Y Hosokawa

Summary

Affiliation: Institute for Developmental Research
Country: Japan

Publications

  1. ncbi A small deletion in the 3'-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Research Institute, Nagoya, Japan
    Int J Cancer 76:791-6. 1998
  2. ncbi Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:616-9. 1999
  3. ncbi Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, 1-1 Kanakoden, Chikusa-ku, Nagoya 464-8681, Japan
    Immunogenetics 50:106-8. 1999
  4. ncbi Truncated TSG101 transcripts in human leukemia and lymphoma cell lines
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, 1 1 Kanakoden, Chikusa ku, Nagoya 464 8681, Japan
    J Cancer Res Clin Oncol 126:79-84. 2000
  5. ncbi The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma
    Y Hosokawa
    Laboratory of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 95:2719-21. 2000
  6. ncbi Target genes downregulated by the BCL-6/LAZ3 oncoprotein in mouse Ba/F3 cells
    Y Hosokawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, 1 1 Kanakoden, Nagoya, Chikusa ku, 464 8681, Japan
    Biochem Biophys Res Commun 283:563-8. 2001
  7. ncbi API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products
    M Motegi
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Pathol 156:807-12. 2000
  8. ncbi Detection of AP12-MALT1 chimaeric gene in extranodal and nodal marginal zone B-cell lymphoma by reverse transcription polymerase chain reaction (PCR) and genomic long and accurate PCR analyses
    M Yonezumi
    Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Chikusa-ku, Nagoya, Japan
    Br J Haematol 115:588-94. 2001
  9. ncbi Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, 464 8681, Japan
    Genomics 61:326-9. 1999
  10. ncbi Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma
    M Suguro-Katayama
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Leukemia 17:2508-12. 2003

Collaborators

Detail Information

Publications33

  1. ncbi A small deletion in the 3'-untranslated region of the cyclin D1/PRAD1/bcl-1 oncogene in a patient with chronic lymphocytic leukemia
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Research Institute, Nagoya, Japan
    Int J Cancer 76:791-6. 1998
    ....
  2. ncbi Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:616-9. 1999
    ....
  3. ncbi Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, 1-1 Kanakoden, Chikusa-ku, Nagoya 464-8681, Japan
    Immunogenetics 50:106-8. 1999
  4. ncbi Truncated TSG101 transcripts in human leukemia and lymphoma cell lines
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, 1 1 Kanakoden, Chikusa ku, Nagoya 464 8681, Japan
    J Cancer Res Clin Oncol 126:79-84. 2000
    ....
  5. ncbi The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma
    Y Hosokawa
    Laboratory of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 95:2719-21. 2000
    ..This study provides the first evidence that the Ikaros gene is rearranged in human hematopoietic malignant disorders. (Blood. 2000;95:2719-2721)..
  6. ncbi Target genes downregulated by the BCL-6/LAZ3 oncoprotein in mouse Ba/F3 cells
    Y Hosokawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, 1 1 Kanakoden, Nagoya, Chikusa ku, 464 8681, Japan
    Biochem Biophys Res Commun 283:563-8. 2001
    ..These findings strongly suggest that three key genes, namely cyclin A2, CXCR4, and IGFBP-4 may play a role in the downstream of the BCL-6 signaling pathway during B-lymphoid differentiation...
  7. ncbi API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products
    M Motegi
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Pathol 156:807-12. 2000
    ..Thus, the RT-PCR assay used here should serve as an effective molecular tool for understanding molecular pathogenesis and the clinical significance of API2-MALT1 for MALT lymphomas...
  8. ncbi Detection of AP12-MALT1 chimaeric gene in extranodal and nodal marginal zone B-cell lymphoma by reverse transcription polymerase chain reaction (PCR) and genomic long and accurate PCR analyses
    M Yonezumi
    Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Chikusa-ku, Nagoya, Japan
    Br J Haematol 115:588-94. 2001
    ....
  9. ncbi Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, 464 8681, Japan
    Genomics 61:326-9. 1999
    ..Fluorescence in situ hybridization using a BAC clone established that the Aiolos gene is mapped to human chromosome band 17q11.2...
  10. ncbi Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma
    M Suguro-Katayama
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Leukemia 17:2508-12. 2003
    ..These results suggest that copy numbers of API2-MALT1 do not reflect tumor cell proportions, and that the number of copies of API2-MALT1 in a tumor cell is different for each clinical sample...
  11. ncbi Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Neurosci Res 35:281-90. 1999
    ....
  12. ncbi A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
    T Akagi
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Oncogene 18:5785-94. 1999
    ..The alteration of MALT1 by translocation strongly suggests that this gene plays an important role in the pathogenesis of MALT lymphoma...
  13. ncbi Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma
    Y Hosokawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, 464 8681, Japan
    Apoptosis 10:25-34. 2005
    ....
  14. ncbi Molecular pathogenesis of MALT lymphoma: two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein
    M Nakagawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
    Leukemia 20:929-36. 2006
    ..We also found that BCL10 and MALT1 are shuttling between nucleus and cytoplasm, and that MALT1 can regulate the subcellular location of BCL10...
  15. ncbi Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus
    K Yasojima
    Department of Biochemistry and Molecular Genetics, Kyoto Prefectural University of Medicine, Japan
    Biochem Biophys Res Commun 231:481-7. 1997
    ..We propose that KF-1 is involved in membranous protein-sorting apparatus similarly to RAPsyn. We mapped the human kf-1 gene to 2p11.2...
  16. ncbi Induction of D2 and D3 cyclin-encoding genes during promotion of the G1/S transition by prolactin in rat Nb2 cells
    Y Hosokawa
    Department of Biochemistry, Mie University Faculty of Medicine, Japan
    Gene 147:249-52. 1994
    ..cDNA clones encoding these rat cyclins D2 and D3 were isolated and analyzed...
  17. ncbi Prolactin induces switching of T-cell receptor gene expression from alpha to gamma in rat Nb2 pre-T lymphoma cells(1)
    Y Hosokawa
    Department of Biochemistry, Mie University Faculty of Medicine, Tsu, Japan
    Biochem Biophys Res Commun 220:958-62. 1996
    ..These results suggest that PRL may participate in the regulation of mammalian T-cell differentiation and development...
  18. ncbi Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase
    N Tsuboyama
    Department of Chemistry, Kochi Medical School, Japan
    Gene 181:161-5. 1996
    ..Northern blots of RNA from rat tissues revealed the highest CDO mRNA level in the liver. Significant levels were observed in the kidney, lung and brain, implying tissue-specific differences in CDO promoter function...
  19. ncbi Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex
    M Nishikimi
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 159:19-25. 1989
    ..Northern blot analysis indicated that rat liver possibly contains different sizes of mRNAs for the Rieske iron-sulfur protein, and Southern blot analysis demonstrated that rats and mice possess a single gene for this protein...
  20. ncbi Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer
    K Inoue
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 21:2471-6. 2001
    ..Our results suggest that PPAR-gamma may play an important role in the pathogenesis and/or progression of lung cancer, and may be a novel therapeutical target for therapy of lung cancer...
  21. ncbi Chromosomal assignment of the gene for the ubiquinone-binding protein of human mitochondrial cytochrome bc1 complex
    Y Hosokawa
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Int 21:41-4. 1990
    ..The results indicated that the human QP-C gene is located on chromosome 8...
  22. ncbi The primary structure of the precursor to core protein II, a putative member of mitochondrial processing protease family, of rat mitochondrial cytochrome bc1 complex deduced from cDNA sequence analysis
    Y Hosokawa
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Int 20:731-7. 1990
    ..Northern blot analysis showed that rat liver poly(A)+ RNA contains a single mRNA of approximately 2000 nucleotides for the core protein II...
  23. ncbi Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography
    Y Nakase
    Department of Surgery and Physiology of Digestive System, Graduate School of Medical Science, Surgery and Regenerative Medicine, Kyoto, Japan
    Br J Cancer 92:562-9. 2005
    ..Measurement of RUNX3 expression and detection of RUNX3 methylation in remnant gastric mucosa may estimate the forward risk of carcinogenesis in the remnant stomach...
  24. ncbi The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis
    M Nishikimi
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Int 20:155-60. 1990
    ..The mature protein consists of the same number of amino acid residues as that of its rat and bovine counterparts, having a homology of about 92% with the latter...
  25. ncbi Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain
    H Suzuki
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 161:371-8. 1989
    ..Two CAAT boxes were found in the promoter region. It is concluded from these results that the isolated human QP gene is functional. Genomic Southern blot analysis showed that the gene is present in a single copy in the human genome...
  26. ncbi The amino acid sequence of the 24-kDa subunit, an iron-sulfur protein, of rat liver mitochondrial NADH dehydrogenase deduced from cDNA sequence
    M Nishikimi
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 157:914-20. 1988
    ....
  27. ncbi Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III
    H Suzuki
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 156:987-94. 1988
    ..This implies that the human QP-C is synthesized without a presequence which is required for import of most nuclear-encoded mitochondrial proteins into mitochondria...
  28. ncbi API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)
    H Suzuki
    Blood 94:3270-1. 1999
  29. ncbi Molecular cloning of human cytosolic purine 5'-nucleotidase
    J Oka
    National Institute of Health and Nutrition, Tokyo, Japan
    Biochem Biophys Res Commun 205:917-22. 1994
    ..Northern blot analysis of human placenta poly(A) +RNA revealed a single band of 3.6 kilobases using the cloned cDNA...
  30. ncbi Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1
    Y Hosokawa
    Division of Maternal and Child Health Science, National Institute of Health and Nutrition, Tokyo, Japan
    Leukemia 7:441-5. 1993
    ..These results indicate that the heterogeneity of the heavy subunit of MPO observed in leukocytes or leukemia could be in part produced by partial or complete skipping of an exon...
  31. ncbi Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells
    Y Hosokawa
    Department of Biochemistry, Mie University Faculty of Medicine, Japan
    Biochem Mol Biol Int 37:393-9. 1995
    ..These results suggest that cyclin E, cdk2, cdk5 and E2F-1 play the roles in the G1/S transition being expressed by a common cellular mechanism(s) in the PRL-stimulated pre-T lymphoma cells...
  32. ncbi Structure and characterization of rat cyclin D3 promoter
    M Yang
    Department of Biochemistry, Mie University Faculty of Medicine, Japan
    Gene 181:153-9. 1996
    ..These results suggest that the cyclin D3 gene is a TATA-less gene whose transcription is regulated by multiple mitogen-inducible transcription factors including an unknown factor...
  33. ncbi Structure of the chicken growth hormone-encoding gene and its promoter region
    M Tanaka
    Department of Biochemistry, Mie University School of Medicine, Japan
    Gene 112:235-9. 1992
    ....