M Yasuda

Summary

Affiliation: Hyogo Institute for Aging Brain and Cognitive Disorders
Country: Japan

Publications

  1. ncbi BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110, USA
    Cancer Res 59:533-7. 1999
  2. ncbi A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation
    M Yasuda
    Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 55:1224-7. 2000
  3. ncbi A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 56:65-9. 1999
  4. pmc Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 68:220-3. 2000
  5. ncbi A novel missense mutation in the presenilin-1 gene in a familial Alzheimer's disease pedigree with abundant amyloid angiopathy
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 232:29-32. 1997
  6. ncbi Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease
    M Yasuda
    Division of Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 155:779-84. 1998
  7. ncbi Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
  8. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
  9. ncbi Phosphorylation of tau is regulated by PKN
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670 0981, Japan
    J Biol Chem 276:10025-31. 2001
  10. ncbi The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002

Collaborators

Detail Information

Publications35

  1. ncbi BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110, USA
    Cancer Res 59:533-7. 1999
    ..These results suggest that although BNIP3 and BNIP3alpha may promote apoptosis simultaneously in most human tissues, BNIP3alpha may play a more universal role...
  2. ncbi A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation
    M Yasuda
    Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 55:1224-7. 2000
    ..This study substantiates the notion that tau mutations at codon 301 can show various phenotypes...
  3. ncbi A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 56:65-9. 1999
    ..To disclose a novel mutation of the presenilin 1 (PS1) gene responsible for early-onset Alzheimer disease and to clarify genotype-phenotype correlation that should help to establish the function of this protein...
  4. pmc Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 68:220-3. 2000
    ..Mutations in PS1 induce increased production of Abeta42(43), resulting in an enhanced overall deposition of Abeta protein within the cerebral cortex...
  5. ncbi A novel missense mutation in the presenilin-1 gene in a familial Alzheimer's disease pedigree with abundant amyloid angiopathy
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 232:29-32. 1997
    ..These results indicate that a mutation at the C-terminus of the third transmembrane domain in the presenilin-1, which is a novel site for mutations, may play a key role in Alzheimer's pathogenesis...
  6. ncbi Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease
    M Yasuda
    Division of Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 155:779-84. 1998
    ..The aim of this study was to examine the relationship between the APOE epsilon 4 allele and whole brain atrophy...
  7. ncbi Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
    ..The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele...
  8. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
    ..The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer's disease...
  9. ncbi Phosphorylation of tau is regulated by PKN
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670 0981, Japan
    J Biol Chem 276:10025-31. 2001
    ..Thus PKN serves as a regulator of microtubules by specific phosphorylation of tau, which leads to disruption of tubulin assembly...
  10. ncbi The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002
    ..One possible reason for this controversy is that previous studies did not consider the effect of patient age at symptom onset...
  11. ncbi Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
    M Hashimoto
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 57:1461-6. 2001
    ..Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial...
  12. pmc Case-control study of presenilin-1 intronic polymorphism in sporadic early and late onset Alzheimer's disease
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji
    J Neurol Neurosurg Psychiatry 66:722-6. 1999
    ..The purpose of this study is to determine whether Alzheimer's disease is associated with presenilin-1 gene polymorphism and the apolipoprotein E genotype in an extended case-control study...
  13. ncbi Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia
    N Hirono
    Divisions of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:1263-8. 2000
    ..We studied the association between the apoE epsilon4 allele and white matter hyperintensities (WMHs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia...
  14. pmc Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease
    Y Yamamoto
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Himeji, Japan
    J Neurol Neurosurg Psychiatry 67:94-6. 1999
    ..In the Japanese population studied here, there was no association between BChE-K and Alzheimer's disease, nor an interaction between BChE-K and APOE epsilon4 allele...
  15. ncbi Cloning of the cDNA encoding rat Presenilin-1
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Gene 186:73-5. 1997
    ..7%). Northern blot analysis of the rat PS-1 cDNA revealed two mRNA species in rat neurotypic pheochromocytoma and glioma cell lines (PC-12 and C6, respectively) that migrated at rates corresponding to approximately 3.0 and 7.5 kb...
  16. ncbi A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 53:864-8. 1999
    ..The similarities between these two families suggest a common genetic mechanism that may account for the peculiar distribution of neuroglial degeneration with tauopathy...
  17. ncbi Delusions of oral parasitosis
    K Maeda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 22:243-8. 1998
    ..3. The authors examined the effect of pimozide, whose efficacy on delusional skin parasitosis has been proven. Taking the neuroleptic at a dose of 2 mg daily relieved the symptoms...
  18. ncbi Clinical and genetic studies of families with the tau N279K mutation (FTDP-17)
    Y Tsuboi
    Mayo Clinic, Jacksonville, FL 32224, USA
    Neurology 59:1791-3. 2002
    ..A founder effect indicated by a shared disease haplotype was seen only in two Japanese families. The N279K mutation can develop independently in different parts of the world...
  19. ncbi Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110, USA
    Oncogene 17:2525-30. 1998
    ..Our results suggest that ceBNIP3 may be a novel component of the C. elegans apoptosis paradigm and may initiate apoptosis by recruiting CED-3 to mitochondria and other cytoplasmic membranes...
  20. pmc Rapidly progressive dementia syndrome associated with a novel four extra repeat mutation in the prion protein gene
    C Yanagihara
    Department of Neurology, Nishi Kobe Medical Center, Kobe 651 2273, Japan
    J Neurol Neurosurg Psychiatry 72:788-91. 2002
    ....
  21. ncbi CD44: functional relevance to inflammation and malignancy
    M Yasuda
    The Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Histol Histopathol 17:945-50. 2002
    ....
  22. ncbi Mitochondria in platinum resistant cells
    S Isonishi
    Department of Obstetrics/Gynecology, Jikei University School of Medicine
    Hum Cell 14:203-10. 2001
    ..These data are strongly suggesting that changes at MT level would impact on the relative resistance of malignant cells to undergo drug-induced apoptosis...
  23. ncbi Fas gene promoter -670 polymorphism in gynecological cancer
    M Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki Osaka, Japan
    Int J Gynecol Cancer 16:179-82. 2006
    ..60, 95% CI = 1.05-2.43) compared with the A allele. Germ-line polymorphism of Fas gene promoter -670 may be associated with the risk of cervical cancer in a Japanese population...
  24. ncbi CD44 stimulation down-regulates Fas expression and Fas-mediated apoptosis of lung cancer cells
    M Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
    Int Immunol 13:1309-19. 2001
    ..This leads to reduced susceptibility of the cells to CTL-mediated cytotoxicity through the Fas-Fas ligand pathway...
  25. ncbi A morphometric study on postnatal development of the external granular layer of mice cerebella, focusing on local difference
    S Yamasaki
    Institute of Health Sciences, Faculty of Medicine, Hiroshima University, Japan
    Hiroshima J Med Sci 50:53-60. 2001
    ..These data may serve as the basis for studies on regional differentiation of the cerebellum...
  26. ncbi Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO
    Y Morita
    Osaka Organic Chemical Industry, Ltd, Kashiwara, Japan
    Biol Pharm Bull 24:607-11. 2001
    ..The acute toxicity of alpha-thujaplicin [50% lethal dose (LD50) value: 256 mg/kg] in mice was as strong as those of beta-dolabrin (LD50 value: 232 mg/kg) and gamma-thujaplicin (LD50 value: 277 mg/kg)...
  27. ncbi Complete primary structure of chicken cardiac C-protein (MyBP-C) and its expression in developing striated muscles
    M Yasuda
    Department of Biology, Faculty of Science, Chiba University, Japan
    J Mol Cell Cardiol 27:2275-86. 1995
    ..Northern blot analysis with the cloned cDNA as a probe demonstrated that mRNA of 5.0 kb is transcribed in both cardiac and embryonic skeletal muscle, and that it is specifically expressed in cardiac muscle among adult tissues...
  28. ncbi Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function
    T Miyakawa
    Laboratory for Neurobiology of Emotion, Brain Science Institute, RIKEN, Hirosawa, Wako Shi, Saitama ken 351 01, Japan
    Science 278:698-701. 1997
    ..These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol...
  29. ncbi Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex
    N Kohmura
    Laboratory of Neurobiology and Behavioral Genetics, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Neuron 20:1137-51. 1998
    ..The diversity of the Cnr family genes suggests that there are molecular mechanisms that govern highly differentiated neural networks in the mammalian CNS...
  30. ncbi Interleukin-1 alpha enhances hepatotoxicity of tumor necrosis factor-alpha in galactosamine-sensitized mice
    J Nagakawa
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 13:485-98. 1991
    ..These results suggest that TNF plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that IL-1 alpha acts synergistically with TNF in this hepatitis model...
  31. ncbi Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin
    E Matsumura
    Osaka University of Pharmaceutical Sciences, Japan
    Biol Pharm Bull 24:299-302. 2001
    ..The acute toxicities [50% lethal dose (LD50) value: intraperitoneal injection, Van der Waedem] of gamma-thujaplicin and beta-dolabrin in mice were 277 mg/kg and 232 mg/kg, respectively...
  32. ncbi Stimulation of beta1 integrin down-regulates ICAM-1 expression and ICAM-1-dependent adhesion of lung cancer cells through focal adhesion kinase
    M Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu
    Cancer Res 61:2022-30. 2001
    ..Our results suggest that such processes can lead to the escape of lung cancer cells in vivo from immunological surveillance...
  33. ncbi Fabry disease: twenty novel alpha-galactosidase A mutations causing the classical phenotype
    G A Ashley
    Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hum Genet 46:192-6. 2001
    ..These studies further define the heterogeneity of mutations in the alpha-Gal A gene causing the classic Fabry disease phenotype, and permit precise heterozygote detection and prenatal diagnosis...
  34. pmc nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression
    M H Khan
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    Am J Pathol 158:1785-91. 2001
    ..These findings suggest that nm23-H1 inhibits the invasive activity of oral squamous cell carcinoma by suppression of cell motility without altering the MMP-2 and MMP-9 status...
  35. doi Purine contents of soybean-derived foods and selected Japanese vegetables and mushrooms
    K Kaneko
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Nucleosides Nucleotides Nucleic Acids 27:628-30. 2008
    ..3-171.8 mg/100 g; Japanese mushrooms, 9.5-142.3 mg/100 g. Since purine levels in these foods did not exceed 200 mg/100 g, we recommend that eating of them should be adopted and good dietary habits followed...