Hiroshi Itoh

Summary

Country: Japan

Publications

  1. doi request reprint MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
  2. doi request reprint Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
  3. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  4. doi request reprint Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
  5. doi request reprint Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 23:575-80. 2010
  6. pmc Bile acid binding resin improves metabolic control through the induction of energy expenditure
    Mitsuhiro Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e38286. 2012
  7. ncbi request reprint Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
    Yasufumi Seki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Front Biosci (Elite Ed) 2:972-9. 2010
  8. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010
  9. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
  10. doi request reprint Feasibility of regression of hypertension using contemporary antihypertensive agents
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 26:1381-8. 2013

Detail Information

Publications89

  1. doi request reprint MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
    ..The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes...
  2. doi request reprint Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
    ....
  3. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  4. doi request reprint Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
    ..A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery...
  5. doi request reprint Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 23:575-80. 2010
    ..Because (P)RR is present in the podocytes, a central component of the glomerular filtration barrier, we hypothesized that aliskiren influences the (P)RR-induced two pathways in human podocytes...
  6. pmc Bile acid binding resin improves metabolic control through the induction of energy expenditure
    Mitsuhiro Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e38286. 2012
    ..However, the mechanisms by which BABR affects glucose homeostasis have not been established. We investigated how BABR affects glycemic control in diet-induced obesity models...
  7. ncbi request reprint Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
    Yasufumi Seki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Front Biosci (Elite Ed) 2:972-9. 2010
    ..Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp...
  8. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010
    ..Candesartan may be a better antihypertensive drug than CCBs to improve subclinical atherosclerosis of patients with MetS...
  9. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
    ..Recent clinical studies have shown that plasma NP levels were lower in subjects with the metabolic syndrome. The present study was conducted to elucidate the roles for NP/cGK cascades in energy metabolism...
  10. doi request reprint Feasibility of regression of hypertension using contemporary antihypertensive agents
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 26:1381-8. 2013
    ..In this study, we investigated whether treatment with candesartan or nifedipine controlled-release (CR) resulted in a sustained regression of hypertension in humans...
  11. doi request reprint Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 33:304-12. 2010
    ..This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients...
  12. doi request reprint Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla
    Kamon Iigaya
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo
    Hypertension 53:42-8. 2009
    ..The QTL on rat chromosome 1 was primarily related to the postsynaptic response of RVLM bulbospinal neurons to brain angiotensin II, whereas both the QTL and other genomic regions influenced the basal activity of RVLM neurons...
  13. ncbi request reprint Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2
    Kaori Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Kidney Int 78:69-78. 2010
    ..Our results suggest that transient high-dose angiotensin receptor blocker treatment effectively induced sustained regression of glomerulosclerosis by a mechanism mediated, in part, by changes in MMP-2 activity...
  14. doi request reprint Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling
    Hidehiro Kaneko
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Cardiovasc Res 91:546-55. 2011
    ..C-reactive protein (CRP) expression is increased with metabolic alterations. We sought to clarify the effect of CRP on the development of obesity-induced metabolic disorders using human CRP-overexpressing transgenic mice (CRPTG)...
  15. ncbi request reprint Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  16. doi request reprint "Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertension 53:83-9. 2009
    ....
  17. pmc Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 19:1496-504. 2013
    ..These results suggest that Sirt1 in PTs protects against albuminuria in diabetes by maintaining NMN concentrations around glomeruli, thus influencing podocyte function. ..
  18. ncbi request reprint Association between beta cell function and future glycemic control in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:517-23. 2013
    ..Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021). In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes...
  19. doi request reprint Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy
    Tatsuhiko Azegami
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 35:492-9. 2012
    ..These results suggest that transient AT1 vaccination is as effective as continuous treatment with ARB, not only for the attenuation of hypertension, but also for the prevention of L-NAME-induced nephropathy in SHR...
  20. ncbi request reprint Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis
    Hidehiro Kaneko
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Circ J 75:2482-90. 2011
    ..The role of Tace in obesity-induced metabolic disorders was to be clarified in this study...
  21. ncbi request reprint Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  22. doi request reprint Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
    Masaki Ryuzaki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 34:301-7. 2011
    ..These results suggest that the ((P)RR)-dependent activation of prorenin contributes to the pathogenesis of slowly progressive nephropathy in the intact kidney in a rat model of renovascular hypertension...
  23. doi request reprint Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
    Kenichiro Kinouchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:1143-7. 2009
    ..Thus, the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension...
  24. ncbi request reprint Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis
    Yusuke Sakamaki
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Nephron Exp Nephrol 115:e22-32. 2010
    ..To investigate the role of individual MMPs, we examined the course of Adriamycin-induced albuminuria and glomerulosclerosis in mice lacking either a gelatinase (MMP-9) or a collagenase (MMP-13)...
  25. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
    ..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...
  26. doi request reprint The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells
    Shintaro Yamaguchi
    Division of Endocrinology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Atherosclerosis 219:468-74. 2011
    ..In the present study, we investigated the role of miR-145 in the differentiation process from human ESCs into ECs and SMCs...
  27. doi request reprint Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch
    Yoshikazu Hara
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Sci Signal 4:ra3. 2011
    ..Thus, inhibition of Rho-Rho-kinase signaling may provide a therapeutic strategy for disrupting a vicious cycle of adipocyte stretch, Rho-Rho-kinase signaling, and inflammation of adipose tissue that contributes to and aggravates obesity...
  28. doi request reprint The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
    ..A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2...
  29. doi request reprint Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings
    Atsuhiro Ichihara
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Hypertens Res 33:177-80. 2010
    ....
  30. doi request reprint Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  31. ncbi request reprint Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats
    Yuki Mizuguchi
    Endocrinology and Anti Ageing Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Clin Exp Pharmacol Physiol 37:569-73. 2010
    ..5. The results of the present study suggest that the improvement in proteinuria following eplerenone treatment is independent of its effects on sodium balance and may be mediated by effects on the expression of slit diaphragm proteins...
  32. pmc Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:13045-56. 2010
    ..Renal Sirt1 can be a potential therapeutic target for the treatment of AKI...
  33. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: characteristics and usefulness of the direct renin inhibitor aliskiren
    Atsuhiro Ichihara
    Department of Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 113:296-300. 2010
    ....
  34. ncbi request reprint Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 60:533-9. 2013
    ..05). Women with late-onset GDM showed significantly lower indices compared with NGT (each p < 0.05). The failure of beta cell to compensate for decreased insulin sensitivity could contribute to the development of the late-onset GDM...
  35. doi request reprint The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    FASEB J 27:2301-15. 2013
    ..2- and 2.5-fold, respectively. DDAH2 overexpression improved GSIS in pancreas-specific Sirt1-deficient mice. In summary, the Sirt1/DDAH2/secretagogin pathway is a novel regulator of GSIS...
  36. ncbi request reprint Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010
    ..We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome...
  37. doi request reprint High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men
    Yoshie Seino
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Metabolism 58:355-60. 2009
    ..Furthermore, it was suggested longitudinally that measuring HMW adiponectin is efficient to predict the progression to metabolic syndrome compared with measuring total adiponectin or HMW-total adiponectin ratio...
  38. ncbi request reprint Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
    ..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM...
  39. doi request reprint A new preventive strategy for hypoglycemia incorporating added food diet in patients with type 2 diabetes who received sitagliptin therapy
    Shu Meguro
    Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Endocr Res 37:175-81. 2012
    ..Further clinical studies will elucidate whether sitagliptin can decrease cardiovascular events as well as normalizing blood glucose and lowering the blood pressure...
  40. pmc MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    BMC Nephrol 13:32. 2012
    ..ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes...
  41. doi request reprint Renal amyloidosis caused by apolipoprotein A-II without a genetic mutation in the coding sequence
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Exp Nephrol 15:774-9. 2011
    ..Here, we report a case of apoAII amyloidosis without a genetic mutation in the coding sequence and discuss the etiology of apoAII amyloidosis...
  42. doi request reprint Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrol Dial Transplant 26:2770-9. 2011
    ..The small G protein, Rho, and its downstream effector Rho-kinase have been shown to be involved in the tissue fibrosis process. This study was undertaken to investigate the role of Rho-kinase in the pathogenesis of these alterations...
  43. pmc Prorenin receptor is essential for normal podocyte structure and function
    Yoichi Oshima
    Department of Endocrinology and Anti Aging Medicine and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 22:2203-12. 2011
    ..In conclusion, the prorenin receptor is important for the maintenance of normal podocyte structure and function...
  44. ncbi request reprint Rho-kinase contributes to pressure-induced constriction of renal microvessels
    Koichiro Homma
    Departments of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 63:1-12. 2014
    ..Furthermore, neuronal NOS-induced nitric oxide modulates the TGF mechanism. This mechanism constitutes a target for Rho-kinase in TGF-mediated AFF constriction. ..
  45. pmc Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice
    Keiko Fujimura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 9:e94373. 2014
    ..Ghrelin/GHSR pathway played an important role in the maintenance of ROS levels in the kidney. ..
  46. pmc C-reactive protein, high-molecular-weight adiponectin and development of metabolic syndrome in the Japanese general population: a longitudinal cohort study
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e73430. 2013
    ..To clarify predictive values of C-reactive protein (CRP) and high-molecular-weight (HMW) adiponectin for development of metabolic syndrome...
  47. pmc The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e78603. 2013
    ..The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase. ..
  48. doi request reprint CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion
    Yuji Nakamura
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G700-7. 2013
    ..Collectively, the CCR2/CCL2 axis-mediated CD11b(+)-cell migration to the pancreas is critically involved in chronic pancreatitis-mediated hyperglycemia through the modulation of GLP-1 receptor expression and insulin secretion...
  49. doi request reprint Pioglitazone reduces urinary albumin excretion in renin-angiotensin system inhibitor-treated type 2 diabetic patients with hypertension and microalbuminuria: the APRIME study
    Akizuki Morikawa
    Department of Internal Medicine, Asahikawa Red Cross Hospital, Akebono 1 1, Asahikawa 070 8530, Japan
    Clin Exp Nephrol 15:848-53. 2011
    ..The aim of his study was to compare the efficacy of pioglitazone with metformin on the reduction of albuminuria in type 2 diabetic patients with hypertension and microalbuminuria treated with renin-angiotensin system inhibitors (RAS-Is)...
  50. ncbi request reprint Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 59:187-95. 2012
    ..Treatment of obesity may be an important strategy to preserve beta cell function in patients with type 2 diabetes...
  51. pmc Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control
    Masanori Mitsuishi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:710-7. 2009
    ..Blockade of angiotensin (Ang) II has been shown to prevent new-onset type 2 diabetes. We focused on the effects of AngII on muscle mitochondria, especially on their biogenesis, as an underlining mechanism of type 2 diabetes...
  52. doi request reprint Renal thrombotic microangiopathy in a patient with septic disseminated intravascular coagulation
    Yusuke Sakamaki
    Department of Internal Medicine, Shizuoka Red Cross Hospital, 8 2 Otemachi, Aoi ku, Shizuoka City, Shizuoka 420 0853, Japan
    BMC Nephrol 14:260. 2013
    ..Here we report a case of TMA that followed disseminated intravascular coagulation (DIC) due to severe infection in a patient with a reduced ADAMTS-13 activity level...
  53. ncbi request reprint Effects of mitiglinide, a short-acting insulin secretagogue, on daily glycemic variability and oxidative stress markers in Japanese patients with type 2 diabetes mellitus
    Noriko Kodani
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Drug Investig 33:563-70. 2013
    ....
  54. doi request reprint Dietary protein decreases exercise endurance through rapamycin-sensitive suppression of muscle mitochondria
    Masanori Mitsuishi
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan and
    Am J Physiol Endocrinol Metab 305:E776-84. 2013
    ....
  55. doi request reprint Change in β-cell mass in Japanese nondiabetic obese individuals
    Kinsei Kou
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 98:3724-30. 2013
    ..The aim of this study was to clarify the change in β-cell mass in Japanese obese individuals...
  56. doi request reprint Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
    Ayako Muraki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Appl Physiol (1985) 113:479-86. 2012
    ..Ubiquinone supplementation with coenzyme Q(10) could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance...
  57. doi request reprint A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 187:4947-53. 2011
    ..We conclude that an FT1D-like phenotype can be induced in the background of autoimmune diabetes by a mimic of viral dsRNA, and this model is useful for understanding human FT1D...
  58. ncbi request reprint Proatherogenic effect of interleukin-18 is exerted with high-fat diet, but not with normal diet in spontaneously hyperlipidemic mice
    Takatoshi Imai
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 18:1090-101. 2011
    ..The purpose of this study was to reveal the effect of increased serum IL-18 within its physiological fluctuations on atherosclerosis development under different conditions of dietary fat content...
  59. doi request reprint Add-on benefits of amlodipine and thiazide in nondiabetic chronic kidney disease stage 1/2 patients treated with valsartan
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:51-8. 2009
    ..These results suggest that 12 months of add-on treatment with either amlodipine or hydrochlorothiazide could have beneficial effects in nondiabetic chronic kidney disease stage 1/2 patients already being treated with valsartan...
  60. pmc Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
    Mitsuhiro Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 286:26913-20. 2011
    ..In contrast, expansion of the BA pool size, which can be achieved by BA administration, could be an interesting strategy to manage the metabolic syndrome...
  61. doi request reprint Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Diabetes Complications 24:424-32. 2010
    ..We investigated the efficacy of epalrestat, an aldose reductase inhibitor, for diabetic peripheral neuropathy in Japanese patients with type 2 diabetes...
  62. pmc Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells
    Ryuji Morizane
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 8:e64843. 2013
    ..This method is an important step toward kidney disease research using pluripotent stem cells, and the development of kidney regeneration therapies...
  63. pmc Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus
    Shu Meguro
    Nephrology, Endocrinology and Metabolism Division, Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Int J Endocrinol 2012:687867. 2012
    ....
  64. ncbi request reprint Regression of atherosclerosis in apolipoprotein E-deficient mice is feasible using high-dose angiotensin receptor blocker, candesartan
    Kaori Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 19:736-46. 2012
    ....
  65. pmc Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance
    Yoshinaga Kawano
    Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes 61:1935-48. 2012
    ..Thus, Pdk1 regulated macrophage infiltration by inhibiting Foxo1-induced Ccr2 expression. This shows that the macrophage Pdk1/Foxo1 pathway is important in regulating insulin sensitivity in vivo...
  66. ncbi request reprint Drug discovery for overcoming chronic kidney disease (CKD): new therapy for CKD by a (pro)renin-receptor-blocking decoy peptide
    Atsuhiro Ichihara
    Department of Anti Aging Medicine and Endocrinology, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 109:20-3. 2009
    ..Thus, (pro)renin-receptor blockade can be a useful therapy for chronic kidney disease with low renin levels in the plasma...
  67. ncbi request reprint T-type Ca channel blockade as a determinant of kidney protection
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 59:84-95. 2010
    ..Thus, the strategy for hypertension treatment with CCBs has entered a new era: treatment selection depends not only on blood pressure control but also on the subtypes of CCBs...
  68. doi request reprint Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents
    Hiroshi Nakatani
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 57:157-62. 2008
    ..The inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development...
  69. doi request reprint The short treatment with the angiotensin receptor blocker candesartan surveyed by telemedicine (STAR CAST) study: rationale and study design
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 31:1843-9. 2008
    ..This study will be the first clinical study to examine if regression from stage 1 (mild) hypertension to prehypertension (high-normal blood pressure) is possible using an ARB or CCB...
  70. ncbi request reprint Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
    ..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)...
  71. pmc CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Rev Diabet Stud 7:209-24. 2010
    ..In the present study, we aimed to examine whether anti-CXCL10 plus CFA treatment can effectively reverse autoimmune diabetes development...
  72. ncbi request reprint Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
    ..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy...
  73. ncbi request reprint Prediction of recovery time from hypoglycemia in patients with insulin overdose
    Takako Ohyama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Endocr J 58:607-11. 2011
    ..This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose...
  74. doi request reprint Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension
    Hirotaka Shibata
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Hypertens 25:514-23. 2012
    ....
  75. ncbi request reprint Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 17:165-72. 2010
    ..The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD...
  76. doi request reprint Activated prorenin as a therapeutic target for diabetic nephropathy
    Atsuhiro Ichihara
    Anti Aging Medicine and Endocrinology and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 82:S63-6. 2008
    ..Receptor-bound prorenin may prove useful as an important therapeutic target for the prevention and regression of end-organ damage in patients with diabetes...
  77. doi request reprint Eradication of Helicobactor pylori may trigger onset of type 1 diabetes: a case report
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1150:208-9. 2008
    ..Although further investigation is needed to understand the pathophysiology of T1D, we would like to emphasize that clinicians should consider the risk of its development after eradication of Helicobactor pylori...
  78. ncbi request reprint Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 55:433-8. 2008
    ..In this study we tested this hypothesis by investigating the effects of dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, on tumor necrosis factor-alpha (TNF-alpha)-induced beta cell dysfunction...
  79. ncbi request reprint Podocytes as a target of prorenin in diabetes
    Mariyo Sakoda
    Department of Internal Medicine, School of Medicine, Keio University of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Curr Diabetes Rev 7:17-21. 2011
    ..Further inquiry regarding podocyte (P)RR intracellular signal transduction will be needed to develop a new therapeutic approach targeting podocyte (P)RR in patients with diabetic nephropathy...
  80. ncbi request reprint A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission
    Yusuke Sakamaki
    Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan
    Intern Med 50:233-8. 2011
    ..68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC...
  81. doi request reprint Clinical importance of Stenotrophomonas maltophilia nosocomial pneumonia due to its high mortality in hemodialysis patients
    Shu Wakino
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Ther Apher Dial 13:193-8. 2009
    ..maltophilia. For pneumonia due to S. maltophilia, new generation fluoroquinolones can be the treatment of choice, although S. maltophilia-related pneumonia should be treated very carefully because of its high fatality rate...
  82. ncbi request reprint Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients
    Katsutoshi Hara
    Clinical Pharmacology Department, GlaxoSmithKline K K, Tokyo, Japan
    Drug Metab Pharmacokinet 23:306-12. 2008
    ..This is the first study to show an association between ALDH2 genetic polymorphisms and ACV elimination rate (t(1/2)) in Japanese end-stage renal disease patients...
  83. doi request reprint Acute interstitial nephritis associated with ulcerative colitis
    Hirobumi Tokuyama
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Clin Exp Nephrol 14:483-6. 2010
    ..Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy...
  84. pmc Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1
    Noriko Suda
    Department of Internal Medicine, School of Medicine, Keio University, Shinjujku ku, Tokyo 160 8582, Japan
    Endocrinology 152:2266-77. 2011
    ..These results showed the physiological roles of Ubc9 and PIAS1 as SF-1 coactivators beyond sumoylation enzymes in adrenocortical steroidogenesis and suggested their possible pathophysiological roles in human cortisol-producing adenomas...
  85. doi request reprint Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery
    Hiroshi Nakatani
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 58:1400-7. 2009
    ..These hormonal changes might explain the mechanism(s) of improved glucose tolerance after bariatric surgery in morbidly obese subjects...
  86. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  87. ncbi request reprint Effects of telmisartan therapy on metabolic profiles and serum high molecular weight (HMW)-adiponectin level in Japanese male hypertensive subjects with abdominal obesity
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:137-42. 2009
    ..We investigated the effects of 3-month telmisartan therapy on various metabolic parameters, including serum HMW adiponectin and high-sensitivity C-reactive protein (hs-CRP) levels in male hypertensive subjects with abdominal obesity...
  88. doi request reprint Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice
    Atsuhiro Ichihara
    Deparment of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Hypertens 2:332-40. 2008
    ..Thus prorenin also contributes to the development of nephropathy in type II diabetes, probably through a (pro)renin receptor-dependent mechanism...
  89. ncbi request reprint Prevention and regression of hypertension: role of renal microvascular protection
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Hypertens Res 32:658-64. 2009
    ..These results suggest that changes in the renal microvasculature may have an important role in the mechanisms of hypertension prevention and regression by ARB...