Tohru Utsunomiya

Summary

Affiliation: Japanese Red Cross
Country: Japan

Publications

  1. pmc Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma
    Tohru Utsunomiya
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima 730 8619, Japan
    World J Gastroenterol 14:1553-8. 2008
  2. ncbi request reprint Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer
    Hisashi Nagahara
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Japan
    Clin Cancer Res 11:6800-6. 2005
  3. doi request reprint The impact of pegylated-interferon α-2b on partial and massive hepatectomy model in rats
    Hiroki Mori
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 59:2300-4. 2012
  4. doi request reprint Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
    Surg Today 42:565-9. 2012
  5. doi request reprint Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Surg Today 42:147-51. 2012
  6. doi request reprint Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima City 770 8503, Japan
    Int J Clin Oncol 16:671-8. 2011
  7. doi request reprint Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, The University of Tokushima Graduate School, Tokushima, Japan
    Hepatogastroenterology 58:1439-44. 2011
  8. doi request reprint Outcome of hepatectomy in hepatocellular carcinoma patients aged 80 years and older
    Eiji Tsujita
    Department of Surgery, Hiroshima Red Cross Hospital, Hiroshima, Japan
    Hepatogastroenterology 59:1553-5. 2012
  9. doi request reprint Leiomyosarcoma originating from the superior mesenteric vein: a case report and review of the literature
    Sosei Kuma
    Department of Surgery, Hiroshima Red Cross Hospital, Hiroshima 730 8619, Japan
    Ann Vasc Surg 22:453-5. 2008
  10. doi request reprint The protective effect of adipose-derived stem cells against liver injury by trophic molecules
    Yu Saito
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Surg Res 180:162-8. 2013

Collaborators

Detail Information

Publications58

  1. pmc Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma
    Tohru Utsunomiya
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima 730 8619, Japan
    World J Gastroenterol 14:1553-8. 2008
    ..To evaluate the impact of obesity on the posto-perative outcome after hepatic resection in patients with hepatocellular carcinoma (HCC)...
  2. ncbi request reprint Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer
    Hisashi Nagahara
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Japan
    Clin Cancer Res 11:6800-6. 2005
    ..Herein, we investigated the clinicopathologic and biological significance of KLK6 gene expression in human gastric cancer...
  3. doi request reprint The impact of pegylated-interferon α-2b on partial and massive hepatectomy model in rats
    Hiroki Mori
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 59:2300-4. 2012
    ..The impact of pegylated-interferon (PEG-IFN) α-2b on liver regeneration has not yet been elucidated...
  4. doi request reprint Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
    Surg Today 42:565-9. 2012
    ..We conducted this study to clarify the role of TS and DPD expressions in gallbladder carcinoma (GBC)...
  5. doi request reprint Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Surg Today 42:147-51. 2012
    ..To investigate the prognostic factors of peripheral-type intrahepatic cholangiocarcinoma (PP-IHCC) and evaluate the surgical outcomes according to surgical strategy alterations...
  6. doi request reprint Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima City 770 8503, Japan
    Int J Clin Oncol 16:671-8. 2011
    ..Histone deacetylase (HDAC) is strongly associated with epigenetic regulation and carcinogenesis, and its inhibitor can induce the differentiation or apoptosis of cancer cells...
  7. doi request reprint Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, The University of Tokushima Graduate School, Tokushima, Japan
    Hepatogastroenterology 58:1439-44. 2011
    ..Hypoxia-inducible factor-1 (HIF-1) is a transcription factor, which plays a central role in biologic processes under hypoxic conditions. The aim of this study was to elucidate the role of HIF-1 in IHCC...
  8. doi request reprint Outcome of hepatectomy in hepatocellular carcinoma patients aged 80 years and older
    Eiji Tsujita
    Department of Surgery, Hiroshima Red Cross Hospital, Hiroshima, Japan
    Hepatogastroenterology 59:1553-5. 2012
    ..The aim of this retrospective study was to determine the effect of age on the outcome of hepatic resection in octogenarian patients with hepatocellular carcinoma (HCC)...
  9. doi request reprint Leiomyosarcoma originating from the superior mesenteric vein: a case report and review of the literature
    Sosei Kuma
    Department of Surgery, Hiroshima Red Cross Hospital, Hiroshima 730 8619, Japan
    Ann Vasc Surg 22:453-5. 2008
    ..Since the tumor was weakly positive for c-kit, she was treated with imatinib mesylate for the recurrent liver tumors. She has survived for about 3 years after undergoing the surgical procedures...
  10. doi request reprint The protective effect of adipose-derived stem cells against liver injury by trophic molecules
    Yu Saito
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Surg Res 180:162-8. 2013
    ..In this study we investigated whether adipose-derived stem cells (ADSCs) had any beneficial protective effects on liver injury and regeneration in vivo. Moreover, we examined whether ADSCs protect hepatocytes via trophic molecules...
  11. doi request reprint A modified liver-hanging maneuver focusing on the ligamentum venosum for left hepatic lobectomy
    Satoru Imura
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Surg Today 42:720-3. 2012
    ..We made modifications to this technique with special reference to the ligamentum venosum for performing a left hepatectomy (LH). The aim of this study was to clarify the usefulness of our new technique...
  12. doi request reprint Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Surg Today 42:135-40. 2012
    ..We conducted this study to clarify if TS and DPD gene expressions are a prognostic indicator for intrahepatic cholangiocarcinoma (IHCC)...
  13. doi request reprint Ultrasound-guided microwave coagulation assists anatomical hepatic resection
    Satoru Imura
    Department of Surgery, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Surg Today 42:35-40. 2012
    ..This report introduces our procedure and evaluates the outcomes of patients treated using this technique...
  14. doi request reprint Role of histone deacetylase expression in intrahepatic cholangiocarcinoma
    Yuji Morine
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Surgery 151:412-9. 2012
    ..The aim of this study was to elucidate the correlation between HDAC expression and tumor malignant behavior including HIF-1α expression in intrahepatic cholangiocarcinoma (IHCC)...
  15. doi request reprint Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older
    Eiji Tsujita
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima 730 8619, Japan
    Surgery 147:696-703. 2010
    ..We sought to evaluate the influence of age on the outcome of repeat hepatectomies in patients > or = 75 years with recurrent hepatocellular carcinoma (HCC)...
  16. ncbi request reprint Clinicopathologic and prognostic values of apolipoprotein D alterations in hepatocellular carcinoma
    Tohru Utsunomiya
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Int J Cancer 116:105-9. 2005
    ..Apo D may be a novel tumor suppressor gene of HCC, and its expression status may be a useful biomarker for predicting the patient outcome...
  17. doi request reprint High dorsal resection for recurrent hepatocellular carcinoma originating in the caudate lobe
    Tohru Utsunomiya
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    Surg Today 39:829-32. 2009
    ....
  18. doi request reprint Hepatocellular carcinoma infiltrated with non-Hodgkin's lymphoma: report of a case
    Tohru Utsunomiya
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    Surg Today 39:1010-2. 2009
    ..The coexistence of HCC and non-Hodgkin's lymphoma (NHL) is extremely rare. and non-Hodgkin's lymphoma (NHL) is extremely rare. We herein report a case of HCC infiltrated with NHL. We herein report a case of HCC infiltrated with NHL...
  19. doi request reprint Surgical results of pancreatoduodenectomy in elderly patients
    Shinichiro Yamada
    Department of Surgery, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, Tokushima, 770 8503, Japan
    Surg Today 42:857-62. 2012
    ..To assess the safety and feasibility of pancreatoduodenectomy (PD) in elderly patients, we investigated the clinical characteristics of patients aged ≥75 years, who underwent this procedure at our hospital...
  20. doi request reprint Laparoscopy-assisted resection for Mesenteric Castleman's disease: Report of a case
    Mitsuhiko Ohta
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, 1 9 6 Senda machi, Naka ku, Hiroshima, 730 8619, Japan
    Surg Today 41:1405-9. 2011
    ..Mesenteric Castleman's disease is rare, and there have been only 42 cases reported in the English literature. We herein discuss the clinical findings of these cases...
  21. ncbi request reprint Characterization of a side population of cancer cells from human gastrointestinal system
    Naotsugu Haraguchi
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu 874 0838, Japan
    Stem Cells 24:506-13. 2006
    ..These findings demonstrate that cancers of the gastrointestinal system do contain SP cells that show some characteristics of so-called stem cells...
  22. ncbi request reprint Significance of skp2 expression in primary breast cancer
    Hideto Sonoda
    Department of Surgery, Kyushu University Hospital at Beppu, Beppu, Japan
    Clin Cancer Res 12:1215-20. 2006
    ..We herein examined the Skp2 expression in breast cancer and attempted to identify any associations between the Skp2 expression status and either the clinicopathologic variables or the patient's prognosis...
  23. ncbi request reprint Cancer stem cells in human gastrointestinal cancers
    Naotsugu Haraguchi
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu 874 0838, Japan
    Hum Cell 19:24-9. 2006
    ..The results demonstrated that cancers of the gastrointestinal system do contain SP cells that show some characters of so-called stem cells. In this paper, we report our study results with a review of the literature...
  24. doi request reprint The long-term outcome of atomic bomb survivors with gastric carcinoma
    Manabu Yamamoto
    Department of Surgery, Hiroshima Atomic Bomb Survivors Hospital, Hiroshima, Japan
    J Surg Oncol 100:594-7. 2009
    ..Subsequently, the incidence of other cancers gradually increased while that of leukemia decreased. We examined the long-term clinical outcome of gastric cancer and second primary cancer in atomic bomb survivors...
  25. ncbi request reprint Prognostic re-evaluation of peritoneal lavage cytology in Japanese patients with gastric carcinoma
    Manabu Yamamoto
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, 1 9 6, Senda machi, Naka ku, Hiroshima 730 8619, Japan
    Hepatogastroenterology 56:261-5. 2009
    ....
  26. ncbi request reprint Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: report of a case
    Tohru Utsunomiya
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, 1 9 6 Senda machi, Naka ku, Hiroshima 730 8619, Japan
    Surg Today 38:65-7. 2008
    ..The primary GIST constitutively had a deletion mutation in exon 11. In addition, the recurrent hepatic tumor developed a secondary point mutation (Val654Ala) in exon 13, which may be responsible for the imatinib resistance...
  27. doi request reprint Regulatory T cells in the blood: a new marker of surgical stress
    Yu Saito
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Surg Today 43:608-12. 2013
    ..The function of regulatory T cells (Foxp3(+)CD4(+)CD25(+) T cells: Treg) after surgery remains unspecified. We investigated the potential role of Treg as a new stress marker for various operations...
  28. doi request reprint Thymidylate synthase (TS) protein expression as a prognostic factor in advanced colorectal cancer: a comparison with TS mRNA expression
    Tateo Nakagawa
    Department of Surgery, The University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 59:1059-62. 2012
    ..The role of intratumoral thymidylate synthase (TS) mRNA or protein expression is still controversial and little has been reported regarding relation of them in colorectal cancer...
  29. doi request reprint Successful case with hemophagocytic syndrome after living donor liver transplantation
    Satoru Imura
    Department of Surgery, University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 59:863-5. 2012
    ..HPS is a fatal complication in immunologically compromised patients but its early diagnosis and appropriate treatment can lead to an improved outcome...
  30. doi request reprint Gastric emptying in Billroth-I and Roux-en-Y reconstruction after distal gastrectomy using C-acetate breath test
    Nobuhiro Kurita
    Department of Surgery, The University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 58:2020-3. 2011
    ..There have been few reports regarding the physiological differences of these two procedures. We compared gastric emptying after Roux-en-Y procedure with the Billroth-I procedure using the 13C-acetate breath test...
  31. ncbi request reprint Expression of cancer-testis antigen (CTA) genes in intrahepatic cholangiocarcinoma
    Tohru Utsunomiya
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumibaru, Beppu 874 0838, Japan
    Ann Surg Oncol 11:934-40. 2004
    ..This characteristic feature of CTA makes them promising antigens for cancer-specific immunotherapy...
  32. doi request reprint CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma
    Mitsuo Shimada
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Kuramoto 3 18 15, Tokushima 770 8503, Japan
    J Gastroenterol 45:896-902. 2010
    ..However, no one has investigated the role of CD133 in intrahepatic cholangiocarcinoma (IHCC). The aim of this study was to clarify the clinical role of CD133 expression in IHCC...
  33. ncbi request reprint Impact of C-reactive protein on prognosis of patients with colorectal carcinoma
    Chie Takasu
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    Hepatogastroenterology 60:507-11. 2013
    ..The aim of this study was to investigate the impact of preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with colorectal carcinoma (CRC)...
  34. doi request reprint Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma
    Lkhagva Ochir Tovuu
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Int J Clin Oncol 18:651-6. 2013
    ..We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC)...
  35. pmc High expression of cancer stem cell markers in cholangiolocellular carcinoma
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Surg Today 43:654-60. 2013
    ..Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC...
  36. ncbi request reprint Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells
    Koshi Mimori
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Clin Cancer Res 10:8243-9. 2004
    ..Recent studies focus on diverse roles of MMP-7, other than as a protease, during cancer progression. MMP-7 activates the epidermal growth factor (EGF) receptor by releasing an EGF ligand, tumor growth factor (TGF)-alpha...
  37. doi request reprint Gastric carcinoma with protein-losing gastroenteropathy: report of a case
    Manabu Yamamoto
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, 1 9 6 Senda machi, Naka ku, Hiroshima 730 8619, Japan
    Surg Today 41:125-9. 2011
    ..Gastric cancer with protein-losing gastroenteropathy is extremely rare, but it can easily be diagnosed if the villous or cauliflower-like features are well defined...
  38. ncbi request reprint Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and a cDNA microarray
    Koujiro Nishida
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Japan
    Cancer Res 65:401-9. 2005
    ....
  39. ncbi request reprint [Long- and short-term survivors after chemotherapy among patients with advanced or recurrent gastric cancer in our hospital]
    Manabu Yamamoto
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
    Gan To Kagaku Ryoho 35:599-602. 2008
    ....
  40. ncbi request reprint [Present status and prospects for chemotherapy for advanced or recurrent gastric cancer in our hospital]
    Manabu Yamamoto
    Dept of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Japan
    Gan To Kagaku Ryoho 35:441-4. 2008
    ..In addition, the prognosis of patients will improve if second- or third-line chemotherapy can be performed...
  41. doi request reprint Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve
    Tohru Utsunomiya
    Department of Surgery, The University of Tokushima, 13 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Gastroenterol 47:470-6. 2012
    ..We evaluated the role of dynamic magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), i.e., EOB-MRI, for determining liver functional reserve...
  42. doi request reprint Prediction of recurrence of hepatocellular carcinoma after curative hepatectomy using preoperative Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein
    Yu Saito
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Hepatol Res 42:887-94. 2012
    ....
  43. doi request reprint Impact of a new refrigerator on the preservation of hepatic grafts
    Mami Kanamoto
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Hepatol Res 42:798-805. 2012
    ..Conclusion:  This new refrigerator can improve preservation injury of hepatic grafts and may provide an innovative technique for liver transplantation...
  44. doi request reprint Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer
    Tomohiko Miyatani
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
    Cancer Lett 318:199-205. 2012
    ..The aim of this study is to evaluate whether TPI augments the radiotherapy for colorectal cancer in vitro and in vivo studies...
  45. doi request reprint Impact of a new refrigerator for the preservation of whole blood
    Mami Kanamoto
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Surg Res 173:180-4. 2012
    ..The purpose of this study was to evaluate the usefulness of this new system in whole blood preservation...
  46. doi request reprint Histone deacetylase inhibitor enhances the anti-tumor effect of gemcitabine: a special reference to gene-expression microarray analysis
    Shuichi Iwahashi
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Oncol Rep 26:1057-62. 2011
    ..01). VPA augmented the effects of GEM by enhancing the gene network mainly including HLA-DRA, possibly through the modification of cancer cell differentiation...
  47. doi request reprint Effects of pegylated interferon α2b on metastasis of hepatocellular carcinoma
    Yusuke Arakawa
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan
    J Surg Res 172:95-101. 2012
    ..We have previously reported anti-metastatic effects of IFN combined chemotherapy on the outcome of HCC patients. The aim of this study was to investigate anti-metastatic effects of IFN...
  48. ncbi request reprint Somatic mutations of epidermal growth factor receptor in colorectal carcinoma
    Hisashi Nagahara
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874 0838, Japan
    Clin Cancer Res 11:1368-71. 2005
    ..However, no mutations have been reported for colorectal carcinoma. We therefore analyzed EGFR mutations in colorectal adenocarcinomas by the combined use of laser microdissection and sequencing of genomic DNA...
  49. ncbi request reprint A gene-expression signature can quantify the degree of hepatic fibrosis in the rat
    Tohru Utsunomiya
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu 874 0838, Japan
    J Hepatol 41:399-406. 2004
    ..A more accurate and objective quantification of hepatic fibrosis would provide clinically useful information for the monitoring of chronic liver disease progression and therapy recommendation...
  50. doi request reprint Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma
    Jun Hanaoka
    Department of Surgery, University of Tokushima, Tokushima, Japan
    Hepatol Res 42:727-31. 2012
    ..We describe a case of huge FNH that was difficult to distinguish from well-differentiated HCC even by current fully preoperative imaging technology and demonstrate the effectiveness of curative surgical resection...
  51. doi request reprint Modified hanging method for liver resection
    Tohru Utsunomiya
    Department of Surgery, The University of Tokushima, l3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    J Hepatobiliary Pancreat Sci 19:19-24. 2012
    ..This report explains the methods and pitfalls of the original and modified LHM. In addition, important anatomical and technical aspects of the mobilization of hepatic lobes are also included...
  52. ncbi request reprint Predictive factors of peritoneal metastasis in gastric cancer
    Nobuhiro Kurita
    Department of Surgery, The University of Tokushima, 770 8503 Kuramoto cho 3 18 15, Tokushima, Japan
    Hepatogastroenterology 57:980-3. 2010
    ..Staging laparoscopy is performed for patients who are diagnosed T3 or T4 preoperatively. The aim of this study is to establish a method for predicting peritoneal metastasis...
  53. ncbi request reprint Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival
    Tohru Utsunomiya
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Clin Cancer Res 8:2591-4. 2002
    ..Thus, we studied the CMAP expression levels using a real-time quantitative reverse transcription-PCR for 79 patients with colorectal cancer, including 17 cases with liver metastasis...
  54. ncbi request reprint MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway
    Koshi Mimori
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Oncogene 22:3463-71. 2003
    ....
  55. doi request reprint Molecular characteristics of non-cancerous liver tissue in non-B non-C hepatocellular carcinoma
    Tohru Utsunomiya
    Department of Surgery, The University of Tokushima, Tokushima, Japan
    Hepatol Res 41:711-21. 2011
    ..A better understanding of the molecular mechanisms underlying the individual predisposition to non-B non-C HCC will lead to improvements in the prevention, early diagnosis and treatment of this neoplastic disease...
  56. ncbi request reprint Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients
    Masahiro Okamoto
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu, 874 0838, Japan
    Ann Surg Oncol 13:947-54. 2006
    ..A molecular analysis of the damaged liver tissues infected with HCV may identify specific gene-expression profiles associated with a risk for liver carcinogenesis...
  57. ncbi request reprint A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease
    Tohru Utsunomiya
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu 874 0838, Japan
    World J Gastroenterol 13:383-90. 2007
    ..To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease...
  58. ncbi request reprint Detection of occult cancer cells in peripheral blood and bone marrow by quantitative RT-PCR assay for cytokeratin-7 in breast cancer patients
    Taka aki Masuda
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Int J Oncol 26:721-30. 2005
    ..QRT-PCR for CK-7 could be a useful and universal method for detecting O.M, and the quantitative detection of CK-7 in P.B. would have a prognostic value as a marker of early recurrence in breast cancer patients with surgery...