Research Topics
| H IishiSummaryCountry: Japan Publications
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Publications
Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsN Uedo
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Cancer Lett 137:131-6. 1999..These findings indicate that limonene inhibits the development of gastric cancers through increased apoptosis and decreased DNA synthesis of gastric cancers, but not through ras oncoprotein plasma membrane association...
Inhibition by rat C-erbB-2/neu antisense oligonucleotide of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsN Uedo
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Int J Cancer 83:670-3. 1999....
Inhibition by amiloride of experimental carcinogenesis induced by azaserine in rat pancreasM Tatsuta
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Cancer Lett 106:23-8. 1996....
K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acidH Narahara
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Int J Cancer 88:157-61. 2000..However, decreased cell proliferation in the colon mucosa may be closely related to the attenuation of DCA-enhanced colon tumorigenesis, but not suppression of K-ras point mutation...
Suppression by verapamil of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in wistar ratsH Iishi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Chemotherapy 47:70-6. 2001....
Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsM Tatsuta
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Int J Cancer 77:467-9. 1998..Our results suggest that adrenoreceptor stimulation enhances gastric carcinogenesis and that such enhancement is mediated through alpha1-adrenoceptors without alpha2-adrenoceptor involvement...
Inhibition by galanin of experimental carcinogenesis induced by azaserine in rat pancreasH Iishi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Int J Cancer 75:396-9. 1998....
Low-protein diet promotes sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Cancer Lett 141:117-22. 1999..These findings indicate that a low-protein diet enhances the effect of NaCl in gastric carcinogenesis and that this enhancement may be mediated by increased cell proliferation and reduced apoptosis of gastric cancers...
Enhancement of dopaminergic agonist bromocriptine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 65:351-4. 1992..These findings indicate that the dopamine agonist bromocriptine promotes gastric carcinogenesis, and that this effect may be related to its effect in increasing proliferation of epithelial cells in the antral mucosa...
Attenuation by all-trans-retinoic acid of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsM Tatsuta
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Br J Cancer 79:732-6. 1999..These findings suggest that RA attenuates gastric carcinogenesis, enhanced by sodium chloride, by increasing apoptosis, decreasing DNA synthesis, and reducing TGF-alpha expression in gastric cancers...
Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesisH Narahara
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3 3, Nakamichi 1 chome, Higashinari ku, 537 8511, Osaka, Japan
Cancer Lett 168:117-24. 2001..Because monochloramine is closely related to Helicobacter pylori-associated gastric carcinogenesis, these findings suggest that ambroxol may prevent H. pylori-associated gastric carcinogenesis...
Roles of ovaries and testes in hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzeneR Yamamoto
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Int J Cancer 49:83-8. 1991..These results indicate that tumorigenesis induced in mouse liver by 3'-Me-DAB is enhanced by the testes and suppressed by the ovaries...
Attenuation by d-limonene of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Yano
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Int J Cancer 82:665-8. 1999..Our findings suggest that limonene attenuates the gastric carcinogenesis enhanced by sodium chloride via increased apoptosis and decreased ODC activity in gastric cancers...
Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Int J Cancer 86:416-20. 2000..Our findings indicate that genistein attenuates cancer metastasis by inhibiting cancer cell invasion into lymphatic vessels through activities that do not affect the growth of intestinal cancers...
Suppression by pravastatin, an inhibitor of p21ras isoprenylation, of hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley ratsM Tatsuta
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Br J Cancer 77:581-7. 1998....
Inhibition by verapamil of cholecystokinin-enhancement of pancreatic carcinogenesis induced by azaserine in Wistar ratsA Nakaizumi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Cancer Lett 105:23-7. 1996..Concomitant administration of verapamil significantly attenuated the enhancing effect of CCK-8. These findings indicate that calcium may play an important role in CCK-enhancement of pancreatic carcinogenesis...
Effect of tetragastrin on azaserine-induced carcinogenesis in rat pancreasM Tatsuta
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Int J Cancer 46:489-92. 1990....
Inhibition by amiloride of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsM Tatsuta
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 67:1011-4. 1993..These findings indicate that amiloride inhibits the development of gastric cancers, and that its effect may be related to its effect in decreasing cell proliferation of the antral mucosa...
Inhibition by neurotensin of azaserine-induced carcinogenesis in rat pancreasM Tatsuta
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Int J Cancer 47:408-12. 1991..These findings indicate that neurotensin inhibits pancreatic carcinogenesis, and that this may be related to the reduction of ATPase-positive lesions and to the inhibition of cell proliferation in neoplastic lesions of the pancreas...
Enhancement by thyroxine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 68:515-8. 1993..These findings indicate that T4 enhances the development of gastric cancers, and that its effect may be related to its effect in increasing proliferation of gastric epithelial cells...
Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane associationI Kaji
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Int J Cancer 93:441-4. 2001....
Effect of 6-hydroxydopamine on gastric carcinogenesis and tetragastrin inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsM Tatsuta
Deparment of Gastrointestinal Oncology, Center for Adult Disease, Osaka, Japan
Cancer Res 49:4199-203. 1989..This effect of 6-OHDA may be related to its ability to inhibit cell proliferation of the antral mucosa...
Promoting effect of ovariectomy on hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzeneS Tsutsui
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Virchows Arch B Cell Pathol Incl Mol Pathol 62:371-5. 1992..The results show that the ovariectomy has the promoting effect on the development of adenomatous nodules in the liver induced by 3'-Me-DAB after 6 months of age...
Inhibition by verapamil of hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley ratsH Uehara
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 68:37-40. 1993..These findings indicate that verapamil inhibits hepatocarcinogenesis and that this may be related to its inhibitory effect on cell proliferation in neoplastic lesions and surrounding hepatocytes...
Induction by bombesin of peritoneal metastasis of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsM Tatsuta
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi 1-chome, Higashinari-ku, Osaka 537-8511, Japan
Gastric Cancer 4:14-9. 2001..Bombesin also increased the activity of Rho protein in the tumors. CONCLUSION: Bombesin significantly increased the incidence of peritoneal metastasis from gastric cancers through the activation of Rho protein...
Clinical features and outcomes of delayed perforation after endoscopic submucosal dissection for early gastric cancerN Hanaoka
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Endoscopy 42:1112-5. 2010..The remaining five patients required emergency surgery. There was no mortality in this case series...
Protection by oral phenylalanine against gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 62:173-6. 1990..These findings indicate that orally administered phenylalanine inhibits the development of gastric cancers...
Effectiveness of endoscopic mucosal resection with submucosal saline injection technique for superficial squamous carcinomas of the esophagusH Narahara
Departments of Gastroenterology and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Gastrointest Endosc 52:730-4. 2000..Therefore, in this study, the effectiveness of endoscopic mucosal resection with submucosal saline injection for removal of superficial esophageal cancers was investigated prospectively...
Inhibitory effect of sialoadenectomy on hepatocellular tumourigenesis in male mice induced by 3'-methyl-4-dimethylaminoazobenzeneR Yamamoto
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Virchows Arch 425:79-82. 1994..The present results indicate that sialoadenectomy inhibits the development of hepatocellular tumours induced by 3'-Me-DAB in male mice, an effect which may be caused by decrease in the serum level of EGF...
Endoscopic submucosal dissection for early gastric cancer performed by supervised residents: assessment of feasibility and learning curveShunsuke Yamamoto
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
Endoscopy 41:923-8. 2009..We investigated whether it was feasible for novice endoscopists to perform ESD for EGC, and how difficult it was to learn the procedure...
Infrared endoscopic system for detection of bleeding points during endoscopic resectionR Ishihara
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Endoscopy 39:E329-30. 2007
Suppressive effect of estrogen on hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzeneR Yamamoto
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Exp Toxicol Pathol 45:325-8. 1993..The present results suggest that the ovarian hormone, estrogen suppresses the development of hepatocellular tumors induced by 3'-Me-DAB, exerting its effect from about 6 months of age...
Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective studyN Hanaoka
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Endoscopy 44:1007-11. 2012..Stricture decreases quality of life and requires multiple endoscopic balloon dilation (EBD) sessions. We investigated the efficacy and safety of a single session of intralesional steroid injections to prevent post-ESD stricture...
Promotion by ethanol of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar ratsH Iishi
Department of Gastrointestinal Oncology, Centre for Adult Diseases, Osaka, Japan
Br J Cancer 59:719-21. 1989..These findings indicate that EtOH promotes gastric carcinogenesis, and that this effect may be related to its effect in increasing proliferation of the antral epithelial cells...
Flat gastric epithelial neoplasm detected by endoscopic screening with autofluorescence imaging video endoscopyK Tatsumi
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Endoscopy 39:E289. 2007
Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethaneM Tasuta
Department of Gastrointestinal Oncology, The Center for Adult Diseases, Osaka, Japan
Br J Cancer 62:368-71. 1990..These findings indicate that neurotensin enhanced the growth of colon tumours, possibly related to its effect in increasing proliferation of colon cancer cells...
A new method of diagnosing gastric intestinal metaplasia: narrow-band imaging with magnifying endoscopyN Uedo
Deparment of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Endoscopy 38:819-24. 2006..The aim of the present study was to clarify the value of NBI-ME for diagnosing gastric intestinal metaplasia...
Correlation between serum prolactin levels and hepatocellular tumorigenesis induced by 3'-methyl-4-dimethylaminoazobenzene in miceR Yamamoto
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan
Br J Cancer 72:17-21. 1995..Thus, it is possible that the suppressive effect of oestrogen on liver tumorigenesis in mice is mediated, at least in part, by prolactin...
Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasm of the pancreasH Uehara
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari, Osaka 537 8511, Japan
Gut 57:1561-5. 2008..The development of ductal carcinoma of the pancreas during follow-up of branch duct IPMNs was investigated...
Endoscopic resection with a two-channel videoendoscope for gastric carcinoid tumorsK Higashino
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Hepatogastroenterology 51:269-72. 2004..To completely remove these tumors, we used a two-channel videoendoscope with which both grasping forceps and a polypectomy snare could be used simultaneously...
Effectiveness of manual cleaning and disinfection of gastroendoscopes with 3% glutaraldehyde for decreasing risk of transmission of hepatitis C virusN Sakai
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Am J Gastroenterol 96:1803-6. 2001..CONCLUSION: Manual cleaning and disinfection of gastroscopes with 3% glutaraldehyde is useful for decreasing the risk of transmission of HCV among patients...
Pre-medication with pronase reduces artefacts during endoscopic ultrasonographyN Sakai
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Aliment Pharmacol Ther 18:327-32. 2003..Gastric mucus usually induces artefacts during endoscopic ultrasonography...
Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholineM Baba
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Gene Ther 8:1149-56. 2001..These results indicate that the bcl-xs plasmid inhibits the occurrence and growth of rat hepatocellular carcinoma and may thus be effective for the prevention and treatment of human liver tumors...
