Katsuya Dezaki

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. doi request reprint Ghrelin function in insulin release and glucose metabolism
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocr Dev 25:135-43. 2013
  2. doi request reprint Islet β-cell ghrelin signaling for inhibition of insulin secretion
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Methods Enzymol 514:317-31. 2012
  3. doi request reprint Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Pharmacol Ther 118:239-49. 2008
  4. pmc Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Tochigi, Japan
    Diabetes 60:2315-24. 2011
  5. doi request reprint Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells
    Boldbaatar Damdindorj
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    FEBS Lett 586:2555-62. 2012
  6. doi request reprint Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells
    Masashi Yoshida
    First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama 330 8503, Japan
    Biochem Biophys Res Commun 396:304-9. 2010
  7. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
  8. ncbi request reprint Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Diabetes 55:3486-93. 2006
  9. doi request reprint Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
  10. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010

Collaborators

  • Masanori Nakata
  • Masafumi Kakei
  • Hideyuki Sone
  • Masaru Koizumi
  • Yusaku Iwasaki
  • Hiroyuki Shimizu
  • Kenju Shimomura
  • Ming Lu
  • Marcelo O Dietrich
  • Yasuo Uchiyama
  • Yoshinori Hosoya
  • Shigeyasu Tanaka
  • Toshihiko Yada
  • Masashi Yoshida
  • Yuko Maejima
  • Boldbaatar Damdindorj
  • Natsu Yoshida
  • Masanobu Kawakami
  • Masatomo Mori
  • Udval Sedbazar
  • Tatsushi Onaka
  • Daisuke Kohno
  • Ken Fujiwara
  • Shiho Yamato Kodera
  • Yifei Yang
  • Hirotaka Aoki
  • Darambazar Gantulga
  • Tomoyuki Kurashina
  • San E Ishikawa
  • Shiho Yamato
  • Hitoshi Sugawara
  • Eisuke Takano
  • Takashi Yashiro
  • Yukari Date
  • Keiji Yamamoto
  • Kazuyuki Shimada
  • Juris Galvanovskis
  • Takanori Murayama
  • Kazuya Sakuma
  • Kazuomi Kario
  • Rauza Rita
  • Akihiko Ando
  • Hideharu Kurita
  • Masato Koike
  • Hideo Toyoshima
  • Shigetomo Suyama
  • Atsushi Aoki
  • Shinsuke Oh-I
  • Tamas L Horvath
  • Koushi Hashimoto
  • Fumihiko Maekawa
  • Masamitsu Nakazato
  • Muhtashan S Mondal
  • Masayasu Kojima
  • Hisayuki Matsuo
  • Kenji Kangawa
  • Terukatsu Arima
  • Hiroshi Hosoda
  • Suzuko Hashiguchi
  • Shigeru Matsukura

Detail Information

Publications24

  1. doi request reprint Ghrelin function in insulin release and glucose metabolism
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocr Dev 25:135-43. 2013
    ..Ghrelin antagonism provides a novel strategy to treat type 2 diabetes with dysregulated insulin release...
  2. doi request reprint Islet β-cell ghrelin signaling for inhibition of insulin secretion
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan
    Methods Enzymol 514:317-31. 2012
    ..Insulinostatic function of the ghrelin-GHS-R system in islets is a potential therapeutic target for type 2 diabetes...
  3. doi request reprint Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Pharmacol Ther 118:239-49. 2008
    ....
  4. pmc Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Tochigi, Japan
    Diabetes 60:2315-24. 2011
    ..This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet β-cells...
  5. doi request reprint Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells
    Boldbaatar Damdindorj
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    FEBS Lett 586:2555-62. 2012
    ....
  6. doi request reprint Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells
    Masashi Yoshida
    First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama 330 8503, Japan
    Biochem Biophys Res Commun 396:304-9. 2010
    ..These results suggest that the cellular metabolism including MgATP production and/or channel phosphorylation/dephosphorylation underlie the physiological modulation of Kv2.1 channels during glucose-induced insulin secretion...
  7. ncbi request reprint Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential
    Toshihiko Yada
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Curr Diabetes Rev 4:18-23. 2008
    ....
  8. ncbi request reprint Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Diabetes 55:3486-93. 2006
    ....
  9. doi request reprint Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
    ..The present results reveal the nesfatin-1-operative oxytocinergic signaling in the PVN that triggers leptin-independent melanocortin-mediated anorexia...
  10. pmc Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis
    Natsu Yoshida
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Aging (Albany NY) 2:775-84. 2010
    ..These results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses...
  11. ncbi request reprint Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents
    Katsuya Dezaki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan
    Diabetes 53:3142-51. 2004
    ..This function of ghrelin, together with inducing GH release and feeding, suggests that ghrelin underlies the integrative regulation of energy homeostasis...
  12. ncbi request reprint Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin
    Katsuya Dezaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji, Shimotsuke, Tochigi, Japan
    Diabetes 56:2319-27. 2007
    ....
  13. doi request reprint Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells
    Masashi Yoshida
    First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 1 847, Saitama, Japan
    FEBS Lett 583:2225-30. 2009
    ..1-specific blocker, guangxitoxin-1E, was unchanged by lowering or increasing glucose concentration. We conclude that glucose metabolism regulates Kv2.1 channels in rats beta-cells via altering MgATP levels...
  14. ncbi request reprint Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells
    Ken Fujiwara
    Department of Integrative Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocrinology 148:2496-504. 2007
    ..The glucose-independent action of OA to stimulate glucagon release from alpha-cells may operate under hypoglycemic conditions when plasma free fatty acids levels are elevated, possibly playing a role in maintaining glucose metabolism...
  15. doi request reprint Bupropion can close KATP channel and induce insulin secretion
    Yifei Yang
    Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    J Pediatr Endocrinol Metab 26:343-6. 2013
    ..This study shows, for the first time, that bupropion has a direct electrophysiological action on pancreatic β-cells and can cause insulin secretion and also highlights the risk of using bupropion during pregnancy...
  16. ncbi request reprint Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca2+ influx through L-type Ca2+ channels in beta-cells and localization in islets
    Katsuya Dezaki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Regul Pept 145:153-8. 2008
    ..NPW directly activates beta-cells to enhance Ca(2+) influx through voltage-dependent L-type Ca(2+) channels and potentiates glucose-induced insulin release...
  17. doi request reprint Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels
    Masaru Koizumi
    Department of Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
    Ann Thorac Surg 91:1032-7. 2011
    ..Ghrelin is known to stimulate appetite and cause weight increase. The objective of this study is to examine the relationship of serum ghrelin levels and weight loss in patients after esophagectomy for cancer...
  18. ncbi request reprint Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings
    Shiho Yamato Kodera
    Division of Anesthesiology, Second Department of General Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Omiya 330 8503, Japan
    Endocr J 60:337-46. 2013
    ..These results indicate that DEX and MED inhibit insulin secretion through an α2-adrenoceptor and PTX-sensitive GTP-binding protein pathway that eventually involves Kv channel activation and Ca(2+) channel inhibition...
  19. ncbi request reprint Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats
    Hirotaka Aoki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Endocr J 60:571-81. 2013
    ..These results demonstrate that long-term ghrelin treatment counteracts salt-induced hypertension in DS rats primarily through diuretic action associated with increased renal NO production, thereby exerting cardio-protective effects...
  20. ncbi request reprint Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  21. ncbi request reprint [Ghrelin in the regulation of glucose and lipid metabolism]
    Katsuya Dezaki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, School of Medicine
    Nihon Rinsho 62:388-91. 2004
  22. ncbi request reprint [Methods for preparation and functional analysis of islet beta-cells]
    Masafumi Kakei
    Department of Internal Medicine, Division of Endocrinology, Diabetes Geriatric Medicine, Akita University School of Medicine
    Nihon Yakurigaku Zasshi 124:345-52. 2004
    ..These primary cultured beta-cells can be used for elucidating signal transduction mechanisms, and evaluating effects of drugs, providing excellent tools for physiological, pharmacological, and disease-oriented studies...
  23. ncbi request reprint Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    Yukari Date
    Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan
    Diabetes 51:124-9. 2002
    ..These findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner...
  24. ncbi request reprint [Ion channel mechanisms in insulin secretion]
    Masafumi Kakei
    Department of Geriatric Medicine, Akita University School of Medicine
    Nihon Rinsho 60:180-9. 2002