Shin Ichi Muramatsu

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. pmc A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    Mol Ther 18:1731-5. 2010
  2. pmc Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice
    Asako Iida
    Division of Neurology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Biomed Res Int 2013:974819. 2013
  3. pmc Current status of Kampo medicine curricula in all Japanese medical schools
    Makoto Arai
    Department of Oriental Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    BMC Complement Altern Med 12:207. 2012
  4. ncbi request reprint Recombinant adeno-associated viral vectors bring gene therapy for Parkinson's disease closer to reality
    Shin Ichi Muramatsu
    Department of Neurology, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi, Japan 3290498
    J Neurol 249:II36-40. 2002
  5. ncbi request reprint Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi, 3290498, Japan
    Expert Opin Biol Ther 5:663-71. 2005
  6. ncbi request reprint Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis
    Li Jun Wang
    Division of Neurology, Department of Medicine, Center for Molecular Medicine, Jichi Medical School, Minamikawachi Machi, Tochigi 329 0498, Japan
    J Neurosci 22:6920-8. 2002
  7. ncbi request reprint Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport
    Yan Yan Lu
    Division of Neurology, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Tochigi 329 0498, Japan
    Neurosci Res 45:33-40. 2003
  8. ncbi request reprint Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector
    Yuhe Liu
    Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical School, Minami Kawachi, Kawachi, Tochigi, Japan
    Mol Ther 12:725-33. 2005
  9. ncbi request reprint Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
    Shin Ichi Muramatsu
    Department of Neurology, Jichi Medical School, Tochigi, 329 0498 Japan
    Hum Gene Ther 13:345-54. 2002
  10. ncbi request reprint Highly efficient gene transfer into primate embryonic stem cells with a simian lentivirus vector
    Takayuki Asano
    Division of Genetic Therapeutics, Jichi Medical School, Tochigi, 329 0498, Japan
    Mol Ther 6:162-8. 2002

Collaborators

Detail Information

Publications36

  1. pmc A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    Mol Ther 18:1731-5. 2010
    ..Our findings provide class IV evidence regarding the safety and efficacy of AADC gene therapy and warrant further evaluation in a randomized, controlled, phase 2 setting...
  2. pmc Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice
    Asako Iida
    Division of Neurology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Biomed Res Int 2013:974819. 2013
    ..These results suggest that tyrosine-mutant AAV9/3 vectors may be effective vehicles for delivery of therapeutic genes, including miRNAs, into the brain and for treating diseases that affect broad areas of the central nervous system...
  3. pmc Current status of Kampo medicine curricula in all Japanese medical schools
    Makoto Arai
    Department of Oriental Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    BMC Complement Altern Med 12:207. 2012
    ..Our aim was to identify problems and suggest solutions for a standardized Kampo educational model for all medical schools throughout Japan...
  4. ncbi request reprint Recombinant adeno-associated viral vectors bring gene therapy for Parkinson's disease closer to reality
    Shin Ichi Muramatsu
    Department of Neurology, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi, Japan 3290498
    J Neurol 249:II36-40. 2002
    ..These results suggest that gene therapy using rAAV vectors may become a novel and feasible treatment for PD...
  5. ncbi request reprint Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi, 3290498, Japan
    Expert Opin Biol Ther 5:663-71. 2005
    ..Vector systems that regulate transgene expression are necessary to increase safety in clinical applications, and the development of such systems is in progress...
  6. ncbi request reprint Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis
    Li Jun Wang
    Division of Neurology, Department of Medicine, Center for Molecular Medicine, Jichi Medical School, Minamikawachi Machi, Tochigi 329 0498, Japan
    J Neurosci 22:6920-8. 2002
    ..Our finding thus indicates that AAV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS...
  7. ncbi request reprint Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport
    Yan Yan Lu
    Division of Neurology, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Tochigi 329 0498, Japan
    Neurosci Res 45:33-40. 2003
    ..This study provides a basis for a strategy of intramuscular AAV-GDNF delivery to protect motoneurons as a possible means of ALS treatment...
  8. ncbi request reprint Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector
    Yuhe Liu
    Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical School, Minami Kawachi, Kawachi, Tochigi, Japan
    Mol Ther 12:725-33. 2005
    ..These findings are of value for further molecular studies of cochlear inner hair cells and for gene replacement strategies to correct recessive genetic hearing loss due to monogenic mutations in these cells...
  9. ncbi request reprint Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
    Shin Ichi Muramatsu
    Department of Neurology, Jichi Medical School, Tochigi, 329 0498 Japan
    Hum Gene Ther 13:345-54. 2002
    ..Our results show that AAV vectors efficiently introduce DA-synthesizing enzyme genes into the striatum of primates with restoration of motor functions. This triple transduction method may offer a potential therapeutic strategy for PD...
  10. ncbi request reprint Highly efficient gene transfer into primate embryonic stem cells with a simian lentivirus vector
    Takayuki Asano
    Division of Genetic Therapeutics, Jichi Medical School, Tochigi, 329 0498, Japan
    Mol Ther 6:162-8. 2002
    ..Furthermore, this highly efficient gene transfer method allows faithful gene delivery to primate ES cells with potential for both research and therapeutic application...
  11. ncbi request reprint Adeno-associated viral vectors for Parkinson's disease
    Shin Ichi Muramatsu
    Division of Neurology, Jichi Medical School, Tochigi 329 0498, Japan
    Int Rev Neurobiol 55:205-22. 2003
  12. ncbi request reprint Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease
    Xiao gang Li
    Division of Neurology, Department of Medicine, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Mol Ther 13:160-6. 2006
    ..Our data demonstrate that viral vector-mediated inducible Cre recombinase can serve as an in vivo molecular switch, allowing spatial and temporal control of transgene expression, thereby potentially increasing the safety of gene therapy...
  13. ncbi request reprint Improved safety of hematopoietic transplantation with monkey embryonic stem cells in the allogeneic setting
    Hiroaki Shibata
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Stem Cells 24:1450-7. 2006
    ..Purging pluripotent cells with this surface marker would be a promising method of producing clinical progenitor cell preparations using human ESCs...
  14. ncbi request reprint Variation in the incidence of teratomas after the transplantation of nonhuman primate ES cells into immunodeficient mice
    Yukiko Kishi
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi 329 0498, Japan
    Cell Transplant 17:1095-102. 2008
    ..The incidence of teratomas varied substantially depending on the transplanted cells and recipient mice. Thus, considerable care must be taken as to tumorigenicity...
  15. ncbi request reprint Adeno-associated virus vectors for gene transfer to the brain
    Takashi Okada
    Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Kawachi, Tochigi 329 0498, Japan
    Methods 28:237-47. 2002
    ....
  16. doi request reprint Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease
    Shin Ichi Muramatsu
    Divison of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Synapse 63:541-8. 2009
    ..PET with multitracers is useful for functional studies in developing cell-based therapies against PD...
  17. pmc Subregional 6-[18F]fluoro-ʟ-m-tyrosine uptake in the striatum in Parkinson's disease
    Sayaka Asari
    Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    BMC Neurol 11:35. 2011
    ....
  18. ncbi request reprint [Gene therapy and cell transplantation for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical School
    Rinsho Shinkeigaku 45:902-4. 2005
    ..Another AAV vector-based clinical trial is also ongoing in which the subthalamic nucleus is transduced to produce inhibitory transmitters...
  19. doi request reprint Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea
    Yuhe Liu
    Division of Genetic Therapeutics, Jichi Medical University, Tochigi, Japan
    Mol Ther 16:474-80. 2008
    ..Our results suggest that AAV1-mediated expression of GDNF using a regulated expression system in the cochlea is a promising strategy to protect the cochlea from aminoglycoside-induced damage...
  20. ncbi request reprint [Gene therapy for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical School
    Nihon Rinsho 63:622-5. 2005
  21. ncbi request reprint [Cell therapy for Parkinson disease]
    Shin Ichi Muramatsu
    Division of Neurology, Jichi Medical University
    Rinsho Shinkeigaku 49:890-2. 2009
    ..Future targets for cell therapy should include some types of Parkinsonism with degeneration of striatal neurons...
  22. doi request reprint Preclinical substantia nigra dysfunction in rapid eye movement sleep behaviour disorder
    Masayuki Miyamoto
    Department of Neurology, Centre of Sleep Medicine, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Sleep Med 13:102-6. 2012
    ..It is hypothesized that SN hyperechogenicity in healthy subjects and patients with idiopathic rapid eye movement (REM) sleep behaviour disorder (iRBD) patients is a marker of vulnerability for Parkinson's disease...
  23. ncbi request reprint [ES cell therapy for Parkinson's disease]
    Yuko Nara
    Divison of Neurology, Department of Medicine, Jichi Medical School
    Nihon Rinsho 62:1643-7. 2004
    ..Transplantation of neuronal stem cells derived from primate ES cells into a primate model of PD restored striatal DA function, suggesting ES cells are suitable donor cells...
  24. doi request reprint The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2
    Shinobu Kuratomi
    Department of Physiology, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Cardiovasc Res 83:682-7. 2009
    ..We aimed to identify cis-elements in the genomic locus of the Hcn4 gene that regulate the transcription of Hcn4...
  25. ncbi request reprint [Gene therapy for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical University
    Rinsho Shinkeigaku 52:896-8. 2012
    ..A similar approach, delivering AAV vector carrying AADC gene into the putamen ameliorated the symptoms in children with AADC deficiency...
  26. doi request reprint Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2
    Yu Miyazaki
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nat Med 18:1136-41. 2012
    ..Our results establish the proof of principle that disease-specific miRNA delivery could be useful in neurodegenerative diseases...
  27. ncbi request reprint [Gene therapy for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Brain Nerve 59:425-30. 2007
    ..Gene therapy using rAAV vectors may be a promising option for treatment of PD in the near future...
  28. doi request reprint ERas is expressed in primate embryonic stem cells but not related to tumorigenesis
    Yujiro Tanaka
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cell Transplant 18:381-9. 2009
    ..Therefore, cynomolgus ES cells are more similar to human than mouse ES cells despite that ERas is expressed in cynomolgus and mouse ES cells but not in human ES cells...
  29. ncbi request reprint [Gene therapy for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical School
    Nihon Rinsho 62:1648-52. 2004
    ..A clinical trial to evaluate the efficacy of subthalamic transduction to produce inhibitory transmitters is underway...
  30. ncbi request reprint Efficient gene transfer of a simian immuno-deficiency viral vector into cardiomyocytes derived from primate embryonic stem cells
    Mihoko Nagata
    Department of Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    J Gene Med 5:921-8. 2003
    ..However, protocols for efficient gene transfer into primate ES-cell-derived cells have not yet been established...
  31. ncbi request reprint Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Hirohide Sawada
    School of Medicine, Fujita Health University, Toyoake, Japan
    J Neurosci Res 85:1752-61. 2007
    ....
  32. pmc Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice
    Hiroyuki Nakai
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 79:214-24. 2005
    ..In addition, the rAAV8 vector may offer a potential therapeutic agent for various diseases affecting nonhepatic tissues, but great caution is required for vector spillover and tight control of tissue-specific gene expression...
  33. ncbi request reprint Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Biomed Sci 9:534-41. 2002
    ..Delivery of restriction enzymes into mitochondria is a novel strategy for gene therapy of a special form of mitochondrial diseases...
  34. ncbi request reprint Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice
    Masaki Wakamatsu
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Yoshino cho 1 403, Kita ku, Saitama shi, Saitama 331 9530, Japan
    Neurobiol Aging 29:574-85. 2008
    ..Our results indicate that truncated human alpha-synuclein is deleterious to the development and/or survival of nigral dopaminergic neurons...
  35. ncbi request reprint Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease
    Masahiro Maruyama
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Ann Neurol 57:832-42. 2005
    ....
  36. ncbi request reprint Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:991-8. 2004
    ..Thus, presynaptic neprilysin has been demonstrated to degrade Abeta efficiently and to retard development of amyloid pathology...