H Watanobe

Summary

Affiliation: International University of Health and Welfare
Country: Japan

Publications

  1. pmc A mechanism underlying the sexually dimorphic ACTH response to lipopolysaccharide in rats: sex steroid modulation of cytokine binding sites in the hypothalamus
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    J Physiol 547:221-32. 2003
  2. ncbi Nitric oxide mediates leptin-induced preovulatory luteinizing hormone and prolactin surges in rats
    H Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Brain Res 923:193-7. 2001
  3. ncbi In vivo release of prolactin-releasing peptide in rat hypothalamus in association with luteinizing hormone and prolactin surges
    H Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, Otawara, Tochigi, Japan
    Neuroendocrinology 74:359-66. 2001
  4. ncbi Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-alpha, but not to interleukin-6, in the rat
    Hajime Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Brain Res Bull 57:151-5. 2002
  5. ncbi Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Regul Pept 105:23-8. 2002
  6. ncbi Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    Neuroendocrinology 78:331-8. 2003
  7. ncbi Leptin regulates growth hormone-releasing factor, somatostatin, and alpha-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo: relation with growth hormone secretion
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi 324 8501, Japan
    J Neurosci 22:6265-71. 2002
  8. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
  9. ncbi Adrenal glucocorticoids do not mediate impaired reproductive function induced by lipopolysaccharide in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Japan
    Neuroendocrinology 78:23-8. 2003
  10. ncbi Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    J Neurochem 85:338-47. 2003

Collaborators

  • T Suda
  • J E Wikberg
  • Helgi B Schioth
  • K Kageyama
  • Aneta Ringholm
  • D Larhammar
  • Takashi Hashimoto
  • Masashi Yoneda
  • Akira Terano
  • Carla Caruso
  • Kimihide Nakamura
  • Toru Kono
  • Shiro Yokohama
  • Mercedes Lasaga
  • Tadahito Shimada
  • Yukiomi Nakade
  • Keisuke Tamori
  • Mieko Kurosawa
  • Anna Valeria Vergoni
  • A Kohsaka
  • M Yoneda
  • Daniela Durand
  • Hideyuki Hiraishi
  • Masaya Tamano
  • Claudia Mohn
  • Armando L Karara
  • Adriana Seilicovich
  • Valeria Rettori
  • Isao Makino
  • Yoichi Sato
  • Alfio Bertolini
  • Gustavo Savino
  • Giorgia Guidetti
  • Y Kakizaki
  • A Terano

Detail Information

Publications40

  1. pmc A mechanism underlying the sexually dimorphic ACTH response to lipopolysaccharide in rats: sex steroid modulation of cytokine binding sites in the hypothalamus
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    J Physiol 547:221-32. 2003
    ..These results suggest that the hypothalamic sensitivity to peripheral IL-1beta and TNF-alpha may be an important mechanism underlying the sexually dimorphic ACTH response to LPS in rats...
  2. ncbi Nitric oxide mediates leptin-induced preovulatory luteinizing hormone and prolactin surges in rats
    H Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Brain Res 923:193-7. 2001
    ..This is the first report to demonstrate a significant intermediary role of NO in leptin-induced preovulatory LH and PRL surges in rats...
  3. ncbi In vivo release of prolactin-releasing peptide in rat hypothalamus in association with luteinizing hormone and prolactin surges
    H Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, Otawara, Tochigi, Japan
    Neuroendocrinology 74:359-66. 2001
    ..A possible involvement of PrRP in the PRL surge was not suggested from the present data. The lack of a significant alteration in PrRP release in the ME-ARC may argue against a direct hypophysiotropic action of the peptide...
  4. ncbi Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-alpha, but not to interleukin-6, in the rat
    Hajime Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Brain Res Bull 57:151-5. 2002
    ..Further evidence for the sexually dimorphic neuroimmunoendocrine activity is reported herein...
  5. ncbi Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Regul Pept 105:23-8. 2002
    ..It seems that the role for leptin in sexual development is permissive, but not decisive, in rats...
  6. ncbi Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    Neuroendocrinology 78:331-8. 2003
    ....
  7. ncbi Leptin regulates growth hormone-releasing factor, somatostatin, and alpha-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo: relation with growth hormone secretion
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi 324 8501, Japan
    J Neurosci 22:6265-71. 2002
    ..These results demonstrate for the first time that leptin can alter the in vivo release of both GRF and SRIH in rat hypothalamus concurrently with the stimulation of GH secretion...
  8. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
    ..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant...
  9. ncbi Adrenal glucocorticoids do not mediate impaired reproductive function induced by lipopolysaccharide in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Japan
    Neuroendocrinology 78:23-8. 2003
    ..These results strongly suggest that glucocorticoids do not have a significant role in mediating the LPS-induced acute suppression of pulsatile LH secretion in orchidectomized rats...
  10. ncbi Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    J Neurochem 85:338-47. 2003
    ..It was also suggested that the MC4-R may be the primary subtype of the MC-Rs mediating this action of alpha-MSH...
  11. ncbi Manipulation of neonatal gonadal steroid milieu and leptin secretion in later life in male and female rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Regul Pept 110:219-24. 2003
    ..However, as intact females still had significantly higher leptin titers than NC males, it is very likely that additional factors may also be responsible for the sexually dimorphic leptin secretion in rats...
  12. ncbi Ciliary neurotrophic factor, a gp130 cytokine, regulates preovulatory surges of luteinizing hormone and prolactin in the rat
    H Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501 Japan
    Neuroendocrinology 74:281-7. 2001
    ..These results demonstrate for the first time a significant role of CNTF in the generation of preovulatory LH and PRL surges in the rat. CNTF may thus be another humoral signal linking nutrition and reproductive function...
  13. ncbi A significant participation of leukemia inhibitory factor in regulating the reproductive function in rats: a novel action of the pleiotropic cytokine
    H Watanobe
    Division of Internal Medicine, Center for Clinical Research, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi, 324 8501, Japan
    Biochem Biophys Res Commun 282:643-6. 2001
    ..0-nmol dose. These results demonstrate for the first time a significant participation of LIF in the generation of LH and PRL surges in the rat. A novel action of the pleiotropic cytokine is reported herein...
  14. ncbi Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan
    Brain Res Bull 54:521-5. 2001
    ..This study corroborated our previous report through a different and direct approach that the melanocortin 4 receptor, but not the melanocortin 3 receptor, plays a significant role in mediating the preovulatory prolactin surge in the rat...
  15. ncbi Normalization of circulating leptin levels by fasting improves the reproductive function in obese OLETF female rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan
    Neuropeptides 35:45-9. 2001
    ....
  16. ncbi The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 257:860-4. 1999
    ..This is the first report describing a physiological role of a specific MC receptor in regulating the reproductive axis...
  17. ncbi A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat
    A Kohsaka
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Aomori, Japan
    Brain Res 898:166-70. 2001
    ..These results demonstrate for the first time a significant participation of orexin-A in the preovulatory LH and PRL surges in the rat...
  18. ncbi A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 259:56-9. 1999
    ..This is the first study to demonstrate in rats with a very similar body weight the existence of a clear sexual difference in plasma leptin levels, and also a suppressive action of T on the adipocyte hormone concentrations...
  19. ncbi A significant role of leukemia inhibitory factor in the brain and periphery in endotoxin stimulation of adrenocorticotropin secretion in the rat
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, Japan
    Brain Res 865:97-101. 2000
    ..This is the first study to demonstrate in vivo that LIF in both the brain and general circulation plays a significant role in mediating endotoxin-stimulated ACTH secretion in the rat...
  20. ncbi Evaluation of the role for prolactin-releasing peptide in prolactin secretion induced by ether stress and suckling in the rat: comparison with vasoactive intestinal peptide
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, Japan
    Brain Res 865:91-6. 2000
    ..These results suggest that PrRP may not play a significant role, or at least play a much weaker role than VIP, in mediating PRL release induced by ether stress and suckling in the rat...
  21. ncbi Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 263:162-5. 1999
    ..It was also suggested that mild hyperleptinemia of 3 days' duration may not significantly affect the hormonal surges...
  22. ncbi Stimulation of prolactin secretion by chronic, but not acute, administration of leptin in the rat
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Brain Res 887:426-31. 2000
    ..Thus, a dose-dependent stimulatory effect of chronic leptin treatment on PRL secretion was indicated. This study demonstrates that chronic, but not acute, administration of leptin stimulates PRL secretion in the rat...
  23. ncbi Evidence that a fast, rate-sensitive negative feedback effect of corticosterone is not a principal mechanism underlying the indomethacin inhibition of interleukin-1 beta-induced adrenocorticotropin secretion in the rat
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan
    Cytokine 10:377-81. 1998
    ..It was concluded that such an action of indomethacin is primarily mediated by its inherent pharmacological action, i.e. the inhibition of endogenous PG production...
  24. ncbi A hypopituitary patient who attained tall stature without growth hormone
    K Kageyama
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori
    Intern Med 37:472-5. 1998
    ..The present patient had hypopituitarism due to perinatal problems but had grown with the aid of non-GH growth-promoting factors, which suggests that man may be able to achieve statural growth even without GH...
  25. ncbi Central regulation of hepatic function by neuropeptides
    M Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Gastroenterol 36:361-7. 2001
    ..Further studies in regard to the physiological relevance of the central action of neuropeptides on specific brain sites should be performed to unravel the underlying pathways that mediate brain-liver interaction...
  26. ncbi A case of cyclical Cushing's disease associated with corticosteroid-binding globulin deficiency: a rare pitfall in the diagnosis of Cushing's disease
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan
    Eur J Endocrinol 133:317-9. 1995
    ..A combination of a decreased serum CBG concentration and periodic secretion of ACTH can be an important pitfall in the diagnosis of Cushing's disease...
  27. ncbi Functional role, structure, and evolution of the melanocortin-4 receptor
    Helgi B Schioth
    Department of Neuroscience, Uppsala University, BMC, 751 24, Uppsala, Sweden
    Ann N Y Acad Sci 994:74-83. 2003
    ..The MC-4 receptor has been remarkably conserved in structure and pharmacology for more than 400 million years, implying that the receptor participated in vital physiological functions early in vertebrate evolution...
  28. ncbi Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
    Carla Caruso
    Centro de Investigaciones en Reproduccion, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Neuroendocrinology 79:278-86. 2004
    ....
  29. ncbi NMDA and group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence
    Carla Caruso
    Centro de Investigaciones en Reproduccion, School of Medicine, University of Buenos Aires, Paraguay 2155, Piso 10, C1121ABG, Argentina
    Neurosci Lett 393:60-4. 2006
    ..These data indicate that glutamate increases SP-LI release from the ARC/ME by acting through NMDA and group I mGluRs in the male rat. This stimulatory effect could be mediated by nitric oxide and prostaglandin production...
  30. ncbi Melanocortins and reproduction
    Helgi B Schioth
    Department of Neuroscience, Division of Pharmacology, Biomedical Centre, Uppsala University, Box 593, 75 124, Uppsala, Sweden
    Brain Res Brain Res Rev 38:340-50. 2002
    ..This review discusses the interplay of hypothalamic regulation of food intake and the hormones involved in the hypothalamic-pituitary-gonadal axis with special emphasis on putative roles of the melanocortin system...
  31. ncbi Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro
    Helgi B Schioth
    Department of Neuroscience, Biomedical Center, Box 593, 751 24 Uppsala University, Uppsala, Sweden
    Regul Pept 106:7-12. 2002
    ..Pharmacological species difference have earlier been reported for the MC1 and MC5 receptors but this is the first report showing important differences between the rat and human MC4 receptors...
  32. pmc Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    J Physiol 545:255-68. 2002
    ....
  33. ncbi Effect of repeated administration of prolactin releasing peptide on feeding behavior in rats
    Anna Valeria Vergoni
    Department of Biomedical Sciences, University of Modena, Modena, Italy
    Brain Res 955:207-13. 2002
    ..None of these tests suggested any specific behavioral effect of PrRP. We conclude that the behavioral pattern induced by PrRP is likely to be different from those induced by many other neuropeptides affecting food intake in rats...
  34. ncbi Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Peptides 26:1573-9. 2005
    ....
  35. ncbi Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Japan
    Hepatology 38:1500-7. 2003
    ..These results suggest that TRH acts in the left DVC to stimulate hepatic blood flow through the left cervical and hepatic vagus, indicating that neuropeptides may act in the specific brain nuclei to regulate hepatic function...
  36. ncbi Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Eur J Pharmacol 478:173-7. 2003
    ..These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in central TRH-induced hepatic cytoprotection...
  37. ncbi Subtype selective binding properties of substituted linear melanocyte stimulating hormone analogues
    Helgi B Schioth
    Department of Neuroscience, Biomedical Center, Uppsala University, Box 593, Uppsala 751 24, Sweden
    Neuropeptides 36:427-34. 2002
    ..The data set also provides useful information for further calculations and modeling of MC receptor binders...
  38. ncbi Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Gastroenterol Hepatol 18:177-84. 2003
    ..In the present study, an effect of lafutidine on hepatic blood flow was investigated in rats that received an intracisternal injection of a subthreshold dose of thyrotropin-releasing hormone (TRH) analog, RX 77368...
  39. ncbi Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in rats
    Yukiomi Nakade
    Second Department of Medicine and Surgery, Asahikawa Medical College, Asahikawa, Japan
    Eur J Pharmacol 460:135-8. 2003
    ..These results further establish a role of endogenous CRF in the brain in hepatic pathophysiological regulation...
  40. ncbi Brain-gut axis of the liver: the role of central neuropeptides
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Gastroenterol 37:151-6. 2002