A Tanaka

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. ncbi request reprint High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8
    A Tanaka
    Department of Pathology, Jichi Medical School, Kawachi, Tochigi, Japan
    Cancer Res 58:2053-6. 1998
  2. pmc Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
    Masako Uchii
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Sunto, Shizuoka, Japan
    Arthritis Res Ther 10:R90. 2008
  3. ncbi request reprint Purification of activins from androgen-independent Shionogi carcinoma cells demonstrates enhanced expression of activin betaB-subunit under androgen-depleted cell conditions in vitro and in vivo
    A Tanaka
    Department of Pathology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    J Cell Physiol 188:194-200. 2001
  4. ncbi request reprint Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system
    A Tanaka
    Department of Pathology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, 329 0498, Tochigi, Japan
    Brain Res 912:105-15. 2001
  5. ncbi request reprint Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions
    Akira Tanaka
    Department of Pathology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Virchows Arch 441:380-4. 2002
  6. ncbi request reprint Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties
    A Tanaka
    Department of Pathology, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 363:226-30. 1995
  7. ncbi request reprint Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells
    M Kobayashi
    Department of Urology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    J Steroid Biochem Mol Biol 77:109-15. 2001
  8. ncbi request reprint Integration of proviral sequences, but not at the common integration sites of the FGF8 locus, in an androgen-dependent mouse mammary Shionogi carcinoma
    K Kuriki
    Department of Pathology, Jichi Medical School, Kawachi, Tochigi, Japan
    Cell Mol Biol (Noisy-le-grand) 46:1147-56. 2000
  9. ncbi request reprint Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors
    K Suzuki
    Department of Urology, Jichi Medical School, Tochigi, Japan
    Virchows Arch 439:616-21. 2001
  10. ncbi request reprint C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal
    S Sakurai
    Department of Pathology, Jichi Medical School, Kawachi gun, Tochigi
    Jpn J Cancer Res 90:1321-8. 1999

Collaborators

  • M Fukayama
  • H Yoshida
  • K Suzuki
  • K Miyamoto
  • K Saito
  • J M Chong
  • K Matsumoto
  • S Sakurai
  • T Sato
  • M Takeda
  • H Sato
  • M Koizumi
  • Y Matsumoto
  • Y Hasegawa
  • N Hanai
  • Y Kobayashi
  • N Minamino
  • Y Hayashi
  • Kazuya Sato
  • K Muroi
  • Norio Takayashiki
  • Kumiko Maruyama-Takahashi
  • Naoki Shimada
  • Hirotoshi Kawata
  • Tomoko Kamiakito
  • Tetsu Akimoto
  • Satsuki Miyata
  • Masako Uchii
  • Hideaki Kusaka
  • Yoshimi Maekawa-Tokuda
  • Kenya Shitara
  • Shiro Akinaga
  • Teruyoshi Imada
  • Toshihiko Ishii
  • Takuya Ogawa
  • K Kuriki
  • Akio Kawakami
  • Masayo Mizogami
  • Natsuyo Noguchi
  • Akiko Fujii
  • M Kobayashi
  • Kentaro Sugano
  • Toshiya Otake
  • Osamu Saito
  • Makoto Inoue
  • Norio Isoda
  • Katsuhiko Nishino
  • Hideaki Takahashi
  • Shigeaki Muto
  • Eiji Kusano
  • Toshihiko Higashizawa
  • T Kamiakito
  • Eiju Watanabe
  • Akira Gomi
  • T Fukasawa
  • Yuichi Tanaka
  • Takashi Yamaguchi
  • Tadafumi Tamura
  • Masakazu Kakuni
  • Toshio Suda
  • Ichiro Miki
  • Jun Ouchi
  • Hiromasa Miyaji
  • Mai Akimaru
  • Norihiro Ishida-Kitagawa
  • Keiichiro Yogo
  • Y Fukasawa
  • Tamayo Hirouchi
  • Takahiro Matsumoto
  • Tatsuo Takeya
  • Masao Tanihara
  • Yuka Sasaki
  • Katsumi Takaba
  • Katsuyuki Nakajima
  • Hiromitsu Nakaya
  • Kentaro Shimokado
  • Kenichi Ohta
  • Masayuki Yoshida
  • Tsuyoshi Chiba
  • Takeshi Fujii
  • Midori Kikuchi
  • Tatsuo Sakurai
  • Shuichi Kawashiri
  • Koroku Kato
  • A Tokue
  • Y Hakamata
  • T Kinouchi
  • M Koike
  • R Ikeno
  • N Koshiishi

Detail Information

Publications25

  1. ncbi request reprint High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8
    A Tanaka
    Department of Pathology, Jichi Medical School, Kawachi, Tochigi, Japan
    Cancer Res 58:2053-6. 1998
    ..These findings strongly suggest that FGF 8 is involved in hormone-related tumorigenesis of the prostate and breast...
  2. pmc Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
    Masako Uchii
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Sunto, Shizuoka, Japan
    Arthritis Res Ther 10:R90. 2008
    ..The aim of the present study was to clarify the role of FGF8 in animal models of osteoarthritis (OA)...
  3. ncbi request reprint Purification of activins from androgen-independent Shionogi carcinoma cells demonstrates enhanced expression of activin betaB-subunit under androgen-depleted cell conditions in vitro and in vivo
    A Tanaka
    Department of Pathology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    J Cell Physiol 188:194-200. 2001
    ..Therefore, expression of activin betaB-subunit, but not its betaA-subunit, is likely to be related with androgen-depleted cell conditions in prostates, and possibly in androgen-related cancers...
  4. ncbi request reprint Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system
    A Tanaka
    Department of Pathology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, 329 0498, Tochigi, Japan
    Brain Res 912:105-15. 2001
    ..Taken together, the present findings strongly suggest that FGF8 acts as a more generalized neurotrophic factor than previously reported...
  5. ncbi request reprint Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions
    Akira Tanaka
    Department of Pathology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Virchows Arch 441:380-4. 2002
    ..These associations support the reported in vitro data demonstrating the regulation of FGF8 by androgens, and also suggest that PSA may be a useful marker for patients with FGF8-expressing breast carcinomas...
  6. ncbi request reprint Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties
    A Tanaka
    Department of Pathology, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 363:226-30. 1995
    ..These in vitro findings suggest that AIGF might be a possible autocrine or paracrine factor in hormone-responsive cancers...
  7. ncbi request reprint Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells
    M Kobayashi
    Department of Urology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    J Steroid Biochem Mol Biol 77:109-15. 2001
    ....
  8. ncbi request reprint Integration of proviral sequences, but not at the common integration sites of the FGF8 locus, in an androgen-dependent mouse mammary Shionogi carcinoma
    K Kuriki
    Department of Pathology, Jichi Medical School, Kawachi, Tochigi, Japan
    Cell Mol Biol (Noisy-le-grand) 46:1147-56. 2000
    ....
  9. ncbi request reprint Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors
    K Suzuki
    Department of Urology, Jichi Medical School, Tochigi, Japan
    Virchows Arch 439:616-21. 2001
    ..Taken together, these findings confirm the involvement of FGF8, FGF4, and FGFR1 in highly proliferative conditions of nonseminomatous germ cell tumors...
  10. ncbi request reprint C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal
    S Sakurai
    Department of Pathology, Jichi Medical School, Kawachi gun, Tochigi
    Jpn J Cancer Res 90:1321-8. 1999
    ..C-kit gene mutations in GIST are not always related to a poor prognosis, but further comparative studies are necessary in Western and Japanese populations...
  11. pmc Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells
    A Tanaka
    Department of Pathology, Osaka University Medical School, Japan
    Proc Natl Acad Sci U S A 89:8928-32. 1992
    ..Thus, it is clear that the androgen-induced growth of SC-3 cells is mediated in an autocrine manner by AIGF, which is secreted by the tumor cells themselves in response to hormonal stimuli...
  12. ncbi request reprint A long course of leukocytopenia and splenomegaly with extramedullary hematopoiesis in the absence of clinically manifested rheumatoid arthritis
    Kazuo Muroi
    Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    J Clin Exp Hematop 50:163-6. 2010
    ..She was almost free of arthralgia one year after splenectomy, although the anti-cyclic citrullinated peptide antibody titers remained high...
  13. doi request reprint Case of unclassified, radiosensitive, malignant neuroepithelial tumor in the temporal lobe of a child
    Satsuki Miyata
    Department of Neurosurgery, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Brain Tumor Pathol 27:45-50. 2010
    ..After 40 Gy radiation, the residual tumor was markedly reduced. Neuroepithelial tumors rarely show such high radiosensitivity, and the reason for the radiosensitivity in the present case may have been the immaturity of the tumor cells...
  14. doi request reprint Steroid treatment in patients with membranous nephropathy and hepatitis B virus surface antigenemia: a report of two cases
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:289-93. 2011
    ..Further studies will be required to determine the optimal timing and appropriate duration of antiviral treatment in such patients requiring long-term immunosuppression...
  15. ncbi request reprint Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor
    T Fukasawa
    Department of Pathology, Jichi Medical School, Minami Kawachi Machi, Kawachi, Tochigi 329 0498, Japan
    Jpn J Cancer Res 91:1241-9. 2000
    ..NF2 contributes as a tumor suppressor in a small subset of GIST. These abnormalities are presumably followed by increased genetic instability...
  16. ncbi request reprint Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II
    Y Fukasawa
    Department of Pathology, Sapporo City General Hospital, Japan
    Pathol Int 48:47-52. 1998
    ..Moreover, the tumor produced IGF-II mRNA as demonstrated by northern blot analysis. Thus, hypoglycemia of this patient was induced by SFT through the production and secretion of IGF-II...
  17. ncbi request reprint Neuroendocrine tissue-specific transcription factor, BETA2/NeuroD, in gastric carcinomas: a comparison with chromogranin A and synaptophysin expressions
    Akiko Fujii
    Department of Pathology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    Pathol Res Pract 199:513-9. 2003
    ..In addition, the negative expression of NeuroD in neuroendocrine carcinomas suggests that other regulatory mechanisms are possibly involved in the development of neuroendocrine carcinoma...
  18. ncbi request reprint Application of the AMeX method to the evaluation of HER-2 status in breast carcinomas: comparison with the results of HercepTest
    Masayo Mizogami
    Division of Pathological Diagnosis, Jichi Medical School Hospital, and Department of Pathology, Jichi Medical School, Tochigi, Japan
    Pathol Int 53:27-9. 2003
    ..Thus, the AMeX method is likely to provide more improved data about the HER-2 status in breast carcinoma specimens...
  19. ncbi request reprint Transcriptional repression of fibroblast growth factor 8 by transforming growth factor-beta in androgen-dependent SC-3 cells
    Norio Takayashiki
    Department of Pathology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    J Steroid Biochem Mol Biol 96:1-12. 2005
    ....
  20. ncbi request reprint Vitamin D3 suppresses the androgen-stimulated growth of mouse mammary carcinoma SC-3 cells by transcriptional repression of fibroblast growth factor 8
    Hirotoshi Kawata
    Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Cell Physiol 207:793-9. 2006
    ..Moreover, VDR repressed the core promoter activity of fgf8 in COS1 cells and in the SC-3 cells. All these findings strongly suggest that vitamin D3 serves as a negative regulator for both androgen-related and fgf8 transcriptions...
  21. doi request reprint A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions
    Kumiko Maruyama-Takahashi
    Antibody Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Chiyoda ku, Tokyo, Japan
    Prostate 68:640-50. 2008
    ..In the present study, we evaluated the anti-tumor activity of KM1334 against androgen-dependent and -independent progression of FGF8b-expressing human prostate cancer xenografts...
  22. ncbi request reprint A novel role of L-serine (L-Ser) for the expression of nuclear factor of activated T cells (NFAT)2 in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis in vitro
    Takuya Ogawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101, Japan
    J Bone Miner Metab 24:373-9. 2006
    ..These results demonstrate a novel role for L-Ser in RANKL-induced osteoclastogenesis in vitro...
  23. ncbi request reprint A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo
    Naoki Shimada
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Tokyo, Japan
    Clin Cancer Res 11:3897-904. 2005
    ..The purpose of this study was to evaluate KM1334 as a therapeutic agent for FGF8-dependent cancer...
  24. ncbi request reprint Remnant lipoprotein-induced smooth muscle cell proliferation involves epidermal growth factor receptor transactivation
    Akio Kawakami
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Building D 256, Bunkyo ku, Tokyo 113 8519, Japan
    Circulation 108:2679-88. 2003
    ..We examined the direct effect of RLPs on the proliferation and signal transduction of SMCs...
  25. ncbi request reprint Effects of fibroblast growth inhibitor on proliferation and metastasis of oral squamous cell carcinoma
    Natsuyo Noguchi
    Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Oral Oncol 39:240-7. 2003
    ..Administration of a fibroblast inhibitor may well be clinically effective for the treatment of oral squamous cell carcinoma...