Atsushi Sanbe

Summary

Affiliation: Iwate Medical University
Country: Japan

Publications

  1. ncbi request reprint Dilated cardiomyopathy: a disease of the myocardium
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate 028 3694, Japan
    Biol Pharm Bull 36:18-22. 2013
  2. pmc Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, 028 3694, Japan
    J Biol Chem 288:8910-21. 2013
  3. pmc Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 6:e18922. 2011
  4. ncbi request reprint Molecular mechanisms of α-crystallinopathy and its therapeutic strategy
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    Biol Pharm Bull 34:1653-8. 2011
  5. doi request reprint Altered magnetic resonance images of brain and social behaviors of hatchling, and expression of thyroid hormone receptor βmRNA in cerebellum of embryos after Methimazole administration
    Gen Haba
    Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Morioka, Iwate, 020 0023, Japan
    Psychopharmacology (Berl) 231:221-30. 2014
  6. pmc Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation
    Yu Tezuka
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 8:e61649. 2013
  7. doi request reprint Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy
    Naoko Matsushita
    Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa Gun, Iwate, Japan Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa Gun, Iwate, Japan
    Clin Exp Pharmacol Physiol 41:89-97. 2014
  8. doi request reprint Upregulation of inorganic pyrophosphatase 1 as a JNK phosphatase in hypothyroid embryonic chick cerebellum
    Yu Tezuka
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate 028 3694, Japan
    Life Sci 128:94-100. 2015
  9. doi request reprint Impaired social behavior in chicks exposed to sodium valproate during the last week of embryogenesis
    Hideo Nishigori
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, 2 1 1 Nishitokuta, Yahaba, Shiwa Gun, Iwate 028 3694, Japan
    Psychopharmacology (Berl) 227:393-402. 2013
  10. pmc Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
    Naoko Matsushita
    Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan
    PLoS ONE 9:e106354. 2014

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Dilated cardiomyopathy: a disease of the myocardium
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate 028 3694, Japan
    Biol Pharm Bull 36:18-22. 2013
    ..Thus, effective prognostic determination and appropriate cardiac care depend on accurate molecular and genetic diagnoses...
  2. pmc Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, 028 3694, Japan
    J Biol Chem 288:8910-21. 2013
    ..A single point mutation of HSPB8, such as K141N, can cause cardiac disease...
  3. pmc Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 6:e18922. 2011
    ..It is also known that progressive mitochondrial abnormalities and apoptotic cell death occur in the hearts of R120G TG mice. The role of mitochondrial dysfunction and apoptosis in disease progression, however, remains uncertain...
  4. ncbi request reprint Molecular mechanisms of α-crystallinopathy and its therapeutic strategy
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    Biol Pharm Bull 34:1653-8. 2011
    ..Moreover, recent findings have indicated that enhancement of HSP induction and inhibition of apoptotic cell death by mitochondrial protection may be a new therapeutic strategy for patients with crystallinopathy...
  5. doi request reprint Altered magnetic resonance images of brain and social behaviors of hatchling, and expression of thyroid hormone receptor βmRNA in cerebellum of embryos after Methimazole administration
    Gen Haba
    Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Morioka, Iwate, 020 0023, Japan
    Psychopharmacology (Berl) 231:221-30. 2014
    ..The effects of low thyroid hormone level during embryogenesis on MRI of the brain and social behaviors of hatchlings were examined using "fertilized hen's egg-embryo-chick" system...
  6. pmc Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation
    Yu Tezuka
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 8:e61649. 2013
    ..Enhanced neurite growth by PPA1 knockdown was also observed in rat cortical neurons. Thus, PPA1 may play a role in neuronal differentiation via JNK dephosphorylation...
  7. doi request reprint Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy
    Naoko Matsushita
    Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa Gun, Iwate, Japan Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa Gun, Iwate, Japan
    Clin Exp Pharmacol Physiol 41:89-97. 2014
    ..05). 4. These findings demonstrate that nicorandil inhibits cardiac electrical remodelling and that the prevention of VT by nicorandil is associated with normalization of connexin 43 expression in this model...
  8. doi request reprint Upregulation of inorganic pyrophosphatase 1 as a JNK phosphatase in hypothyroid embryonic chick cerebellum
    Yu Tezuka
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate 028 3694, Japan
    Life Sci 128:94-100. 2015
    ..However, little is known about the mechanisms underlying the direct adverse effects of fetal thyroid dysfunction on neuronal development...
  9. doi request reprint Impaired social behavior in chicks exposed to sodium valproate during the last week of embryogenesis
    Hideo Nishigori
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, 2 1 1 Nishitokuta, Yahaba, Shiwa Gun, Iwate 028 3694, Japan
    Psychopharmacology (Berl) 227:393-402. 2013
    ..To evaluate direct exposure to sodium valproate (VPA) during embryogenesis, we administered VPA to chick embryos and examined their social behaviors after hatching...
  10. pmc Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
    Naoko Matsushita
    Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan
    PLoS ONE 9:e106354. 2014
    ..However, the mechanisms are still unknown. We examined the effects of chronic administration of olmesartan on heart failure and ventricular arrhythmia in Gαq-TG mice...