M Ohwada

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. ncbi request reprint Involvement of microsatellite instability in lymph node metastasis of endometrial carcinoma
    Michitaka Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, 329 0498, Tochigi, Japan
    Cancer Genet Cytogenet 132:152-5. 2002
  2. ncbi request reprint Neuroendocrine small cell carcinoma of the uterine cervix showing polypoid growth and complicated by pregnancy
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Gynecol Oncol 81:117-9. 2001
  3. ncbi request reprint Problems with peritoneal cytology in second-look laparotomy performed in patients with epithelial ovarian carcinoma
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Cancer 93:376-80. 2001
  4. ncbi request reprint Micrometastatic p53-positive cells in the lymph nodes of early stage epithelial ovarian cancer: prognostic significance
    M Suzuki
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    Oncology 60:170-5. 2001
  5. ncbi request reprint Establishment and characterization of a new cell line (SKS) from neuroendocrine small cell carcinoma of the uterine cervix and its chemosensitivity
    Y Saga
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Oncology 60:367-72. 2001
  6. ncbi request reprint Omental metastases in clinical stage I endometrioid adenocarcinoma
    H Fujiwara
    Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan
    Int J Gynecol Cancer 18:165-7. 2008
  7. ncbi request reprint Assisted reproductive technologies in conjunction with conservatively treated endometrial adenocarcinoma. A case report
    S Ogawa
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi Machi, Tochigi 329 0498, Japan
    Gynecol Obstet Invest 51:214-6. 2001
  8. ncbi request reprint Phase I trial of paclitaxel, doxorubicin, and carboplatin (TAC) for the treatment of endometrial cancer
    M Shimada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Int J Gynecol Cancer 17:210-4. 2007
  9. ncbi request reprint C-kit overexpression in neuroendocrine small cell carcinoma of the uterine cervix
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Kawachi, Tochigi, Japan
    Eur J Gynaecol Oncol 27:53-5. 2006
  10. doi request reprint Frequency and characteristics of endometrial carcinoma and atypical hyperplasia detected on routine infertility investigations in young women: a report of six cases
    H Fujiwara
    Department of Obstetrics and Gynecology, Jichi Medical University, 3311 1, Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Hum Reprod 24:1045-50. 2009

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Involvement of microsatellite instability in lymph node metastasis of endometrial carcinoma
    Michitaka Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, 329 0498, Tochigi, Japan
    Cancer Genet Cytogenet 132:152-5. 2002
    ..These results suggest that MSI is also involved in lymph node metastasis in the development and/or progression of endometrial carcinoma in some patients...
  2. ncbi request reprint Neuroendocrine small cell carcinoma of the uterine cervix showing polypoid growth and complicated by pregnancy
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Gynecol Oncol 81:117-9. 2001
    ..Neuroendocrine small cell carcinoma of the uterine cervix is an aggressive disease, and it rarely is complicated by pregnancy...
  3. ncbi request reprint Problems with peritoneal cytology in second-look laparotomy performed in patients with epithelial ovarian carcinoma
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Cancer 93:376-80. 2001
    ..The recurrence rate of ovarian carcinoma is high even when a second-look laparotomy (SLL) is negative. In the current study, the accuracy of peritoneal cytology as an evaluation method of SLL was examined...
  4. ncbi request reprint Micrometastatic p53-positive cells in the lymph nodes of early stage epithelial ovarian cancer: prognostic significance
    M Suzuki
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    Oncology 60:170-5. 2001
    ..05). Detection of micrometastasis of the regional lymph nodes of ovarian cancer by immunohistochemical staining of p53 protein may be useful in predicting the prognosis of patients with stage I or II epithelial ovarian cancer...
  5. ncbi request reprint Establishment and characterization of a new cell line (SKS) from neuroendocrine small cell carcinoma of the uterine cervix and its chemosensitivity
    Y Saga
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Oncology 60:367-72. 2001
    ..SKS cells are useful as a model of neuroendocrine small cell carcinoma of the cervix, and chemotherapy using gemcitabine may possibly be effective in this malignancy...
  6. ncbi request reprint Omental metastases in clinical stage I endometrioid adenocarcinoma
    H Fujiwara
    Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan
    Int J Gynecol Cancer 18:165-7. 2008
    ..However, omental metastases are a significant poor prognostic factor, and intraoperative examination of the omentum by close inspection and palpation as well as pathologic examination, if possible, may be indicated...
  7. ncbi request reprint Assisted reproductive technologies in conjunction with conservatively treated endometrial adenocarcinoma. A case report
    S Ogawa
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi Machi, Tochigi 329 0498, Japan
    Gynecol Obstet Invest 51:214-6. 2001
    ..We conclude that ART combined with progesterone treatment might be a powerful option for the treatment of infertile patients with early stage, well-differentiated endometrial adenocarcinoma...
  8. ncbi request reprint Phase I trial of paclitaxel, doxorubicin, and carboplatin (TAC) for the treatment of endometrial cancer
    M Shimada
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Int J Gynecol Cancer 17:210-4. 2007
    ..The recommended dose of TAC therapy for endometrial cancer was doxorubicin 45 mg/m(2) for day 1, TXL 150 mg/m(2) and CBDCA AUC 5 for day 2...
  9. ncbi request reprint C-kit overexpression in neuroendocrine small cell carcinoma of the uterine cervix
    M Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School, Kawachi, Tochigi, Japan
    Eur J Gynaecol Oncol 27:53-5. 2006
    ..Few studies have investigated whether c-kit is overexpressed in NESCC. To investigate whether NESCC can be a target for molecular targeted therapy with tyrosine kinase inhibitors, we examined the expression of c-kit in this tumor...
  10. doi request reprint Frequency and characteristics of endometrial carcinoma and atypical hyperplasia detected on routine infertility investigations in young women: a report of six cases
    H Fujiwara
    Department of Obstetrics and Gynecology, Jichi Medical University, 3311 1, Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Hum Reprod 24:1045-50. 2009
    ..Routine infertility investigations may provide an opportunity to examine the corpus uteri of young women in whom examination is otherwise limited, contributing to the early detection of EC/AH...
  11. ncbi request reprint High-grade endometrial stromal sarcoma after treatment with tamoxifen in a patient treated for breast cancer
    Y Saga
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Int J Gynecol Cancer 13:690-2. 2003
    ..The patient has now survived disease-free for 37 months after surgery...
  12. ncbi request reprint Chemosensitivity and p53-Bax pathway-mediated apoptosis in patients with uterine cervical cancer
    H Sultana
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Ann Oncol 14:214-9. 2003
    ..To determine whether and how apoptosis through the p53-Bax pathway affects sensitivity to chemotherapy in cervical cancer...
  13. doi request reprint Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice
    Yuji Takei
    Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Mol Cancer Ther 7:704-11. 2008
    ..PTEN gene therapy could have therapeutic potential for ovarian cancer and exerts some of this effect by inhibiting angiogenesis...
  14. ncbi request reprint Establishment of a new cell line (TAYA) of clear cell adenocarcinoma of the ovary and its radiosensitivity
    Yasushi Saga
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Oncology 62:180-4. 2002
    ..In contrast, the 50% growth inhibitory dose (ID50) of radiation was 1.8 Gy, showing that the cells were highly sensitive to radiation. Thus, radiotherapy may be effective for treatment of clear cell adenocarcinoma of the ovary...
  15. ncbi request reprint Unsuspected uterine carcinosarcoma (heterologous) diagnosed following conservative therapies with medroxyprogesterone acetate for presumed early-stage endometrial carcinoma
    Hiroyuki Fujiwara
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi Machi, Tochigi, Japan
    Am J Reprod Immunol 47:129-31. 2002
  16. ncbi request reprint Mechanisms of cisplatin resistance in clear cell carcinoma of the ovary
    Hiroaki Itamochi
    Department of Obstetrics and Gynecology, Tottori University, Yonago, Japan
    Oncology 62:349-53. 2002
    ..8 h). A significant reverse correlation between the S-phase fraction and the response to CDDP was observed (r = 0.647, p < 0.05). The present study suggests that the resistance of CCC to CDDP may be caused by low cell proliferation...
  17. ncbi request reprint Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers
    Masaaki Komatsu
    Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Mol Cancer Ther 5:767-75. 2006
    ..683; p = 0.042)...
  18. ncbi request reprint Inhibition of peritoneal dissemination of ovarian cancer by tyrosine kinase receptor inhibitor SU6668 (TSU-68)
    Shizuo Machida
    Department of Obstetrics and Gynecology, Jichi Medical School, Yakushiji, Minami Kawachi, Tochigi 329 0498, Japan
    Int J Cancer 114:224-9. 2005
    ..These effects were observed with both the VEGF- and PDGF-hypersecretory cell lines. Our results suggest that molecular targeting with oral SU6668 will become a new therapeutic strategy targeting peritoneally disseminated ovarian cancer...
  19. ncbi request reprint PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy
    Yasunobu Kanamori
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36 1 Nishimachi, Yonago 683 8504, Japan
    Int J Cancer 100:686-9. 2002
    ..PTEN-positive staining was a significant prognostic indicator of favorable survival for patients with advanced endometrial carcinoma who underwent postoperative chemotherapy...
  20. ncbi request reprint A feasibility study of paclitaxel and carboplatin therapy in Japanese patients with epithelial ovarian cancer
    Yuji Takei
    Department of Obstetrics and Gynecology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Oncol Rep 10:951-5. 2003
    ..Although hematological toxicity was relatively marked, this regimen can be applied in Japanese women...
  21. ncbi request reprint Localization of mast cells in endometrial cysts
    Hiroyuki Fujiwara
    Department of Gynecology, Omiya Medical Center, Jichi Medical School, Amanuma cho, Saitama, Japan
    Am J Reprod Immunol 51:341-4. 2004
    ..Although the presence of mast cells in endometriosis lesions has been reported, there have been no reports of their pathological localization in ovarian endometrial cysts...
  22. ncbi request reprint Role of immunoreactions and mast cells in pathogenesis of human endometriosis--morphologic study and gene expression analysis
    Ryo Konno
    Department of Gynecology, Omiya Medical Center, Jichi Medical School, Amanuma cho, Omiya, Saitama, Japan
    Hum Cell 16:141-9. 2003
    ..To investigate the pathophysiology of human endometriosis, we examined by morphological and molecular biological methods...
  23. ncbi request reprint [Present status and problems in screening for endometrial cancer]
    Mitsuaki Suzuki
    Department of Obstetrics and Gynecology, Jichi Medical School
    Nihon Rinsho 62:429-32. 2004
  24. ncbi request reprint Immunohistochemical study of osteopontin and L-selectin in a rat endometriosis model and in human endometriosis
    Kohei Odagiri
    Department of Gynecology, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    Fertil Steril 88:1207-11. 2007
    ..To investigate the localization of the proteins osteopontin (OPN) and L-selectin (SELL)...
  25. ncbi request reprint Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor
    Shizuo Machida
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Oncology 65:89-93. 2003
    ..The relationship between the abnormal expression of fragile histidine triad (FHIT) and the prognosis in advanced cervical cancer was investigated, focusing on the relation with radiosensitivity...
  26. ncbi request reprint Phase I study of combination chemotherapy using irinotecan hydrochloride and nedaplatin for advanced or recurrent cervical cancer
    Shizuo Machida
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Oncology 65:102-7. 2003
    ..We performed a phase I clinical study to evaluate combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin (CPT-11/nedaplatin) for cervical cancer...
  27. ncbi request reprint Is peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?
    Yasushi Saga
    Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Gynecol Oncol 103:277-80. 2006
    ..The goal of this study was to investigate whether intraoperative peritoneal cytology serves as a prognostic factor in patients with the endometrial cancer limited to the disease confined to the uterus...
  28. ncbi request reprint Phase I and pharmacological study of single paclitaxel administered weekly for heavily pre-treated patients with epithelial ovarian cancer
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan
    Anticancer Res 22:1833-8. 2002
    ..In this phase I trial, 80 mg/m2/week of paclitaxel was recommended as the phase II dose for outpatients...
  29. ncbi request reprint Microsatellite instability and expression of mismatch repair genes in sporadic endometrial cancer coexisting with colorectal or breast cancer
    Katsumi Takano
    Department of Biochemistry and Molecular Oncology, Graduate School, University of Tsukuba, Ibaraki 305 8575, Japan
    Oncol Rep 13:11-6. 2005
    ..Presence of MSI in sporadic endometrial cancer may be a useful marker to predict the risk of colorectal cancer...
  30. ncbi request reprint Clinicopathologic study of 56 patients with endometrial cancer during or after adjuvant tamoxifen use for their breast cancers
    Toru Hachisuga
    Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, 45 1, 7 chome, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Gynecol Oncol 95:139-44. 2004
    ..The aim of this study was to describe the clinicopathologic features and prognosis of endometrial cancer patients diagnosed during or after tamoxifen treatment for breast cancer...
  31. ncbi request reprint [Maximal cytoreductive surgery in patients with advanced ovarian cancer for improving the prognosis]
    Michitaka Ohwada
    Department of Obstetrics and Gynecology, Jichi Medical School
    Nihon Rinsho 62:535-9. 2004