- Ito H, Mori K, Harada M, Minato M, Naito E, Takeuchi M, et al. Serial brain imaging analysis of stroke-like episodes in MELAS. Brain Dev. 2008;30:483-8 pubmed publisher..These results suggest that the stroke-like episodes is related to vasogenic edema, hyperperfusion, and neuronal damage. Acute oxidative phosphorylation defect may have a crucial role in the pathophysiology of stroke-like episodes...