprint Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Curr Pharm Des 18:4854-64. 2012
  7. ncbi request reprint Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes
    T Yada
    Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Ann N Y Acad Sci 921:473-7. 2000
  8. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
  9. ncbi request reprint Current status of PACAP as a regulator of insulin secretion in pancreatic islets
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Ann N Y Acad Sci 805:329-40; discussion 341-2. 1996
  10. pmc Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    J Physiol 505:319-28. 1997

Collaborators

Detail Information

Publications22

  1. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
    ..These results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses...
  2. pmc Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus
    Yuko Maejima
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 3:1092-7. 2011
    ..Our results suggest that postprandial increase in plasma insulin/ghrelin ratio and insulin inhibition of ghrelin action on ARC NPY neurons cooperate to effectively inhibit the neuron activity and terminate feeding...
  3. pmc Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
    Yuko Maejima
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    Aging (Albany NY) 3:1169-77. 2011
    ..Peripheral Oxt treatment provides a new therapeutic avenue for treating obesity and hyperphagia...
  4. pmc Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity
    Yusaku Iwasaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    PLoS ONE 8:e67198. 2013
    ..Pancreas-innervating NGNs may effectively sense dynamic changes of insulin released in response to nutritional states. These interactions could serve to convey the changes in pancreatic and systemic insulin to the brain...
  5. ncbi request reprint Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain
    Masanori Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Pharm Des 19:6960-5. 2013
    ..Here, we review the by now published studies on nesfatin-1/NUCB2 localization and action in islets and discuss the physiological and pathophysiological roles of the nesfatin-1/NUCB2 in glucose and energy metabolism. ..
  6. ncbi request reprint Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Curr Pharm Des 18:4854-64. 2012
    ....
  7. ncbi request reprint Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes
    T Yada
    Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Ann N Y Acad Sci 921:473-7. 2000
    ..In conclusion, PACAP potentiates not only insulin secretion but also insulin action in adipocytes, thereby exhibiting antidiabetic actions at two important steps of glucose metabolism (Fig. 2)...
  8. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
    ....
  9. ncbi request reprint Current status of PACAP as a regulator of insulin secretion in pancreatic islets
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Ann N Y Acad Sci 805:329-40; discussion 341-2. 1996
    ..Finally, we hypothesize that PACAP is a pancreatic peptide of both neural and islet origin and functions as an intrinsic potentiator of glucose-induced insulin secretion in pancreatic islets (FIG 6)...
  10. pmc Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    J Physiol 505:319-28. 1997
    ....
  11. ncbi request reprint Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus
    M Toriya
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimostuke, Tochigi, Japan
    J Neuroendocrinol 22:987-95. 2010
    ..These results indicate that the CRH-urocortin-CRH-R2 pathway in the PVN and connected areas mediates the long-term effects of BDNF to depress feeding and promote lipolysis...
  12. ncbi request reprint Single pancreatic beta-cells from normal rats exhibit an initial decrease and subsequent increase in cytosolic free Ca2+ in response to glucose
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Cell Calcium 13:69-76. 1992
    ....
  13. ncbi request reprint Young adult-specific hyperphagia in diabetic Goto-kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus
    F Maekawa
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    J Neuroendocrinol 18:748-56. 2006
    ..These results demonstrate that young adult GK rats display hyperphagia in association with leptin resistance and increased NPY mRNA level in the ARC...
  14. ncbi request reprint Intraperitoneal PACAP administration decreases blood glucose in GK rats, and in normal and high fat diet mice
    T Yada
    Department of Physiology, Jichi Medical School, Tochigi, Japan
    Ann N Y Acad Sci 921:259-63. 2000
    ..001) without altering baseline insulin levels. We conclude that PACAP reduces circulating glucose in animal models of type 2 diabetes and glucose intolerance. The mechanism of this action needs to be established...
  15. pmc Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Br J Pharmacol 126:1205-13. 1999
    ..Precaution should be paid to these findings when HMG-CoA reductase inhibitors are used clinically, particularly in patients with type 2 diabetes...
  16. ncbi request reprint Glucose metabolism by rat pancreatic beta-cells produces dual change in cytosolic Ca2+
    T Yada
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Jpn J Physiol 43:S115-8. 1993
    ....
  17. ncbi request reprint Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control
    M Nakata
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Diabetologia 49:1881-92. 2006
    ..Based on these findings, the aim of this study was to investigate the effects of statins on adipocytes, which play pivotal roles in glucose metabolism...
  18. ncbi request reprint Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus
    S Muroya
    Department of Physiology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329-0498, Japan
    Neurosci Lett 309:165-8. 2001
    ..The results demonstrate that glucose-sensitive orexin neurons are present in the LH and that these neurons may play a role in linking the metabolic state in the body to the orexigenic, and could also, awakening signaling in the brain...
  19. pmc The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition
    S Fujitani
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Br J Pharmacol 120:1191-8. 1997
    ..7. The results indicate that A-4166 acts more effectively than sulphonylureas to increase [Ca2+]i in beta-cells during metabolic inhibition...
  20. ncbi request reprint Spontaneous and secretagogue-induced changes in cytosolic free Ca concentration measured by microfluorimetry with fura-2 on single bovine adrenal chromaffin cells
    M Sorimachi
    Department of Physiology, Kagoshima University School of Medicine, Japan
    Jpn J Physiol 39:687-701. 1989
    ....