Research Topics

Kazuo Eguchi


Affiliation: Jichi Medical School
Country: Japan


  1. Eguchi K, Miyashita H, Takenaka T, Tabara Y, Tomiyama H, Dohi Y, et al. High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study. Hypertens Res. 2018;41:947-956 pubmed publisher
    ..The results were essentially unchanged when brachial DBP was additionally adjusted. In conclusion, in treated hypertensives, high central SBP was associated with worse cardiovascular outcomes. ..
  2. Eguchi K, Hoshide S, Ishikawa S, Shimada K, Kario K. Short sleep duration is an independent predictor of stroke events in elderly hypertensive patients. J Am Soc Hypertens. 2010;4:255-62 pubmed publisher
    ..52; P = 0.001). Shorter sleep duration was an independent risk for future incidence of stroke events in hypertensive patients, especially those with SCIs. ..
  3. Eguchi K, Pickering T, Hoshide S, Ishikawa J, Ishikawa S, Schwartz J, et al. Ambulatory blood pressure is a better marker than clinic blood pressure in predicting cardiovascular events in patients with/without type 2 diabetes. Am J Hypertens. 2008;21:443-50 pubmed publisher
    ..These findings suggest that ABPM is a better predictor of cardiovascular risk than clinic BP, and that this holds true for patients with or without T2DM. ..
  4. Eguchi K, Matsui Y, Shibasaki S, Hoshide S, Kabutoya T, Ishikawa J, et al. Controlling evening BP as well as morning BP is important in hypertensive patients with prediabetes/diabetes: the JMS-1 study. Am J Hypertens. 2010;23:522-7 pubmed publisher
    ..In particular, this suggests the hypothesis that aggressive control of evening home BP might be equally or more important to morning BP in hypertensives with prediabetes/T2DM. ..
  5. Eguchi K, Schwartz J, Pickering T, Hoshide S, Ishikawa J, Shimada K, et al. Increased heart rate variability during sleep is a predictor for future cardiovascular events in patients with type 2 diabetes. Hypertens Res. 2010;33:737-42 pubmed publisher
    ..In conclusion, increased HR variability during sleep was a predictor for incident CVD in T2DM, but not in non-diabetics. Increased HR variability at night would reflect pathophysiological mechanism of T2DM. ..
  6. request reprint
    Eguchi K. Blood Pressure Variability/Dipper/Non-dipper in Hypertension and Diabetes. Curr Hypertens Rev. 2014;: pubmed
    ..There have been a number of papers about BP variability in recent years. In this chapter, the significance of BP variability in patients with diabetes will be reviewed. ..
  7. Eguchi K, Hoshide S, Komori T, Nagasaka S, Kario K. A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study. Am J Hypertens. 2015;28:971-9 pubmed publisher
    ..In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80 mm Hg was 129/78 mm Hg with regard to the extent of microvascular disease. ..
  8. Eguchi K, Pickering T, Schwartz J, Hoshide S, Ishikawa J, Ishikawa S, et al. Short sleep duration as an independent predictor of cardiovascular events in Japanese patients with hypertension. Arch Intern Med. 2008;168:2225-31 pubmed publisher
    ..Physicians should inquire about sleep duration in the risk assessment of patients with hypertension. ..
  9. Eguchi K. Tom Pickering as a clinical scientist: masked hypertension. Blood Press Monit. 2010;15:85-9 pubmed publisher
    ..The biggest theme in the field of hypertension is how we can detect masked hypertension. I present two interesting cases of possible masked hypertension in this commentary. ..

More Information


  1. Eguchi K, Hoshide S, Kario K. Effects of Celiprolol and Bisoprolol on Blood Pressure, Vascular Stiffness, and Baroreflex Sensitivity. Am J Hypertens. 2015;28:858-67 pubmed publisher
    ..On the other hand, bisoprolol may be useful in hypertensives with cardiac or vascular diseases who have advanced atherosclerotic changes and sympathetic nervous system activation. ..
  2. Komori T, Eguchi K, Saito T, Nishimura Y, Hoshide S, Kario K. Riser Blood Pressure Pattern Is Associated With Mild Cognitive Impairment in Heart Failure Patients. Am J Hypertens. 2016;29:194-201 pubmed publisher
    ..01) after adjusting for significant covariates. The riser pattern was associated with mild CI in HF patients. An abnormal circadian BP rhythm in HF patients is clinically significant as a potential indicator of subclinical brain damage. ..
  3. Eguchi K, Hoshide S, Miyashita H, Nagasaka S, Kario K. Why the radial augmentation index is low in patients with diabetes: The J-HOP study. Atherosclerosis. 2016;246:338-43 pubmed publisher
    ..As renal function decreases, a cPP increase may overcome the increase of augmentation pressure in the DM group. ..
  4. Eguchi K, Boden Albala B, Jin Z, Rundek T, Sacco R, Homma S, et al. Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population. Am J Cardiol. 2008;101:1787-91 pubmed publisher
    ..Presence of T2DM increased the risk of LV hypertrophy by about 1.5-fold, and it possibly interacted with central obesity. ..
  5. request reprint
    Eguchi K. Effects of Antihypertensive Therapy on Blood Pressure Variability. Curr Hypertens Rep. 2016;18:75 pubmed
    ..However, in high-risk patients, those with cardiovascular or cerebrovascular diseases, the clinical significance should be considered in individual basis. Especially, reduction of BPV would be an important strategy for these patients. ..
  6. Eguchi K, Komori T, Saito T, Hoshide S, Kario K. An ?-glucosidase inhibitor could reduce T-wave alternans in type 2 diabetes patients. J Electrocardiol. 2018;51:21-26 pubmed publisher
    ..However, TWA was significantly lower during the miglitol period compared to control period (63±4.8 vs. 75.8±5.1?V, p=0.032). An ?-GI, miglitol, can reduce TWA by reducing the fluctuation of glucose in heart disease patients with T2DM. ..