Kenji Nakai

Summary

Affiliation: Iwate Medical University
Country: Japan

Publications

  1. ncbi request reprint Construction of a three-dimensional outline of the heart and conduction pathway by means of a 64-channel magnetocardiogram in patients with atrial flutter and fibrillation
    Kenji Nakai
    The Department of Laboratory Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka, Japan, 020 8505
    Int J Cardiovasc Imaging 21:555-61; discussion 563-4. 2005
  2. ncbi request reprint Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction
    K Nakai
    Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Coron Artery Dis 9:329-34. 1998
  3. doi request reprint Novel algorithm for identifying T-wave current density alternans using synthesized 187-channel vector-projected body surface mapping
    Kenji Nakai
    Department of Internal Medicine of Dentistry, Iwate Medical University, 19 1 Uchimaru, Morioka, Iwate, 020 8505, Japan
    Heart Vessels 26:160-7. 2011
  4. ncbi request reprint [Development of three-dimensional analysis of current density distribution by 64-ch magentocardiography and clinical application]
    Kenji Nakai
    Department of Internal Medicine of Dentistry, Iwate Medical University, Morioka 020 8505, Japan
    Rinsho Byori 56:1118-24. 2008
  5. doi request reprint Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients
    Kenji Nakai
    Iwate Medical University, Department of Laboratory Medicine, Morioka 020 8505, Japan
    Pharmacogenomics 8:713-9. 2007
  6. ncbi request reprint Three-dimensional spectral map of atrial fibrillation by a 64-channel magnetocardiogram
    Kenji Nakai
    Department of Laboratory Medicine, Iwate University, Morioka, Japan
    J Electrocardiol 41:123-30. 2008
  7. ncbi request reprint Ethnic differences in CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu) genotypes in Japanese and Israeli populations
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Life Sci 78:107-11. 2005
  8. ncbi request reprint Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Life Sci 75:1003-10. 2004
  9. ncbi request reprint Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD
    K Nakai
    Laboratory Medicine, Iwate Medical University, Morioka, Japan
    Am J Cardiovasc Drugs 1:353-61. 2001
  10. ncbi request reprint Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population
    K Nakai
    Second Department of Internal Medicine and Memorial Heart Center, Iwate Medical University, Tokyo, Japan
    Coron Artery Dis 11:47-51. 2000

Detail Information

Publications30

  1. ncbi request reprint Construction of a three-dimensional outline of the heart and conduction pathway by means of a 64-channel magnetocardiogram in patients with atrial flutter and fibrillation
    Kenji Nakai
    The Department of Laboratory Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka, Japan, 020 8505
    Int J Cardiovasc Imaging 21:555-61; discussion 563-4. 2005
    ....
  2. ncbi request reprint Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction
    K Nakai
    Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Coron Artery Dis 9:329-34. 1998
    ..To investigate the genetic contribution for myocardial infarction...
  3. doi request reprint Novel algorithm for identifying T-wave current density alternans using synthesized 187-channel vector-projected body surface mapping
    Kenji Nakai
    Department of Internal Medicine of Dentistry, Iwate Medical University, 19 1 Uchimaru, Morioka, Iwate, 020 8505, Japan
    Heart Vessels 26:160-7. 2011
    ..We conclude that a novel algorithm using 187-ch SAVP-ECG might provide new insights into body surface TWCA...
  4. ncbi request reprint [Development of three-dimensional analysis of current density distribution by 64-ch magentocardiography and clinical application]
    Kenji Nakai
    Department of Internal Medicine of Dentistry, Iwate Medical University, Morioka 020 8505, Japan
    Rinsho Byori 56:1118-24. 2008
    ..In future, further technical development in the fields of MCG measurement would be necessary for avoiding the used of unshielded room or liquid He...
  5. doi request reprint Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients
    Kenji Nakai
    Iwate Medical University, Department of Laboratory Medicine, Morioka 020 8505, Japan
    Pharmacogenomics 8:713-9. 2007
    ....
  6. ncbi request reprint Three-dimensional spectral map of atrial fibrillation by a 64-channel magnetocardiogram
    Kenji Nakai
    Department of Laboratory Medicine, Iwate University, Morioka, Japan
    J Electrocardiol 41:123-30. 2008
    ..In conclusion, 3D spectral mapping using 64-channel MCG may represent a meaningful noninvasive strategy for patients with AFIB who receive an interventional procedure...
  7. ncbi request reprint Ethnic differences in CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu) genotypes in Japanese and Israeli populations
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Life Sci 78:107-11. 2005
    ..85/0.15) and Yemenite Jews (0.849/0.151). Thus, the CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu) variants were rare in the Japanese population, and showed different frequencies in the four Jewish ethnic groups examined...
  8. ncbi request reprint Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505, Japan
    Life Sci 75:1003-10. 2004
    ..We demonstrated an ethnic difference of CAD-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry. Further study is necessary to prove causal relation with CAD-associated SNPs and the prevalence of CAD...
  9. ncbi request reprint Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD
    K Nakai
    Laboratory Medicine, Iwate Medical University, Morioka, Japan
    Am J Cardiovasc Drugs 1:353-61. 2001
    ..Individual therapeutic strategies based on single nucleotide polymorphism may become increasingly important for preventive treatment against polygenic CAD...
  10. ncbi request reprint Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population
    K Nakai
    Second Department of Internal Medicine and Memorial Heart Center, Iwate Medical University, Tokyo, Japan
    Coron Artery Dis 11:47-51. 2000
    ..C677T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene [alanine/valine (A/V) polymorphism], one of the key enzymes involved in catalyzing the remethylation of homocysteine, has recently been reported...
  11. ncbi request reprint Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka, Japan
    Hum Mutat 20:133-8. 2002
    ..MALDI-TOF-MS provided high performance with a multiplex assay design for analysis of CAD-related SNPs by increasing the throughput while maintaining a high level of accuracy...
  12. ncbi request reprint Three-dimensional recovery time dispersion map by 64-channel magnetocardiography may demonstrate the location of a myocardial injury and heterogeneity of repolarization
    Kenji Nakai
    The Department of Laboratory Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka, 020 8505, Japan
    Int J Cardiovasc Imaging 22:573-80. 2006
    ..In this study, we report on a 3D function map of recovery time (RT) dispersions as measured by 64-channel magnetocardiography (MCG)...
  13. ncbi request reprint Newly developed signal-averaged vector-projected 187-channel electrocardiogram can evaluate the spatial distribution of repolarization heterogeneity
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Iwate, Japan
    Int Heart J 49:153-64. 2008
    ..52x + 15, r = 0.63, P = 0.01 for corrected Tp-e dispersion). RTc and corrected Tp-e dispersion maps by 187-ch SAVP-ECG based on vector-projection theory can evaluate the spatial distribution of myocardial repolarization heterogeneity...
  14. ncbi request reprint Clinical significance of combined CYP2C9 and VKORC1 genotypes in Japanese patients requiring warfarin
    You Miyagata
    Division of Oral Surgery, Faculty of Dentistry, Iwate Medical University, Iwate, Japan
    Int Heart J 52:44-9. 2011
    ..Thus, CYP2C9 and VKORC1 haplotype analysis allows prediction of warfarin maintenance dosage. The findings may provide a personalized use of warfarin in the field of oral surgery...
  15. ncbi request reprint Development of a signal-averaged vector-projected 187-channel high-resolution electrocardiogram for the evaluation of the spatial location of high-frequency potentials and abnormal ventricular repolarization
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Iwate, Japan
    Int Heart J 48:701-13. 2007
    ..The 187-ch SAVP-ECG might be useful for evaluating the spatial distribution of nonuniform conduction and ventricular repolarization heterogeneity...
  16. ncbi request reprint Detection of peripartum myocardial burden by vector-projected 187 channel electrocardiography and serum NT-proBNP
    Miyuki Terata
    Department of Obstetrics and Gynecology, Iwate Medical University, Japan
    Int Heart J 54:140-5. 2013
    ..We propose that both repolarization indexes such as RTc dispersion by DREAM-ECG and serum biochemical markers may identify pregnant women at high risk of developing severe myocardial damage in the peripartum period...
  17. ncbi request reprint Serum levels of cardiac troponin I and other marker proteins in patients with chronic renal failure
    Keiko Nakai
    Department of Laboratory Medicine, Iwate Medical University, 19 1 Uchimaru, 020 8505, Morioka, Japan
    Clin Exp Nephrol 8:43-7. 2004
    ..We evaluated the clinical utility of cardiac troponin I (cTnI) as a marker of AMI, particularly in patients with CRF...
  18. doi request reprint Interlead difference between T-peak to T-end intervals in resynchronization patients with an implantable cardioverter-defibrillator
    Atsushi Suzuki
    Department of Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    J Electrocardiol 43:706-12. 2010
    ....
  19. ncbi request reprint Body surface two-dimensional spectral map of atrial fibrillation using vector-projected 187 channel electrocardiography
    Kenji Nakai
    Department of Internal Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka, Iwate, Japan
    Int Heart J 53:5-10. 2012
    ..In conclusion, novel body surface spectral mapping using 187ch VP-ECG may represent a 2-dimensional spectral feature that may be related to atrial refractoriness and organization...
  20. ncbi request reprint [Development of 64-channel magnetocardiography and clinical application]
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505
    Rinsho Byori 54:844-9. 2006
    ..However, there are several problems such as sealed room installation and the use of liquid helium. In the future, a newer technology that does not require liquid helium and a sealed room will be necessory...
  21. ncbi request reprint Development and significance of a fetal electrocardiogram recorded by signal-averaged high-amplification electrocardiography
    Risa Hayashi
    Department of Obstetrics and Gynecology, Iwate Medical University, Iwate, Japan
    Int Heart J 50:161-71. 2009
    ..In conclusion, we have developed a fetal ECG recording method using the SAVP-ECG system, which we used to evaluate autonomic nervous system development...
  22. doi request reprint Serum levels of cystatin C in patients with malignancy
    Keiko Nakai
    Department of Laboratory Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka 020 8505, Japan
    Clin Exp Nephrol 12:132-9. 2008
    ..However, some reports have shown that serum levels of cystatin C increase independently of GFR. In this study, we evaluated the clinical utility of cystatin C in monitoring GFR, especially in patients with a malignancy...
  23. doi request reprint Prenatal diagnosis of polymorphic ventricular tachycardia using 64-channel magnetocardiography
    Akimune Fukushima
    Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Iwate 020 8505, Japan
    Heart Vessels 25:270-3. 2010
    ..Echocardiography demonstrated moderate left ventricular dysfunction in the neonate requiring implantation with a permanent pacemaker...
  24. pmc Assessment of fetal autonomic nervous system activity by fetal magnetocardiography: comparison of normal pregnancy and intrauterine growth restriction
    Akimune Fukushima
    Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Morioka 020 8505, Japan
    J Pregnancy 2011:218162. 2011
    ..To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and intrauterine growth restriction (IUGR) cases using fetal magnetocardiography (FMCG)...
  25. ncbi request reprint [Educational program of clinical laboratory medicine to develop the ability to use proper laboratory examinations in medical practice]
    Keiko Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505
    Rinsho Byori 51:1132-7. 2003
    ..We need further trials to achieve the goal, i.e. education to develop the ability to use proper laboratory examinations in medical practice, as a good clinical doctor...
  26. ncbi request reprint Risk factors for development of pre-diabetic state from normal glucose regulation
    Michiko Orisaka
    Iwate Health Service Association, Morioka, Iwate, Japan
    Tohoku J Exp Med 210:279-83. 2006
    ..The present study demonstrates that the subjects with high risks for PDS could be identified from several clinical parameters and that they should be encouraged to improve their living habits not to develop diabetes mellitus...
  27. ncbi request reprint [Biochemical marker for myocardial injury]
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University, Morioka 020 8505
    Rinsho Byori 50:1140-5. 2002
    ..In future, inflammation marker such as the high sensitivity CRP and an activated platelet may be thought to become important...
  28. ncbi request reprint [Long-term prognosis of myocardial infarction]
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University
    Nihon Rinsho 61:656-61. 2003
  29. ncbi request reprint [NMP (nuclear matrix protein)]
    Kenji Nakai
    Department of Laboratory Medicine, Iwate Medical University School of Medicine
    Nihon Rinsho 63:812-4. 2005
  30. doi request reprint Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008
    ..Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes...