N Hamajima

Summary

Affiliation: Institute for Developmental Research
Country: Japan

Publications

  1. ncbi Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 91:865-8. 2000
  2. ncbi Tea polyphenol intake and changes in serum pepsinogen levels
    N Hamajima
    Division of Epidemiology, Aichi Cancer Center Hospital
    Jpn J Cancer Res 90:136-43. 1999
  3. ncbi Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 92:383-9. 2001
  4. ncbi Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 6:13-8. 2001
  5. ncbi Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 92:488-93. 2001
  6. ncbi PCR-CTPP: a new genotyping technique in the era of genetic epidemiology
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Expert Rev Mol Diagn 1:119-23. 2001
  7. ncbi No association of the 5' promoter region polymorphism of CYP17 with breast cancer risk in Japan
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 91:880-5. 2000
  8. ncbi Detection of gene-environment interaction by case-only studies
    N Hamajima
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 29:490-3. 1999
  9. ncbi Possible risk reduction in esophageal cancer associated with MPO -463 A allele
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
    J Epidemiol 11:109-14. 2001
  10. pmc Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin
    K Matsuo
    Division of Epidemiology and Prevention, Nagoya, Japan
    Epidemiol Infect 130:227-33. 2003

Collaborators

Detail Information

Publications50

  1. ncbi Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 91:865-8. 2000
    ..It is simpler than PCR-RFLP (restriction fragment length polymorphism), which requires incubation with a restriction enzyme, and is suitable for genotyping in studies of genetic epidemiology involving hundreds of samples...
  2. ncbi Tea polyphenol intake and changes in serum pepsinogen levels
    N Hamajima
    Division of Epidemiology, Aichi Cancer Center Hospital
    Jpn J Cancer Res 90:136-43. 1999
    ..This result suggests that additional polyphenol intake for 1 year in Japanese does not improve pepsinogen levels, which are considered to reflect stomach atrophy, a high-risk condition for stomach cancer...
  3. ncbi Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 92:383-9. 2001
    ..The results suggested that the T allele of IL-1B C - 31T is associated with vulnerability to persistent HP infection, and that the vulnerability is modified by smoking...
  4. ncbi Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 6:13-8. 2001
    ..In order to examine the impact of this polymorphism on breast cancer risk in Japan, a case-control study was conducted, at Aichi Cancer Center Hospital...
  5. ncbi Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 92:488-93. 2001
    ..These findings are consistent with the results for IL-1B in our earlier study, suggesting that inflammatory responses in the gastric mucosa may influence persistent HP infection, and that smoking and milk intake may be effect-modifiers...
  6. ncbi PCR-CTPP: a new genotyping technique in the era of genetic epidemiology
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Expert Rev Mol Diagn 1:119-23. 2001
    ....
  7. ncbi No association of the 5' promoter region polymorphism of CYP17 with breast cancer risk in Japan
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Jpn J Cancer Res 91:880-5. 2000
    ....
  8. ncbi Detection of gene-environment interaction by case-only studies
    N Hamajima
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 29:490-3. 1999
    ..The newly introduced case-only study was compared with traditional case-control study in terms of statistical power to detect significant gene-environment interaction...
  9. ncbi Possible risk reduction in esophageal cancer associated with MPO -463 A allele
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
    J Epidemiol 11:109-14. 2001
    ..Although there are limitations for interpretation of this study because of prevalent case-control study and partial statistical significance, these results suggest that MPO -463 A allele reduce the risk of esophageal cancer...
  10. pmc Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin
    K Matsuo
    Division of Epidemiology and Prevention, Nagoya, Japan
    Epidemiol Infect 130:227-33. 2003
    ..Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication...
  11. ncbi Effect of body size on breast-cancer risk among Japanese women
    K Hirose
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 80:349-55. 1999
    ..These findings suggest that avoidance of marked weight gain during adult life, especially after natural menopause and/or after age 60, may reduce the risk of breast cancer...
  12. ncbi Smoking habit and interleukin lB C-31T polymorphism
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
    J Epidemiol 11:120-5. 2001
    ..42-1.61) for the examinees. Although not significant for the examinees, the observed associations suggest that this polymorphism may influence smoking behavior through an inflammatory response of the respiratory tract to cigarette smoke...
  13. ncbi Association of family history and other risk factors with breast cancer risk among Japanese premenopausal and postmenopausal women
    K Hirose
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
    Cancer Causes Control 12:349-58. 2001
    ..They imply that avoidance of obesity after menopause may reduce the risk of breast cancer, regardless of FH...
  14. ncbi Alcohol, smoking, and dietary status and susceptibility to malignant lymphoma in Japan: results of a hospital-based case-control study at Aichi Cancer Center
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Chikusa ku, Nagoya 464 86811
    Jpn J Cancer Res 92:1011-7. 2001
    ..From the previous study on genetic background for ML [Matsuo et al., Blood, 97, 3205 - 3209 (2001)], genetic variation combined with limited environmental factors should be targeted in future studies...
  15. ncbi Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation
    Y Atsuta
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Bone Marrow Transplant 37:289-96. 2006
    ..Our patients could not be accurately classified when the proposed prognostic models from Western countries were used, thus indicating the need for a different model to identify high-risk patients...
  16. pmc Influence of smoking and CYP2C19 genotypes on H. pylori eradication success
    T Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan
    Epidemiol Infect 135:171-6. 2007
    ..7%, PM 20.0%), indicating possible interactions with CYP2C19 polymorphisms. Smoking has a greater influence on H. pylori eradication than the CYP2C19 genotype. Interaction between smoking and CYP2C19 should be examined in the future...
  17. ncbi Influence of habitual smoking on gastric cancer by histologic subtype
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:39-43. 1999
    ..Risk patterns were less clear in females. Our results suggest that habitual smoking is associated more likely with the differentiated type of gastric cancer, particularly in younger cases...
  18. ncbi Adjustment of prognostic effects in prevalent case-control studies on genotype
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 11:204-10. 2001
    ..An actual prevalent case-control study on breast cancer is used to demonstrate the three approaches. They are useful to compensate the disadvantage of prevalent case-control studies...
  19. ncbi Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan
    M Inoue
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Lett 167:175-82. 2001
    ..Although careful interpretation is needed, these results suggest the possibility that regular green tea consumption may be preventive against recurrence of breast cancer in early stage cases...
  20. ncbi Different susceptibility of each L-myc genotype to esophageal cancer risk factors
    H Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 92:735-9. 2001
    ..40, respectively. The age-sex-adjusted ORs for both factors combined were 12.77, 18.45 and 1.44, respectively. These results suggested that the L-myc polymorphism might modify the effects of lifestyle factors on esophageal cancer risk...
  21. ncbi Association of polymorphisms in the beta-2 and beta-3 adrenoceptor genes with risk of colorectal cancer in Japanese
    T Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 6:117-22. 2001
    ..To examine links between polymorphisms in these genes and the risk of colorectal cancer in Japanese, we conducted the present hospital-based case-referent study...
  22. ncbi Comparative case-referent study of risk factors among hormone-related female cancers in Japan
    K Hirose
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya
    Jpn J Cancer Res 90:255-61. 1999
    ..The results obtained from this study suggested that avoidance of weight gain may reduce the risk of female hormone-related cancers...
  23. ncbi The interaction of host genetic factors and Helicobacter pylori infection
    T Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Inflammopharmacology 15:10-4. 2007
    ..Prevention of gastric cancer requires the development of better screening strategies for determining eradication candidates and further improvement of treatments of Helicobacter pylori infection...
  24. pmc Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer
    X E Huang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Breast Cancer Res 3:264-9. 2001
    ....
  25. pmc Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas
    T Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Br J Cancer 84:1199-206. 2001
    ..This study suggests cooked/raw fish consumption lowers the risk of adenocarcinoma of the lung in Japanese...
  26. ncbi No substantial difference in genotype frequencies of interleukin and myeloperoxidase polymorphisms between malignant lymphoma patients and non-cancer controls
    K Matsuo
    Aichi Cancer Center Research Institute, Division of Epidemiology and Prevention, 1 1 Kanokoden Chikusa ku Nagoya 464 8681, Japan
    Haematologica 86:602-8. 2001
    ..We examined the association between malignant lymphoma risk and the polymorphisms of the IL-1 gene family [IL-1B -31 C/T, IL-1A -889 C/T, and IL-1RN 86-bp variable number of terminal repeat (VNTR)] and myeloperoxidase (MPO -463 G/A)...
  27. ncbi Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody
    Y Ikehara
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 10:971-7. 2001
    ..Immunohistochemical analysis supported the finding that Se and Le genotypes affected the expression of H. pylori adhesin ligands. We conclude that Se and Le genotypes affect susceptibility to H. pylori infection...
  28. ncbi Family history and subsite of gastric cancer: data from a case-referent study in Japan
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nahoya, Japan
    Int J Cancer 76:801-5. 1998
    ..Our results suggest that the risk of gastric cancer in relation to family history varies by subsite and, furthermore, that the subsite-specific risk of gastric cancer is linked to a maternal history of gastric cancer...
  29. ncbi Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Carcinogenesis 22:913-6. 2001
    ..Taking the observed high risk of esophageal cancer in association with the ALDH2 Lys487 allele into consideration, reducing alcohol intake may be most protective among Lys487 allele carriers of this polymorphism...
  30. ncbi ALDH2 polymorphisms and bone mineral density in an elderly Japanese population
    J Yamaguchi
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 4668550, Aichi, Japan
    Osteoporos Int 17:908-13. 2006
    ..Osteoporosis is a multifactorial genetic disease which greatly increases the risk of bone fracture in elderly persons...
  31. ncbi Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women
    S Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Eur J Clin Nutr 64:400-9. 2010
    ..To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study...
  32. ncbi Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis
    T Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Cancer Res 6:4055-63. 2000
    ..Whether p53 alteration also provides information that can alter treatment decisions should be asked in clinical trials...
  33. pmc Interleukin 1B proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy
    T Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gut 55:158-64. 2006
    ..We examined the association between proinflammatory cytokine gene polymorphisms, presence of gastric atrophy, and risk of GORD in H pylori positive and negative subjects in Japan...
  34. ncbi Agreement of endoscopic findings and serum pepsinogen levels as an indicator of atrophic gastritis
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 7:261-3. 1998
    ..Serum pepsinogen assays identify the majority of patients with atrophic gastritis, although they are less useful in assessing the degree of atrophy in detail...
  35. ncbi Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Jap
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:331-7. 2004
    ..62, 95% CI: 1.23-2.14, P=0.0007 for OS). This superiority of FK506 was not observed in SIB-HSCT cases. These findings indicate that the use of FK506 instead of CSP for GVHD prophylaxis is beneficial for patients undergoing UD-HSCT...
  36. ncbi SEREX analysis of gastric cancer antigens
    Y Obata
    Aichi Cancer Center, Research Institute and Department of Genetics and Pathology, Aichi Cancer Center Hospital, Nagoya, Japan
    Cancer Chemother Pharmacol 46:S37-42. 2000
    ..To evaluate the clinical usefulness of these antigens we are now examining their expression in normal and malignant tissues...
  37. ncbi Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    K Matsuo
    Division of Epidemiology and Prevention, the Department of Hematology and Chemotherapy, the Nagoya University Graduate School of Medicine, Japan
    Blood 97:3205-9. 2001
    ..Further studies to confirm the association and detailed biologic mechanisms are now required...
  38. doi Morphological features of elderly patients with obstructive sleep apnoea syndrome: a prospective controlled, comparative cohort study
    M Tagaya
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Clin Otolaryngol 36:139-46. 2011
    ..To investigate the pharyngeal morphologic features and its pathogenic role on obstructive sleep apnoea syndrome in the elderly population...
  39. ncbi Allogeneic myeloablative transplantation for patients aged 50 years and over
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:29-35. 2004
    ..0303, respectively). These findings indicate that allogeneic c-HSCT should be offered to patients over 50 years only if the increased risk of TRM is acceptable, and that a non-TBI regimen is preferable when the transplant is performed...
  40. ncbi Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity
    M Kouwaki
    Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 4:2999-3004. 1998
    ..The present data represent the first molecular genetic analysis of DPD deficiency accompanied by severe 5-FU toxicity in a Japanese patient...
  41. ncbi Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype
    R Suzuki
    Division of Molecular Medicine, Department of Hematology and Chemotherapy, Nagoya, Japan
    Blood 96:2993-3000. 2000
    ..Effective therapeutic approaches should be explored for high-risk ALCL patients, who can be identified by means of a prognostic model, including CD56...
  42. pmc Detection of cyclin D1 overexpression by real-time reverse-transcriptase-mediated quantitative polymerase chain reaction for the diagnosis of mantle cell lymphoma
    R Suzuki
    Divisions of Molecular Medicine, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Am J Pathol 159:425-9. 2001
    ..25 for other B-cell lymphomas and 0.000014 approximately 0.083 for myeloid leukemia, suggesting that a cutoff value can be set at 0.25. The RQ-PCR of cyclin D1 is convenient and especially useful for the diagnosis of MCL...
  43. pmc Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients
    A Watarai
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabet Med 23:894-9. 2006
    ..Therefore, the present study was conducted to determine whether genetic variations of AR may determine susceptibility to diabetic macroangiopathy...
  44. ncbi Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese
    K Yoshida
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 10:403-5. 2001
    ....
  45. ncbi Cytomegalovirus antigenemia and outcome of patients treated with pre-emptive ganciclovir: retrospective analysis of 241 consecutive patients undergoing allogeneic hematopoietic stem cell transplantation
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 32:801-7. 2003
    ..Optimal pre-emptive strategy needs to be determined...
  46. ncbi Helicobacter pylori seropositivity among 963 Japanese Brazilians according to sex, age, generation, and lifestyle factors
    L S Ito
    JICA Trainee, Aichi Cancer Center Research Institute, Nagoya 464-8681
    Jpn J Cancer Res 92:1150-6. 2001
    ..This is the largest study of HP infection among Japanese Brazilians, and the results indicated a similar pattern of age-specific infection rate to that for Japanese in Japan...
  47. pmc Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease
    N Hamajima
    Cancer Research UK Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Cancer 87:1234-45. 2002
    ....
  48. ncbi [Association between the interleukin 1B (C-31T) polymorphism and Helicobacter pylori infection in health checkup examinees]
    N Katsuda
    Nagoya City Nishi Health Center, Nagoya City Kita Health Center
    Nihon Koshu Eisei Zasshi 48:604-12. 2001
    ..The present investigation was conducted to determine the HP infection rate with reference to the Interleukin-1 beta gene (IL-1B) polymorphism and assess the interactions with smoking reported for outpatients...
  49. ncbi Psychological effects of forest environments on healthy adults: Shinrin-yoku (forest-air bathing, walking) as a possible method of stress reduction
    E Morita
    Department of Health Promotion and Human Behaviour, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Public Health 121:54-63. 2007
    ..The aims of this study were: (1) to evaluate the psychological effects of shinrin-yoku in a large number of participants; and (2) to identify the factors related to these effects...
  50. pmc Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene
    N Hamajima
    Department of Pediatrics, Nagoya City University Medical School, Nagoya City Higashi General Hospital, Nagoya, Japan
    Am J Hum Genet 63:717-26. 1998
    ..There was no significant difference, in residual activity, between mutations observed in the symptomatic and those observed in the asymptomatic individuals...