Akira Morimoto

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. doi request reprint Therapeutic outcome of multifocal Langerhans cell histiocytosis in adults treated with the Special C regimen formulated by the Japan LCH Study Group
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, 3311 1 Yakushi ji, Shimotsuke, Tochigi, Japan
    Int J Hematol 97:103-8. 2013
  2. doi request reprint Nationwide survey of bisphosphonate therapy for children with reactivated Langerhans cell histiocytosis in Japan
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Pediatr Blood Cancer 56:110-5. 2011
  3. doi request reprint Nationwide survey of single-system single site Langerhans cell histiocytosis in Japan
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Pediatr Blood Cancer 54:98-102. 2010
  4. ncbi request reprint Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child
    Aya Ogami
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:427-30. 2004
  5. ncbi request reprint Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    Haematologica 88:1238-44. 2003
  6. doi request reprint Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan
    Nobuhiro Suzuki
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Pediatr 155:235-8.e1. 2009
  7. doi request reprint Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine: a nationwide survey in Japan
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Int J Hematol 91:646-51. 2010
  8. ncbi request reprint Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis: Results from the Japan Langerhans Cell Histiocytosis Study Group-96 protocol study
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Cancer 107:613-9. 2006
  9. ncbi request reprint A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 83:51-4. 2006
  10. doi request reprint Late appearance of a Philadelphia chromosome in a patient with therapy-related acute myeloid leukemia and high expression of EVI1
    Shigeki Yagyu
    Department of Pediatrics, Kyoto City Hospital, 1 2 Mibuhigushitakada cho, Nakagyo ku, Kyoto, Japan
    Cancer Genet Cytogenet 180:115-20. 2008

Detail Information

Publications51

  1. doi request reprint Therapeutic outcome of multifocal Langerhans cell histiocytosis in adults treated with the Special C regimen formulated by the Japan LCH Study Group
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, 3311 1 Yakushi ji, Shimotsuke, Tochigi, Japan
    Int J Hematol 97:103-8. 2013
    ..This was particularly evident for patients with multifocal SS disease, but half of those with MS disease also benefited...
  2. doi request reprint Nationwide survey of bisphosphonate therapy for children with reactivated Langerhans cell histiocytosis in Japan
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Pediatr Blood Cancer 56:110-5. 2011
    ..Several studies have suggested that Langerhans cell histiocytosis (LCH) is responsive to treatment with bisphosphonates (BPs). However the efficacy and safety of BPs therapy for childhood LCH is unknown...
  3. doi request reprint Nationwide survey of single-system single site Langerhans cell histiocytosis in Japan
    Akira Morimoto
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Pediatr Blood Cancer 54:98-102. 2010
    ....
  4. ncbi request reprint Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child
    Aya Ogami
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:427-30. 2004
    ..Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare...
  5. ncbi request reprint Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    Haematologica 88:1238-44. 2003
    ..However, results of previous reports have been controversial. This study was undertaken to clarify the influence of GST polymorphism on the outcome of childhood B-precursor acute lymphoblastic leukemia (ALL)...
  6. doi request reprint Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan
    Nobuhiro Suzuki
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Pediatr 155:235-8.e1. 2009
    ..To assess the etiology, prognosis, and appropriate treatment of hemophagocytic lymphohistiocytosis (HLH) in neonates...
  7. doi request reprint Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine: a nationwide survey in Japan
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Int J Hematol 91:646-51. 2010
    ..On the other hand, in the patients having reactivation while off therapy, 6 of 7 patients showed good response. These findings suggest that 2-CdA is effective for reactivated LCH while off therapy...
  8. ncbi request reprint Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis: Results from the Japan Langerhans Cell Histiocytosis Study Group-96 protocol study
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Cancer 107:613-9. 2006
    ..To overcome these issues, the Japan LCH Study Group-96 (JLSG-96) protocol was conducted prospectively from 1996 to 2001 in Japan...
  9. ncbi request reprint A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 83:51-4. 2006
    ....
  10. doi request reprint Late appearance of a Philadelphia chromosome in a patient with therapy-related acute myeloid leukemia and high expression of EVI1
    Shigeki Yagyu
    Department of Pediatrics, Kyoto City Hospital, 1 2 Mibuhigushitakada cho, Nakagyo ku, Kyoto, Japan
    Cancer Genet Cytogenet 180:115-20. 2008
    ..These results suggest that EVI1 overexpression was the major factor contributing to leukemogenesis, and the late appearance of the Ph chromosome is closely associated with the progression to an aggressive form of leukemia...
  11. doi request reprint Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: a nationwide survey in Japan
    Takeshi Asano
    Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Inzai City, Chiba, Japan
    Pediatr Blood Cancer 59:110-4. 2012
    ..Although HLH can be also observed after hematopoietic stem cell transplantation (HSCT), the incidence and clinical features of HLH after HSCT remain obscure...
  12. ncbi request reprint Control of hepatic veno-occlusive disease with an antithrombin-III concentrate-based therapy
    Noriko Shin-Nakai
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan
    Pediatr Int 48:85-7. 2006
  13. ncbi request reprint Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Crit Rev Oncol Hematol 53:209-23. 2005
    ..In the near future, an entire pathogenesis should be clarified in order to establish appropriate therapies including immunotherapy, HSCT and gene therapy...
  14. ncbi request reprint Successful autologous peripheral blood stem cell transplantation with rituximab administration for pediatric diffuse large B-cell lymphoma
    Toshihiko Imamura
    Department of Pediatrics, Matushita Memorial Hospital, Moriguchi, Japan
    Pediatr Hematol Oncol 23:19-24. 2006
    ....
  15. doi request reprint Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan
    Shouichi Ohga
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pediatr Blood Cancer 54:299-306. 2010
    ..Post-transplant outcomes of hemophagocytic lymphohistiocytosis (HLH) patients were analyzed in Japan where Epstein-Barr virus (EBV)-associated severe forms are problematic...
  16. doi request reprint Successful treatment with pulse cyclophosphamide of a steroid-refractory hepatitic variant of liver acute graft-vs.-host disease in a child
    Yuta Kawahara
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    Pediatr Transplant 16:E315-9. 2012
    ..This single case report suggests that pulse Cy may be a promising therapy for steroid-refractory GVHD, especially hepatitic GVHD, but needs to be further tested in clinical trials...
  17. ncbi request reprint Invasive adenoviral infection in a recipient of unrelated bone marrow transplantation: Problems with diagnostic PCR
    Hiroyuki Ishida
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi Shi, Japan
    Pediatr Blood Cancer 44:416-9. 2005
    ..We suspect that conventional/real-time PCR failed to detect AdV due to nine silent single base substitutions in the extracted AdV genome. Treatment with 1 mg/kg cidofovir (CDV) intravenously three times a week was effective...
  18. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases
    Kanako Hatta
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamigyo ku, Kyoto, Japan
    Haematologica 92:1470-4. 2007
    ..In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases...
  19. doi request reprint Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: the AML99 trial from the Japanese Childhood AML Cooperative Study Group
    Ichiro Tsukimoto
    Department of Pediatrics, Toho University School of Medicine, Tokyo, Japan
    J Clin Oncol 27:4007-13. 2009
    ..To improve the prognosis in children with newly diagnosed acute myeloid leukemia (AML) by introducing a dose-dense intensive chemotherapy regimen and an appropriate risk stratification system...
  20. ncbi request reprint Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL)
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pediatr Blood Cancer 46:482-8. 2006
    ..Classification of familial hemophagocytic lymphohistiocytosis (FHL) into FHL2, FHL3, and other subtypes based on genetic abnormalities has recently become possible. We studied the phenotypic differences among these subtypes in Japan...
  21. ncbi request reprint Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Hematol 82:427-32. 2007
    ..None had homozygous nonsense mutations. Our data suggest that nonsense perforin gene mutations yield early onset and missense mutations late onset in FHL2 cases...
  22. ncbi request reprint Prognostic value of early response to treatment combined with conventional risk factors in pediatric acute lymphoblastic leukemia
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
    Int J Hematol 81:228-34. 2005
    ..Our new prognostic definition (R1, R2, R3) incorporating day 14 marrow findings is useful to tailor early-phase treatments for better therapeutic results in childhood ALL...
  23. ncbi request reprint Early blastic transformation following complete cytogenetic response in a pediatric chronic myeloid leukemia patient treated with imatinib mesylate
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:320-2. 2004
    ..CML patients who respond slowly to imatinib may still be candidates for allo-SCT, even when a major cytogenetic response is obtained...
  24. ncbi request reprint Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation
    Toshihiko Imamura
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan
    Int J Hematol 80:186-9. 2004
    ..The patient continues to be well and in remission 3 years after stem cell transplantation...
  25. pmc Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group
    Takuya Kamio
    Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Haematologica 96:814-9. 2011
    ..However, detailed analyses of relapses in aplastic anemia children are limited...
  26. ncbi request reprint Successful non-T-cell-depleted HLA-haploidentical 3-loci mismatched bone marrow transplantation
    Shigeki Yagyu
    Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan
    Eur J Haematol 74:529-32. 2005
    ..Our case suggests that non-TCD HLA-haploidentical 3-loci mismatched BMT can be safely performed from mother to offspring even when feto-maternal microchimerism is barely detectable with the current detection procedure...
  27. ncbi request reprint A preparatory regimen of total body irradiation, busulphan and melphalan for allogeneic bone marrow transplantation in childhood high-risk leukemia and lymphoma
    Takao Yoshihara
    Department of Pediatrics, Matsushita Memorial Hospital, 5 55, Sotojima cho, Moriguchi Shi, Osaka, 570 8540, Japan
    Anticancer Res 23:1739-42. 2003
    ....
  28. ncbi request reprint Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kajii cho Hirokoji Kamigyo ku, Kyoto, Japan
    Leuk Lymphoma 46:729-35. 2005
    ..Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration...
  29. doi request reprint Frequency and clinical features of the JAK2 V617F mutation in pediatric patients with sporadic essential thrombocythemia
    Takuya Nakatani
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Pediatr Blood Cancer 51:802-5. 2008
    ..While several recent studies have focused on the role of the JAK2 V617F mutation in pediatric ET, the frequency of pediatric ET cases with this mutation and the associated clinical features remain unclear...
  30. doi request reprint Successful management of severe L-asparaginase-associated pancreatitis by continuous regional arterial infusion of protease inhibitor and antibiotic
    Akira Morimoto
    Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cancer 113:1362-9. 2008
    ..The authors investigated whether rapidly treating children with AAP by continuous regional arterial infusion (CRAI) of protease inhibitor and antibiotic would quickly resolve AAP...
  31. ncbi request reprint Use of rituximab to treat refractory Diamond-Blackfan anemia
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Eur J Haematol 74:442-4. 2005
    ..Rituximab may be a successful therapy for refractory DBA where B cells play a crucial role in the pathogenesis of the severe anemia...
  32. ncbi request reprint Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Blood 105:3442-8. 2005
    ..These results suggest an association between the type of genetic mutation in FHL cases and the magnitude of CTL cytolytic activity and age at onset...
  33. ncbi request reprint A case of a ewing sarcoma family tumor in the urinary bladder after treatment for acute lymphoblastic leukemia
    Shinya Osone
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Pediatr Hematol Oncol 29:841-4. 2007
    ..These findings support the diagnosis of Ewing sarcoma family of tumor. After adjuvant multidrug chemotherapy, the patient has shown no evidence of disease for more than 2 years...
  34. ncbi request reprint Hb Bristol-Alesha presenting thalassemia-type hyperunstable hemoglobinopathy
    Gen Kano
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 80:410-5. 2004
    ....
  35. ncbi request reprint High serum values of soluble CD154, IL-2 receptor, RANKL and osteoprotegerin in Langerhans cell histiocytosis
    Rumiko Ishii
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Pediatr Blood Cancer 47:194-9. 2006
    ..To determine useful biochemical markers in Langerhans cell histiocytosis (LCH), we analyzed the serum levels of soluble CD154 (sCD154), IL2 receptor (sIL2-R), receptor activator of NF-kappaB ligand (sRANKL), and osteoprotegerin (OPG)...
  36. doi request reprint A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia
    Takahiro Ikeda
    Department of Pediatrics, Division of Virology, Jichi Medical University School of Medicine, Tochigi, Japan
    J Pediatr Hematol Oncol 34:375-7. 2012
    ..T-cell subsets analysis at the onset of hepatitis might be useful for predicting development of hepatitis-associated aplastic anemia...
  37. doi request reprint Another promising treatment option for neuroblastoma-associated opsoclonus-myoclonus syndrome by oral high-dose dexamethasone pulse: lymphocyte markers as disease activity
    Makiko Oguma
    Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi 329 0498, Japan
    Brain Dev 34:251-4. 2012
    ..These aberrant values in PB were reversed by DEX pulse therapy and correlated well with the neurological symptoms. A prospective study that assesses the efficacy of this promising and inexpensive treatment for OMS is warranted...
  38. ncbi request reprint Successful treatment of congenital systemic juvenile xanthogranuloma with Langerhans cell histiocytosis-based chemotherapy
    Takuya Nakatani
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:371-4. 2004
    ..The LCH-based multiagent chemotherapy including cytarabine, vincristine, methotrexate, and prednisolone ameliorated the symptoms rapidly. She was treated for 12 months and is currently doing well as a normally developing 2-year-old...
  39. ncbi request reprint Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11)
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kaiji cho, Hirokoji, Kamigyo ku, Kyoto, Japan
    Genes Chromosomes Cancer 36:413-9. 2003
    ..Through a similar mechanism, we believe that MOZ, fused to an unidentified partner gene at 2p23, may have caused an alteration in histone acetylation, resulting in the development of tMDS in this patient...
  40. ncbi request reprint Rapidly progressing fatal adult multi-organ Langerhans cell histiocytosis complicated with fatty liver disease
    Mitsuhiro Yuasa
    Departments of Hematology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Clin Exp Hematop 52:121-6. 2012
    ..This case indicates that some multi-system LCH patients with hypopituitarism and hypothalamic dysfunction show very rapid progression and are difficult to treat...
  41. doi request reprint Cost effectiveness of prophylactic treatment with activated prothrombin complex concentrate in a patient with inhibitor-positive hemophilia A
    Sachie Nakamura
    Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, Japan
    Blood Coagul Fibrinolysis 23:235-7. 2012
    ..This reduced the frequency and severity of bleeding and ended the need for hospitalization. This, together with a decreased requirement for bypass agents, APCC treatment significantly reduced the cost of treatment for this patient...
  42. pmc Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report
    Hideki Yoshida
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan
    J Hematol Oncol 2:40. 2009
    ..HS and Evans' syndrome have different mechanisms of pathophysiology one another. We reported the quite rare case of an infant who had these diseases concurrently. Possible explanations of the unexpected complication are discussed...
  43. ncbi request reprint Systemic juvenile idiopathic arthritis mimics multicentric Castleman's disease
    Shinya Osone
    Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, 602 8566 Kyoto, Japan
    Clin Rheumatol 22:484-6. 2003
    ..The patient's symptoms and hypercytokinemia disappeared soon after corticosteroid treatment was started. This case demonstrates that overproduction of IL-6 is common to systemic JIA and multicentric Castleman's disease...
  44. ncbi request reprint Prospective study of a pirarubicin, intermediate-dose cytarabine, and etoposide regimen in children with Down syndrome and acute myeloid leukemia: the Japanese Childhood AML Cooperative Study Group
    Kazuko Kudo
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Clin Oncol 25:5442-7. 2007
    ..To evaluate a less intensive chemotherapeutic regimen specifically designed for patients with Down syndrome (DS) and acute myeloid leukemia (AML), and to determine the prognostic factors for event-free survival...
  45. ncbi request reprint Successful transplantation of haploidentical CD34+ selected bone marrow cells for an infantile case of severe combined immunodeficiency with aspergillus pneumonia
    Takao Yoshihara
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi Shi, Osaka, Japan
    Pediatr Hematol Oncol 19:439-43. 2002
    ..Conquest of aspergillus pneumonia in SCID infants could be achieved by CD34+ bone marrow cell transplantation together with appropriate anti-fungal treatment...
  46. doi request reprint Congenital hemophagocytic lymphohistiocytosis in a preterm infant: cytokine profile and a review of the disease
    Asami Maruyama
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    J Pediatr Hematol Oncol 33:e209-12. 2011
    ....
  47. doi request reprint Langerhans cell histiocytosis case with dense metaphyseal band sign
    Ichiro Kikkawa
    Departments of Pediatric Orthopedics Pediatric Radiology Pediatrics, Jichi Children s Medical Center Tochigi, Shimotsuke, Japan
    Pediatr Int 55:96-8. 2013
    ..After that treatment, X-ray photographs of the patient's body showed dense metaphyseal band sign. There have been few such cases reported until now...
  48. ncbi request reprint A novel missense mutation (1060G --> C) in the phosphoglycerate kinase gene in a Japanese boy with chronic haemolytic anaemia, developmental delay and rhabdomyolysis
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Br J Haematol 122:1009-13. 2003
    ..The patient developed the full clinical symptoms of PGK1 deficiency including haemolytic anaemia, myopathy, central nervous system disorder and growth retardation, which is unusual...
  49. ncbi request reprint Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kajiicho 465 Hirokoji, Kamigyoku, Kyoto 602 8566, Japan
    Br J Haematol 117:525-30. 2002
    ..Only one case of T lineage ALL expressed a small-sized isoform of Helios (designated as He6). It was also found that the expression of Ai1 and He1 was low in Ik6-positive patients (Fisher's exact test; Ai1 P = 0.005, Hel P = 0.035)...
  50. ncbi request reprint Hemophagocytic syndrome associated with severe adenoviral pneumonia: usefulness of real-time polymerase chain reaction for diagnosis
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 77:295-8. 2003
    ..This approach may provide important clues for improving outcomes and clarifying the exact etiology in cases of often fatal, infection-associated HPS...
  51. doi request reprint Mesenteric venous thrombosis in a child with type 2 protein S deficiency
    Takahiro Hayakawa
    Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    J Pediatr Hematol Oncol 33:141-3. 2011
    ..Sequence analysis detected a heterozygous K196E mutation in the PROS1 gene. Type 2 PS deficiency was diagnosed. This is the first report of mesenteric vein thrombosis in a child with a type 2 PS deficiency...