Kentaro Sugano

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. pmc Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
    Kentaro Sugano
    Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    BMC Gastroenterol 13:54. 2013
  2. pmc Should We Still Subcategorize Helicobacter pylori-Associated Dyspepsia as Functional Disease?
    Kentaro Sugano
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    J Neurogastroenterol Motil 17:366-71. 2011
  3. pmc Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
    Kentaro Sugano
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    J Gastroenterol 47:540-52. 2012
  4. pmc Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:724-35. 2011
  5. ncbi request reprint New diagnostic approaches for early detection of gastric cancer
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School, Fukuoka, Japan
    Dig Dis 22:327-33. 2004
  6. doi request reprint Gastric cancer: pathogenesis, screening, and treatment
    Kentaro Sugano
    Department of Medicine, Jichi Medical University, Yakushiji 3311 1, Shimotsuke City, Tochigi, Japan
    Gastrointest Endosc Clin N Am 18:513-22, ix. 2008
  7. ncbi request reprint Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Japan
    J Gastroenterol 41:954-61. 2006
  8. ncbi request reprint Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway
    Kouji Hama
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 340:742-50. 2006
  9. doi request reprint Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation
    Hiroyuki Mutoh
    Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Biochem J 427:423-34. 2010
  10. ncbi request reprint Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines
    Hiroyoshi Aoki
    Department of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi cho, Kawachi gun, Tochigi 329 0498, Japan
    Am J Physiol Cell Physiol 292:C259-68. 2007

Detail Information

Publications108 found, 100 shown here

  1. pmc Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
    Kentaro Sugano
    Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    BMC Gastroenterol 13:54. 2013
    ..The proton pump inhibitor esomeprazole has been found to be effective for gastroprotection in NSAID users, but few long-term studies have been conducted in Japan...
  2. pmc Should We Still Subcategorize Helicobacter pylori-Associated Dyspepsia as Functional Disease?
    Kentaro Sugano
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    J Neurogastroenterol Motil 17:366-71. 2011
    ..pylori infection as having dyspeptic symptoms. It is time to establish the Asian consensus to declare that H. pylori infection should be separated from functional dyspepsia...
  3. pmc Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
    Kentaro Sugano
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    J Gastroenterol 47:540-52. 2012
    ....
  4. pmc Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:724-35. 2011
    ..This study sought to examine the efficacy of low-dose lansoprazole (15 mg once daily) for the secondary prevention of LDA-associated gastric or duodenal ulcers...
  5. ncbi request reprint New diagnostic approaches for early detection of gastric cancer
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School, Fukuoka, Japan
    Dig Dis 22:327-33. 2004
    ..Other new modalities using a variety of optical devices have been developed but the real value of their utility still remains to be proven in the actual clinical settings...
  6. doi request reprint Gastric cancer: pathogenesis, screening, and treatment
    Kentaro Sugano
    Department of Medicine, Jichi Medical University, Yakushiji 3311 1, Shimotsuke City, Tochigi, Japan
    Gastrointest Endosc Clin N Am 18:513-22, ix. 2008
    ..Endoscopic resection of high-grade dysplasia is also encouraged in the United States not only for proper diagnosis but also for achieving cure without surgical intervention...
  7. ncbi request reprint Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Japan
    J Gastroenterol 41:954-61. 2006
    ..pylori cure are still uncertain. We examined the association of plasma ghrelin levels with gastric ghrelin production and body weight change before and after H. pylori eradication...
  8. ncbi request reprint Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway
    Kouji Hama
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 340:742-50. 2006
    ..These results suggest that Ang II enhances activated PSC proliferation by blocking autocrine TGF-beta1-mediated growth inhibition by inducing Smad7 expression via a PKC-dependent pathway...
  9. doi request reprint Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation
    Hiroyuki Mutoh
    Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Biochem J 427:423-34. 2010
    ..In conclusion, Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach...
  10. ncbi request reprint Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines
    Hiroyoshi Aoki
    Department of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi cho, Kawachi gun, Tochigi 329 0498, Japan
    Am J Physiol Cell Physiol 292:C259-68. 2007
    ..Furthermore, IL-1beta and IL-6 promote PSC activation by enhancing COX-2 expression indirectly through Smad2/3-dependent pathway by increasing TGF-beta1 secretion from PSCs...
  11. pmc Usefulness and safety of 0.4% sodium hyaluronate solution as a submucosal fluid "cushion" for endoscopic resection of colorectal mucosal neoplasms: a prospective multi-center open-label trial
    Shoji Hirasaki
    Department of Internal Medicine, Sumitomo Besshi Hospital, Ehime, Japan
    BMC Gastroenterol 9:1. 2009
    ..To evaluate the usefulness of 0.4% SH as a submucosal injection solution for colorectal endoscopic resection, we conducted an open-label clinical trial on six referral hospitals in Japan...
  12. ncbi request reprint Double-balloon enteroscopy through a Roux-en-Y anastomosis for EMR of an early carcinoma in the afferent duodenal limb
    Akiko Kuno
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School, Yakushiji, Minami Kawachi, Tochigi 329 0498, Japan
    Gastrointest Endosc 60:1032-4. 2004
  13. ncbi request reprint Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Int J Dev Biol 49:867-71. 2005
    ....
  14. ncbi request reprint Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Cancer Res 64:7740-7. 2004
    ..We successfully showed that long-term intestinal metaplasia induces invasive gastric carcinoma. These results indicate that intestinal metaplasia itself plays a significant role in the genesis and progression of gastric carcinoma...
  15. ncbi request reprint Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells
    Hiroyoshi Aoki
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    J Cell Biochem 99:221-8. 2006
    ..In addition, IL-6 activated ERK in PSCs. These data indicate the existence of autocrine loop between IL-6 and TGF-beta1 through ERK- and Smad2/3-dependent pathways in activated PSCs...
  16. ncbi request reprint Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis
    Hiroto Kita
    Department of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke 329 0498, Japan
    J Gastroenterol 41:1053-63. 2006
    ..Distinct genes may be involved in the development of flat adenoma. The aim of this study was to profile gene expression changes in flat adenomas in the colon...
  17. doi request reprint Diagnosis of elevated-type early gastric cancers by the optimal band imaging system
    Mitsuyo Yoshizawa
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Gastrointest Endosc 69:19-28. 2009
    ....
  18. doi request reprint Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane
    Satoshi Shinozaki
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    J Cell Physiol 216:38-46. 2008
    ..These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1...
  19. ncbi request reprint The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School Yakushiji 3311 1, Minamikawachimachi, Kawachigun, Tochigi 329 0498, Japan
    Differentiation 74:313-21. 2006
    ..Based on these results, we hypothesize that Cdx2 is involved in activating Math1 expression in intestinal epithelial cells...
  20. ncbi request reprint Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases
    Hironori Yamamoto
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Clin Gastroenterol Hepatol 2:1010-6. 2004
    ..A specialized system for a new method for enteroscopy, the double-balloon method, was developed. The aim of this study was to evaluate the usefulness of this endoscopic system for small-intestinal disorders...
  21. doi request reprint Identification of the transforming activity of Indian hedgehog by retroviral expression screening
    Hisashi Hatanaka
    Division of Functional Genomics, Jichi Medical University, Tochigi, Japan
    Cancer Sci 101:60-4. 2010
    ..Our data thus implicate a direct role of IHH in the carcinogenesis of BTC with APBDJ...
  22. doi request reprint Diagnosis of endoscopic Barrett's esophagus by transnasal flexible spectral imaging color enhancement
    Hiroyuki Osawa
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Gastroenterol 44:1125-32. 2009
    ....
  23. doi request reprint Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach
    Hirotsugu Sakamoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Scand J Gastroenterol 45:1273-80. 2010
    ..Our aim is to evaluate the expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach...
  24. ncbi request reprint Long-term outcomes for patients with solitary hepatocellular carcinoma treated by laparoscopic microwave coagulation
    Chiaki Kawamoto
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School, Tochigi, Japan
    Cancer 103:985-93. 2005
    ..In the current study, the efficacy of LMC was assessed...
  25. doi request reprint Nonsteroidal anti-inflammatory drug-induced small-bowel lesions identified by double-balloon endoscopy: endoscopic features of the lesions and endoscopic treatments for diaphragm disease
    Yoshikazu Hayashi
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, 329 0498, Japan
    J Gastroenterol 44:57-63. 2009
    ..The aim of this study was to clarify the clinical features of the disease and evaluate the effectiveness of endoscopic balloon dilation therapy for diaphragm disease, using double-balloon endoscopy (DBE)...
  26. doi request reprint Risk factors for recurrent bile duct stones after endoscopic papillary balloon dilation: long-term follow-up study
    Akira Ohashi
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Dig Endosc 21:73-7. 2009
    ..Little is known about the long-term results of endoscopic papillary balloon dilation (EPBD) for bile duct stones...
  27. doi request reprint Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach
    Hiroyuki Mutoh
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    FEBS J 276:5821-31. 2009
    ..In conclusion, transgenic Cdx2 induced endogenous Cdx1 through the binding of Cdx2 to the unmethylated Cdx1 promoter region in the intestinal metaplasia of the Cdx2-transgenic mouse stomach...
  28. doi request reprint Safety and efficacy of double-balloon enteroscopy in pediatric patients
    Naoyuki Nishimura
    Department of Medicine, Jichi Medical University, Tochigi, Japan
    Gastrointest Endosc 71:287-94. 2010
    ..Although double-balloon enteroscopy (DBE) is performed increasingly often in adults, few findings are available on the use of DBE in pediatric patients in the published literature...
  29. doi request reprint Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection
    Hiroyuki Mutoh
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Cancer Sci 101:1783-9. 2010
    ..The present results suggest that intestinal metaplasia and gastric carcinoma themselves induce MCP-1 expression independently of H. pylori infection...
  30. ncbi request reprint Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy
    Yoshikazu Hayashi
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    World J Gastroenterol 11:4861-4. 2005
    ..To clarify clinical features of the NSAID-induced small bowel lesions using a new method of endoscopy...
  31. ncbi request reprint Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine
    Keijiro Sunada
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    World J Gastroenterol 11:1087-9. 2005
    ..To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine...
  32. ncbi request reprint Endoscopic observation of Meckel's diverticulum by double balloon endoscopy: report of five cases
    Satoshi Shinozaki
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    J Gastroenterol Hepatol 23:e308-11. 2008
    ..The aim of this study was to compare endoscopic findings of three hemorrhagic and two non-hemorrhagic Meckel's diverticula in patients with obscure GI bleeding using this novel technique...
  33. ncbi request reprint Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells
    Hiroyoshi Aoki
    Department of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Kawachi gun, Tochigi 329 0498, Japan
    Am J Physiol Cell Physiol 290:C1100-8. 2006
    ..We propose that an autocrine loop exists between TGF-beta(1) and IL-1beta in activated PSCs through Smad3- and ERK-dependent pathways...
  34. ncbi request reprint Technical modification of the double-balloon endoscopy to access to the proximal side of the stenosis in the distal colon
    Tomonori Yano
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Gastrointest Endosc 62:302-4. 2005
    ..The inability to pass endoscopes beyond strictures is a considerable problem in patients with a colonic stricture...
  35. ncbi request reprint Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice
    Hiroyuki Mutoh
    Department of Gastroenterology, Jichi Medical School, Yakushiji 3311 1, Minamikawachimachi, Kawachigun, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 294:470-9. 2002
    ..The transgenic mouse is a very useful model for clarifying physiological differentiation of gastric and intestinal cell lineages and analyzing the molecular events from intestinal metaplasia to adenocarcinoma...
  36. doi request reprint Endoscopic submucosal dissection for superficial duodenal neoplasms
    Tetsuro Honda
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    Dig Endosc 21:270-4. 2009
    ..Of these, nine underwent ESD. We report our experience with duodenal ESD with a combination of ST hood and hook knife...
  37. doi request reprint Cell lineage dynamics in the process leading to intestinal metaplasia
    Hirotsugu Sakamoto
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:620-8. 2011
    ..In this study, we investigated the temporal relationship between cell lineage changes and intestine-specific gene expression in the process leading to intestinal metaplasia, using Cdx2-transgenic mice...
  38. doi request reprint Diagnosis of depressed-type early gastric cancer using small-caliber endoscopy with flexible spectral imaging color enhancement
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Dig Endosc 24:231-6. 2012
    ..The aim of the present study was to evaluate the detection of depressed-type early gastric cancer using small-caliber endoscopy with the FICE system...
  39. ncbi request reprint Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration
    Hiroyuki Osawa
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 344:680-7. 2006
    ..These results indicate that Shh promotes the proliferation of RGM-1 cells through an intracellular calcium- and ERK-dependent but transcription-independent pathway via Patched/Smoothened receptor system...
  40. ncbi request reprint Endoscopic classification of vascular lesions of the small intestine (with videos)
    Tomonori Yano
    Tochigi, Japan
    Gastrointest Endosc 67:169-72. 2008
    ..For selection of the appropriate treatment, it is necessary to distinguish between venous and arterial lesions...
  41. doi request reprint Multiple gastric carcinoids associated with parietal cell hyperplasia: intraoperative detection with a radiolabeled somatostatin analog
    Yoshinori Hosoya
    Department of Surgery, Jichi Medical University, 3311 1 Shimotsuke, Tochigi 329 0498, Japan
    Gastric Cancer 11:123-6. 2008
    ..Hyperplasia of parietal cells was observed, suggesting early-stage type A chronic atrophic gastritis. The antrum contained increased numbers of gastrin-positive cells, which probably caused the preoperative hypergastrinemia...
  42. doi request reprint Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa
    Hiroyuki Mutoh
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Differentiation 81:92-8. 2011
    ..In conclusion, Sox2 expression is maintained while gastric phenotype is completely lost in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach...
  43. doi request reprint Nonsurgical management of small-bowel polyps in Peutz-Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy
    Hirotsugu Sakamoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Gastrointest Endosc 74:328-33. 2011
    ..The major problem in the management of Peutz-Jeghers syndrome (PJS) is small-bowel polyps, which can cause intussusception and bleeding. Double-balloon endoscopy (DBE) enables endoscopic resection of small-bowel polyps...
  44. ncbi request reprint Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation
    Kouji Hama
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 315:905-11. 2004
    ..These results indicate that Ang II stimulates PSC proliferation through EGF receptor transactivation-ERK activation pathway...
  45. ncbi request reprint Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB
    Hiroyuki Mutoh
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, 329 0431, Japan
    J Gastroenterol 42:719-29. 2007
    ..However, the relationship between CDX2 attenuation and COX-2 overexpression in colorectal carcinoma has not been established. Here, we investigated the mechanistic link between CDX2 downregulation and COX-2 upregulation...
  46. ncbi request reprint Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi, Japan 329 0498
    J Clin Endocrinol Metab 90:10-6. 2005
    ..pylori-positive subjects. These findings suggest that impaired gastric ghrelin production in association with atrophic gastritis induced by H. pylori infection accounts for the decrease in plasma ghrelin concentration...
  47. ncbi request reprint [Clinical value of enteroscopic examinations using the double-balloon endoscope]
    Hironori Yamamoto
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School
    Nihon Shokakibyo Gakkai Zasshi 101:976-82. 2004
  48. ncbi request reprint A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis
    Hirotsugu Sakamoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Tochigi 329 0 431, Japan
    Hum Pathol 38:66-71. 2007
    ..We found that 10.7% (11/103) of nontumorous gallbladders resected because of cholelithiasis under laparoscopy revealed intestinal metaplasia with Cdx2 expression...
  49. doi request reprint Asian consensus report on functional dyspepsia
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    J Gastroenterol Hepatol 27:626-41. 2012
    ....
  50. doi request reprint SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans
    Miho Sashikawa Kimura
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:1292-9. 2011
    ..This study aimed to investigate SOX9 expression in the corpus and pyloric regions of the normal human stomach, premalignant intestinal metaplasia, and gastric carcinoma by using immunohistochemistry...
  51. ncbi request reprint Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Gastrointest Endosc 67:226-34. 2008
    ..This imaging technique is based on narrowing the bandwidth of conventional image arithmetically by using spectral estimation technology...
  52. doi request reprint Intestinal metaplasia in gallbladder correlates with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary duct
    Hirotsugu Sakamoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Hum Pathol 40:1762-7. 2009
    ..0%, P = .005). In conclusion, intestinal metaplasia in the gallbladder is significantly correlated with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary ductal arrangement...
  53. doi request reprint Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening
    Hisashi Hatanaka
    Division of Functional Genomics, Jichi Medical University, Tochigi, Japan
    Cancer Sci 101:54-9. 2010
    ..Furthermore, short-chain fatty acids potentiated the mitogenic action of FFAR2 in 3T3 cells. Our data thus, for the first time, implicate FFAR2 in carcinogenesis of the digestive tract...
  54. ncbi request reprint Gastrointestinal stromal tumor in the jejunum: diagnosis and control of bleeding with electrocoagulation by using double-balloon enteroscopy
    Makoto Nishimura
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, 329 0498, Tochigi, Yakushiji, Minamikawachi, Japan
    J Gastroenterol 39:1001-4. 2004
    ..Double-balloon enteroscopy was useful for the diagnosis as well as the control of bleeding in this patient...
  55. doi request reprint Long-term outcome of patients with obscure gastrointestinal bleeding investigated by double-balloon endoscopy
    Satoshi Shinozaki
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Clin Gastroenterol Hepatol 8:151-8. 2010
    ..It is often difficult to determine the cause of obscure gastrointestinal bleeding (OGIB). We evaluated the diagnostic yield and long-term outcome of patients with OGIB by using double-balloon endoscopy (DBE)...
  56. ncbi request reprint Reduced expression of sulfatides and galactosylceramide 3'-sulfotransferase in the gastric mucosa of chronic gastritis
    Hiroyuki Osawa
    Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    J Clin Gastroenterol 42:23-8. 2008
    ..Sulfatides highly expressed in the normal gastric mucosa play important roles in gastric mucosal protection. However, it is unknown whether the sulfatides expression changes in chronic gastritis...
  57. ncbi request reprint [Plasma and gastric ghrelin levels in subjects with Helicobacter pylori infection]
    Hiroyuki Osawa
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School
    Nihon Rinsho 63:127-31. 2005
  58. ncbi request reprint Double-balloon endoscopy for ileal GI stromal tumor
    Michiko Iwamoto
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Gastrointest Endosc 62:440-1; discussion 441. 2005
  59. doi request reprint Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study
    Keigo Mitsui
    Division of Gastroenterology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Gastrointest Endosc 70:498-504. 2009
    ..However, although CE and DBE have greatly simplified the task, DBE studies have yet to provide sufficient data on the diagnosis and outcome of patients with SBTs...
  60. ncbi request reprint Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
    Akashi Eda
    Department of Internal Medicine, Jichi Medical School, Yakushiji, Kawachi, Tochigi 329 0438, Japan
    J Gastroenterol 38:14-22. 2003
    ..The present study was designed to examine the expression of CDX 1/2 in inflammatory esophageal mucosa with or without Barrett's epithelium...
  61. ncbi request reprint [A clinicopathological study of 10 cases of primary small bowel adenocarcinoma]
    Shunichi Misawa
    Department of Surgery, Jichi Medical University, Japan
    Nihon Shokakibyo Gakkai Zasshi 108:429-35. 2011
    ..The 4 patients with stage II tumor and 2 patients with stage III tumor underwent curative-intent surgery. The 4 patients with stage II tumor are all surviving without evidence of disease now...
  62. ncbi request reprint [Proton pump inhibitor in the management of acid-related disorders in Japan: history and perspective]
    Kentaro Sugano
    Department of Medicine, Jichi Medical University
    Nihon Rinsho 65:2375-81. 2007
    ..In the next decades, we should promote our activity to produce solid new evidence for better management of ARD from Japan to the world...
  63. pmc Phlegmonous gastritis after endoscopic submucosal dissection for early gastric cancer
    Hironari Ajibe
    Department of Internal Medicine, Division of Gastroenterology Jichi Medical University, Tochigi, Japan
    Therap Adv Gastroenterol 1:91-5. 2008
    ..In patients with poorer general conditions, phlegmonous gastritis should be considered as a serious complication after ESD, indicating a requirement of antibiotic prophylaxis...
  64. ncbi request reprint Direct observation with double-balloon enteroscopy of an intestinal intramural hematoma resulting in anticoagulant ileus
    Satoshi Shinozaki
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Dig Dis Sci 49:902-5. 2004
    ..We have demonstrated that enteroscopy using the double-balloon method is a useful diagnostic tool in the evaluation of a patient suspected to have anticoagulant ileus...
  65. ncbi request reprint Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells
    Tomohiko Miyata
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 323:118-24. 2004
    ..We suggest that syntaxin 4 is involved in the intracellular transport of MT1-MMP toward the plasma membrane...
  66. ncbi request reprint The First International Workshop on Double Balloon Endoscopy: a consensus meeting report
    Kentaro Sugano
    Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Gastrointest Endosc 66:S7-11. 2007
  67. ncbi request reprint Clinical importance of the location of lesions with regard to mesenteric or antimesenteric side of the small intestine
    Keijiro Sunada
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Gastrointest Endosc 66:S34-8. 2007
  68. ncbi request reprint Gastrointestinal angiodysplasia in a patient with type 2 von Willebrand's disease and analysis of exon 28 of the von Willebrand factor gene
    Yukihiro Satoh
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    Am J Gastroenterol 99:2495-8. 2004
    ..This mutation was identical with a previously reported mutation in a patient with von Willebrand's disease complicated with gastrointestinal angiodysplasia...
  69. ncbi request reprint Double-balloon endoscopy for jejunal hemangioma (with video)
    Michiko Iwamoto
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Gastrointest Endosc 66:184-5; discussion 185. 2007
  70. ncbi request reprint Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia
    Akashi Eda
    Department of Gastroenterology, Jichi Medical School, Kawachi, Tochigi, Japan
    J Gastroenterol 37:94-100. 2002
    ..Accordingly, we examined the expression of CDX1/2 and its association with the expression of other intestinal metaplasia-associated genes during the development of intestinal metaplasia...
  71. ncbi request reprint Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori
    Kiichi Satoh
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School, Tochigi, Japan
    Helicobacter 7:192-8. 2002
    ..We investigated expression of CDX2 protein in the gastric mucosa with and without IM before and after eradication of H. pylori...
  72. ncbi request reprint [H. pylori and para-neuron secretion (gastrin, somatostatin, histamine)]
    Hiroyuki Mutoh
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School
    Nihon Rinsho 60:252-5. 2002
  73. doi request reprint Steroid treatment in patients with membranous nephropathy and hepatitis B virus surface antigenemia: a report of two cases
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:289-93. 2011
    ..Further studies will be required to determine the optimal timing and appropriate duration of antiviral treatment in such patients requiring long-term immunosuppression...
  74. doi request reprint Assessment of atrophic gastritis using the OLGA system
    Kiichi Satoh
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    Helicobacter 13:225-9. 2008
    ..The aim of this study was to assess the severity of atrophic gastritis using the OLGA system...
  75. ncbi request reprint A new method of enteroscopy--the double-balloon method
    Hironori Yamamoto
    Department of Gastroenterology, Jichi Medical School, Minamikawachi Kawachi, Japan
    Can J Gastroenterol 17:273-4. 2003
    ..It constitutes an important advance in the diagnosis and management of bleeding and other small intestinal disorders...
  76. ncbi request reprint Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions
    Hirohide Ohnishi
    Department of Gastroenterology, Jichi Medical School, Tochigi 329 0498, Japan
    J Biol Chem 279:8873-8. 2004
    ..We propose that TGF-beta(1) differentially regulates PSC activation, proliferation, and TGF-beta(1) mRNA expression through Smad2-, Smad3-, and ERK-dependent pathways, respectively...
  77. ncbi request reprint Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate
    Hironori Yamamoto
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Gastrointest Endosc 56:507-12. 2002
    ..The aim of this study was to evaluate the clinical outcome of endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate...
  78. ncbi request reprint A case of successful enteroscopic balloon dilation for late anastomotic stricture of choledochojejunostomy after living donor liver transplantation
    Hidenori Haruta
    Department of Transplant Surgery, Jichi Medical School, Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    Liver Transpl 11:1608-10. 2005
    ..In conclusion, endoscopic balloon dilation of biliary-enteric anastomotic stricture using a new enteroscopic method can be regarded as an alternative choice to percutaneous transhepatic management and surgical re-anatomists...
  79. ncbi request reprint Molecular abnormalities in the precancerous conditions of the stomach
    Kentaro Sugano
    Division of Gastroenterology, Jichi Medical School, Minamikawachi, Tochigi
    Intern Med 42:283-4. 2003
  80. ncbi request reprint Usefulness and safety of 0.4% sodium hyaluronate solution as a submucosal fluid "cushion" in endoscopic resection for gastric neoplasms: a prospective multicenter trial
    Hironori Yamamoto
    Current affiliations Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Gastrointest Endosc 67:830-9. 2008
    ..Sodium hyaluronate (SH) solution has been used for submucosal injection in endoscopic resection to create a long-lasting submucosal fluid "cushion."..
  81. ncbi request reprint Prevention of gastric cancer: urgent need to implement Helicobacter pylori eradication therapy as a primary preventive measure in Japan
    Kentaro Sugano
    Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, 329 0498, Japan
    J Gastroenterol 42:1-2. 2007
  82. doi request reprint Clinicopathological study of lymph-node metastasis in 1,389 patients with early gastric cancer: assessment of indications for endoscopic resection
    Hidenori Haruta
    Clinical Institute of Digestive Disease Surgical Branch, Jichi Medical University, Tochigi, Japan
    J Dig Dis 9:213-8. 2008
    ..Further experience in the treatment of EGC and a clearer delineation of the factors related to lymph-node metastasis would permit a more accurate assessment of endoscopic resection...
  83. ncbi request reprint [Strategy for peptic ulcer therapy in the era of H. pylori eradication therapy]
    Kentaro Sugano
    Department of Internal Medicine, Division of Gastroenterology, Jichi Medical School
    Nihon Rinsho 62:477-82. 2004
    ....
  84. ncbi request reprint [Role of proton pump inhibitors in the eradication therapy for Helicobacter pylori (overviews)]
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical School
    Nihon Rinsho 60:627-31. 2002
  85. ncbi request reprint [Helicobacter pylori eradication therapy for peptic ulcer disease]
    Kiichi Satoh
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University
    Nihon Rinsho 67:2322-6. 2009
    ..H. pylori eradication therapy is effective for prevention of development of NSAID-ulcers in NSAID-naïve patients. For prevention of recurrence of NSAID-ulcers, therapy with proton pump inhibitor is effective...
  86. ncbi request reprint Calcified bile duct stone not crushable by endotriptor or mechanical lithotriptor: case report
    Kenji Utsunomiya
    Department of Gastroenterology, Jichi Medical School, Tochigi, Japan
    Surg Laparosc Endosc Percutan Tech 12:184-6. 2002
    ..When abdominal radiography shows apparent calcified bile duct stone, it should be cautioned that the stone is sometimes too hard to be crushed, even with use of the endotriptor as well as a mechanical lithotriptor...
  87. ncbi request reprint Photodynamic effects on rabbit auricular veins after photosensitization with porfimer sodium: Implications of the results with respect to the treatment of esophageal varices with photodynamic therapy
    Nobuhiko Nagamine
    Department of Gastroenterology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Kawachi gun, Tochigi 329 0498, Japan
    Gastrointest Endosc 55:420-4. 2002
    ..This report describes observed hemodynamic and histologic changes in rabbit auricles after photodynamic therapy and the feasibility of photodynamic therapy for esophageal varices...
  88. doi request reprint Leukemic cell infiltration into the large intestine in a patient with acute myelogenous leukemia
    Michiko Iwamoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
    Gastrointest Endosc 67:353-4. 2008
  89. ncbi request reprint [Useful clinical laboratory tests for early diagnosis of gastrointestinal diseases]
    Yumiko Ishino
    Nihon Naika Gakkai Zasshi 94:2508-13. 2005
  90. doi request reprint Asia-Pacific consensus guidelines on gastric cancer prevention
    Kwong Ming Fock
    Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:351-65. 2008
    ..Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer...
  91. ncbi request reprint Grading of gastritis: an impossible dream?
    Kentaro Sugano
    Gastric Cancer 5:58-60. 2002
  92. ncbi request reprint Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Japan
    Gastrointest Endosc 66:S72-7. 2007
    ..Double balloon endoscopy (DBE) and videocapsule endoscopy (VCE) have been useful in managing obscure GI bleeding (OGIB)...
  93. ncbi request reprint New system of double-balloon enteroscopy for diagnosis and treatment of small intestinal disorders
    Hinonori Yamamoto
    Gastroenterology 125:1556; author reply 1556-7. 2003
  94. ncbi request reprint Diagnosis and treatment of small-bowel stricture by double balloon endoscopy
    Akira Fukumoto
    Department of Endoscopy, Hiroshima University Hospital, Japan
    Gastrointest Endosc 66:S108-12. 2007
    ..It has recently become possible to examine the entire small bowel and perform balloon dilatation for stricture by means of double balloon endoscopy (DBE)...
  95. doi request reprint Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by double-balloon endoscopy: a Japanese multicenter study
    Takayuki Matsumoto
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Scand J Gastroenterol 43:490-6. 2008
    ..The aim of this study was to determine the prevalence of NSAIDs enteropathy in subjects indicated for double-balloon endoscopy (DBE)...
  96. ncbi request reprint Aberrant expression of CDX2 in the metaplastic epithelium and inflammatory mucosa of the gallbladder
    Hiroyuki Osawa
    Am J Surg Pathol 28:1253-4. 2004
  97. ncbi request reprint Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes
    Hiroshi Seno
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 22:729-37. 2007
    ..The present study examines the significance of gene polymorphisms of various cytokines in the development of gastric cancer following H. pylori infection...
  98. ncbi request reprint Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan
    Choitsu Sakamoto
    Nippon Medical School, Tokyo, Japan
    Eur J Clin Pharmacol 62:765-72. 2006
    ..The role of Helicobacter pylori infection in NSAIDs-related UGIB remains to be studied. We conducted a case-control study in Japan to investigate these related topics...
  99. ncbi request reprint Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps
    Michiko Iwamoto
    Department Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pediatr Res 57:4-9; discussion 1-3. 2005
    ..Thus, beta-catenin accumulation may be intrinsic to the formation of juvenile-type polyps through an as-yet-undefined mechanism...
  100. ncbi request reprint [Early diagnosis and non-surgical treatment of cancers of the stomach and large intestine]
    Kentaro Sugano
    Nihon Naika Gakkai Zasshi 96:498-504. 2007
  101. ncbi request reprint Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Am J Gastroenterol 100:2100-15. 2005
    ..pylori-associated diseases...