Daisuke Ito

Summary

Country: Japan

Publications

  1. doi request reprint Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Ann Neurol 69:152-62. 2011
  2. pmc Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research
    Takuya Yagi
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e41572. 2012
  3. doi request reprint Accelerating progress in induced pluripotent stem cell research for neurological diseases
    Daisuke Ito
    Departments of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Ann Neurol 72:167-74. 2012
  4. doi request reprint Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hum Mol Genet 21:635-46. 2012
  5. doi request reprint Seipinopathy: a novel endoplasmic reticulum stress-associated disease
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Brain 132:8-15. 2009
  6. doi request reprint Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 31:266-77. 2008
  7. pmc Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Neurology 77:1636-43. 2011
  8. ncbi request reprint Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Ann Neurol 61:237-50. 2007
  9. pmc Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43
    Yoshinori Nishimoto
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 285:608-19. 2010
  10. pmc Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy
    Yoshihiro Nihei
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 288:8043-52. 2013

Collaborators

Detail Information

Publications63

  1. doi request reprint Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Ann Neurol 69:152-62. 2011
    ..To gain insight into the pathogenesis of FUS proteinopathy, we examined the biochemical and cellular characteristics of mutant FUS in expressing cells...
  2. pmc Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research
    Takuya Yagi
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e41572. 2012
    ....
  3. doi request reprint Accelerating progress in induced pluripotent stem cell research for neurological diseases
    Daisuke Ito
    Departments of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Ann Neurol 72:167-74. 2012
    ....
  4. doi request reprint Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hum Mol Genet 21:635-46. 2012
    ..These findings suggest that ERPO, such as seipin IB, are a novel adaptation machinery against the accumulation of unfolded proteins in the ER...
  5. doi request reprint Seipinopathy: a novel endoplasmic reticulum stress-associated disease
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Brain 132:8-15. 2009
    ..Further study of the pathological mechanisms of the mutant forms of seipin may lead to important new insights into motor neuron diseases, including other spastic paraplegia diseases and amyotrophic lateral sclerosis...
  6. doi request reprint Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 31:266-77. 2008
    ..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases...
  7. pmc Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Neurology 77:1636-43. 2011
    ....
  8. ncbi request reprint Molecular pathogenesis of seipin/BSCL2-related motor neuron diseases
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Ann Neurol 61:237-50. 2007
    ..To clarify the molecular pathogenesis of seipin-related motor neuron diseases, we expressed wild-type and mutant seipin proteins in neuronal and nonneuronal cells...
  9. pmc Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43
    Yoshinori Nishimoto
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 285:608-19. 2010
    ..Our findings provide new biological and pathological insight into the development of TDP-43 proteinopathies...
  10. pmc Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy
    Yoshihiro Nihei
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 288:8043-52. 2013
    ..We found that SBMA-iPSCs possess disease-specific biochemical features and could thus open new avenues of research into not only SBMA, but also other polyglutamine diseases...
  11. doi request reprint Modeling familial Alzheimer's disease with induced pluripotent stem cells
    Takuya Yagi
    Department of Neurology, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hum Mol Genet 20:4530-9. 2011
    ..Our findings demonstrate that the FAD-iPSC-derived neuron is a valid model of AD and provides an innovative strategy for the study of age-related neurodegenerative diseases...
  12. ncbi request reprint G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1121:246-9. 2006
    ..48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population...
  13. ncbi request reprint A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia
    Hidenori Hattori
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Brain Res 1108:221-3. 2006
    ..7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia...
  14. doi request reprint Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation
    Yuji Kurihara
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, 2 1 1 Kitasenzoku, Ota ku, Tokyo, 145 8515, Japan
    Clin Exp Metastasis 26:425-32. 2009
    ..Genetic or pharmacological inhibition of COX-2 may therefore be a beneficial strategy in the treatment of OSCC...
  15. pmc Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS)
    Yoshihiro Nihei
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 287:41310-23. 2012
    ....
  16. ncbi request reprint [Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]
    Keiko Ishii
    Department of Laboratory Medicine, Keio University, Shinjuku ku, Tokyo 160 8582
    Rinsho Byori 52:22-7. 2004
    ..05). Thus, GPIb alpha 145Met and p22phox 72 Tyr are the genetic factors associated with the risk of ischemic CVD in the Japanese. Carrying both of the two mutations might be associated with developing CVD at a younger age...
  17. ncbi request reprint T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease
    Hidenori Hattori
    Departments of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosci Lett 374:132-5. 2005
    ..Our results show that these CX3CR1 gene polymorphisms are not associated with an increased risk for ischemic CVD in the Japanese population...
  18. ncbi request reprint [Modeling familial Alzheimer's disease with induced pluripotent stem cells]
    Takuya Yagi
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 52:1134-6. 2012
    ..Our findings demonstrate that the FAD-iPSC-derived neuron is a valid model of AD and provides an innovative strategy for the study of late-onset neurodegenerative diseases...
  19. doi request reprint N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress
    Takuya Yagi
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Hum Mol Genet 20:3831-40. 2011
    ....
  20. ncbi request reprint [Progress in induced pluripotent stem cell research for age-related neurodegenerative diseases]
    Daisuke Ito
    Department of Neurology, Keio University, Japan
    Brain Nerve 65:283-8. 2013
    ....
  21. ncbi request reprint [Seipin/BSCL2-related motor neuron disease: Seipinopathy is a novel conformational disease associated with endoplasmic reticulum stress]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 47:329-35. 2007
    ..Our findings suggest that seipin-related motor neuron diseases, seipinopathies are novel conformational diseases, and we propose that the pathological process of these diseases is tightly associated with ER stress-mediated cell death...
  22. doi request reprint Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure
    Arifumi Kosakai
    Department of Neurology, Keio University School of Medicine, Japan
    Brain Res 1382:109-17. 2011
    ..The present study provides new insights into the pathology of age-related degeneration of dopaminergic neurons possibly related to Klotho-mediated regulation of vitamin D...
  23. doi request reprint Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir
    Takuya Yagi
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Clin Neurol Neurosurg 112:153-6. 2010
    ....
  24. pmc Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
    Yoichi Imaizumi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Mol Brain 5:35. 2012
    ..The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2...
  25. ncbi request reprint [Advances in induced pluripotent stem cell research for neurological diseases]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 50:449-54. 2010
    ..This review summarizes the current studies applying iPS cells in the field of neurology and discusses their potential and limitations for therapy against neurological diseases...
  26. ncbi request reprint [BSCL2-related neurologic disorders/seipinopathy: endoplasmic reticulum stress in neurodegeneration]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 51:1186-8. 2011
    ..Further study of the pathological mechanisms of the mutant forms of seipin may lead to important new insights into motor neuron diseases, including other spastic paraplegia diseases and amyotrophic lateral sclerosis...
  27. doi request reprint Gene expression analysis by oligonucleotide microarray in oral leukoplakia
    Yuri Kuribayashi
    Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Pathol Med 38:356-61. 2009
    ..We need to identify the new genetic diagnosis system of the epithelial dysplasia...
  28. ncbi request reprint Corneal endothelial degeneration in dentatorubral-pallidoluysian atrophy
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 59:289-91. 2002
    ..However, only a few reports have studied disturbances outside the central nervous system. We described 2 unrelated patients with DRPLA accompanied by corneal endothelial degeneration...
  29. ncbi request reprint Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation
    Kenichi Miyaoka
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan
    J Surg Res 125:144-50. 2005
    ..This prospective study assessed the risk of SIRS and MODS after orthognathic surgery by measuring the circulating levels of inflammatory cytokines such as IL-6 and IL-10 as well as the neutrophil functions as a marker of organ failure...
  30. ncbi request reprint Effects of fibroblasts derived from the olfactory bulb and nasal olfactory mucosa on proliferation of olfactory ensheathing cells harvested from the olfactory bulb
    Sho Yui
    Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 73:133-7. 2011
    ..These results indicated that coculture with both OB-Fibs and OM-Fibs promoted the proliferation of OB-OECs...
  31. ncbi request reprint Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44
    Yuriko Kinugasa
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan
    Clin Exp Metastasis 21:737-45. 2004
    ..Genetic or pharmacological inhibition of COX-2 may therefore be a beneficial strategy in the treatment of OSCC patients...
  32. ncbi request reprint [Conjoint pathological cascades mediated by RNA-binding proteins, TDP-43, FUS and ataxin-2]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Rinsho Shinkeigaku 52:1221-3. 2012
    ..Thus, we propose that aberrant distribution of the RNA-binding proteins TDP-43, FUS, and ataxin-2 into the cytoplasm leads to impairment of the RNA quality control system, forming the core of the ALS/FTLD-U degenerative cascade...
  33. ncbi request reprint Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin-proteasome system
    Takuya Yagi
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 66:83-91. 2014
    ..These data provide new pathological insights into HMSN-P, and we suspect that the pathogenesis is tightly associated with disruption of intracellular protein homeostasis and ER stress. ..
  34. doi request reprint Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis
    Yuji Nakatsuji
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Immunol 188:4858-65. 2012
    ..Furthermore, patients with high Sema4A levels have more severe disabilities and are unresponsive to IFN-β treatment. Taken together, our results suggest that Sema4A is involved in the pathogenesis of MS by promoting Th17 skewing...
  35. ncbi request reprint [Ischemic brain and endoplasmic reticulum stress]
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University
    Nihon Rinsho 64:127-31. 2006
  36. ncbi request reprint [Study of genotype frequencies of ANP 664G/A polymorphism in normal subjects and CVD patients, and its association with plasma ANP levels]
    Atsumi Ohta
    Department of Laboratory Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 161 8582
    Rinsho Byori 50:296-300. 2002
    ..9708). These results suggest that there is a racial difference in the allele frequency of 664G/A, and that this polymorphism may not be a major risk factor for CVD in the Japanese, nor is it a major determinant of plasma ANP level...
  37. ncbi request reprint A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 924:98-108. 2002
    ..These data clearly indicate that NS-7 provides very efficient neuroprotection in the acute phase of cerebral ischemia, and sustains the normal function of PKA...
  38. ncbi request reprint Retinopathy: an overlooked adverse effect of interferon-beta treatment of multiple sclerosis
    Masayuki Ohira
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 58:54-6. 2009
    ..Therefore, IFN-retinopathy may be uncommon in MS, but neurologist should be mindful of this adverse effect and regularly check the fundus, particularly in patients with possible risk factor, diabetes mellitus...
  39. pmc Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties
    Daisuke Ito
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Knapp R212, 924 East 57th St, Chicago, IL 60637, USA
    Mol Cell Biol 24:9456-69. 2004
    ..Consequently, induced STC2 expression is an essential feature of survival component of the UPR...
  40. ncbi request reprint CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer
    Tomohiko Mori
    Department of Surgery and Surgical Basic Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Mol Cancer Ther 3:29-37. 2004
    ..Taken together, SDF-1/CXCR4 axis is involved in pancreatic cancer metastasis through migration and invasion. The small molecule antagonists against CXCR4 such as TN14003 might be an effective anti-metastatic agent for pancreatic cancer...
  41. ncbi request reprint Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL
    Yayoi Otsuka
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 56:75-84. 2008
    ..These findings suggest that MELhipod8 cells could provide a mechanism for downregulation of the AHSP gene in prion diseases...
  42. ncbi request reprint Heteroduplex joint formation by a stoichiometric complex of Rad51 and Rad52 of Saccharomyces cerevisiae
    Naoto Arai
    Department of Applied Biological Science, Nihon University College of Bioresource Sciences, Fujisawa shi, Kanagawa, Japan
    J Biol Chem 280:32218-29. 2005
    ....
  43. ncbi request reprint Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer
    Tomohiko Mori
    Department of Surgery and Surgical Basic Science, Kyoto University, Japan
    Surgery 138:71-7. 2005
    ..However, a number of tumor cell lines are known to be resistant to TRAIL-induced apoptosis. The purpose of this study was to determine the mechanisms of resistance to TRAIL in pancreatic cancer cells...
  44. ncbi request reprint Analysis of E-, N-cadherin, alpha-, beta-, and gamma-catenin expression in human pancreatic carcinoma cell lines
    Eiji Toyoda
    Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
    Pancreas 30:168-73. 2005
    ..The aim of this study was to analyze the expressions of E- and N-cadherins and catenins in human pancreatic cancer cell lines...
  45. ncbi request reprint Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
    Hongyan Diao
    Division of Molecular Immunology, Hokkaido University, Sapporo 060 0815, Japan
    Immunity 21:539-50. 2004
    ..These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases...
  46. ncbi request reprint Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver
    Masayuki Koizumi
    Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
    Surgery 136:449-57. 2004
    ..In this study, we analyzed the plasticity of the liver by enforced expression of PDX-1 in streptozotocin (STZ)-treated mice under the condition of hepatic regeneration...
  47. ncbi request reprint Metastin and its variant forms suppress migration of pancreatic cancer cells
    Toshihiko Masui
    Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 315:85-92. 2004
    ..These data suggest that the metastin receptor, hOT7T175, is one of the promising targets for suppression of metastasis, and that small metastin variants could be an anti-metastatic agent to pancreatic cancer...
  48. ncbi request reprint Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines
    Ming Heng Li
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo 145 8515, Japan
    Oral Oncol 40:63-70. 2004
    ..p21 was remarkably up-regulated, but it was speculated that its activity might be cancelled by an increased binding to CDK4...
  49. ncbi request reprint Age-related increases in LPS-stimulated nitric oxide production from cultured rat bone marrow cells
    Kazumasa Ota
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, 2 1 1 Kitasenzoku, Ota ku, Tokyo 145 8515, Japan
    Maturitas 45:247-55. 2003
    ..To understand bone metabolism during senescence, we examined age-related change in nitric oxide (NO) production from bone marrow cells stimulated by lipopolysaccharide (LPS)...
  50. ncbi request reprint Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants
    Gopal Thinakaran
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, IL, USA
    Methods Mol Biol 232:203-16. 2003
  51. ncbi request reprint Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells
    Kazuhiro Kami
    Department of Surgery and Basic Surgical Science, Kyoto University, Sakyo, Japan
    Surgery 138:299-305. 2005
    ..We have reported that its expression is correlated with shorter survival of pancreatic cancer patients, so regulation of this molecule could be a new strategy for fighting pancreatic cancer...
  52. ncbi request reprint Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003)
    Daisuke Ito
    Laboratories of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Am Vet Med Assoc 227:1454-60. 2005
    ..To determine whether magnetic resonance imaging findings in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion were predictive of clinical outcome...
  53. ncbi request reprint Bcl-XL antisense oligonucleotides coupled with antennapedia enhances radiation-induced apoptosis in pancreatic cancer
    Toshihiko Masui
    Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
    Surgery 140:149-60. 2006
    ..The aim of this study was to examine the effects of the Bcl-XL antisense oligonucleotide for radiosensitivity of in vitro and in vivo pancreatic cancer using oligonucleotide conjugated with antennapedia...
  54. pmc Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer
    Eiji Toyoda
    Department of Hepato Biliary Pancreatic Surgery and Transplantation, Kyoto University, Japan
    J Exp Clin Cancer Res 27:30. 2008
    ..To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus...
  55. doi request reprint Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice
    Dmitry V Kuprash
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
    Cancer Lett 268:70-5. 2008
    ....
  56. ncbi request reprint Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors
    Masayasu Iwase
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Ota ku, Tokyo 145 8515, Japan
    Int J Oncol 31:1141-7. 2007
    ..These findings could potentially lead to new strategies for improving the efficacy of anticancer drugs in OSCC cells...
  57. ncbi request reprint Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells
    Tomohiko Mori
    Department of Surgery, Division of Hepato Biliary Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, Japan
    J Surg Res 142:281-6. 2007
    ..The present study was conducted to further examine TRAIL-based therapeutic strategies by aiming to restore functional apoptotic pathways in resistant pancreatic cancer cells...
  58. ncbi request reprint Ubiquitylation-independent ER-associated degradation of an AE1 mutant associated with dominant hereditary spherocytosis in cattle
    Daisuke Ito
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Cell Sci 119:3602-12. 2006
    ..These findings indicate that AE1 R664X protein, which is associated with dominant hereditary spherocytosis, has a dominant-negative effect on the expression of wild-type AE1...
  59. ncbi request reprint Lumenal localization in the endoplasmic reticulum of the C-terminal tail of an AE1 mutant responsible for hereditary spherocytosis in cattle
    Daisuke Ito
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 54:191-7. 2007
    ..These findings indicate that the truncated C-terminal region of R664X AE1 has lumenal localization in the endoplasmic reticulum and is not accessible to proteasomal machineries in the cytosol...
  60. ncbi request reprint Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck
    Daisuke Ito
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 120:2618-24. 2007
    ....
  61. ncbi request reprint Thalidomide suppresses melanoma growth by activating natural killer cells in mice
    Ai Kawamata
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo 145 8515, Japan
    Oncol Rep 16:1231-6. 2006
    ..Production of the cytotoxic molecule perforin was also augmented. These data suggest that Thd strongly activates NK cell activity in mice, possibly resulting in enhanced tumor surveillance defense...
  62. ncbi request reprint Forced expression of PDX-1 induces insulin production in intestinal epithelia
    Masayuki Koizumi
    Department of Surgery, Kyoto University, Kyoto, Japan
    Surgery 140:273-80. 2006
    ..Our study was designed to investigate the effects of forced expression of pdx-1 in ileal epithelia by adenovirus-mediated gene transfer...
  63. ncbi request reprint Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo
    Koichiro Abe
    Laboratory of Molecular Immunoregulation, Center for Cancer Research and Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
    Blood 101:1477-83. 2003
    ..Second, the microenvironment in peripheral lymphoid organs associated with LTalpha/LTbeta-LTbetaR signaling and chemokine production is critical for recruitment efficiency of DCs, and this pathway is indispensable...