M Yokoyama

Summary

Affiliation: Japan Tobacco Inc
Country: Japan

Publications

  1. ncbi Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos
    C Meno
    Tokyo Metropolitan Institute of Medical Science, Japan
    Nature 381:151-5. 1996
  2. ncbi Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
    M Yokoyama
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama, Kanagawa, 236, Japan
    Genomics 59:40-50. 1999
  3. ncbi Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein
    Y Kuroiwa
    Gene Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Genet 12:186-90. 1996
  4. ncbi Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles
    M Yokoyama
    Life Science Research Laboratory, Japan Tobacco, Inc, Kanagawa, Japan
    DNA Res 3:311-20. 1996
  5. ncbi Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    H Watanabe
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Yokohama Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 75:28-33. 2000
  6. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
  7. ncbi Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains
    M Yokoyama
    Pharmaceutical Basic Research Laboratories Aobadai Japan Tobacco, Inc, Yokohama, Kanagawa
    Biochim Biophys Acta 1353:13-7. 1997
  8. ncbi Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum
    M Yokoyama
    Life Science Research Laboratory, Japan Tobaco, Inc, Kanagawa, Japan
    Brain Res Mol Brain Res 42:135-9. 1996
  9. ncbi Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines
    K Akiyama
    Pharmaceutical Frontiers Research Laboratories, Japan Tobacco, Inc, Yokohama
    Biochem Mol Biol Int 47:563-8. 1999
  10. ncbi Purification, identification, and cDNA cloning of Jun a 2, the second major allergen of mountain cedar pollen
    M Yokoyama
    Meiji Milk Products Company, Ltd, 540 Naruda, Odawara, Kanagawa, 250 0862, Japan
    Biochem Biophys Res Commun 275:195-202. 2000

Detail Information

Publications45

  1. ncbi Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos
    C Meno
    Tokyo Metropolitan Institute of Medical Science, Japan
    Nature 381:151-5. 1996
    ..These results suggest that lefty may be involved in setting up L-R asymmetry in the organ systems of mammals...
  2. ncbi Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
    M Yokoyama
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama, Kanagawa, 236, Japan
    Genomics 59:40-50. 1999
    ..These data suggest that this family of proteins may be involved in determining and maintaining a cell-specific phenotype through regulation of certain genes responsive to second messenger-mediated signals...
  3. ncbi Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein
    Y Kuroiwa
    Gene Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Genet 12:186-90. 1996
    ..This region is syntenic with human chromosome 19q13.1-13.3 (refs 10,11), where the genes for myotonic dystrophy and a putative tumour suppressor gene are located...
  4. ncbi Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles
    M Yokoyama
    Life Science Research Laboratory, Japan Tobacco, Inc, Kanagawa, Japan
    DNA Res 3:311-20. 1996
    ....
  5. ncbi Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    H Watanabe
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Yokohama Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 75:28-33. 2000
    ..These data indicate that the decreased expression of KCNQ2 might cause a hyperexcitability of the CNS, which accounts for the mechanism of BFNC...
  6. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
    ..10 or mKQT2.11) were abundantly found on the 11th day after gestation. Although these mKQT2 isoforms had the characteristic structure of voltage-gated K+ channels, functional expression of K+ currents were not detected in Xenopus oocytes...
  7. ncbi Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains
    M Yokoyama
    Pharmaceutical Basic Research Laboratories Aobadai Japan Tobacco, Inc, Yokohama, Kanagawa
    Biochim Biophys Acta 1353:13-7. 1997
    ..A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes...
  8. ncbi Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum
    M Yokoyama
    Life Science Research Laboratory, Japan Tobaco, Inc, Kanagawa, Japan
    Brain Res Mol Brain Res 42:135-9. 1996
    ..The results suggest that the human as well as the mouse neuroD may play some important functions not only in the fetal brain but also in the fetal brain but also in the matured neurons of the cerebellum...
  9. ncbi Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines
    K Akiyama
    Pharmaceutical Frontiers Research Laboratories, Japan Tobacco, Inc, Yokohama
    Biochem Mol Biol Int 47:563-8. 1999
    ..These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN...
  10. ncbi Purification, identification, and cDNA cloning of Jun a 2, the second major allergen of mountain cedar pollen
    M Yokoyama
    Meiji Milk Products Company, Ltd, 540 Naruda, Odawara, Kanagawa, 250 0862, Japan
    Biochem Biophys Res Commun 275:195-202. 2000
    ....
  11. pmc Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
    A Kushi
    Central Pharmaceutical Research Institute, Pharmaceutical Frontiers Research Laboratory, Japan Tobacco Inc, 1 13 2, Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236, Japan
    Proc Natl Acad Sci U S A 95:15659-64. 1998
    ..This model will be useful for studying the mechanism of mild obesity and abnormal insulin metabolism in noninsulin-dependent diabetes mellitus...
  12. ncbi Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization
    T Kaneko-Ishino
    Gene Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Genet 11:52-9. 1995
    ..Peg1/Mest is widely expressed in mesodermal tissues and belongs to the alpha/beta hydrolase fold family. A similar approach with androgenones can be used to identify imprinted genes that are expressed from the maternal genome only...
  13. ncbi Heparin and heparan sulfate inhibit extracellular signal-regulated kinase activation and myocardial cell hypertrophy induced by endothelin-1
    K Mizutani
    Division of Surgical Pathology, Division of Cardiovascular and Respiratory Internal Medicine, Kobe University Graduate School of Medicine
    Kobe J Med Sci 47:47-58. 2001
    ..Moreover, heparin and HS inhibited ET-1-induced [3H] leucine incorporation. These results suggest that heparin and HS inhibit ET-1 induced myocardial cell hypertrophy through the inhibition of gene expression and protein synthesis...
  14. ncbi Structure and chromosome mapping of the human small maf-genes MAFG and MAFK
    T Iwata
    Department of Pediatrics, Faculty of Sciences, Hirosaki University, Hirosaki, Japan
    Cytogenet Cell Genet 82:88-90. 1998
    ..Human MAFG and MAFK are located at 17q25 and 7p22, respectively. Thus, small maf genes are not clustered in a single locus...
  15. ncbi Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1746-8. 2001
    ..Our in vitro system will provide a useful tool to further analyze the physiological significance of the peripheral clock in cardiovascular function...
  16. ncbi Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
    K Kitamura
    Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Development 126:5749-58. 1999
    ....
  17. ncbi Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin
    K Terui
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 192:259-73. 2000
    ..The dynamic changes in the levels of different transcription factors that occur during primary megakaryocytic differentiation suggest that the levels of these factors may influence the progression to specific hematopoietic pathways...
  18. ncbi Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat
    S Inamoto
    The Second Department of Pathology, andThe First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Pathol Int 50:480-5. 2000
    ....
  19. ncbi Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform
    R Kanezaki
    Department of Pediatrics, School of Medicine and Department of Biology, Faculty of Sciences, Hirosaki University, Hirosaki 036 8563, Japan
    J Biol Chem 276:7278-84. 2001
    ..These results suggested that BACH1t recruits BACH1 to the nucleus through BTB domain-mediated interaction...
  20. ncbi Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15
    S Sasaki
    Department of Pediatrics, School of Medicine, Hirosaki University, Japan
    Oncogene 19:3739-49. 2000
    ..Among 25 informative cases, five (20%) showed LOH. These results indicate that BACH2 plays important roles in regulation of B cell development...
  21. ncbi Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model
    Y Yamashita
    Department of Experimental Pathology, Cancer Institute, Tokyo, 170 8455, Japan
    Biochem Biophys Res Commun 275:134-40. 2000
    ..We also found that Erc was expressed at higher levels in primary RCs compared with the normal kidney of the Eker rat. Erc may be related to carcinogenesis in the Tsc2 gene mutant (Eker) rat model...
  22. ncbi Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis
    E Ito
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Nature 362:466-8. 1993
    ..The GATA-1-expressing cells in 10-week-old testis were found only in contact with the basement membrane of seminiferous tubules, suggesting that GATA-1 regulates genes during the earliest stages of spermatogenesis...
  23. ncbi Transgenic mouse model of hemifacial microsomia: cloning and characterization of insertional mutation region on chromosome 10
    H Naora
    Department of Anatomy, Shimane Medical University, Izumo, Japan
    Genomics 23:515-9. 1994
    ..These results suggest that the Hfm locus is necessary for prenatal development and that this strain is a useful animal model for investigating the genetic predisposition to HFM in humans...
  24. ncbi Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa
    Biochim Biophys Acta 1328:83-9. 1997
    ..The mouse NPY-Y5 receptor gene can map about 10 kbp upstream of the transcriptional initiation sites of the NPY-Y1 receptor gene with an opposite orientation...
  25. ncbi Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
    T Toki
    Department of Pediatrics, Hirosaki University, Japan
    Oncogene 14:1901-10. 1997
    ..The results suggest that the small Maf family proteins function in human cells through interaction with various basic-leucine zipper-type transcription factors...
  26. ncbi Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    S B Raharjo
    Division of Molecular Medicine, International Center for Medical Research, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 276:25612-20. 2001
    ..Our results suggest that the unique subcellular localization and secretion of SEP proteins provide a novel model of protein trafficking within the secretory pathway...
  27. ncbi Expression of cathepsin B and cystatin C in human breast cancer
    M Yano
    Department of Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
    Surg Today 31:385-9. 2001
    ..This report documents the first simultaneous investigation of cathepsin B and cystatin C in breast cancer tissues...
  28. ncbi Spatial expression patterns of genes involved in cyclic AMP responses in Dictyostelium discoideum development
    M Tsujioka
    Department of Biology, Graduate School of Science, Osaka University, Machikaneyama-cho 1-16, Toyonaka, Osaka 560-0043, Japan
    Dev Growth Differ 43:275-83. 2001
    ..Promoter analyses of genes in particular classes should enhance understanding of the regulation of dynamic and coordinated gene expression during morphogenesis...
  29. ncbi Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate
    N Danziger
    INSERM U114 Chaire de Neuropharmacologie, College de France, Paris
    J Neurochem 64:1016-25. 1995
    ..Finally, physiological importance of PEA-15 phosphorylation was illustrated by immunoreactivity observed in brain homogenates of different mammals, birds, amphibians, and fish...
  30. ncbi Identification of a component that induces flowering of Lemna among the reaction products of alpha-ketol linolenic acid (FIF) and norepinephrine
    S Yamaguchi
    Basic Research Center, Shiseido Co. Ltd, Tsuzuki-ku, Yokohama, 224-8558 Japan
    Plant Cell Physiol 42:1201-9. 2001
    ..Various catecholamines and related substances were investigated for the ability to develop flower-inducing activity upon incubation with FIF. The essential structures were catechol and ethylamine groups (dopamine)...
  31. ncbi Antigenic properties of the GroEL-like protein of Campylobacter rectus
    D Hinode
    Department of Preventive Dentistry, School of Dentistry, The University of Tokushima, Tokushima 770 8504, Japan
    Oral Microbiol Immunol 17:16-21. 2002
    ..These results suggest that the GroEL-like protein and the S-layer protein of C. rectus may share the same carbohydrate epitopes...
  32. ncbi Liver metastases are less established after gasless laparoscopy than after carbon dioxide pneumoperitoneum and laparotomy in a mouse model
    H Ishida
    Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350 8550, Japan
    Surg Endosc 16:193-6. 2002
    ....
  33. ncbi Induction of apoptosis by castration in epithelium of the mouse seminal vesicles
    N Tanji
    Department of Urology, Ehime University School of Medicine, Shitsukawa, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Arch Androl 49:409-15. 2003
    ..It would appear that a proportion of SV epithelial cells dependent on testicular androgens for survival is smaller before day 20 than after day 20...
  34. pmc A novel point mutation (G-1 to T) in a 5' splice donor site of intron 13 of the dystrophin gene results in exon skipping and is responsible for Becker muscular dystrophy
    Y Hagiwara
    Department of Pediatrics, Kobe University School of Medicine, Japan
    Am J Hum Genet 54:53-61. 1994
    ..Analysis of the genomic context of the G-1-to-T mutation at the 5' splice site supports the exon-definition model of pre-mRNA splicing and contributes to the understanding of splice-site selection...
  35. ncbi Highly potent nociceptin analog containing the Arg-Lys triple repeat
    K Okada
    Laboratory of Structure Function Biochemistry, Kyushu University, Fukuoka, 812 8581, Japan
    Biochem Biophys Res Commun 278:493-8. 2000
    ....
  36. ncbi Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome
    T Maekawa
    Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 274:17813-9. 1999
    ..The ATF-2 null mutants should enhance our understanding of the mechanism of severe neonatal respiratory distress...
  37. ncbi Overexpression of a minor component of myelin basic protein isoform (17.2 kDa) can restore myelinogenesis in transgenic shiverer mice
    M Kimura
    Division of Molecular Life Science, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa 259 11, Japan
    Brain Res 785:245-52. 1998
    ..2-kDa MBP isoform is present, has the ability to elicit CNS myelination in transgenic shi mice. This transgenic strategy will be useful for elucidating the role of each type of MBP isoform in CNS myelinogenesis...
  38. pmc Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy
    N Shiga
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, Japan
    J Clin Invest 100:2204-10. 1997
    ..This is the first evidence that partial skipping of an exon harboring a nonsense mutation is due to disruption of a splicing enhancer sequence...
  39. ncbi Mutational analysis of the cardiac actin gene in familial and sporadic dilated cardiomyopathy
    E Takai
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Am J Med Genet 86:325-7. 1999
    ..Although some genetic polymorphisms exist in the cardiac actin gene, mutations of the gene are rarely responsible for DCM, at least in the Japanese patients...
  40. ncbi Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
    K Ikeda
    Division of Genetics, International Center for Medical Research, Kobe University School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 274:32469-77. 1999
    ..These findings suggest that SEP is a novel metalloprotease that possesses a broad substrate specificity and that it may be involved in the metabolism of biologically active peptides intracellulary as well as extracellularly...
  41. ncbi Severe impairment of B cell function in lpr/lpr mice expressing transgenic Fas selectively on B cells
    H Komano
    Department of Immunology, Mitsubishi Kasei Institute of Life Sciences, Machida, Japan
    Int Immunol 11:1035-42. 1999
    ..These observations suggested that the observed B cell defect was probably attributable to the destruction of activated B cells expressing transgenic Fas by aggressive lpr/lpr T cells...
  42. pmc A novel methodology for analysis of cell distribution in chimeric mouse organs using a strain specific antibody
    M Kusakabe
    Institute for Laboratory Animal Research, Nagoya University School of Medicine, Japan
    J Cell Biol 107:257-65. 1988
    ..This cell marker system has proven useful for analysis of cell lineage and cell renewal systems in many organs of chimeric mice...
  43. ncbi The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human
    A Estelles
    INSERM U114 and Chaire de Neuropharmacologie du Coll├Ęge de France, 75231 Paris Cedex 05, France
    J Biol Chem 271:14800-6. 1996
    ....
  44. ncbi Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans
    M Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Germany
    Pancreas 18:240-6. 1999
    ..These findings indicate that FGF/receptor expression is altered after AP, and raise the possibility that FGFs may be involved in the process of pancreatic exocrine regeneration during recovery from AP...
  45. ncbi Aberrant regulation of imprinted gene expression in Gtl2lacZ mice
    Y Sekita
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cytogenet Genome Res 113:223-9. 2006
    ..Therefore, the paternal or maternal inheritance of the TG results in the down-regulation in cis of either Pegs or Megs, respectively, suggesting that the TG insertion influences the mechanism regulating the entire imprinted region...