Makoto Inoue

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. ncbi request reprint Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus
    S Homma
    Division of Nephrology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    Am J Nephrol 21:415-9. 2001
  2. ncbi request reprint Changes in peritoneal coagulation and fibrinolysis after discontinuation of chronic peritoneal dialysis
    Sumiko Homma
    Division of Nephrology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Perit Dial Int 22:178-83. 2002
  3. ncbi request reprint Impaired urinary concentrating ability in genetically polyuric mice
    Sumiko Homma
    Department of Nephrology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Nephron 92:889-97. 2002
  4. ncbi request reprint [Case of Henoch-Schönlein purpura nephritis associated with IgA monoclonal gammopathy of undetermined significance]
    Daishi Meguro
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    Nihon Jinzo Gakkai Shi 51:145-9. 2009
  5. doi request reprint Accelerated recovery from nephrotic syndrome with acute renal failure by double filtration plasmapheresis in a patient with lupus podocytopathy
    Yoshitaka Iwazu
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Clin Exp Nephrol 16:485-9. 2012
  6. doi request reprint Patients with adult minimal change nephrotic syndrome treated with long-term cyclosporine did not experience a reduction in their eGFR
    Makoto Inoue
    Jichi Medical University, Department of Medicine, Division of Nephrology, Tochigi, Japan
    Clin Nephrol 79:101-6. 2013
  7. doi request reprint Nephrotic syndrome and renal failure in a patient with metastatic breast cancer
    Hiromichi Yoshizawa
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:567-71. 2011
  8. doi request reprint Matrix metalloproteinase levels in the drained dialysate reflect the peritoneal solute transport rate: a multicentre study in Japan
    Ichiro Hirahara
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Nephrol Dial Transplant 26:1695-701. 2011
  9. doi request reprint Successful relatively low-dose corticosteroid therapy for diclofenac-induced acute interstitial nephritis with severe renal failure
    Makoto Inoue
    Department of Internal Medicine, Division of Nephrology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Clin Exp Nephrol 12:296-9. 2008
  10. ncbi request reprint DNA microarray analysis of the epithelial-mesenchymal transition of mesothelial cells in a rat model of peritoneal dialysis
    Toshimi Imai
    Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    Adv Perit Dial 27:11-5. 2011

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Marked atherosclerosis in a patient with familiar lecithin: cholesterol acyltransferase deficiency associated with end-stage renal disease and diabetes mellitus
    S Homma
    Division of Nephrology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    Am J Nephrol 21:415-9. 2001
    ..Marked atherosclerosis characterized by medial calcification in small arteries was observed at autopsy. The genesis of the atherosclerosis seemed to be on the basis of a combination of factors...
  2. ncbi request reprint Changes in peritoneal coagulation and fibrinolysis after discontinuation of chronic peritoneal dialysis
    Sumiko Homma
    Division of Nephrology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Perit Dial Int 22:178-83. 2002
    ..To study changes in peritoneal function after transfer from chronic peritoneal dialysis (CPD) to hemodialysis (HD), especially the effects on peritoneal coagulation, fibrinolytic markers, and mesothelium...
  3. ncbi request reprint Impaired urinary concentrating ability in genetically polyuric mice
    Sumiko Homma
    Department of Nephrology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Nephron 92:889-97. 2002
    ..These results indicate that impaired cAMP accumulation due to low AdC activity may be related to the impaired renal concentrating ability observed in this new strain of mice...
  4. ncbi request reprint [Case of Henoch-Schönlein purpura nephritis associated with IgA monoclonal gammopathy of undetermined significance]
    Daishi Meguro
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    Nihon Jinzo Gakkai Shi 51:145-9. 2009
    ..However, we must bear in mind the latent presence of IgA-MGUS in cases of HSPN...
  5. doi request reprint Accelerated recovery from nephrotic syndrome with acute renal failure by double filtration plasmapheresis in a patient with lupus podocytopathy
    Yoshitaka Iwazu
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Clin Exp Nephrol 16:485-9. 2012
    ....
  6. doi request reprint Patients with adult minimal change nephrotic syndrome treated with long-term cyclosporine did not experience a reduction in their eGFR
    Makoto Inoue
    Jichi Medical University, Department of Medicine, Division of Nephrology, Tochigi, Japan
    Clin Nephrol 79:101-6. 2013
    ..The long-term efficacy and safety of cyclosporine (CyA) in the treatment of adult minimal change nephrotic syndrome (MCNS) was examined...
  7. doi request reprint Nephrotic syndrome and renal failure in a patient with metastatic breast cancer
    Hiromichi Yoshizawa
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:567-71. 2011
    ..Further studies and accumulated experience with renal biopsy are required to better determine the relationship between pathological alterations and prognostic characteristics among patients with pamidronate-associated renal impairments...
  8. doi request reprint Matrix metalloproteinase levels in the drained dialysate reflect the peritoneal solute transport rate: a multicentre study in Japan
    Ichiro Hirahara
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Nephrol Dial Transplant 26:1695-701. 2011
    ..To perform PD safely and adequately, it is necessary to monitor peritoneal injury. The aim of this study was to investigate the potential of matrix metalloproteinases (MMPs) as new indicators of peritoneal injury...
  9. doi request reprint Successful relatively low-dose corticosteroid therapy for diclofenac-induced acute interstitial nephritis with severe renal failure
    Makoto Inoue
    Department of Internal Medicine, Division of Nephrology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Clin Exp Nephrol 12:296-9. 2008
    ..Our findings suggest that corticosteroid treatment should be reserved for patients with the protracted deterioration of renal function even after discontinuation of offending trigger agents...
  10. ncbi request reprint DNA microarray analysis of the epithelial-mesenchymal transition of mesothelial cells in a rat model of peritoneal dialysis
    Toshimi Imai
    Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan
    Adv Perit Dial 27:11-5. 2011
    ....
  11. doi request reprint A case of IgG4-related tubulointerstitial nephritis with left hydronephrosis after a remission of urinary tract tuberculosis
    Toshimi Imai
    Division of Nephrology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi, 329 0498, Japan
    Rheumatol Int 33:2141-4. 2013
    ..The case suggests that an abnormal reaction to tuberculosis may be associated with a predominance of type-2 helper T-cell immunity, thus resulting in IgG4-related systemic disease. ..
  12. doi request reprint Accelerated recovery from Candida peritonitis of enteric origin by early surgical drainage in a peritoneal dialysis patient
    Itsuro Kazama
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan
    Clin Exp Nephrol 15:957-61. 2011
    ..This case also demonstrated the importance of laparotomy to confirm the enteric origin of the fungus, and the efficacy of early surgical drainage for the treatment...
  13. ncbi request reprint The potential of matrix metalloproteinase-2 as a marker of peritoneal injury, increased solute transport, or progression to encapsulating peritoneal sclerosis during peritoneal dialysis--a multicentre study in Japan
    Ichiro Hirahara
    Division of Nephrology, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Shimotsuke City, Tochigi 329 0498, Japan
    Nephrol Dial Transplant 22:560-7. 2007
    ..The mortality rate of EPS is extremely high. To perform PD safely, monitoring of peritoneal injury that leads to EPS is a necessity...
  14. ncbi request reprint [Difficult hemodialysis induction due to subclavian steal syndrome in a patient with Takayasu's arteritis]
    Akiko Hashimoto
    Nephrology Center, Jichi Medical University, Tochigi, Japan
    Nihon Jinzo Gakkai Shi 53:1034-40. 2011
    ..The present case suggests that cerebral blood flow measurement using brain SPECT is useful for evaluating cerebral hemodynamics before AV fistula creation among patients with Takayasu's arteritis...
  15. doi request reprint Steroid treatment in patients with membranous nephropathy and hepatitis B virus surface antigenemia: a report of two cases
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:289-93. 2011
    ..Further studies will be required to determine the optimal timing and appropriate duration of antiviral treatment in such patients requiring long-term immunosuppression...
  16. ncbi request reprint Reversible acute renal failure associated with clomipramine-induced interstitial nephritis
    Akira Onishi
    Division of Nephrology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi 329 0498, Japan
    Clin Exp Nephrol 11:241-3. 2007
    ..5 mg/kg per day, his urinary output improved, along with improvement of his renal function; therefore hemodialysis was finally discontinued. To our knowledge, this is the first case report of AIN induced by clomipramine...
  17. doi request reprint Renal failure caused by plasma cell infiltration in multiple myeloma
    Shiho Hanawa
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:586-90. 2011
    ....
  18. ncbi request reprint Rapid formation of Aspergillus mycetoma in a patient receiving corticosteroid treatment. Serial radiographic observation over two months
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Shimotsuke
    Intern Med 46:733-7. 2007
    ..The rapid development of pulmonary aspergillosis associated with the formation of an Aspergillus mycetoma should be attributed to the loss of normal immune mechanisms due to immunosuppressive treatment...
  19. ncbi request reprint Serial Tc-99m MAG3 renography evaluating the recovery of acute kidney injury associated with minimal change nephrotic syndrome
    Hidenori Kanazawa
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
    Intern Med 52:987-91. 2013
    ..The potential impact of serial renal scanning in MCNS patients with AKI will also be discussed...
  20. ncbi request reprint [Case of lupus nephritis and enteritis associated with bilateral hydronephrosis]
    Maki Kato
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    Nihon Jinzo Gakkai Shi 51:569-75. 2009
    ..We should bear in mind the possible association of several disorders, including nephrotic syndrome, enteritis, and hydronephrosis due to cystitis, in cases presenting with SLE...
  21. ncbi request reprint The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells
    Makoto Inoue
    Division of Nephrology, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Exp Nephrol 10:267-74. 2002
    ..To elucidate the mechanism of the action of this drug, we investigated cytokine-stimulated nitric oxide (NO) metabolism by ticlopidine in cultured rat vascular smooth muscle cells (VSMC)...
  22. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:2925-31. 2005
    ..To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU)...
  23. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  24. doi request reprint VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Atherosclerosis 200:51-7. 2008
    ..These results indicate that the FGF-2-mediated enhancement of PlGF expression was dependent on VEGF function, and the FGF-2/VEGF axis participates in FGF-2-mediated angiogenesis indirectly via PlGF as well as directly...
  25. ncbi request reprint New approaches to study the development of morphine tolerance and dependence
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, 852 8521, Nagasaki, Japan
    Life Sci 74:313-20. 2003
    ....
  26. ncbi request reprint Early dynamic SPECT imaging in acute viral encephalitis
    Hiroshi Kataoka
    Department of Neurology, Nara Medical University, Kashihara, Nara, Japan
    J Neuroimaging 17:304-10. 2007
    ..The purpose of this study was to evaluate the clinical usefulness of dynamic Tc-ECD SPECT in patients with acute viral encephalitis...
  27. ncbi request reprint Newly-developed Sendai virus vector for retinal gene transfer: reduction of innate immune response via deletion of all envelope-related genes
    Yusuke Murakami
    Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gene Med 10:165-76. 2008
    ..We recently developed a novel rSeV from which all envelope-related genes were deleted (rSeV/dFdMdHN) and, in the present study, assess host immune responses following retinal gene transfer...
  28. ncbi request reprint Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease
    Isao Nakao
    Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Immunol 180:6262-9. 2008
    ..These findings collectively suggest that pendrin can induce mucus production in airway epithelial cells and may be a therapeutic target candidate for bronchial asthma and COPD...
  29. ncbi request reprint Recombinant sendai virus-mediated gene transfer to adipose tissue-derived stem cells (ASCs)
    Hiroshi Yukawa
    Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya 461 0047, Japan
    Cell Transplant 17:43-50. 2008
    ..In conclusion, this is the first report describing the successful use of SeV-mediated gene transfer in ASCs, and the results indicate that SeV may thus provide advantages with respect to safety issues in gene therapy...
  30. ncbi request reprint [Clinical features of endophthalmitis after cataract surgery evaluated by the presence of background factors]
    Yuko Ninomiya
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Nihon Ganka Gakkai Zasshi 112:525-30. 2008
    ....
  31. ncbi request reprint The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Brain Res Bull 60:275-81. 2003
    ..Altogether, these findings indicate that the ANF test is a highly sensitive and less stressful technique to study in vivo mechanisms of pain at the peripheral nerve ending...
  32. ncbi request reprint Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    J Neurosci 23:6529-36. 2003
    ..These findings suggest that GluRepsilon1 has locus-specific roles in the development of morphine analgesic tolerance and physical dependence...
  33. ncbi request reprint Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice
    M Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Pharmacol Exp Ther 306:709-17. 2003
    ..Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain...
  34. doi request reprint Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury
    Toshiaki Makino
    Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, 3 1 Mizuho ku, Nagoya 467 8603, Japan
    Drug Metab Dispos 36:1438-43. 2008
    ..3MGA accumulated by liver fibrosis resulted in the increased excretion through renal tubule and might be strongly related to the pathogenesis of pseudoaldosteronism because 11beta-HSD2 is expressed in renal tubular epithelial cells...
  35. ncbi request reprint Anti-inflammatory and cytotoxic activities of five Veronica species
    U Sebnem Harput
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 25:483-6. 2002
    ..On the other hand, chloroform fractions of Veronica species except for V. cymbalaria showed similar cytotoxic activity against KB and B16 melanoma cells...
  36. ncbi request reprint Subtotal nephrectomy stimulates cyclooxygenase 2 expression and prostacyclin synthesis in the rat remnant kidney
    Naoshi Horiba
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Nephron 91:134-41. 2002
    ..Several studies have suggested that COX is activated in renal insufficiency, but little is known about the relationship between progression of renal insufficiency and the COX isoforms...
  37. ncbi request reprint Antimetastatic activity of acteoside, a phenylethanoid glycoside
    Takamasa Ohno
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 25:666-8. 2002
    ..3 +/- 3.4d compared with 52.1 +/- 2.5d in control mice. This result suggests that acteoside showed suppressive effect on lung metastasis of B16 melanoma cells...
  38. ncbi request reprint Suppressive effect of Shichimotsu-koka-to (Kampo medicine) on pulmonary metastasis of B16 melanoma cells
    Takamasa Ohno
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Biol Pharm Bull 25:880-4. 2002
    ..These findings may suggest that macrophage function-modulating activity by SKT appears to underlie its antimetastatic activity, which leads to a decrease in the number of lung metastatic surface nodules and the extension of life span...
  39. ncbi request reprint Suppression of macrophage function by substances with a molecular weight lower than 3000 Da in B16 melanoma-conditioned medium
    Makoto Inoue
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Biol Pharm Bull 25:907-12. 2002
    ..We propose that these activities may help metastatic B16 melanoma cells to escape a host immunosurveillance system and to metastasize to target organs...
  40. ncbi request reprint Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice
    Akira Takeiri
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba shi, Shizuoka 412 8513, Japan
    Chem Res Toxicol 16:171-9. 2003
    ....
  41. ncbi request reprint NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neurosci Lett 397:249-53. 2006
    ..All these results suggest that NSAID zaltoprofen possesses novel anti-nociceptive mechanism, which inhibits B2-type BK receptor function in nerve endings...
  42. ncbi request reprint Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy
    Kousuke Noda
    Department of Pathology, Keio University School of Medicine, Toyama, Japan
    Invest Ophthalmol Vis Sci 44:2163-70. 2003
    ..To investigate the matrix metalloproteinase (MMP) species and their activation associated with the pathogenesis of proliferative diabetic retinopathy (PDR)...
  43. ncbi request reprint Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Pharmacol Exp Ther 308:1158-64. 2004
    ..Altogether, these findings confirm a switching of receptor and fiber subtype for BK nociception after peripheral nerve injury, which might contribute to the pathobiology of neuropathic pain...
  44. ncbi request reprint Visual recovery after vitrectomy for macular hole using 25-gauge instruments
    Hajime Shinoda
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol 86:151-5. 2008
    ..To determine whether vitrectomy with 25-gauge instruments contributes to better postoperative visual recovery after macular hole (MH) surgery...
  45. ncbi request reprint Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Nat Med 10:712-8. 2004
    ..Inhibitors of Rho and Rho kinase also prevented these signs of neuropathic pain. These results imply that receptor-mediated LPA signaling is crucial in the initiation of neuropathic pain...
  46. ncbi request reprint Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2483-9. 2006
    ..Angiogenesis contributes to the inflammatory process; however, the molecular and cellular mechanisms of the links among the inflammatory pathway, arteriogenesis, and angiogenesis have not been well elucidated...
  47. ncbi request reprint Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-beta gene
    Satoko Shibata
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 177:3564-76. 2006
    ....
  48. ncbi request reprint Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2252-9. 2006
    ..The aim of the current study was to determine the involvement of the renin-angiotensin system (RAS) with the development of CNV, using human surgical samples and the murine model of laser-induced CNV...
  49. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  50. pmc Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 2:16. 2006
    ..These results also suggest that the EPF analysis is useful for the evaluation of plasticity in sensory functions in animal disease models...
  51. ncbi request reprint Antioxidant and immuno-enhancing effects of Echinacea purpurea
    Satoshi Mishima
    API Co, Ltd NAGARAGAWA Research Center, Nagara, Gifu, Japan
    Biol Pharm Bull 27:1004-9. 2004
    ..purpurea than helper T cells and suppressor T cell these results reflect activation. In addition, we think that these results reflect cell-mediated immune responses...
  52. ncbi request reprint Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors
    Mitsugu Tanii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Circ Res 98:55-62. 2006
    ....
  53. ncbi request reprint pX gene causes hypercholesterolemia in hypercholesterolemia-resistant BALB/c mice
    Ayano Koizumi
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Biol Pharm Bull 28:1731-5. 2005
    ....
  54. ncbi request reprint Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:5545-52. 2006
    ..To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU)...
  55. ncbi request reprint Suppressive effect of Dai-bofu-to on collagen-induced arthritis
    Makoto Inoue
    Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 27:857-62. 2004
    ..In conclusion, immunomodulatory and anti-osteoclastogenetic effects might be involved in the suppression of arthritis by DBT...
  56. ncbi request reprint Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007
    ..To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation...
  57. ncbi request reprint Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice
    Takashi Koto
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4328-34. 2007
    ..To investigate the role of eicosapentaenoic acid (EPA), the major omega-3 polyunsaturated fatty acid (PUFA), in the development of choroidal neovascularization (CNV), together with underlying molecular mechanisms...
  58. ncbi request reprint In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector
    Kumi Yoshida
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 361:811-6. 2007
    ..To our knowledge, this is the first demonstration of the in vivo reconstruction of hematopoietic series by cytoplasmically gene transferred BMCs, that warrants further investigation to realize this strategy in clinical settings...
  59. ncbi request reprint Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats
    Makoto Inoue
    Department of Ophthalmology, Duke University, DUMC, Durham, NC, USA
    Ophthalmic Res 36:31-7. 2004
    ..Pancreatic islet survival in the subretinal space is MHC dependent. Accumulation of infiltrating lymphocytes may be suppressed by a modified immune response...
  60. pmc Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
    Kanako Izumi-Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:2149-58. 2007
    ....
  61. ncbi request reprint beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages
    Akira Matsumoto
    Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, 1 100 Kusumoto cho, Chikusa ku, Nagoya 464 8650, Japan
    Biochem Pharmacol 74:256-64. 2007
    ..Taking into account that the pharmacodynamics difference between beta-cryptoxanthin and atRA, beta-cryptoxanthin appears to exert beneficial effects on atherogenesis through RAR activation in the manner different from atRA...
  62. ncbi request reprint [Mucosal immunotherapy for alzheimer's disease with viral vectors]
    Hideo Hara
    Department of Vascular Dementia Research, NILS, National Center for Geriatrics and Gerontology, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:53-6. 2007
    ....
  63. ncbi request reprint Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:2321-6. 2007
    ..The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE inhibition...
  64. pmc Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells
    Takashi Koto
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:1389-97. 2007
    ..These in vitro and in vivo data indicate that claudin-5 is a target molecule of hypoxia leading to the disruption of the barrier function of neural vasculature...
  65. ncbi request reprint Recombinant Sendai virus vector induces complete remission of established brain tumors through efficient interleukin-2 gene transfer in vaccinated rats
    Yasuo Iwadate
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:3821-7. 2005
    ..We also estimated the therapeutic efficacy of the novel vector system against a rat glioblastoma model...