K Yamada

Summary

Affiliation: Institute for Developmental Research
Country: Japan

Publications

  1. ncbi request reprint Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant
    K Yamada
    Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya cho, Kasugai, Aichi 480 0392, Japan
    Yeast 15:1125-32. 1999
  2. doi request reprint Molecular analysis of two enzyme genes, HPRT1 and PRPS1, causing X-linked inborn errors of purine metabolism
    Y Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 29:291-4. 2010
  3. ncbi request reprint Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe
    C W Nakagawa
    Department of Genetics, Institute for Developmental Research, Kagiya cho, Kasugai, Aichi 480 0392, Japan aichi jp
    J Biochem 127:233-8. 2000
  4. pmc Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features
    K Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
    Am J Hum Genet 69:1178-85. 2001
  5. ncbi request reprint Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families
    Y Yamada
    Department of Genetics, Inst Developmental Res, Aichi Human Service Center, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 23:1169-72. 2004
  6. ncbi request reprint The role of catalase in hydrogen peroxide resistance in fission yeast Schizosaccharomyces pombe
    N Mutoh
    Department of Genetics, Institute for Developmental Research, Aichi, Japan
    Can J Microbiol 45:125-9. 1999
  7. ncbi request reprint Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease
    N Wakamatsu
    Department of Genetics, Central Hospital, Aichi Human Service Center, Kasugai, Aichi, Japan
    Nat Genet 27:369-70. 2001
  8. ncbi request reprint Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression
    T Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, 910-1193, Fukui, Japan
    Gene 273:251-7. 2001
  9. ncbi request reprint Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y
    K Yamada
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, Tennessee, 37232 0615, USA
    Biochem Biophys Res Commun 261:614-21. 1999
  10. ncbi request reprint Cloning and functional expression of an E box-binding protein from rat granulosa cells
    K Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193 and CREST, JST Japan Science and Technology, Japan
    Biol Reprod 64:1315-9. 2001

Detail Information

Publications63

  1. ncbi request reprint Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant
    K Yamada
    Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya cho, Kasugai, Aichi 480 0392, Japan
    Yeast 15:1125-32. 1999
    ..The catalase gene disruptant of S. pombe harbouring multicopy plasmid containing gpx1(+) restored the hypersensitivity to H(2)O(2) of the catalase gene disruptant. These results suggest that Gpx1 acts as a scavenger of H(2)O(2) in vivo...
  2. doi request reprint Molecular analysis of two enzyme genes, HPRT1 and PRPS1, causing X-linked inborn errors of purine metabolism
    Y Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 29:291-4. 2010
    ..In these four patients, we also performed molecular analysis of PRPS1, but no mutations in PRPP synthetase were found...
  3. ncbi request reprint Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe
    C W Nakagawa
    Department of Genetics, Institute for Developmental Research, Kagiya cho, Kasugai, Aichi 480 0392, Japan aichi jp
    J Biochem 127:233-8. 2000
    ..The activity of catalase is not increased in pap1 cells by several stresses, despite mRNA induction, suggesting that Pap1 plays some role in the expression of catalase activity...
  4. pmc Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features
    K Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
    Am J Hum Genet 69:1178-85. 2001
    ....
  5. ncbi request reprint Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families
    Y Yamada
    Department of Genetics, Inst Developmental Res, Aichi Human Service Center, Aichi, Japan
    Nucleosides Nucleotides Nucleic Acids 23:1169-72. 2004
    ....
  6. ncbi request reprint The role of catalase in hydrogen peroxide resistance in fission yeast Schizosaccharomyces pombe
    N Mutoh
    Department of Genetics, Institute for Developmental Research, Aichi, Japan
    Can J Microbiol 45:125-9. 1999
    ..pombe plays an important role in resistance to high concentrations of hydrogen peroxide but offers little in the way of protection from the hydrogen peroxide generated in small amounts under normal growth conditions...
  7. ncbi request reprint Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease
    N Wakamatsu
    Department of Genetics, Central Hospital, Aichi Human Service Center, Kasugai, Aichi, Japan
    Nat Genet 27:369-70. 2001
    ..SIP1 is located in the deleted segment at 2q22 from a patient with a de novo t(2;13)(q22;q22) translocation. SIP1 seems to have crucial roles in normal embryonic neural and neural crest development...
  8. ncbi request reprint Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression
    T Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, 910-1193, Fukui, Japan
    Gene 273:251-7. 2001
    ..This clearly indicates that the bullfrog receptor is a counterpart of mammalian NPR-A, and is specific for ANP or BNP but not for CNP...
  9. ncbi request reprint Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y
    K Yamada
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, Tennessee, 37232 0615, USA
    Biochem Biophys Res Commun 261:614-21. 1999
    ..Both transcripts were expressed ubiquitously, although the 5-kilobase transcript is of greater abundance in most tissues examined. The human ZHX1 gene is located on chromosome 8q, between markers CHCL.GATA50B06 and CHLC. GATA7G07...
  10. ncbi request reprint Cloning and functional expression of an E box-binding protein from rat granulosa cells
    K Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193 and CREST, JST Japan Science and Technology, Japan
    Biol Reprod 64:1315-9. 2001
    ..Thus, we report molecular cloning, expression, and functional characterization of full-length rat USF2 cDNA...
  11. ncbi request reprint Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary
    K Miyamoto
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Arch Biochem Biophys 390:93-100. 2001
    ....
  12. ncbi request reprint Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family
    T Inazu
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui, 910 1193, Japan
    Biochem Biophys Res Commun 265:87-93. 1999
    ..Distributions of N-terminal and C-terminal PH domains of pleckstrin 2 were quite different from each other, suggesting that these PH domains may interact with distinct factor(s)...
  13. ncbi request reprint Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns
    A Fukui
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:47143-9. 2001
    ..In oviparous animals, the duplicated TLRs in the pattern-recognition system may function for host-pathogen discrimination in a manner that is distinct from that in mammals...
  14. ncbi request reprint Structure and chromosome mapping of the human SIX4 and murine Six4 genes
    H Ozaki
    Department of Biology, Jichi Medical School, Tochigi, Japan
    Cytogenet Cell Genet 87:108-12. 1999
    ..The structure, including the 5' upstream region of both genes, was well conserved suggesting the conserved function and regulation of these genes. Human SIX4 was mapped to chromosome 14q23...
  15. ncbi request reprint Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA
    K Yamada
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi 470 1192, Toyoake, Japan
    Gene 255:15-24. 2000
    ..Potential regulatory regions included consensus binding sites for AP-2, TF-IIIA, Sp-1, and YY-1 located in the 5'-flanking region of the NTAK gene...
  16. ncbi request reprint Tocopherol-associated protein is a ligand-dependent transcriptional activator
    J Yamauchi
    Division of Applied Food Research, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjyuku, Japan
    Biochem Biophys Res Commun 285:295-9. 2001
    ..These results suggest that the biological function of alpha-tocopherol is not only as an antioxidant but also as a transcriptional regulator of gene expression via association with a transcription factor TAP...
  17. ncbi request reprint Mutational analysis of the functional motifs of RuvB, an AAA+ class helicase and motor protein for holliday junction branch migration
    H Iwasaki
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Microbiol 36:528-38. 2000
    ....
  18. ncbi request reprint Isolation and characterization of three novel serine protease genes from Xenopus laevis
    K Yamada
    Graduate School of Human Informatics, Nagoya University, Furo cho, Chikusa ku, 464 8601, Nagoya, Japan
    Gene 252:209-16. 2000
    ..These results suggest that these proteases may play important roles during early Xenopus development, such as regulation of cell movement in gastrulae...
  19. ncbi request reprint Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice
    K Yamada
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Endocr J 48:241-7. 2001
    ..The coding sequence of Txn was identical in the three strains. These data suggest that neither of the two genes is a common susceptiblity gene between type 1 and type 2 diabetes in mice...
  20. pmc cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein
    T Tanaka
    Department of Biochemistry, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Biochem J 339:111-7. 1999
    ..These results indicate that Hex functions as a transcriptional repressor and may be involved in the differentiation and/or maintenance of the differentiated state in hepatocytes...
  21. ncbi request reprint Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells
    M Fujii
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    FEBS Lett 375:263-7. 1995
    ..Also in various immortalized cell lines tested, the gene was not expressed. In normal diploid fibroblasts, the gene was constitutively expressed during cell-cycle and population doubling levels (PDLs)...
  22. ncbi request reprint Cloning and expression of cDNA for arginine-specific ADP-ribosyltransferase from chicken bone marrow cells
    M Tsuchiya
    Department of Biochemistry, Shimane Medical University, Japan
    J Biol Chem 269:27451-7. 1994
    ..Highly conserved regions were observed among the deduced amino acid sequences of AT1, AT2, rabbit skeletal muscle transferase, and rodent T-cell surface antigen RT6s...
  23. ncbi request reprint Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development
    D Watanabe
    Research Institute for Microbial Diseases, Osaka University, Japan
    J Biol Chem 269:7744-9. 1994
    ..Calmegin is a novel Ca(2+)-binding protein that is specifically expressed in spermatogenesis. The highly regulated, specific, and abundant expression of calmegin suggests that it has important roles in spermatogenesis...
  24. ncbi request reprint Cloning of inv, a gene that controls left/right asymmetry and kidney development
    T Mochizuki
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, School of Medicine, Japan
    Nature 395:177-81. 1998
    ..Transgenic introduction of a minigene encoding the candidate protein restores normal left/right asymmetry and kidney development in the inv mutant, confirming the identity of the candidate gene...
  25. pmc Clinical and molecular analysis of Mowat-Wilson syndrome associated with ZFHX1B mutations and deletions at 2q22-q24.1
    N Ishihara
    J Med Genet 41:387-93. 2004
  26. ncbi request reprint Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B
    M Yoneda
    Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Neurology 59:1637-40. 2002
    ..This suggests that screening for ZFHX1B mutations is warranted even in the absence of typical clinical features of the syndrome...
  27. ncbi request reprint A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4
    S Higashiyama
    Department of Biochemistry, Osaka University Medical School, Suita
    J Biochem 122:675-80. 1997
    ..Thus, NTAK appears to be a new member of the EGF family displaying neuregulin properties...
  28. ncbi request reprint Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2
    M Nakano
    Genetics, The Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders 5, Boston, Massachusetts, USA
    Nat Genet 29:315-20. 2001
    ..These findings confirm the hypothesis that CFEOM2 results from the abnormal development of nIII/nIV (ref. 7) and emphasize a critical role for ARIX in the development of these midbrain motor nuclei...
  29. ncbi request reprint Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene
    M Nakano
    Department of Human Genetics, Nagasaki University School of Medicine, Sakamoto 1 12 4, Nagasaki, Japan
    Gene 225:59-65. 1998
    ..Furthermore, the expression patterns of the two genes in tissues are similar each other. Thus, the human ZIS may act as a transcriptional factor to regulate transcription and/or splicing, as does the rat Zis...
  30. ncbi request reprint Enhanced oxidative damage induced by total body irradiation in mice fed a low protein diet
    S J Shin
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Int J Radiat Biol 78:425-32. 2002
    ..To examine the influence of the level of dietary protein on oxidative damage to lipid and protein in the liver and on chromosomal damage in the bone marrow after total body irradiation (TBI)...
  31. ncbi request reprint Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family
    T Mizutani
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
    Mol Endocrinol 15:1693-705. 2001
    ....
  32. ncbi request reprint [Schizophrenia and ocular misalignment: phenotypic and genetic association analysis]
    Y Yoshikawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute
    Seishin Shinkeigaku Zasshi 106:1585-92. 2004
    ..This study also highlights the unique nature of the polyalanine length variations found in PMX2B...
  33. ncbi request reprint Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Diabetes Res Clin Pract 53:67-71. 2001
    ..3 cM)-Tcf2-(0.5 cM)-D11MIT195. A variant with insertion of C between -205 and -204 in the promoter region of Tcf2 was identified in NSY mice, but not NOD and C3H/He mice...
  34. ncbi request reprint Lack of association between hepatocyte nuclear factor-1beta gene and common forms of type 2 diabetes in the Japanese population
    N Babaya
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes Nutr Metab 14:220-4. 2001
    ..These results suggest that mutations in the HNF-1beta gene derived from a limited number of founders are not a major cause of common forms of Type 2 diabetes, even in the genetically homogeneous Japanese population...
  35. ncbi request reprint Two types of HKT transporters with different properties of Na+ and K+ transport in Oryza sativa
    T Horie
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma-shi, Nara 630-0101, Japan
    Plant J 27:129-38. 2001
    ..These results suggest that two isoforms of HKT transporters, a Na+ transporter (OsHKT1) and a Na+- and K+-coupled transporter (OsHKT2), may act harmoniously in the salt tolerant indica rice...
  36. ncbi request reprint Genetic polymorphisms and antiviral activity in the bovine MX1 gene
    Y Nakatsu
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Anim Genet 35:182-7. 2004
    ..These results indicate that the bovine MX1 protein has potent antiviral activity...
  37. ncbi request reprint Sp family members stimulate transcription of the hex gene via interactions with GC boxes
    E Kikkawa
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan
    J Biochem 130:885-91. 2001
    ..Thus, we conclude that Sp1 and Sp3 stimulate transcription of the Hex gene in both MH(1)C(1) and K562 cells...
  38. ncbi request reprint Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity
    K Yamada
    Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan
    Int J Obes Relat Metab Disord 26:132-6. 2002
    ..We tested the hypothesis that polymorphisms in the cocaine- and amphetamine-regulated-transcript (CART) gene is associated with the development of obesity...
  39. ncbi request reprint Neuropathy in miniature swine after administration of the mutant diphtheria toxin-based immunotoxin, pCD3-CRM9
    P Gargollo
    Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Building 149-9019, 13th Street, Boston, MA 02129, USA
    Transplantation 72:818-22. 2001
    ..A possible reason for CRM9-associated neurotoxicity in swine, but not primates, is suggested on the basis of a known amino acid difference in the exodomain of the DT receptor (proHB-EGF) of swine compared with that of primates...
  40. pmc Fluorescent quenching-based quantitative detection of specific DNA/RNA using a BODIPY((R)) FL-labeled probe or primer
    S Kurata
    Kankyo Engineering Corporation, 1 Kimitsu, Kimitsu-shi, Chiba 299-1141, Japan
    Nucleic Acids Res 29:E34. 2001
    ..This widely applicable technique will be used directly with larger samples or in conjunction with the polymerase chain reaction to quantify small DNA samples...
  41. ncbi request reprint Gene cloning of immunogenic antigens overexpressed in pancreatic cancer
    T Nakatsura
    Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, 2 2 1 Honjo, Kumamoto, 860 0811, Japan
    Biochem Biophys Res Commun 281:936-44. 2001
    ..These molecules identified may provide good diagnostic markers for cancer cells...
  42. ncbi request reprint Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency
    N Harada
    Division of Molecular Genetics, Fujita Health University, Aichi, Japan
    J Biol Chem 267:4781-5. 1992
    ..During the transient expression in COS-7 cells, the aromatase cDNA of the patient was found to produce a protein with a trace of activity. This is the first report of a genetic defect for aromatase deficiency...
  43. ncbi request reprint Cloning and expression of the cDNA for canine interleukin-12
    F Okano
    Toray Industries, Inc, Chemicals Research Laboratories, Nagoya, Japan
    J Interferon Cytokine Res 17:713-8. 1997
    ..The cloned canine IL-12 will be useful for canine therapeutic applications...
  44. ncbi request reprint High sensitivity to hepato-tumorigenesis in hypocatalasemic C3H/C(s)b/Gen mice exposed to low doses of 252Cf fission neutrons and 60Co gamma-rays
    K Yamada
    Department of Cancer Research, Hiroshima University, Japan
    Anticancer Res 17:2041-7. 1997
    ..Therefore, the implication of oxygen radicals in hepato-tumorigenesis was strongly suggested and high sensitivity of C(s)b to low doses of radiation would be useful to investigate the mechanism of radiation tumorigenesis...
  45. ncbi request reprint Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32
    H Nakano
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Genomics 42:26-32. 1997
    ..Fluorescence in situ hybridization confirmed regional localization to human chromosome 1q32...
  46. ncbi request reprint Assignment of the ATBF1 transcription factor gene (Atbf1) to mouse chromosome band 8E1 by in situ hybridization
    K Yamada
    Cytogenetics Laboratory, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Cytogenet Cell Genet 75:30-1. 1996
  47. ncbi request reprint Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1
    K Yamada
    Cytogenetics Laboratory, Graduate School of Environmental Earth Science, Faculty of Science, Hokkaido University, Sapporo, Japan
    Genomics 29:552-3. 1995
  48. ncbi request reprint Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning
    A M Chan
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 12:1259-66. 1996
    ..The 3.0 and 2.4 kilobasepair (kb) transcripts of the NET1 gene was ubiquitously expressed in all tissues examined. Using fluorescence in situ hybridization, we localized the NET1 gene to the short arm of human chromosome 10 at band p15...
  49. ncbi request reprint Molecular cloning of the human histamine H1 receptor gene
    H Fukui
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan
    Biochem Biophys Res Commun 201:894-901. 1994
    ..5-kilobase nucleotides was present in the brain. H1 receptor mRNA was most abundant in the placenta. The human H1 receptor gene was mapped to the chromosome 3p25 by the fluorescence in situ hybridization method...
  50. ncbi request reprint Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript
    M Taira
    Department of Biochemistry, Chiba University School of Medicine, Japan
    Biochim Biophys Acta 1007:203-8. 1989
    ..In the testis, an additional PRPS1-related transcript of 1.4 kb was noted in rats, mice and humans. This transcript may belong to a group of testis-specific gene expressions or functions...
  51. ncbi request reprint Cloning, sequencing, and heterologous expression of rat methionine synthase cDNA
    K Yamada
    Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Japan
    Biosci Biotechnol Biochem 62:2155-60. 1998
    ..A high-level expression of catalytically active enzyme in insect cells was done by infection with a baculovirus containing the rat methionine synthase cDNA...
  52. ncbi request reprint Vacuolar processing enzyme is up-regulated in the lytic vacuoles of vegetative tissues during senescence and under various stressed conditions
    T Kinoshita
    Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
    Plant J 19:43-53. 1999
    ..Taken together, the results suggest that vegetative VPE might regulate the activation of some functional proteins in the lytic vacuoles...
  53. ncbi request reprint Novel properties of the Thermus thermophilus RuvB protein, which promotes branch migration of Holliday junctions
    K Yamada
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Mol Gen Genet 261:1001-11. 1999
    ....
  54. ncbi request reprint Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene
    K Yamada
    Institute for Comprehensive Medical Science, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Biochem Biophys Res Commun 278:134-9. 2000
    ..A DNA motif for GCM protein binding exists in the 5'-flanking region that is highly homologous with that of the mouse gene. The location of this gene was mapped to chromosome 6 using fluorescence in situ hybridization...
  55. ncbi request reprint Distinct expression of two types of Xenopus Patched genes during early embryogenesis and hindlimb development
    T Takabatake
    Radioisotope Research Center, Nagoya University, Furo cho, Chikusa ku, 464 8602, Nagoya, Japan
    Mech Dev 98:99-104. 2000
    ..Despite the difference in their expression patterns, both are induced in animal cap explants synergistically by Shh and Noggin, showing a conserved regulation in their activation mechanisms...
  56. ncbi request reprint Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage
    V W Keng
    Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya, 464 8601, Japan
    Biochem Biophys Res Commun 276:1155-61. 2000
    ..These results indicate that Hex plays an essential role in progenitor cells which commit to the hepatic endoderm and in the hematopoietic differentiation of the monocyte lineage...
  57. pmc Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation
    D Fagegaltier
    UPR du CNRS Structure des Macromolécules Biologiques et Mécanismes de Reconnaissance, Institut de Biologie Moleculaire et Cellulaire, 15, rue René Descartes, 67084 Strasbourg Cedex, France
    EMBO J 19:4796-805. 2000
    ..Therefore, the role carried out by a single elongation factor in eubacterial selenoprotein translation is devoted to two or more specialized proteins in eukaryotes...
  58. ncbi request reprint Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Diabetologia 43:932-8. 2000
    ..The aim of this study was to clarify the influence of age on the pathogenesis of diabetes and to analyse a candidate gene for Type II diabetes in this strain...
  59. ncbi request reprint An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12
    K Yamada
    Department of Human Genetics, Nagasaki University School of Medicine, Japan
    Eur J Hum Genet 8:535-9. 2000
    ..The mapping of the CPP3 locus to 20p12-q12 not only expands our understanding of the genetic heterogeneity in autosomal dominant posterior polar cataracts but also is a clue for the positional cloning of the disease gene...
  60. pmc Possible association of BLM in decreasing DNA double strand breaks during DNA replication
    W Wang
    Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai
    EMBO J 19:3428-35. 2000
    ..The BLM(-/-)/RAD54(-/-) cells showed a slow growth phenotype and an increased incidence of chromosome-type breaks/gaps while each single mutant showed relatively small numbers of chromosome-type breaks/gaps...
  61. ncbi request reprint Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta
    J C Wang
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 275:18418-23. 2000
    ..These results lead us to suggest that TLE proteins could influence the expression of mammalian genes regulated by HNF3...
  62. ncbi request reprint Identification of proteins that interact with NF-YA
    K Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    FEBS Lett 460:41-5. 1999
    ..Two different domains of NF-YA, a glutamine-rich region and a serine/threonine-rich region, are necessary for the interactions with ZHX1 and SRF, respectively...
  63. ncbi request reprint Porcine diacylglycerol kinase sequence has zinc finger and E-F hand motifs
    F Sakane
    Department of Biochemistry, Sapporo Medical College, Japan
    Nature 344:345-8. 1990
    ..These properties of 80K DGK indicate that its action is probably linked with both of the second messengers diacylglycerol and inositol 1,4,5-trisphosphate...