Hiroaki Aoyama

Summary

Affiliation: Institute of Environmental Toxicology
Country: Japan

Publications

  1. ncbi request reprint Observation of X-Y chromosomal configuration in spermatocytes of infertile PD strain male rats
    Hitoshi Hojo
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Mitsukaido, Ibaraki 303 0043, Japan
    Congenit Anom (Kyoto) 42:327-30. 2002
  2. ncbi request reprint Effects of dinoseb, 4,6-dinitro-o-cresol, and 2,4-dinitrophenol on rat Sertoli-germ cell co-cultures
    Ken L Takahashi
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Ibaraki, Japan
    Reprod Toxicol 17:247-52. 2003
  3. ncbi request reprint Reproductive toxicities of methoxychlor based on estrogenic properties of the compound and its estrogenic metabolite, hydroxyphenyltrichloroethane
    Hiroaki Aoyama
    Toxicology Division, Institute of Environmental Toxicology, Joso, Ibaraki, Japan Electronic address
    Vitam Horm 94:193-210. 2014
  4. doi request reprint Developmental neurotoxicity testing: scientific approaches towards the next generation to protect the developing nervous system of children. An overview of the Developmental Neurotoxicity Symposium in 2011
    Hiroaki Aoyama
    Toxicology Division, Institute of Environmental Toxicology, Joso, Ibaraki, Japan
    Congenit Anom (Kyoto) 52:119-21. 2012
  5. doi request reprint Two-generation reproduction toxicity study in rats with methoxychlor
    Hiroaki Aoyama
    Laboratories of Reproductive Toxicology, Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Congenit Anom (Kyoto) 52:28-41. 2012
  6. ncbi request reprint Historical control data on reproductive abilities and incidences of spontaneous fetal malformations in Wistar Hannover GALAS rats
    Hiroaki Aoyama
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Mitsukaido, Ibaraki 303 0043, Japan
    Congenit Anom (Kyoto) 42:194-201. 2002
  7. ncbi request reprint A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats
    Hiroaki Aoyama
    Laboratory of Reproductive Toxicology, Chemistry Division, Institute of Environmental Toxicology, 4321 Uchimoriya machi, Mitsukaido shi, Ibaraki 303 0043, Japan
    J Toxicol Sci 30:59-78. 2005
  8. ncbi request reprint Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male rats after treatment with 4,6-dinitro-o-cresol
    Ken L Takahashi
    Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Reprod Toxicol 22:501-7. 2006
  9. ncbi request reprint Two-generation reproduction toxicity study in rats with 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT)
    Hitoshi Hojo
    Laboratories of Reproductive Toxicology, Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Congenit Anom (Kyoto) 46:105-14. 2006
  10. ncbi request reprint Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals
    Ken L Takahashi
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, 4321 Uchimoriya machi, Mitsukaido shi, Ibaraki, Japan
    Reprod Toxicol 18:581-8. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Observation of X-Y chromosomal configuration in spermatocytes of infertile PD strain male rats
    Hitoshi Hojo
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Mitsukaido, Ibaraki 303 0043, Japan
    Congenit Anom (Kyoto) 42:327-30. 2002
    ..These results suggest that abnormal X-Y chromosome association in the germ cells is not a significant cause of spermatogenic breakdown in pd/pd males...
  2. ncbi request reprint Effects of dinoseb, 4,6-dinitro-o-cresol, and 2,4-dinitrophenol on rat Sertoli-germ cell co-cultures
    Ken L Takahashi
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Ibaraki, Japan
    Reprod Toxicol 17:247-52. 2003
    ..These results demonstrate that DNBP, DNOC, and DNP have in vitro toxicity to these cell populations at high concentration, and suggest the possibility that DNOC and DNP also cause testicular damage in experimental animals and humans...
  3. ncbi request reprint Reproductive toxicities of methoxychlor based on estrogenic properties of the compound and its estrogenic metabolite, hydroxyphenyltrichloroethane
    Hiroaki Aoyama
    Toxicology Division, Institute of Environmental Toxicology, Joso, Ibaraki, Japan Electronic address
    Vitam Horm 94:193-210. 2014
    ..The no-observed-adverse-effect level of methoxychlor among reliable experimental animal studies in terms of the reproductive toxicity is 10 ppm (equivalent to 0.600 mg/kg/day) in a two-generation reproduction toxicity study...
  4. doi request reprint Developmental neurotoxicity testing: scientific approaches towards the next generation to protect the developing nervous system of children. An overview of the Developmental Neurotoxicity Symposium in 2011
    Hiroaki Aoyama
    Toxicology Division, Institute of Environmental Toxicology, Joso, Ibaraki, Japan
    Congenit Anom (Kyoto) 52:119-21. 2012
    ..This overview provides a history of the DNT Committee, as well as a brief summary of the DNT Symposium in 2011...
  5. doi request reprint Two-generation reproduction toxicity study in rats with methoxychlor
    Hiroaki Aoyama
    Laboratories of Reproductive Toxicology, Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Congenit Anom (Kyoto) 52:28-41. 2012
    ..Neither systemic nor reproductive toxicities appeared in the 10 ppm group...
  6. ncbi request reprint Historical control data on reproductive abilities and incidences of spontaneous fetal malformations in Wistar Hannover GALAS rats
    Hiroaki Aoyama
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, Mitsukaido, Ibaraki 303 0043, Japan
    Congenit Anom (Kyoto) 42:194-201. 2002
    ..These results suggest that this strain of rat can be used in reproductive and developmental toxicity studies, although the sensitivity to toxicants remains to be elucidated...
  7. ncbi request reprint A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats
    Hiroaki Aoyama
    Laboratory of Reproductive Toxicology, Chemistry Division, Institute of Environmental Toxicology, 4321 Uchimoriya machi, Mitsukaido shi, Ibaraki 303 0043, Japan
    J Toxicol Sci 30:59-78. 2005
    ..These results suggest that 2,4-DCP has weak reproductive toxicity, possibly based on endocrine activity. However, the basic mechanisms for apparent estrogenic effects of 2,4-DCP remain to be elucidated...
  8. ncbi request reprint Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male rats after treatment with 4,6-dinitro-o-cresol
    Ken L Takahashi
    Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Reprod Toxicol 22:501-7. 2006
    ....
  9. ncbi request reprint Two-generation reproduction toxicity study in rats with 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT)
    Hitoshi Hojo
    Laboratories of Reproductive Toxicology, Toxicology Division, Institute of Environmental Toxicology, Ibaraki, Japan
    Congenit Anom (Kyoto) 46:105-14. 2006
    ..However, these changes never resulted in substantial reproductive disorders...
  10. ncbi request reprint Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals
    Ken L Takahashi
    Laboratory of Reproductive Toxicology, Toxicology Division I, Institute of Environmental Toxicology, 4321 Uchimoriya machi, Mitsukaido shi, Ibaraki, Japan
    Reprod Toxicol 18:581-8. 2004
    ..DNP also caused slightly increased incidence of tailless sperm on D14. These results demonstrate that DNBP, DNOC, and DNP manifest similar spermatotoxic effects at or around a lethal dose in rats...
  11. ncbi request reprint A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats
    Akira Sato
    Toxicology Division, Institute of Environmental Toxicology, 4321 Uchimoriya machi, Joso, Ibaraki 303 0043, Japan
    Mutat Res Fundam Mol Mech Mutagen 762:17-23. 2014
    ..749-1G>T/+ heterozygotes having externally undetectable thyroidal lesions...
  12. ncbi request reprint Curly vibrissae, a new mutation in the Wistar-derived rat
    Sakiko Fujii
    Toxicology Division, Safety Research Institute for Chemical Compounds Co, Ltd, Sapporo, Hokkaido, Japan
    Congenit Anom (Kyoto) 43:65-71. 2003
    ..Lactating females usually lose their abdominal hair. Both sexes of cv/cv homozygotes have normal reproductive ability. No internal malformations accompany vibrissa and hair abnormalities...
  13. doi request reprint Historical control data on prenatal developmental toxicity studies in rabbits
    Makoto Ema
    Study Group for Historical Control Data on Prenatal Developmental Toxicity Studies in Rabbits, Research Institute of Sciencefor Safety and Sustainability, National Institute of Advanced IndustrialScience and Technology AIST, 16 1 Onogawa, Tsukuba, Ibaraki, Japan
    Congenit Anom (Kyoto) 52:155-61. 2012
    ....
  14. ncbi request reprint Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane
    Hiroaki Aoyama
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, MD C2 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 209:226-35. 2005
    ..These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice...
  15. ncbi request reprint Changes of estrous cycles with aging in female F344/n rats
    Keiko Sone
    Animal Facility for Aging Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    Exp Anim 56:139-48. 2007
    ..However, other aging characteristics are unknown in postmenopausal women. Therefore, we must be careful when extrapolating the aging changes of reproduction in F344/N rats to human beings...
  16. ncbi request reprint Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), an
    Makoto Ema
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Congenit Anom (Kyoto) 47:74-6. 2007
    ..The DNT Committee of the JTS also commented on the draft document of the RPA. These comments were sent to the OECD Secretariat. The DNT Committee of the JTS expects the comments to be useful for the finalization of these draft documents...