Affiliation: International University of Health and Welfare
Watanobe H, Yoneda M, Kohsaka A, Kakizaki Y, Suda T, Schioth H. Normalization of circulating leptin levels by fasting improves the reproductive function in obese OLETF female rats. Neuropeptides. 2001;35:45-9 pubmed
Watanobe H. In vivo release of prolactin-releasing peptide in rat hypothalamus in association with luteinizing hormone and prolactin surges. Neuroendocrinology. 2001;74:359-66 pubmed
..A possible involvement of PrRP in the PRL surge was not suggested from the present data. The lack of a significant alteration in PrRP release in the ME-ARC may argue against a direct hypophysiotropic action of the peptide...
Watanobe H, Schioth H. Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis. Regul Pept. 2002;105:23-8 pubmed
..It seems that the role for leptin in sexual development is permissive, but not decisive, in rats. ..
Watanobe H, Schioth H, Izumi J. Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats. J Neurochem. 2003;85:338-47 pubmed
..It was also suggested that the MC4-R may be the primary subtype of the MC-Rs mediating this action of alpha-MSH. ..
Watanobe H, Hayakawa Y. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology. 2003;144:4868-75 pubmed
..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant. ..
Watanobe H, Yoneda M. Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats. Neuroendocrinology. 2003;78:331-8 pubmed