Affiliation: Japan BCG Central Laboratory
- Recombinant Mycobacterium bovis BCG vector system expressing SIV Gag protein stably and persistently induces antigen-specific humoral immune response concomitant with IFN gamma response, even at three years after immunizationMamoru Kawahara
National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Clin Immunol 129:492-8. 2008..This suggests that the rBCG vector system expressing an appropriate size of foreign antigen gene should be suited for the induction of the antigen-specific humoral immunity concomitant with an IFN gamma response...
- Intradermal and oral immunization with recombinant Mycobacterium bovis BCG expressing the simian immunodeficiency virus Gag protein induces long-lasting, antigen-specific immune responses in guinea pigsMamoru Kawahara
National Institute of Infectious Diseases, 1 23 1 Toyama, Tokyo 162 8640, Japan
Clin Immunol 119:67-78. 2006....
- Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-GuÃ©rin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigenMamoru Kawahara
AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
Vaccine 21:158-66. 2002..Thus, inoculation with rBCG-HIV by combined routes represents an effective vaccination strategy to elicit high levels of HIV-1-specific immune responses...
- Oral recombinant Mycobacterium bovis bacillus Calmette-GuÃ©rin expressing HIV-1 antigens as a freeze-dried vaccine induces long-term, HIV-specific mucosal and systemic immunityMamoru Kawahara
National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan
Clin Immunol 105:326-31. 2002....
- Dynamics of gamma interferon, interleukin-12 (IL-12), IL-10, and transforming growth factor beta mRNA expression in primary Mycobacterium bovis BCG infection in guinea pigs measured by a real-time fluorogenic reverse transcription-PCR assayMamoru Kawahara
National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan
Infect Immun 70:6614-20. 2002..Thus, our quantitative assay would be of use for the development of vaccines using guinea pig models...