Research Topics
| Yoshiko MiuraSummaryAffiliation: Japan Advanced Institute of Science and Technology Country: Japan Publications
| Collaborators
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Detail Information
Publications
Inhibition of Alzheimer amyloid aggregation with sulfated glycopolymersYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan
Biomacromolecules 8:2129-34. 2007..Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect...- A globotriaosylceramide (Gb3Cer) mimic peptide isolated from phage display library expressed strong neutralization to Shiga toxinsYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
Biochim Biophys Acta 1760:883-9. 2006..Neutralization activity was confirmed by in vitro assay with HeLa cells. The Gb3 mimic peptide potentially has great promise for use against Stxs... - Peptides binding to a Gb3 mimic selected from a phage libraryYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464 8603, Japan
Biochim Biophys Acta 1673:131-8. 2004..The Stx-1 binding was inhibited by the peptides... - A micropatterned multifunctional carbohydrate display by an orthogonal self-assembling strategyHajime Sato
Department of Materials, Physics, and Energy Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Biomacromolecules 8:753-6. 2007 - Self-assembled monolayers of globotriaosylceramide (Gb3) mimics: surface-specific affinity with shiga toxinsYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
Anal Biochem 310:27-35. 2002..The results suggest that the alkyl chain of the glycolipid takes part in the binding to Stx-2 but not to Stx-1, which is also supported by the computer simulation of Stx-1 with a Gb3 model substance... - Design of multifunctional peptides expressing both antimicrobial activity and shiga toxin neutralization activityYoshinao Yamada
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan
Bioorg Med Chem 14:77-82. 2006..3 microg/mL (4.2-16.7 microM). The present peptide design has a prospect of developing potent multifunctional drugs to destroy proteinaceous toxin-producing bacteria and to simultaneously neutralize the toxins released by bacteriolysis... - One-pot alpha-glycosylation pathway via the generation in situ of alpha-glycopyranosyl imidates in N,N-dimethylformamideYuko Shingu
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan
Carbohydr Res 340:2236-44. 2005..The one-pot alpha-glycosylation methodology performed in DMF was assessed also with different types of acceptor substrates including tertiary alcohols and an anomeric mixture of 1-OH sugars... - Micropatterned carbohydrate displays by self-assembly of glycoconjugate polymers on hydrophobic templates on siliconYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, 464 8603, Japan
Biomacromolecules 5:1708-13. 2004..Protein micropatterning by molecular recognition on the carbohydrate substrates was also successful... 
Surface modification of siliceous materials using maleimidation and various functional polymers synthesized by reversible addition-fragmentation chain transfer polymerizationHirokazu Seto
Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
ACS Appl Mater Interfaces 4:5125-33. 2012..The surface modification method using maleimidation and reversible addition-fragmentation chain transfer polymerization can be used for preparing platforms for microarrays and micropatterning of proteins...- Selective protein separation using siliceous materials with a trimethoxysilane-containing glycopolymerHirokazu Seto
Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, 744 Motooka, Fukuoka 819 0395, Japan
ACS Appl Mater Interfaces 4:411-7. 2012..Moreover, the concanavalin A adsorbed onto the poly(Man-r-TMS)-immobilized membrane was recoverable by permeation of a mannose derivative at high concentration... - Chemoenzymatically synthesized glycoconjugate polymersYoshiko Miura
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Aichi 464 8603, Japan
Biomacromolecules 4:410-5. 2003..The biodegradability of these polymers was modest but higher than PVA... - Syntheses of sulfo-glycodendrimers using click chemistry and their biological evaluationYoshiko Miura
Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
Molecules 17:11877-96. 2012..The addition of the sulfonated GlcNAc dendrimers of G1 and G2 exhibited an inhibition effect on the aggregation of the amyloid beta peptide, reduced the b-sheet conformation, and led to a reduction in the level of nanofiber formation... - Self-assembly of amphiphilic dendritic dipeptides into helical poresVirgil Percec
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
Nature 430:764-8. 2004..We expect that this class of self-assembling dendrimers will allow the design of a variety of biologically inspired systems with functional properties arising from their porous structure...