T Taniguchi

Summary

Affiliation: Hyogo Institute for Aging Brain and Cognitive Disorders
Country: Japan

Publications

  1. ncbi request reprint Phosphorylation of tau is regulated by PKN
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670 0981, Japan
    J Biol Chem 276:10025-31. 2001
  2. ncbi request reprint Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia
    M Nakai
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670-0981, Japan
    Neurochem Int 38:593-600. 2001
  3. ncbi request reprint Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS
    H Hasegawa
    Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji 670-0981, Japan
    Neuroreport 12:2567-71. 2001
  4. ncbi request reprint Cloning of the cDNA encoding rat Presenilin-1
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Gene 186:73-5. 1997
  5. ncbi request reprint Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's
    M Hatakeyama
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 244:551-6. 1989
  6. ncbi request reprint Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin
    M Ito
    Third Division, Kobe University School of Medicine, Japan
    J Biol Chem 268:18300-5. 1993
  7. ncbi request reprint Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene
    S Sakamoto
    Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783-8505, Japan
    J Biol Chem 276:37237-41. 2001
  8. ncbi request reprint Characterization of the DNA binding domain of the mouse IRF-2 protein
    K Uegaki
    Institute for Protein Research, Osaka University, Japan
    Protein Eng 6:195-200. 1993
  9. pmc Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction
    N Kobayashi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Proc Natl Acad Sci U S A 90:4201-5. 1993
  10. pmc Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
    Y Fujii
    Department of Molecular Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, USA
    EMBO J 18:5028-41. 1999

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Phosphorylation of tau is regulated by PKN
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670 0981, Japan
    J Biol Chem 276:10025-31. 2001
    ..Thus PKN serves as a regulator of microtubules by specific phosphorylation of tau, which leads to disruption of tubulin assembly...
  2. ncbi request reprint Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia
    M Nakai
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670-0981, Japan
    Neurochem Int 38:593-600. 2001
    ....
  3. ncbi request reprint Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS
    H Hasegawa
    Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji 670-0981, Japan
    Neuroreport 12:2567-71. 2001
    ..Our findings suggest involvement of the MAPK pathway through phosphoinositol 3-kinase in the phosphorylation of MARCKS in rat cultured microglia, an event may be associated with mechanisms activating microglia in AD...
  4. ncbi request reprint Cloning of the cDNA encoding rat Presenilin-1
    T Taniguchi
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Gene 186:73-5. 1997
    ..7%). Northern blot analysis of the rat PS-1 cDNA revealed two mRNA species in rat neurotypic pheochromocytoma and glioma cell lines (PC-12 and C6, respectively) that migrated at rates corresponding to approximately 3.0 and 7.5 kb...
  5. ncbi request reprint Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's
    M Hatakeyama
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 244:551-6. 1989
    ..Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA...
  6. ncbi request reprint Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin
    M Ito
    Third Division, Kobe University School of Medicine, Japan
    J Biol Chem 268:18300-5. 1993
    ..The availability of this receptor cDNA will help to clarify the precise role of CCK in the central nervous system as well as digestive organs...
  7. ncbi request reprint Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene
    S Sakamoto
    Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783-8505, Japan
    J Biol Chem 276:37237-41. 2001
    ..Moreover, a supershift assay indicated that Sp1 bound to this TRE in TPA-treated THP-1 cells. These results suggest that in TPA-treated cells the binding of Sp1 to the TRE of the IFNGR1 promoter causes the up-regulation of this gene...
  8. ncbi request reprint Characterization of the DNA binding domain of the mouse IRF-2 protein
    K Uegaki
    Institute for Protein Research, Osaka University, Japan
    Protein Eng 6:195-200. 1993
    ..These results showed that this peptide fragment, IRF-2(113), may be a good material for investigation of the DNA binding domain of IRF-2 and of the DNA-protein interaction...
  9. pmc Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction
    N Kobayashi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Proc Natl Acad Sci U S A 90:4201-5. 1993
    ..Taken together with previous results, our current study suggests that different src-PTKs, each of which is expressed in a cell-type-specific manner, can participate in the IL-2 signal transduction...
  10. pmc Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
    Y Fujii
    Department of Molecular Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, USA
    EMBO J 18:5028-41. 1999
    ..Our results provide new insights into the structure and function of this family of transcription factors...
  11. ncbi request reprint Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway
    Y Minami
    Institute for Molecular and Cellular Biology Osaka University, Japan
    Immunity 2:89-100. 1995
    ..Thus, Syk PTK may be a critical integral member of the signaling molecules engaged by the IL-2R...
  12. ncbi request reprint Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus
    N Hata
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
    Biochem Biophys Res Commun 285:518-25. 2001
    ..Thus, the constitutive IFN-alpha/beta signal provides a foundation for the IRF-7-mediated enhancement of its own production in response to virus infection...
  13. ncbi request reprint Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells
    X Wu
    Zhejiang Respiratory Drugs Research Laboratory of State Foods and Drugs Administration of China, Medical School of Zhejiang University, No 388 Yuhangtang Road, Hangzhou 310058, China
    Cell Death Differ 14:1792-801. 2007
    ....
  14. pmc Splice isoforms of alpha(1a)-adrenoceptor in rabbit
    F Suzuki
    Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
    Br J Pharmacol 129:1569-76. 2000
    ..3-AR had the highest potency of noradrenaline in functional studies in spite of the lowest receptor density. These findings suggest that the structure of C-terminus of alpha(1a)-ARs may give the characteristic functional profile...
  15. ncbi request reprint Cloning of rabbit alpha(1b)-adrenoceptor and pharmacological comparison of alpha(1a)-, alpha(1b)- and alpha(1d)-adrenoceptors in rabbit
    H Piao
    Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, 910 1193, Fukui, Japan
    Eur J Pharmacol 396:9-17. 2000
    ..These results indicate a high identity of structural and pharmacological profiles of three distinct alpha(1)-adrenoceptor subtypes between rabbit and other species, but there are species differences in their distribution...
  16. ncbi request reprint Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
    A Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Science 288:2357-60. 2000
    ..This aspect of signaling cross talk by IFNs may apply to other cytokines...
  17. ncbi request reprint Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase
    R Ohki
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 275:22627-30. 2000
    ..cyclin B1 regulation pathway. Thus, Reprimo may be a new member involved in the regulation of p53-dependent G(2) arrest of the cell cycle...
  18. ncbi request reprint Effect of asymmetric modification on the conformation of ascidiacyclamide analogs
    A Asano
    Osaka University of Pharmaceutical Sciences, Osaka, Japan
    J Pept Res 60:10-22. 2002
    ..In the cytotoxicity test using P388 cells, [Val1]ASC exhibited the strongest activity, whereas the epimers of ASC ([d-Ile1] and [Val3]ASCs), showed fairly moderate activities...
  19. ncbi request reprint Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
    M Sato
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Immunity 13:539-48. 2000
    ..These results demonstrate the essential and distinct roles of thetwo factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response...
  20. ncbi request reprint Leptin stimulates rat aortic smooth muscle cell proliferation and migration
    A Oda
    First Division, Department of Internal Medicine, Kobe University School of Medicine
    Kobe J Med Sci 47:141-50. 2001
    ..These results demonstrate that leptin is a proliferative and migratory factor for VSMC, implying that leptin may play a role in the formation and development of vascular lesions...
  21. ncbi request reprint Molecular characterization and nuclear localization of rat timeless-like gene product
    S Sakamoto
    Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783 8505, Japan
    Biochem Biophys Res Commun 279:131-8. 2000
    ..6% of transfected cells. These results suggest that the interaction of rPER2 with rTLP may influence the regulation of circadian clock components in nucleus after rPER2 is translocated into the nucleus...
  22. ncbi request reprint Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
    I Garcia-Higuera
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 7:249-62. 2001
    ..The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes...
  23. ncbi request reprint [Rapid acid extrusion response triggered by alpha-1a adrenoceptor in CHO cells]
    T Taniguchi
    Department of Pharmacology, School of Medicine, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Fukui 910-1193, Japan
    Nippon Yakurigaku Zasshi 118:283-8. 2001
    ....
  24. pmc Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells
    T Taniguchi
    Department of Pharmacology, School of Medicine, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Fukui 910-1193, Japan
    J Physiol 535:107-13. 2001
    ..alpha(1b) AR drives only the steady phase acid extrusion response, which is mainly mediated by NHEs other than NHE1...
  25. ncbi request reprint Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole
    J Kakimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Yamashina, Japan
    Eur J Pharmacol 417:59-67. 2001
    ..These results suggest that talipexole and pramipexole may have protective effects against the neurodegeneration, which is induced by intracellular accumulation of cytochrome c and alpha-synuclein...
  26. ncbi request reprint Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling
    Y Mitani
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
    Genes Cells 6:631-40. 2001
    ..Our results also suggest the assembly of cytokine receptor subunits, which may represent a 'receptosome'-like structure, allowing the unique signalling cross talks to occur...
  27. ncbi request reprint Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes
    R Yoshio
    Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, Japan
    Jpn J Pharmacol 86:189-95. 2001
    ..The present results show that many 5-HT-receptor antagonists and agonists have high affinity to alpha1-adrenoceptors, but suggest that there is deviation between their functional affinities and binding affinities for some drugs...
  28. ncbi request reprint Gene induction pathways mediated by distinct IRFs during viral infection
    T Nakaya
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan
    Biochem Biophys Res Commun 283:1150-6. 2001
    ..The differential utilization of these induction pathways for these genes during viral infection may reflect their distinct functional roles in the efficient antiviral response...
  29. ncbi request reprint Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Neurosci Res 64:553-63. 2001
    ..The counter regulatory control of GARG16 and RXRalpha mRNA expression is believed to be an example of a fine-tuned cellular mechanism to react to inflammatory stimuli...
  30. ncbi request reprint Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease
    S Shimohama
    Department of Neurology, Faculty of Medicine, Kyoto University, Japan
    Alzheimer Dis Assoc Disord 12:384-6. 1998
    ..Western analysis using a specific antibody showed that the protein levels for RACK1 were not significantly different in AD brains than in controls, indicating that RACK1 is preserved in AD...
  31. ncbi request reprint Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Neurosci Lett 255:57-60. 1998
    ..These observations suggest that p53-null mutation may influence the activation and proliferation of glial cells rather than neuronal death...
  32. ncbi request reprint Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family
    J Furui
    Institute for Protein Research, Osaka University, Suita, Osaka, 565, Japan
    Structure 6:491-500. 1998
    ..Elucidation of the structures of members of the IRF family is therefore useful to the understanding of the regulation and evolution of the immune system at the structural level...
  33. ncbi request reprint Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses
    S Takahashi
    Department of Immunology, Kochi Medical School, Japan
    FEBS Lett 368:455-60. 1995
    ..Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses...
  34. pmc Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
    T Matsuyama
    Amgen Institute, University of Toronto, Ontario, Canada
    Nucleic Acids Res 23:2127-36. 1995
    ..The expression pattern and DNA binding activities suggest that LSIRF plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells...
  35. pmc Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
    T Kurosaki
    Department of Cardiovascular Molecular Biology, Lederle Laboratories, Pearl River, New York 10965
    J Exp Med 179:1725-9. 1994
    ..These results suggest that the Src-PTK associated with BCR phosphorylates the tyrosine residue(s) of Syk upon receptor stimulation, enhancing the activity of Syk...
  36. pmc Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Mol Cell Biol 14:1500-9. 1994
    ..In addition, one potential IFN-gamma-activated sequence was found within the IRF-1 promoter. Thus, these results may shed light on the complex gene network involved in regulation of the IFN system...
  37. ncbi request reprint Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
    T Fujita
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 337:270-2. 1989
    ..This may be the first demonstration of the specific induction of silent chromosomal genes by transfection of a single transcription factor gene in mammalian cells...
  38. ncbi request reprint New human gene encoding a positive modulator of HIV Tat-mediated transactivation
    H Shibuya
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 357:700-2. 1992
    ..Furthermore, we provide evidence that expression of MSS1 enhances the Tat-mediated transactivation. Our results suggest that MSS1 has a key role in activation of HIV genes regulated by Tat...
  39. ncbi request reprint Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 58:729-39. 1989
    ..Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects...
  40. ncbi request reprint Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells
    T Taniguchi
    Medical Research Laboratory, Kochi Medical School, Japan
    Eur J Biochem 171:571-5. 1988
    ..These results suggest that the gene expression for poly(ADP-ribose) synthetase is depressed during the interferon-gamma-induced activation process of macrophage tumor cells...
  41. ncbi request reprint Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association
    M Hatakeyama
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 252:1523-8. 1991
    ..Treatment of T lymphocytes with IL-2 promotes p56lck kinase activity. These data suggest the participation of p56lck as a critical signaling molecule downstream of IL-2R via a novel interaction...
  42. pmc The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment
    H Shibuya
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nucleic Acids Res 18:3697-703. 1990
    ..By applying the RFLP linkage analysis, the IL-2R beta gene has been assigned to chromosome 22q12-13...
  43. ncbi request reprint Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene
    T Kawakami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    FEBS Lett 358:225-9. 1995
    ..These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation...
  44. ncbi request reprint Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma
    N Kobayashi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Gene 130:303-4. 1993
    ..The primary amino acid sequence deduced from the nucleotide sequence exhibits 70% overall similarity with human IL-2R gamma and, in particular, the predicted cytoplasmic region shows a higher degree of similarity (about 84.7%)...
  45. pmc Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
    T Miyazaki
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113, Japan
    Genes Dev 12:770-5. 1998
    ..Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway...
  46. ncbi request reprint cDNA cloning and characterization of neuron-specific enolase from chicken
    M Tanaka
    Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Japan
    Biochim Biophys Acta 1395:28-33. 1998
    ..Northern blot analysis has revealed that the mRNA for gamma-enolase (2.3 kb) is expressed in the brain and, to much less but significant extents, in the pituitary and adrenal gland of the chicken...
  47. ncbi request reprint Molecular cloning of bovine CD14 gene
    A Ikeda
    Institute of Society for Techno Innovation for Agriculture, Forestry and Fisheries, Ibaraki, Japan
    J Vet Med Sci 59:715-9. 1997
    ..Northern blot analysis revealed that CD14 mRNA (1.5 kb) was expressed in the lung. Expression of CD14 mRNA was stimulated about 2-fold in bovine peripheral blood macrophage activated with LPS in vitro...
  48. ncbi request reprint A new protein containing an SH2 domain that inhibits JAK kinases
    T A Endo
    Institute of Life Science, Kurume University, Aikawamachi, Japan
    Nature 387:921-4. 1997
    ..JAB and CIS appear to function as negative regulators in the JAK signalling pathway...
  49. ncbi request reprint Cloning, functional expression and tissue distribution of rabbit alpha1a-adrenoceptor
    S Miyamoto
    Department of Pharmacology, Fukui Medical School, Matsuoka, Japan
    Life Sci 60:2069-74. 1997
    ..Competitive RT/PCR has detected the mRNA in variety of rabbit tissues, especially abundantly in liver, vas deferens, brain, and aorta, but not in heart...
  50. ncbi request reprint Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor
    F Suzuki
    Department of Pharmacology, Fukui Medical School, Japan
    Biochim Biophys Acta 1323:6-11. 1997
    ..Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex...
  51. ncbi request reprint Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease
    H Matsushima
    Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Neurochem 67:317-23. 1996
    ....
  52. pmc A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes
    T Yamagata
    Third Department of Internal Medicine, Tokyo University, Japan
    Mol Cell Biol 16:1283-94. 1996
    ..These results suggest that a novel mechanism of gene regulation by "differential repression" is used by multiple members of repressor proteins with different repressive effects on the IFN-responsive genes...
  53. ncbi request reprint Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    K Yamaguchi
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Science 270:2008-11. 1995
    ..Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members...
  54. ncbi request reprint Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
    H Harada
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 259:971-4. 1993
    ..This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors...
  55. pmc The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    EMBO J 10:3191-7. 1991
    ..Our results indicate the critical role of the two Trp residues in the proper folding of the IL-2R beta extracellular domain and point to the general functional importance of the WS motif in the new cytokine receptor family...