E Tachikawa

Summary

Affiliation: Iwate Medical University
Country: Japan

Publications

  1. ncbi request reprint In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins
    Eiichi Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, Morioka 020 8505, Japan
    Biochem Pharmacol 66:2213-21. 2003
  2. ncbi request reprint Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal medullary function in vitro by ginseng
    Eiichi Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University
    J Pharmacol Sci 95:140-4. 2004
  3. ncbi request reprint Characterization of the functional subunit combination of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, Morioka 020 8505, Japan
    Neurosci Lett 312:161-4. 2001
  4. ncbi request reprint Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, 020 8505, Morioka, Japan
    Biochem Pharmacol 62:943-51. 2001
  5. ncbi request reprint Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, 020 8505, Morioka, Japan
    Biochem Pharmacol 60:433-40. 2000
  6. ncbi request reprint Effects of ginseng saponins on responses induced by various receptor stimuli
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Eur J Pharmacol 369:23-32. 1999
  7. ncbi request reprint Pathway for Ca2+ influx into cells by trichosporin-B-VIa, an alpha-aminoisobutyric acid-containing peptide, from the fungus Trichoderma polysporum
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Biochim Biophys Acta 1282:140-8. 1996
  8. ncbi request reprint p-chloromercuribenzoate causes Ca2+-dependent exocytotic catecholamine secretion from cultured bovine adrenal medullary cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    J Neurochem 53:19-26. 1989
  9. ncbi request reprint Stimulation of catecholamine synthesis in cultured bovine adrenal medullary cells by leptin
    K Utsunomiya
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    J Neurochem 76:926-34. 2001
  10. ncbi request reprint Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
    Atsushi Kakizaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 536:223-31. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins
    Eiichi Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, Morioka 020 8505, Japan
    Biochem Pharmacol 66:2213-21. 2003
    ..The inhibitory effect of ginsenoside metabolites is probably one of the mechanisms of action responsible for the pharmacological effects of ginseng...
  2. ncbi request reprint Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal medullary function in vitro by ginseng
    Eiichi Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University
    J Pharmacol Sci 95:140-4. 2004
    ..It is highly possible that these effects of ginsenosides and their metabolites are associated with the anti-stress action of ginseng...
  3. ncbi request reprint Characterization of the functional subunit combination of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, Morioka 020 8505, Japan
    Neurosci Lett 312:161-4. 2001
    ..Further, the results indicate that the utilization of the nicotinic agonists as selective ligands for the subunit combination of nAChRs may be not suitable for the characterization of nAChRs...
  4. ncbi request reprint Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Uchimaru 19 1, 020 8505, Morioka, Japan
    Biochem Pharmacol 62:943-51. 2001
    ..In addition to this action, the ginsenoside at higher concentrations modulates the fluidity of the plasma membrane, which probably contributes to the observed reduction in the secretion of catecholamines...
  5. ncbi request reprint Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, 020 8505, Morioka, Japan
    Biochem Pharmacol 60:433-40. 2000
    ..Furthermore, the results indicate that the inhibitory effect of magnolia bark may be associated with its pharmacological effect on activities of the nervous system...
  6. ncbi request reprint Effects of ginseng saponins on responses induced by various receptor stimuli
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Eur J Pharmacol 369:23-32. 1999
    ....
  7. ncbi request reprint Pathway for Ca2+ influx into cells by trichosporin-B-VIa, an alpha-aminoisobutyric acid-containing peptide, from the fungus Trichoderma polysporum
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Biochim Biophys Acta 1282:140-8. 1996
    ..On the other hand, the peptide at the higher concentrations seems to damage cell membranes...
  8. ncbi request reprint p-chloromercuribenzoate causes Ca2+-dependent exocytotic catecholamine secretion from cultured bovine adrenal medullary cells
    E Tachikawa
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    J Neurochem 53:19-26. 1989
    ..These results indicate that catecholamine secretion due to p-chloromercuribenzoate occurs by Ca2+-dependent exocytosis...
  9. ncbi request reprint Stimulation of catecholamine synthesis in cultured bovine adrenal medullary cells by leptin
    K Utsunomiya
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    J Neurochem 76:926-34. 2001
    ..e., one is dependent on tyrosine hydroxylase phosphorylation mediated through the MAPK pathway and the second is independent of enzyme phosphorylation...
  10. ncbi request reprint Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
    Atsushi Kakizaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 536:223-31. 2006
    ....
  11. ncbi request reprint Inhibition by pregnenolone sulfate of nicotinic acetylcholine response in adrenal chromaffin cells
    Kenzo Kudo
    Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan
    Eur J Pharmacol 456:19-27. 2002
    ..Our results further indicate that pregnenolone sulfate may modulate nicotinic receptor-mediated responses in the brain...
  12. ncbi request reprint Transbilayer transport of a propyltrimethylammonium derivative of diphenylhexatriene (TMAP-DPH) in bovine blood platelets and adrenal chromaffin cells
    Shuji Kitagawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
    J Pharm Pharmacol 54:1631-6. 2002
    ..The saturation phenomenon suggested the presence of the regulatory process in the transbilayer transport of TMAP-DPH...
  13. ncbi request reprint Dendritic cells maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in digestive tracts, drive a potent Th1 polarization
    Masao Takei
    Division of Cellular Allergology, Research Center Borstel, Parkallee 22 D 23845, Germany
    Biochem Pharmacol 68:441-52. 2004
    ..These results suggest that M4 may be used on DC-based vaccines for cancer immunotherapy...
  14. ncbi request reprint Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells
    Shuji Kitagawa
    Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 30:1979-81. 2007
    ..Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp...