K Ohtsuka

Summary

Affiliation: Institute for Developmental Research
Country: Japan

Publications

  1. ncbi Molecular chaperone function of mammalian Hsp70 and Hsp40--a review
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Hyperthermia 16:231-45. 2000
  2. pmc Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cell Stress Chaperones 5:98-112. 2000
  3. ncbi Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2
    M Hata
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, 464, Japan
    Genomics 38:446-9. 1996
  4. ncbi Cloning and expression of murine sp40 gene: differences in initiation sites between heat-induced and constitutive transcripts
    M Hata
    Cell Stress Biology Research Group, Aichi Cancer Center Research Institute, Nagoya, Japan
    DNA Seq 11:213-23. 2000
  5. ncbi Characterization of a processed pseudogene of human psiHSP40 on chromosome 2q32
    M Hata
    Cell and Stress Biology, Research Group, Aichi Cancer Research Center Research Institute, Nagoya, Japan
    DNA Seq 12:293-7. 2001
  6. ncbi Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis
    M Hata
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Biochim Biophys Acta 1397:43-55. 1998
  7. ncbi Murine cDNA encoding a novel type I HSP40/DNAJ homolog, mmDjA4(1)
    M Hata
    Cell Stress Biology Research Group, Aichi Cancer Center Research Institute, Chikusa ku, 464 8681, Nagoya, Japan
    Biochim Biophys Acta 1493:208-10. 2000
  8. ncbi Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Biochem Biophys Res Commun 197:235-40. 1993
  9. ncbi Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein
    I Izawa
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 275:34521-7. 2000
  10. ncbi Gene structural analysis and expression of human renal dipeptidase
    S Satoh
    Product Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Biotechnol Prog 10:134-40. 1994

Collaborators

Detail Information

Publications13

  1. ncbi Molecular chaperone function of mammalian Hsp70 and Hsp40--a review
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Hyperthermia 16:231-45. 2000
    ..In this review, the focus will be on the mammalian Hsp40, a homologue of bacterial DnaJ heat shock protein, and the beneficial functions of molecular chaperones...
  2. pmc Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cell Stress Chaperones 5:98-112. 2000
    ....
  3. ncbi Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2
    M Hata
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, 464, Japan
    Genomics 38:446-9. 1996
    ..The 5' region of the gene is highly GC rich, and there are multiple basal elements for transcription factors including typical heat shock elements. The Hsp40 gene has been assigned to chromosome 19 band p13.2 by in situ hybridization...
  4. ncbi Cloning and expression of murine sp40 gene: differences in initiation sites between heat-induced and constitutive transcripts
    M Hata
    Cell Stress Biology Research Group, Aichi Cancer Center Research Institute, Nagoya, Japan
    DNA Seq 11:213-23. 2000
    ..To our knowledge, this is the first report on the heat shock-dependent usage of transcriptional start sites of a heat shock gene...
  5. ncbi Characterization of a processed pseudogene of human psiHSP40 on chromosome 2q32
    M Hata
    Cell and Stress Biology, Research Group, Aichi Cancer Research Center Research Institute, Nagoya, Japan
    DNA Seq 12:293-7. 2001
    ..PsiHSP40 was assigned to chromosome 2q32 by in situ hybridization. This is the first report of a pseudogene for a member of the DnaJ (Hsp40) family protein gene...
  6. ncbi Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis
    M Hata
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Biochim Biophys Acta 1397:43-55. 1998
    ..These results indicate that Hsp40 is a real heat shock protein. It is also shown that the HSE found in the first intron might not be the essential element for heat shock response...
  7. ncbi Murine cDNA encoding a novel type I HSP40/DNAJ homolog, mmDjA4(1)
    M Hata
    Cell Stress Biology Research Group, Aichi Cancer Center Research Institute, Chikusa ku, 464 8681, Nagoya, Japan
    Biochim Biophys Acta 1493:208-10. 2000
    ..Northern blot analysis showed that mmDjA4 is specifically expressed in mouse testis and heart. This is the fourth member of the mammalian type I HSP40/DNAJ family to be identified...
  8. ncbi Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ
    K Ohtsuka
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Biochem Biophys Res Commun 197:235-40. 1993
    ..Nucleotide sequence identity between hsp40 and HDJ1 (another human DnaJ homologue) is more than 98%, suggesting that these two proteins are the same gene product...
  9. ncbi Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein
    I Izawa
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 275:34521-7. 2000
    ..Taken together, these results suggest that Mrj may play an important role in the regulation of K8/18 filament organization as a K18-specific co-chaperone working together with Hsp/c70...
  10. ncbi Gene structural analysis and expression of human renal dipeptidase
    S Satoh
    Product Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Biotechnol Prog 10:134-40. 1994
    ..Northern blotting hybridization analysis showed that renal dipeptidase mRNA is only transcribed in kidney...
  11. ncbi Autoimmunity to heat shock protein 40 in ulcerative colitis
    S Sato
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    J Int Med Res 32:141-8. 2004
    ..Our study suggests that autoimmunity against HSP40 may have a beneficial effect in UC patients by limiting the extent of the disease...
  12. ncbi Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells
    H Hattori
    Department of Oral Surgery, Nagoya University School of Medicine, Japan
    Cell Struct Funct 17:77-86. 1992
    ..The intracellular localization of hsp40 was very similar to that of hsp70, suggesting that these two hsps colocalize in heat-shocked HeLa cells...
  13. ncbi Inducers and co-inducers of molecular chaperones
    K Ohtsuka
    Laboratory of Cell and Stress Biology, Department of Environmental Biology, Chubu University, Kasugai, Aichi, Japan
    Int J Hyperthermia 21:703-11. 2005
    ..In this review, we summarize recent studies of chemical compounds that could induce or enhance the expression of molecular chaperones or HSPs...