Takumi Satoh

Summary

Affiliation: Iwate University
Country: Japan

Publications

  1. ncbi request reprint [Cyclopentenone prostaglandin derivatives as neuroprotective compounds]
    Takumi Satoh
    Tanpakushitsu Kakusan Koso 47:2032-6. 2002
  2. ncbi request reprint Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 380:298-302. 2009
  3. doi request reprint Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 379:537-41. 2009
  4. ncbi request reprint Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    J Neurochem 104:1116-31. 2008
  5. ncbi request reprint Neuroprotective effects of phenylenediamine derivatives independent of an antioxidant pathway in neuronal HT22 cells
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 418:102-5. 2007
  6. ncbi request reprint Redox regulation of neuronal survival mediated by electrophilic compounds
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020 8551, Japan
    Trends Neurosci 30:37-45. 2007
  7. doi request reprint Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    J Neurochem 119:569-78. 2011
  8. ncbi request reprint [Neurotrophin-like low molecular weight compounds]
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka shi, Iwate 020 8551, Japan
    Nihon Yakurigaku Zasshi 120:327-34. 2002
  9. ncbi request reprint Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Eur J Neurosci 17:2249-55. 2003
  10. ncbi request reprint Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 371:1-5. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint [Cyclopentenone prostaglandin derivatives as neuroprotective compounds]
    Takumi Satoh
    Tanpakushitsu Kakusan Koso 47:2032-6. 2002
  2. ncbi request reprint Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 380:298-302. 2009
    ..This report is the first report to show that Keap1 is a key regulator of cell defense mechanisms of CNS neurons against oxidative stress...
  3. doi request reprint Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 379:537-41. 2009
    ..These results suggest that para- and ortho-dihydroquinones may be neuroprotective compounds active against oxidative stress...
  4. ncbi request reprint Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    J Neurochem 104:1116-31. 2008
    ....
  5. ncbi request reprint Neuroprotective effects of phenylenediamine derivatives independent of an antioxidant pathway in neuronal HT22 cells
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 418:102-5. 2007
    ..By studying the structure-function relationship of these compounds, we found the structure of phenyl-amine-phenyl-amine-phenyl (or butyl) to be essential for the neuroprotective effects...
  6. ncbi request reprint Redox regulation of neuronal survival mediated by electrophilic compounds
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020 8551, Japan
    Trends Neurosci 30:37-45. 2007
    ....
  7. doi request reprint Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    J Neurochem 119:569-78. 2011
    ..These results suggest that D1 is a novel pro-electrophilic compound that activates both the Nrf2 and HSF-1 pathways, and may thus offer protection from oxidative and ER stress...
  8. ncbi request reprint [Neurotrophin-like low molecular weight compounds]
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka shi, Iwate 020 8551, Japan
    Nihon Yakurigaku Zasshi 120:327-34. 2002
    ..In this paper, we present a review of these compounds as therapeutic agents against several neurodegenerative diseases...
  9. ncbi request reprint Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Eur J Neurosci 17:2249-55. 2003
    ..NEPP11 is the first molecular probe reported to have a neuroprotective action through induction of HO-1 in neuronal cells...
  10. ncbi request reprint Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 371:1-5. 2004
    ..These results indicate that ebselen protects neuronal cells against the oxidative stress at multiple steps, including an increase in glutathione, a ROS-scavenging activity and the induction of HO-1 protein...
  11. ncbi request reprint Contribution of reduced and oxidized glutathione to signals detected by magnetic resonance spectroscopy as indicators of local brain redox state
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Neurosci Res 55:34-9. 2006
    ..The estimated concentration of GSH in the human brain was 1.9+/-0.37 mM (mean+/-S.D., n=4). In conclusion, MEGA-PRESS allowed us to assess GSH levels in vivo non-invasively...
  12. doi request reprint Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Ueda 4 3 5, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 434:260-5. 2008
    ..These results suggest that the neuroprotective effects of CA critically require both free carboxylic acid and catechol hydroxyl moieties. Thus, the hydrophilicity of CA might be a critical feature for its neuroprotective effects...
  13. doi request reprint Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells
    Yosei Tamaki
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, 020 8551 Iwate, Japan
    Planta Med 76:683-8. 2010
    ....
  14. doi request reprint Carnosic acid (CA) prevents lipid accumulation in hepatocytes through the EGFR/MAPK pathway
    Ting Wang
    Department of Gastroenterology and Hepatology, Iwate Medical University, Morioka, Iwate, Japan
    J Gastroenterol 47:805-13. 2012
    ..We recently demonstrated that CA protects against steatosis in ob/ob mice. In the present report, we investigated the molecular mechanism by which CA inhibits lipids accumulation both in vivo and in vitro...
  15. ncbi request reprint Diterpene para-hydroquinone compounds derived from cryptoquinone inhibit adipocyte differentiation of mouse 3T3-L1 cells and activate the Nrf2/ARE pathway
    Shunsuke Sasaki
    Department of Welfare Engineering, Faculty of Engineering, Iwate University
    Biosci Biotechnol Biochem 77:2131-3. 2013
    ..The actions might have been mediated, at least in part, by activation of the antioxidant-response element induction of phase 2 enzymes and increases in total glutathione. ..
  16. doi request reprint A novel di terpene para-hydroquinone compound derived from cryptoquinone protects neuronal cells against oxidative stress and activates the Nrf2/ARE pathway
    Shunsuke Sasaki
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Neurosci Lett 548:132-6. 2013
    ..DA1 had a very broad safety zone (199.41 fold) at least in our system. Thus, DA1 is a novel neuroprotective pro-electrophilic diterpene from green plant. ..
  17. doi request reprint Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
    Toshiyuki Takahashi
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 382:549-54. 2009
    ....
  18. doi request reprint Strongylophorine-8, a pro-electrophilic compound from the marine sponge Petrosia (Strongylophora) corticata, provides neuroprotection through Nrf2/ARE pathway
    Shunsuke Sasaki
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 415:6-10. 2011
    ..STR8 is the first example of a neuroprotective pro-electrophilic compound from marine organisms...
  19. doi request reprint Phenylenediamine derivatives induce GDF-15/MIC-1 and inhibit adipocyte differentiation of mouse 3T3-L1 cells
    Mika Yanagitai
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    Biochem Biophys Res Commun 417:294-8. 2012
    ..Thus, we identified the compounds as inducers of GDF-15/MIC-1 and suggest that such induction may have led to inhibition of adipocyte differentiation, which could account for the weight-loss effect of these compounds...
  20. doi request reprint Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia
    Mika Yanagitai
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 418:22-6. 2012
    ..Thus, CA is a unique pro-electrophilic compound that provides both a protective effect on neurons and an anti-inflammatory one on microglia through induction of phase 2 genes...
  21. ncbi request reprint [Cysteine-mediated signaling pathway by a novel electrophilic compound, NEPP11]
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Japan
    Seikagaku 79:28-34. 2007
  22. doi request reprint Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
    Ting Wang
    Department of Gastroenterology and Hepatology, Iwate Medical University Department of Welfare Engineering, Faculty of Engineering, Iwate University Department of Pathology, Iwate Medical University School of Medicine, Morioka Immunology Frontier Research Center, Osaka University, Osaka Research and Development Center, Nagase, Tokyo, Japan
    Hepatol Res 41:87-92. 2011
    ..In addition, IPGTT revealed that CA significantly improved glucose tolerance. Conclusion:  These data suggest that CA is a novel therapeutic agent for obesity-related non-alcoholic fatty liver disease...
  23. ncbi request reprint Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
    Takumi Satoh
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan Electronic address
    Free Radic Biol Med 66:45-57. 2014
    ..Given the contribution of oxidative stress to the pathology of multiple neurodegenerative diseases, the Keap1/Nrf2/ARE pathway represents a promising drug target for these PED/PAT agents...
  24. doi request reprint Inhibition of glycogen synthase kinase-3β by falcarindiol isolated from Japanese Parsley (Oenanthe javanica)
    Jun Yoshida
    Chemical Biology Laboratory, The United Graduate School of Agricultural Sciences, Graduate School of Agriculture, and Faculty of Agriculture, Iwate University, Morioka, Iwate 020 8550, Japan
    J Agric Food Chem 61:7515-21. 2013
    ..javanica extract containing falcarindiol (15 mg/kg). These findings indicate that Japanese parsley could be a useful food ingredient against type-2 diabetes and Alzheimer's disease. ..
  25. pmc Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
    Takumi Satoh
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan Electronic address
    Free Radic Biol Med 65:645-57. 2013
    ..Given the contribution of oxidative stress to the pathology of multiple neurodegenerative diseases, the Keap1/Nrf2/ARE pathway represents a promising drug target for these PED/PAT agents. ..