Kazuhiko Kotani

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. ncbi request reprint Development of a new point-of-care testing system for measuring white blood cell and C-reactive protein levels in whole blood samples
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi 329 0498, Japan Electronic address
    Clin Chim Acta 433:145-9. 2014
  2. pmc The effect of antihypertensive drugs on endothelial function as assessed by flow-mediated vasodilation in hypertensive patients
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Int J Vasc Med 2012:453264. 2012
  3. pmc Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    J Clin Biochem Nutr 45:329-34. 2009
  4. pmc LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto
    Int J Prev Med 3:160-6. 2012
  5. pmc The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    J Clin Med Res 3:319-24. 2011
  6. pmc Correlation Between High-sensitivity C-reactive Protein and Reactive Oxygen Metabolites During A One-year Period Among Asymptomatic Subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    J Clin Med Res 4:52-5. 2012
  7. pmc White Blood Cells, Neutrophils, and Reactive Oxygen Metabolites among Asymptomatic Subjects
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Int J Prev Med 3:428-31. 2012
  8. ncbi request reprint Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, 329 0498, Japan
    Singapore Med J 55:202-8. 2014
  9. pmc High-density lipoprotein and prostate cancer: an overview
    Kazuhiko Kotani
    Cardiopulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Epidemiol 23:313-9. 2013
  10. pmc Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study
    Kenta Okada
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Jichi Medical University, Tochigi 320 0498, Japan
    Tob Induc Dis 10:12. 2012

Detail Information

Publications93

  1. ncbi request reprint Development of a new point-of-care testing system for measuring white blood cell and C-reactive protein levels in whole blood samples
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi 329 0498, Japan Electronic address
    Clin Chim Acta 433:145-9. 2014
    ..There is a growing need for point-of-care testing (POCT) of WBC and CRP, and more advances in convenient devices are required. We developed an analyzer-free POCT system for measuring WBC and CRP using a low volume blood sample...
  2. pmc The effect of antihypertensive drugs on endothelial function as assessed by flow-mediated vasodilation in hypertensive patients
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Int J Vasc Med 2012:453264. 2012
    ..Antihypertensive treatment can improve endothelial dysfunction when assessed by FMD, although there are conflicting data that require further research...
  3. pmc Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    J Clin Biochem Nutr 45:329-34. 2009
    ..The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction...
  4. pmc LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto
    Int J Prev Med 3:160-6. 2012
    ..The aim of the present study was to investigate the correlation between the mean LDL particle size and the oxidative stress status as evaluated by the d-ROMs in dyslipidemic patients...
  5. pmc The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    J Clin Med Res 3:319-24. 2011
    ..The present study investigated the association between the A-3826G polymorphism and low HDL-cholesterolemia in non-obese and obese subjects...
  6. pmc Correlation Between High-sensitivity C-reactive Protein and Reactive Oxygen Metabolites During A One-year Period Among Asymptomatic Subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    J Clin Med Res 4:52-5. 2012
    ....
  7. pmc White Blood Cells, Neutrophils, and Reactive Oxygen Metabolites among Asymptomatic Subjects
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Int J Prev Med 3:428-31. 2012
    ..The objective of the present study was to investigate the association among white blood cell (WBC) counts, neutrophil counts as a WBC subpopulation, and diacron reactive oxygen metabolites (d-ROMs) levels in an asymptomatic population...
  8. ncbi request reprint Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, 329 0498, Japan
    Singapore Med J 55:202-8. 2014
    ....
  9. pmc High-density lipoprotein and prostate cancer: an overview
    Kazuhiko Kotani
    Cardiopulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Epidemiol 23:313-9. 2013
    ..More epidemiologic research, in combination with experimental studies, is needed in this field. ..
  10. pmc Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study
    Kenta Okada
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Jichi Medical University, Tochigi 320 0498, Japan
    Tob Induc Dis 10:12. 2012
    ..abstract:..
  11. pmc Japan Diabetes Outcome Intervention Trial-1 (J-DOIT1), a nationwide cluster randomized trial of type 2 diabetes prevention by telephone-delivered lifestyle support for high-risk subjects detected at health checkups: rationale, design, and recruitment
    Naoki Sakane
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    BMC Public Health 13:81. 2013
    ..This paper describes the study design and recruitment of the study subjects...
  12. doi request reprint Oxidized lipoprotein(a) and cardio-ankle vascular index (CAVI) in hypertensive subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Heart Vessels 28:461-6. 2013
    ..These findings suggest that the oxidative modification of Lp(a) may be associated with arterial stiffness in hypertensive, but not non-hypertensive, female subjects...
  13. pmc Correlation between reactive oxygen metabolites & atherosclerotic risk factors in patients with type 2 diabetes mellitus
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    Indian J Med Res 137:742-8. 2013
    ..The present study was aimed to investigate the correlation of the oxidative stress status, as evaluated by the d-ROMs, with atherosclerotic risk factors in T2DM patients, in comparison to controls...
  14. doi request reprint Association between remnant-like particle cholesterol and gamma-glutamyltransferase in dyslipidemic patients
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Med Princ Pract 22:189-93. 2013
    ..To investigate the correlation between gamma-glutamyltransferase (GGT) and remnant-like particle cholesterol (RLP-C) in dyslipidemic patients...
  15. ncbi request reprint Circulating soluble receptor for advanced glycation end products is inversely correlated to oxidized low-density lipoproteins in asymptomatic subjects
    K Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    J Int Med Res 40:1878-83. 2012
    ..A previous study reported that oxidized low-density lipoprotein (oxLDL) can be one of the RAGE ligands. The present cross-sectional study investigated the clinical association between sRAGE and oxLDL in humans...
  16. doi request reprint Association between angiotensin II Type 2 receptor gene A/C3123 polymorphism and high-density lipoprotein cholesterol with hypertension in asymptomatic women
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Med Princ Pract 22:65-9. 2013
    ..The present study investigated the association between the angiotensin II type 2 receptor (AT2R) gene adenine/cytosine (A/C)-3123 polymorphism and cardiometabolic variables in subjects with and without hypertension...
  17. doi request reprint Association between reactive oxygen metabolites and paraoxonase 1 activity during a physical activity increase intervention with older Japanese people
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Australas J Ageing 31:222-6. 2012
    ....
  18. doi request reprint Levels of reactive oxygen metabolites in patients with knee osteoarthritis
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Australas J Ageing 30:231-3. 2011
    ..The present study aimed to compare oxidative status levels of patients with and without knee OA, using the Reactive Oxygen Metabolites (d-ROMs, Diacron, Italy) test, which has proved to be clinically useful as an oxidative stress marker...
  19. doi request reprint Oxidized high-density lipoprotein is associated with increased plasma glucose in non-diabetic dyslipidemic subjects
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto City, Kyoto 612 8555, Japan
    Clin Chim Acta 414:125-9. 2012
    ..This study investigated the association of oxHDL with plasma glucose (PG) and the other atherosclerotic risk variables in non-diabetic dyslipidemic subjects...
  20. ncbi request reprint Adiponectin and smoking status: a systematic review
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    J Atheroscler Thromb 19:787-94. 2012
    ..Smoking and adiponectin are individually associated with cardiometabolic pathologies. The present systematic review was carried out in order to summarize the association between the smoking status and circulating adiponectin levels...
  21. ncbi request reprint Pedometer step counts and oxidized low-density lipoprotein levels among asymptomatic subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Ann Clin Lab Sci 42:435-8. 2012
    ....
  22. ncbi request reprint Paraoxonase-1 gene Q192R polymorphism and reactive oxygen metabolites
    K Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Centre, 1 1 Fukakusa Mukaihata, Fushimi ku, Kyoto 612 8555, Japan
    J Int Med Res 40:1513-8. 2012
    ..In this study, the diacron reactive oxygen metabolites (d-ROMs) test was used to investigate the relationship between Q192R polymorphism and oxidative stress-related markers in Japanese subjects...
  23. doi request reprint The correlation between the cardio-ankle vascular index (CAVI) and serum amyloid A in asymptomatic Japanese subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Heart Vessels 27:499-504. 2012
    ..SAA may be a positive inflammatory factor associated with arterial stiffness, and the clinical relevance and the biological mechanism for this relationship should be established in future studies...
  24. ncbi request reprint C-reactive protein and reactive oxygen metabolites in subjects with metabolic syndrome
    K Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Centre, 1 1 Fukakusa Mukaihata, Fushimi ku, Kyoto 612 8555, Japan
    J Int Med Res 40:1074-81. 2012
    ..This cross-sectional study investigated the correlation between diacron reactive oxygen metabolites (d-ROMs) and high-sensitivity C-reactive protein (hs-CRP) in subjects with or without metabolic syndrome...
  25. ncbi request reprint The correlation between serum amyloid A and reactive oxygen metabolites in a young Mongolian population
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    Ethn Dis 22:329-34. 2012
    ..Our study investigated the correlation among the d-ROMs test (a measure of the total oxidant capacity of blood), serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in a young Mongolian population...
  26. ncbi request reprint Association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    Ethn Dis 22:324-8. 2012
    ....
  27. doi request reprint Oxidative stress and metabolic syndrome in a Japanese female population
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Australas J Ageing 31:124-7. 2012
    ..The aim of the present study was to investigate the possible association between oxidative stress as evaluated by the d-ROMs test and the MetS component number, in a Japanese female population...
  28. ncbi request reprint Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi 320 0498, Japan
    Pharmacol Rep 64:212-6. 2012
    ..The results suggest that atorvastatin may beneficially reduce SAA-LDL, and SAA-LDL may be a sensitive measure for monitoring the efficacy and antioxidant functions of atorvastatin...
  29. doi request reprint Effect of ezetimibe on remnant-like particle cholesterol in subjects with metabolic syndrome
    Kazuhiko Kotani
    Department of Preventive Medicine and Diabetes Education, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Med Princ Pract 21:134-8. 2012
    ..To investigate the influence of ezetimibe monotherapy on remnant-like particle cholesterol (RLP-C) in subjects with metabolic syndrome (MetS)...
  30. doi request reprint FTO gene polymorphisms and platelet counts in a general Japanese population
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    J Investig Med 60:514-6. 2012
    ..The FTO gene polymorphisms may be associated with the minor but significant modulation of platelet counts in this population...
  31. doi request reprint A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population
    K Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Exp Clin Endocrinol Diabetes 120:59-61. 2012
    ..The present data suggest that the ACACB gene C>T polymorphism may therefore be associated with chronic inflammation in this population...
  32. ncbi request reprint Influence of ezetimibe monotherapy on ischemia-modified albumin levels in hypercholesterolemic patients
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    Pharmacol Rep 63:1248-51. 2011
    ....
  33. doi request reprint Continuous positive air pressure treatment reduces serum advanced glycation end products in patients with obstructive sleep apnoea syndrome: a pilot study
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Prim Care Respir J 20:336-7. 2011
    ..At baseline, OSAS patients had significantly higher levels of AGEs than controls. Six months after nCPAP initiation, AGEs decreased significantly. nCPAP treatment could lower AGEs in patients with OSAS...
  34. ncbi request reprint The relationship between adiponectin and blood pressure in premenopausal and postmenopausal women
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, 329 0498, Japan
    Clin Invest Med 34:E125-30. 2011
    ..The present study cross-sectionally compared the relationship between adiponectin and BP in pre- and postmenopausal women...
  35. ncbi request reprint The association between circulating secreted protein acidic and rich in cysteine (SPARC) and glycosylated haemoglobin (HbA(1c)) during lifestyle-modified weight reduction intervention in obese male subjects
    K Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    J Int Med Res 39:528-32. 2011
    ..The relationship between SPARC and HbA(1c) may merit further investigation with regard to its association with postprandial or long-term glucose variation in obese male subjects...
  36. pmc Leptin:adiponectin ratio and metabolic syndrome in the general Japanese population
    Kazuhiko Kotani
    Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Korean J Lab Med 31:162-6. 2011
    ....
  37. ncbi request reprint Association between lipoprotein(a) and oxygen reactive metabolite in asymptomatic subjects
    Kazuhiko Kotani
    Department of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Japan
    Pol Arch Med Wewn 121:247-52. 2011
    ..Lipoprotein(a) [Lp(a)] is generally considered a risk factor for cardiovascular disease (CVD). The coexistence of Lp(a) and oxidative status may be associated with the pathophysiology of the Lp(a)-CVD linkage...
  38. pmc The relationship between oxidized lipoprotein(a) and carotid atherosclerosis in asymptomatic subjects: a comparison with native lipoprotein(a)
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Lipids Health Dis 10:174. 2011
    ..This study aimed to investigate the association between the serum oxLp(a) and carotid artery intima-media thickness (CIMT), in comparison to the serum Lp(a) levels, among asymptomatic subjects...
  39. doi request reprint A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute for Endocrine Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Atherosclerosis 204:526-31. 2009
    ..In the present report, we investigated the levels of SAA-LDL and AT-LDL in relation to the components of the MetS. We also assessed the effect of weight reduction therapy on serum SAA-LDL and AT-LDL levels among obese subjects...
  40. ncbi request reprint Correlation between ischaemia-modified albumin and intermediate-density lipoprotein in haemodialysis patients with end-stage renal disease
    K Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    J Int Med Res 39:1541-5. 2011
    ....
  41. ncbi request reprint Paraoxonase-1 and ischemia-modified albumin in patients with end-stage renal disease
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, Japan
    J Physiol Biochem 67:437-41. 2011
    ..Although the pathogenic link between PON-1 and IMA remains speculative, considering both biomarkers may provide new insights into the prevention of CVD in ESRD patients...
  42. pmc The association between adiponectin, HDL-cholesterol and α1-antitrypsin-LDL in female subjects without metabolic syndrome
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Lipids Health Dis 9:147. 2010
    ..The aim of the present study was to investigate the association between AT-LDL and anti-atherosclerotic variables such as HDL-cholesterol and adiponectin in subjects with and without metabolic syndrome (MetS)...
  43. doi request reprint The effects of lifestyle modification on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in subjects with primary lipid disorder
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi 329 0498, Japan
    Clin Chim Acta 409:67-9. 2009
    ..Our aim was to investigate the effects of lifestyle modification on serum amyloid A-LDL (SAA-LDL), a new oxLDL, in subjects with primary lipid disorder...
  44. ncbi request reprint Relationship between the abdominal wall fat index and blood pressure in elderly women: a comparison with the body mass index
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fushimi ku, Kyoto 612 8555, Japan
    Aging Clin Exp Res 21:349-52. 2009
    ..Few studies, however, have compared the AFI with the BMI as a measure of obesity. Older women were examined to determine the associations among BMI, AFI and cardiometabolic variables...
  45. pmc Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Int J Med Sci 7:90-3. 2010
    ..The objective of this study was to investigate the effects of cardio-metabolic variables such as cholesterol on serum aspirin esterase activity in older people who participated in an intervention study on physical activity...
  46. ncbi request reprint Serum adiponectin multimer complexes and liver cancer risk in a large cohort study in Japan
    Kazuhiko Kotani
    Department of Public Health, Jichi Medical University, Tochigi, Japan
    Asian Pac J Cancer Prev 10:87-90. 2009
    ..22-1.15]), albeit without statistical significance (set at p<0.05). Higher percentages of circulating LMW adiponectin may lead to a reduction of liver cancer risk and relationships with multimer composition may merit further study...
  47. doi request reprint Influence of smoking habits on the GA/HbA1c ratio in patients with type 1 diabetes mellitus
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Med Princ Pract 19:415-7. 2010
    ..To assess the influence of smoking on glycated albumin (GA) to hemoglobin A1c (HbA1c) ratio among type 1 diabetes mellitus (T1DM) patients...
  48. pmc Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Diabetol Metab Syndr 2:50. 2010
    ..Aspirin esterase (AE) activity can account for part of aspirin pharmacokinetics in the circulation, possibly being associated with the impairment of aspirin effectiveness as an inhibitor of platelet aggregation...
  49. doi request reprint Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Clin Chem Lab Med 48:1773-6. 2010
    ..The present study investigated whether the association between coffee and the eGFR was independent of chronic inflammation, and whether adding sugar to coffee could affect the eGFR...
  50. doi request reprint Remnant-like particle cholesterol and serum amyloid A-low-density lipoprotein levels in obese subjects with metabolic syndrome
    Kazuhiko Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Fushimi ku, Kyoto, Japan
    J Clin Lipidol 5:395-400. 2011
    ..In the present study, we aimed to investigate the correlation between RLP-C and SAA-LDL in obese subjects with MetS in comparison to those without MetS...
  51. ncbi request reprint The influence of metabolic syndrome and chronic kidney disease on hemorheology assessed by the microchannel method
    Kazuhiko Kotani
    Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Fushimi ku, Kyoto, Japan
    J Physiol Anthropol 29:157-60. 2010
    ..6±3.5) or non-CKD and MetS (50.0±12.2). The influence of the combination of MetS and CKD was clearer in men, relative to women. Abnormal hemorheology as assessed using MC-FAN may be enhanced by the combination of MetS and CKD...
  52. doi request reprint Relationship between reactive oxygen metabolites and carotid intima-media thickness in subjects with hypercholesterolemia
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Med Princ Pract 19:496-8. 2010
    ..It was the aim of this study to investigate whether there is any relationship between oxidative stress, as assessed by the diacron reactive oxygen metabolite (d-ROM) test, and carotid atherosclerosis among hypercholesterolemic patients...
  53. pmc The association between blood glucose and oxidized lipoprotein(a) in healthy young women
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Lipids Health Dis 9:103. 2010
    ..The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose...
  54. ncbi request reprint Serum amyloid A low-density lipoprotein levels and smoking status in obese Japanese patients
    K Kotani
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Centre, Kyoto, Japan
    J Int Med Res 39:1917-22. 2011
    ..This significant difference was reduced after adjusting for multiple confounders, including lipid levels. Smoking may be associated with increased levels of SAA-LDL in an obese Japanese population, but further studies are needed...
  55. pmc Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome
    Noriko Satoh-Asahara
    Division of Diabetic Research, Clinical Research Institute, Diabetes Center, Department of Nephrology, National Hospital Organization, Kyoto Medical Center, 1 1 Fukakusa Mukaihata cho, Fushimi ku, Kyoto 612 8555, Japan
    Clin J Am Soc Nephrol 6:265-73. 2011
    ..This study was designed to elucidate the association of urinary CysC (U-CysC), a marker of renal tubular dysfunction, with CVD and CKD risk factors in patients with obesity and MS...
  56. doi request reprint The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population
    Taku Hamada
    Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrinology and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    Metabolism 57:410-5. 2008
    ..Furthermore, this polymorphism, when expressed in its homozygous form, reduced the prevalence of obesity in Japanese...
  57. doi request reprint Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome
    Noriko Satoh
    Clinical Research Institute for Endocrine Metabolic Diseases, Kyoto Medical Center, Kyoto, Japan
    Hypertens Res 31:1921-30. 2008
    ..Therefore, the determination of arterial stiffness by CAVI may be useful for evaluating and managing the CVD risks of MS patients...
  58. ncbi request reprint The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study
    Kokoro Tsuzaki
    Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Metabolism 56:1689-93. 2007
    ..The present findings suggest that the beta(3)-AR gene polymorphism plays a role in the genetic predisposition to increased sdLDL, independently of insulin resistance...
  59. ncbi request reprint Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene with small dense low-density lipoprotein in the general population
    Taku Hamada
    Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrinology and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    Metabolism 56:1345-9. 2007
    ..040). In conclusion, the Pro12Ala polymorphism in the PPARgamma2 gene was positively associated with an enlarged area of sdLDL4-7. This polymorphism may play a role in the genetic predisposition to increases in sdLDL4-7...
  60. doi request reprint An association between angiotensin II type 2 receptor gene A/C3123 polymorphism and glycemic control marker in a general Japanese population
    Kazuhiko Kotani
    Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Mol Biol Rep 36:917-20. 2009
    ..Conclusion These results suggest that the AT2R A/C3123 polymorphism could be a polymorphic marker related to glycemic control, as presented in HbA1c, among general Japanese women...
  61. pmc Epidemiologic features of Kawasaki disease in Japan: results of the 2009-2010 nationwide survey
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Epidemiol 22:216-21. 2012
    ..Although the number of patients and incidence rate of Kawasaki disease (KD) are increasing in Japan, the most recent epidemiologic features of KD are not known...
  62. ncbi request reprint The UCP2-866 A/A genotype is associated with low density lipoprotein particle sizes in the general population
    Taku Hamada
    Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrinology and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Med Sci Monit 14:CR107-11. 2008
    ..The purpose of this study was to investigate whether the UCP2-866 G/A SNP was associated with serum LDL particle characteristics in a general Japanese population...
  63. ncbi request reprint Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome
    Noriko Satoh
    Clinical Research Institute for Endocrine Metabolic Diseases, National Hospital Organization, Kyoto Medical Center, 1 1 Fukakusa Mukaihata cho, Fushimi ku, Kyoto 612 8555, Japan
    Diabetes Care 30:144-6. 2007
  64. doi request reprint The relationship between serum C-reactive protein and daily physical activity in Japanese hypertensive patients
    Shuumarjav Uurtuya
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Clin Exp Hypertens 32:517-22. 2010
    ..05). The data suggest that regular physical activity could reduce the CRP levels in HT patients, thereby maybe preventing CVD...
  65. ncbi request reprint Comparative study of atherosclerotic parameters in Mongolian and Japanese patients with hypertension and diabetes mellitus
    Shuumarjav Uurtuya
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    J Atheroscler Thromb 17:181-8. 2010
    ..Our study objective was to examine atherosclerotic profiles in HT and DM patients in both countries...
  66. ncbi request reprint Oxidative stress, inflammation, and atherosclerotic changes in retinal arteries in the Japanese population; results from the Mima study
    Naoki Sakane
    Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Endocr J 55:485-8. 2008
    ..These results suggest that oxidative stress and chronic inflammation promote atherosclerosis in the retinal arteries in the general population...
  67. ncbi request reprint The correlation between CVR-R and carotid atherosclerosis in type 2 diabetes mellitus patients with diabetic neuropathy
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Physiol Anthropol 29:149-52. 2010
    ..042), but not CVR-R(rest) or CVR-R(breath), in multivariate analyses adjusted for all the data. Therefore, the CVR-R(dif) may serve as a clinical index for the diabetic autonomic neuropathy-atherosclerosis relation in type 2 DM patients...
  68. doi request reprint Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome
    Noriko Satoh
    Division of Diabetic Research, National Hospital Organization, Kyoto Medical Center, Fushimi ku, Kyoto, Japan
    Hypertens Res 32:1004-8. 2009
    ....
  69. doi request reprint Urinary protein as a marker for systolic blood pressure reduction in patients with type 2 diabetes mellitus participating in an in-hospital diabetes education program
    Kenta Okada
    Department of Internal Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    Hosp Pract (1995) 39:70-5. 2011
    ..361; 95% confidence interval, 1.29-8.79; P = 0.013). The data suggest that UP may be a marker related to the management of SBP through lifestyle modifications in patients with T2DM...
  70. ncbi request reprint [Common carotid arterial diameter and coronary artery disease]
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke 329 0498, Japan
    Rinsho Byori 59:643-8. 2011
    ..50 (95% confidence interval = 1.71-11.84, p < 0.01), and the ratio were not largely altered in multivariate logistic regression analyses. The CCA diameter may therefore serve as a useful predictive marker for CAD in men...
  71. doi request reprint The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study
    Kokoro Tsuzaki
    Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Metabolism 61:17-21. 2012
    ..133, P = .030), adiponectin levels (β = -0.242, P < .001), and the SNP276 G allele (β = -0.142, P = .014). Our findings indicated that adiponectin and SNP276 of the adiponectin gene may modify the size of HDL particles...
  72. ncbi request reprint Lipid-lowering effects of ezetimibe for hypercholesterolemic patients with and without type 2 diabetes mellitus
    Kenta Okada
    Utsunomiya Social Insurance Hospital, Tochigi, Japan
    Endocr J 57:903-8. 2010
    ..Taken together, these findings indicate that ezetimibe could reduce the levels of atherogenic lipoproteins to a greater extent in hypercholesterolemic patients with T2DM than in those without T2DM...
  73. pmc The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein: results from the Mima study
    Kokoro Tsuzaki
    Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    BMC Med Genet 11:150. 2010
    ..We investigated whether the Clock 3111 T/C SNP may affect lipids and lipoproteins including sdLDL...
  74. ncbi request reprint The improvement of sweet taste sensitivity with decrease in serum leptin levels during weight loss in obese females
    Mika Umabiki
    Laboratory of Health Science, Food Science and Nutrition Course, Graduate School of Human Environment Science, Kyoto Prefectural University, Kyoto, Japan
    Tohoku J Exp Med 220:267-71. 2010
    ..In conclusion, the serum leptin levels are decreased significantly during a weight-loss program in obese females, which may be associated with the decrease in the sweet taste threshold...
  75. ncbi request reprint Determinants of carotid atherosclerosis in the general Mongolian population
    Shuumarjav Uurtuya
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Ethn Dis 20:257-60. 2010
    ..The present population-based survey was a cross-sectional investigation of the determinants of carotid IMT in the general Mongolian population...
  76. ncbi request reprint Unfavorable blood rheology is closely associated with arterial stiffness in obese patients
    Noriko Satoh
    Clinical Research Institute for Endocrine Metabolic Disease, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan
    Endocr J 56:915-8. 2009
    ..Furthermore, weight reduction intervention significantly decreased BPT. Assessment of rheology may be associated with pulse-wave velocity, and useful to manage obese patients...
  77. doi request reprint The relationship between urinary 8-hydroxydeoxyguanosine and metabolic risk factors in asymptomatic subjects
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Japan
    Med Princ Pract 20:187-90. 2011
    ..The aim of this study was to investigate the relationship between metabolic risk factors and oxidative stress using urinary 8-hydroxydeoxyguanosine (8-OHdG), a recently utilized biological marker, in asymptomatic subjects...
  78. doi request reprint The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population
    Kazuhiko Kotani
    Department of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Clin Chem Lab Med 46:1434-7. 2008
    ..The associations between coffee consumption and CRP should be established by studies on various populations, yet studies in Japanese people, who do not necessarily consume as much coffee daily, are limited...
  79. ncbi request reprint Comparative study of the cardio-ankle vascular index and ankle-brachial index between young Japanese and Mongolian subjects
    Shuumarjav Uurtuya
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Hypertens Res 32:140-4. 2009
    ..28) showed a correlation in the Japanese subjects. These results suggest that Mongolian subjects may be at higher risk of CVD, even among younger individuals, than Japanese subjects...
  80. pmc Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance
    Naoki Sakane
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    BMC Public Health 11:40. 2011
    ..The results of 3 years' intervention are summarized...
  81. doi request reprint The effect of prepregnancy body mass index on singleton cesarean delivery among term nulliparous women in Japanese population
    Izumi Chihara
    Department of Public Health, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Arch Gynecol Obstet 284:1117-22. 2011
    ..The aim of the study was to examine the effect of prepregnancy body mass index (BMI) on singleton cesarean delivery among term nulliparous women using a national sample from the Human Milk Survey...
  82. pmc Dietary salt reduction in rural patients with albuminurea using family and community support: the Mima study
    Shinji Fujiwara
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1 1 Mukuihata cho, Fushimi ku, Kyoto 612 8555, Japan
    Asia Pac Fam Med 9:6. 2010
    ..The primary outcome was change in urine albumin-creatinine ratio (ACR)...
  83. ncbi request reprint Educational courses for physiological function examination at Jichi Medical University: practical trainings in ultrasonography
    Kiyoka Omoto
    1st Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330 8503, Japan
    Rinsho Byori 59:776-80. 2011
    ..The aims and the specifics of the trainings adopted in the seminar of ultrasound and the required or the optional subjects of Bedside Learning (BSL) at Jichi Medical University are reported...
  84. ncbi request reprint Lack of association of the Trp64Arg polymorphism of beta3-adrenergic receptor gene with energy expenditure in response to caffeine among young healthy women
    Taku Hamada
    Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Tohoku J Exp Med 214:365-70. 2008
    ..These findings suggest that the genotypes of beta(3)-AR Trp64Arg polymorphism might be not associated with caffeine-induced increases in EE levels...
  85. doi request reprint The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus
    Michiaki Miyamoto
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Acta Diabetol 49:63-8. 2012
    ....
  86. ncbi request reprint Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
    Ann Nutr Metab 54:197-201. 2009
    ..Obesity has an inflammatory component, but interestingly there are no studies on serum AGE levels in obesity or on the effects of LCD as a therapeutic measure on these markers of glycation...
  87. pmc Influence of Physical Activity Intervention on Circulating Soluble Receptor for Advanced Glycation end Products in Elderly Subjects
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    J Clin Med Res 3:252-7. 2011
    ....
  88. ncbi request reprint Association between serum C-reactive protein and metabolic syndrome in Mongolian patients in comparison to Japanese patients
    Uurtuya Shuumarjav
    Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan
    Ethn Dis 21:74-8. 2011
    ..The present study's aim was to investigate the relationship between serum C-reactive protein (CRP) and MetS in the Mongolian population in comparison to the Japanese population...
  89. ncbi request reprint Characteristics and validity of a web-based Kawasaki disease surveillance system in Japan
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Epidemiol 20:429-32. 2010
    ..Although regular nationwide surveys of Kawasaki disease (KD) are conducted in Japan, there is no system for detecting the real-time epidemic status of this disease...
  90. ncbi request reprint Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, benidipine hydrochloride in rats
    Naoki Sakane
    Department of Preventive Medicine, Clinical Research Institute, Center for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Japan
    Endocr J 54:771-5. 2007
    ..We concluded that benidipine up-regulates not only UCP1 gene expression in BAT but also UCP3 gene expression in BAT and gastrocnemius muscle, which may contribute to thermogenesis in rats...
  91. ncbi request reprint Effects of a self-help group for diabetes care in long-term patients with type 2 diabetes mellitus: an experience in a Japanese rural community
    Kazuhiko Kotani
    Department of Clinical Laboratory Medicine, Tottori University, Yonago83 8503, Japan
    Aust J Rural Health 12:251-2. 2004
  92. ncbi request reprint Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Epidemiol 20:302-7. 2010
    ..The most recent epidemiologic features of Kawasaki disease (KD) are unknown...