Kuniyasu Soda

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. pmc Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama City, Saitama, Japan
    PLoS ONE 8:e64357. 2013
  2. doi request reprint Food polyamine and cardiovascular disease--an epidemiological study
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Jichi Medical University, Saitama, Japan
    Glob J Health Sci 4:170-8. 2012
  3. doi request reprint Polyamine intake, dietary pattern, and cardiovascular disease
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Saitama City, Saitama 330 0834, Japan
    Med Hypotheses 75:299-301. 2010
  4. doi request reprint Polyamine-rich food decreases age-associated pathology and mortality in aged mice
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Exp Gerontol 44:727-32. 2009
  5. ncbi request reprint Long-term oral polyamine intake increases blood polyamine concentrations
    Kuniyasu Soda
    Cardiovascular Research Institute, and 2 Department of Surgery, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Saitama, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:361-6. 2009
  6. ncbi request reprint Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia
    Alper Celik
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Oncol Rep 21:1105-11. 2009
  7. ncbi request reprint Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion
    Yoshihiko Kano
    Department of Surgery, Omiya Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya, Saitama City, Saitama 330 0834, Japan
    Cancer Immunol Immunother 56:771-81. 2007
  8. ncbi request reprint Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine
    Masaki Kanzaki
    Department of Surgery, Omiya Medical Center, Jichi Medical School, 1 847 Amanuma cho, Saitama City, Saitama 330 8503, Japan
    Cytokine 32:234-9. 2005
  9. ncbi request reprint Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte
    Kuniyasu Soda
    Department of Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    J Immunol 175:237-45. 2005
  10. pmc Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area
    Yoshihiko Kano
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    PLoS ONE 8:e56056. 2013

Collaborators

Detail Information

Publications15

  1. pmc Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama City, Saitama, Japan
    PLoS ONE 8:e64357. 2013
    ..93 mm, respectively (Mann-Whitney test, p = 0.039). Spermine seems to play important roles in inhibiting age-associated and polyamine-deficient induced abnormal gene methylation as well as pathological changes including tumorigenesis...
  2. doi request reprint Food polyamine and cardiovascular disease--an epidemiological study
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Jichi Medical University, Saitama, Japan
    Glob J Health Sci 4:170-8. 2012
    ..183, p = 0.006) and whole milk (r = 0.113, p = 0.041) showed positive associations with CVD. The inverse association between dietary polyamines and CVD mortality revealed by the present study merits further evaluation...
  3. doi request reprint Polyamine intake, dietary pattern, and cardiovascular disease
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Saitama City, Saitama 330 0834, Japan
    Med Hypotheses 75:299-301. 2010
    ..This in turn increases availability of arginine for synthesis of nitric oxide, which plays an important role in preserving normal vascular physiology...
  4. doi request reprint Polyamine-rich food decreases age-associated pathology and mortality in aged mice
    Kuniyasu Soda
    Department of Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Exp Gerontol 44:727-32. 2009
    ..As these pathological changes are associated with senescence, oral polyamine appears to inhibit the progression of age-associated pathologies...
  5. ncbi request reprint Long-term oral polyamine intake increases blood polyamine concentrations
    Kuniyasu Soda
    Cardiovascular Research Institute, and 2 Department of Surgery, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Saitama, Japan
    J Nutr Sci Vitaminol (Tokyo) 55:361-6. 2009
    ..The long-term oral intake of enhanced polyamine diets increases blood polyamine levels in both mice and humans...
  6. ncbi request reprint Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia
    Alper Celik
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Oncol Rep 21:1105-11. 2009
    ..Because malonyl-CoA inhibits the rate-limiting step in the beta-oxidation of fatty acids, the decreased malonyl-CoA and the background metabolic alterations may contribute to the accelerated lipolysis of cancer cachexia...
  7. ncbi request reprint Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion
    Yoshihiko Kano
    Department of Surgery, Omiya Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya, Saitama City, Saitama 330 0834, Japan
    Cancer Immunol Immunother 56:771-81. 2007
    ..510, P = 0.008: n = 25). Increased blood spermine levels may be an important factor in the suppression of anti-tumor immune cell function...
  8. ncbi request reprint Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine
    Masaki Kanzaki
    Department of Surgery, Omiya Medical Center, Jichi Medical School, 1 847 Amanuma cho, Saitama City, Saitama 330 8503, Japan
    Cytokine 32:234-9. 2005
    ....
  9. ncbi request reprint Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte
    Kuniyasu Soda
    Department of Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    J Immunol 175:237-45. 2005
    ..Putrescine had no effect on the expressions of membrane molecules. Polyamines, especially spermine, decrease LFA-1 (CD11a/CD18) expression on human lymphocyte and adhesion capacity of PBMCs to HUVECs...
  10. pmc Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area
    Yoshihiko Kano
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    PLoS ONE 8:e56056. 2013
    ..The results of this study suggest that polyamine-induced suppression of LFA-1 expression occurs via enhanced methylation of ITGAL...
  11. doi request reprint Spermine accelerates hypoxia-initiated cancer cell migration
    Shingo Tsujinaka
    Department of Surgery, Jichi Medical University, Saitama City, Saitama 330 8503, Japan
    Int J Oncol 38:305-12. 2011
    ..3, 2.8, and 3.2 times greater, respectively, compared to cells with 0 µM spermine under normoxia. Increased extracellular spermine enhances the invasion potential of cancer cells under hypoxia...
  12. doi request reprint The importance of tissue environment surrounding the tumor on the development of cancer cachexia
    Fumihiro Chiba
    Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya, Saitama City, Saitama 330 8503, Japan
    Int J Oncol 44:177-86. 2014
    ..Further, multiple factors likely mediate the mechanisms of cancer cachexia. Finally, this animal model was suitable for the investigation of the mechanisms involved in cachexia of cancer patients...
  13. pmc The mechanisms by which polyamines accelerate tumor spread
    Kuniyasu Soda
    Department of Surgery and Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya, Saitama City, Saitama 330 0834, Japan
    J Exp Clin Cancer Res 30:95. 2011
    ..Recent investigations revealed that increased polyamine availability enhances the capability of cancer cells to invade and metastasize to new tissues while diminishing immune cells' anti-tumor immune functions...
  14. ncbi request reprint Biclonal extramedullary plasmacytoma arising in the peritoneal cavity: report of a case
    Takayoshi Yoshida
    Department of Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    Surg Today 34:379-82. 2004
    ..After a temporary regression following surgery and chemotherapy, the tumor grew rapidly. Although there was no evidence of progression to multiple myeloma, the patient died of cachexia less than 4 months after surgery...
  15. ncbi request reprint Excessive increase of serum interleukin 6 jeopardizes host defense against multi-bacterial infection
    Kuniyasu Soda
    Department of Surgery, Omiya Medical Center, Jichi Medical School, 1 847 Amanuma, Saitama Saitama city 330 0834, Japan
    Cytokine 21:295-302. 2003
    ....