Research Topics
| T TaniguchiSummaryAffiliation: Hyogo Institute for Aging Brain and Cognitive Disorders Country: Japan Publications
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Detail Information
Publications
Phosphorylation of tau is regulated by PKNT Taniguchi
Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670 0981, Japan
J Biol Chem 276:10025-31. 2001..Thus PKN serves as a regulator of microtubules by specific phosphorylation of tau, which leads to disruption of tubulin assembly...- Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microgliaM Nakai
Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji 670-0981, Japan
Neurochem Int 38:593-600. 2001.... - Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKSH Hasegawa
Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji 670-0981, Japan
Neuroreport 12:2567-71. 2001..Our findings suggest involvement of the MAPK pathway through phosphoinositol 3-kinase in the phosphorylation of MARCKS in rat cultured microglia, an event may be associated with mechanisms activating microglia in AD... - Cloning of the cDNA encoding rat Presenilin-1T Taniguchi
Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
Gene 186:73-5. 1997..7%). Northern blot analysis of the rat PS-1 cDNA revealed two mRNA species in rat neurotypic pheochromocytoma and glioma cell lines (PC-12 and C6, respectively) that migrated at rates corresponding to approximately 3.0 and 7.5 kb... - Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA'sM Hatakeyama
Institute for Molecular and Cellular Biology, Osaka University, Japan
Science 244:551-6. 1989..Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA... - Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrinM Ito
Third Division, Kobe University School of Medicine, Japan
J Biol Chem 268:18300-5. 1993..The availability of this receptor cDNA will help to clarify the precise role of CCK in the central nervous system as well as digestive organs... - Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain geneS Sakamoto
Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783-8505, Japan
J Biol Chem 276:37237-41. 2001..Moreover, a supershift assay indicated that Sp1 bound to this TRE in TPA-treated THP-1 cells. These results suggest that in TPA-treated cells the binding of Sp1 to the TRE of the IFNGR1 promoter causes the up-regulation of this gene... - Characterization of the DNA binding domain of the mouse IRF-2 proteinK Uegaki
Institute for Protein Research, Osaka University, Japan
Protein Eng 6:195-200. 1993..These results showed that this peptide fragment, IRF-2(113), may be a good material for investigation of the DNA binding domain of IRF-2 and of the DNA-protein interaction... 
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transductionN Kobayashi
Institute for Molecular and Cellular Biology, Osaka University, Japan
Proc Natl Acad Sci U S A 90:4201-5. 1993..Taken together with previous results, our current study suggests that different src-PTKs, each of which is expressed in a cell-type-specific manner, can participate in the IL-2 signal transduction...- Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequencesY Fujii
Department of Molecular Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, USA
EMBO J 18:5028-41. 1999..Our results provide new insights into the structure and function of this family of transcription factors... - Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathwayY Minami
Institute for Molecular and Cellular Biology Osaka University, Japan
Immunity 2:89-100. 1995..Thus, Syk PTK may be a critical integral member of the signaling molecules engaged by the IL-2R... - Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virusN Hata
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Biochem Biophys Res Commun 285:518-25. 2001..Thus, the constitutive IFN-alpha/beta signal provides a foundation for the IRF-7-mediated enhancement of its own production in response to virus infection... - Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cellsX Wu
Zhejiang Respiratory Drugs Research Laboratory of State Foods and Drugs Administration of China, Medical School of Zhejiang University, No 388 Yuhangtang Road, Hangzhou 310058, China
Cell Death Differ 14:1792-801. 2007.... - Splice isoforms of alpha(1a)-adrenoceptor in rabbitF Suzuki
Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
Br J Pharmacol 129:1569-76. 2000..3-AR had the highest potency of noradrenaline in functional studies in spite of the lowest receptor density. These findings suggest that the structure of C-terminus of alpha(1a)-ARs may give the characteristic functional profile... - Cloning of rabbit alpha(1b)-adrenoceptor and pharmacological comparison of alpha(1a)-, alpha(1b)- and alpha(1d)-adrenoceptors in rabbitH Piao
Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, 910 1193, Fukui, Japan
Eur J Pharmacol 396:9-17. 2000..These results indicate a high identity of structural and pharmacological profiles of three distinct alpha(1)-adrenoceptor subtypes between rabbit and other species, but there are species differences in their distribution... - Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domainsA Takaoka
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Science 288:2357-60. 2000..This aspect of signaling cross talk by IFNs may apply to other cytokines... - Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phaseR Ohki
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 275:22627-30. 2000..cyclin B1 regulation pathway. Thus, Reprimo may be a new member involved in the regulation of p53-dependent G(2) arrest of the cell cycle... - Effect of asymmetric modification on the conformation of ascidiacyclamide analogsA Asano
Osaka University of Pharmaceutical Sciences, Osaka, Japan
J Pept Res 60:10-22. 2002..In the cytotoxicity test using P388 cells, [Val1]ASC exhibited the strongest activity, whereas the epimers of ASC ([d-Ile1] and [Val3]ASCs), showed fairly moderate activities... - Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionM Sato
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
Immunity 13:539-48. 2000..These results demonstrate the essential and distinct roles of thetwo factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response... - Leptin stimulates rat aortic smooth muscle cell proliferation and migrationA Oda
First Division, Department of Internal Medicine, Kobe University School of Medicine
Kobe J Med Sci 47:141-50. 2001..These results demonstrate that leptin is a proliferative and migratory factor for VSMC, implying that leptin may play a role in the formation and development of vascular lesions... - Molecular characterization and nuclear localization of rat timeless-like gene productS Sakamoto
Laboratory of Molecular Biology, Medical Research Center, Kochi Medical School, Okoh, Nankoku, Kochi 783 8505, Japan
Biochem Biophys Res Commun 279:131-8. 2000..6% of transfected cells. These results suggest that the interaction of rPER2 with rTLP may influence the regulation of circadian clock components in nucleus after rPER2 is translocated into the nucleus... - Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayI Garcia-Higuera
Department of Pediatric Oncology, Dana Farber Cancer Institute, and Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 7:249-62. 2001..The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes... - [Rapid acid extrusion response triggered by alpha-1a adrenoceptor in CHO cells]T Taniguchi
Department of Pharmacology, School of Medicine, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Fukui 910-1193, Japan
Nippon Yakurigaku Zasshi 118:283-8. 2001.... - Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cellsT Taniguchi
Department of Pharmacology, School of Medicine, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Fukui 910-1193, Japan
J Physiol 535:107-13. 2001..alpha(1b) AR drives only the steady phase acid extrusion response, which is mainly mediated by NHEs other than NHE1... - Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexoleJ Kakimura
Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Yamashina, Japan
Eur J Pharmacol 417:59-67. 2001..These results suggest that talipexole and pramipexole may have protective effects against the neurodegeneration, which is induced by intracellular accumulation of cytochrome c and alpha-synuclein... - Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signallingY Mitani
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Genes Cells 6:631-40. 2001..Our results also suggest the assembly of cytokine receptor subunits, which may represent a 'receptosome'-like structure, allowing the unique signalling cross talks to occur... - Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypesR Yoshio
Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, Japan
Jpn J Pharmacol 86:189-95. 2001..The present results show that many 5-HT-receptor antagonists and agonists have high affinity to alpha1-adrenoceptors, but suggest that there is deviation between their functional affinities and binding affinities for some drugs... - Gene induction pathways mediated by distinct IRFs during viral infectionT Nakaya
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan
Biochem Biophys Res Commun 283:1150-6. 2001..The differential utilization of these induction pathways for these genes during viral infection may reflect their distinct functional roles in the efficient antiviral response... - Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microgliaY Kitamura
Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
J Neurosci Res 64:553-63. 2001..The counter regulatory control of GARG16 and RXRalpha mRNA expression is believed to be an example of a fine-tuned cellular mechanism to react to inflammatory stimuli... - Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer diseaseS Shimohama
Department of Neurology, Faculty of Medicine, Kyoto University, Japan
Alzheimer Dis Assoc Disord 12:384-6. 1998..Western analysis using a specific antibody showed that the protein levels for RACK1 were not significantly different in AD brains than in controls, indicating that RACK1 is preserved in AD... - Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouseY Kitamura
Department of Neurobiology, Kyoto Pharmaceutical University, Japan
Neurosci Lett 255:57-60. 1998..These observations suggest that p53-null mutation may influence the activation and proliferation of glial cells rather than neuronal death... - Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix familyJ Furui
Institute for Protein Research, Osaka University, Suita, Osaka, 565, Japan
Structure 6:491-500. 1998..Elucidation of the structures of members of the IRF family is therefore useful to the understanding of the regulation and evolution of the immune system at the structural level... - Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapsesS Takahashi
Department of Immunology, Kochi Medical School, Japan
FEBS Lett 368:455-60. 1995..Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses... - Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)T Matsuyama
Amgen Institute, University of Toronto, Ontario, Canada
Nucleic Acids Res 23:2127-36. 1995..The expression pattern and DNA binding activities suggest that LSIRF plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells... - Syk activation by the Src-family tyrosine kinase in the B cell receptor signalingT Kurosaki
Department of Cardiovascular Molecular Biology, Lederle Laboratories, Pearl River, New York 10965
J Exp Med 179:1725-9. 1994..These results suggest that the Src-PTK associated with BCR phosphorylates the tyrosine residue(s) of Syk upon receptor stimulation, enhancing the activity of Syk... - Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon systemH Harada
Institute for Molecular and Cellular Biology, Osaka University, Japan
Mol Cell Biol 14:1500-9. 1994..In addition, one potential IFN-gamma-activated sequence was found within the IRF-1 promoter. Thus, these results may shed light on the complex gene network involved in regulation of the IFN system... - Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1T Fujita
Institute for Molecular and Cellular Biology, Osaka University, Japan
Nature 337:270-2. 1989..This may be the first demonstration of the specific induction of silent chromosomal genes by transfection of a single transcription factor gene in mammalian cells... - New human gene encoding a positive modulator of HIV Tat-mediated transactivationH Shibuya
Institute for Molecular and Cellular Biology, Osaka University, Japan
Nature 357:700-2. 1992..Furthermore, we provide evidence that expression of MSS1 enhances the Tat-mediated transactivation. Our results suggest that MSS1 has a key role in activation of HIV genes regulated by Tat... - Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genesH Harada
Institute for Molecular and Cellular Biology, Osaka University, Japan
Cell 58:729-39. 1989..Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects... - Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cellsT Taniguchi
Medical Research Laboratory, Kochi Medical School, Japan
Eur J Biochem 171:571-5. 1988..These results suggest that the gene expression for poly(ADP-ribose) synthetase is depressed during the interferon-gamma-induced activation process of macrophage tumor cells... - Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular associationM Hatakeyama
Institute for Molecular and Cellular Biology, Osaka University, Japan
Science 252:1523-8. 1991..Treatment of T lymphocytes with IL-2 promotes p56lck kinase activity. These data suggest the participation of p56lck as a critical signaling molecule downstream of IL-2R via a novel interaction... - The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignmentH Shibuya
Institute for Molecular and Cellular Biology, Osaka University, Japan
Nucleic Acids Res 18:3697-703. 1990..By applying the RFLP linkage analysis, the IL-2R beta gene has been assigned to chromosome 22q12-13... - Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta geneT Kawakami
Institute for Molecular and Cellular Biology, Osaka University, Japan
FEBS Lett 358:225-9. 1995..These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation... - Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gammaN Kobayashi
Institute for Molecular and Cellular Biology, Osaka University, Japan
Gene 130:303-4. 1993..The primary amino acid sequence deduced from the nucleotide sequence exhibits 70% overall similarity with human IL-2R gamma and, in particular, the predicted cytoplasmic region shows a higher degree of similarity (about 84.7%)... - Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwayT Miyazaki
Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113, Japan
Genes Dev 12:770-5. 1998..Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway... - cDNA cloning and characterization of neuron-specific enolase from chickenM Tanaka
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Japan
Biochim Biophys Acta 1395:28-33. 1998..Northern blot analysis has revealed that the mRNA for gamma-enolase (2.3 kb) is expressed in the brain and, to much less but significant extents, in the pituitary and adrenal gland of the chicken... - Molecular cloning of bovine CD14 geneA Ikeda
Institute of Society for Techno Innovation for Agriculture, Forestry and Fisheries, Ibaraki, Japan
J Vet Med Sci 59:715-9. 1997..Northern blot analysis revealed that CD14 mRNA (1.5 kb) was expressed in the lung. Expression of CD14 mRNA was stimulated about 2-fold in bovine peripheral blood macrophage activated with LPS in vitro... - A new protein containing an SH2 domain that inhibits JAK kinasesT A Endo
Institute of Life Science, Kurume University, Aikawamachi, Japan
Nature 387:921-4. 1997..JAB and CIS appear to function as negative regulators in the JAK signalling pathway... - Cloning, functional expression and tissue distribution of rabbit alpha1a-adrenoceptorS Miyamoto
Department of Pharmacology, Fukui Medical School, Matsuoka, Japan
Life Sci 60:2069-74. 1997..Competitive RT/PCR has detected the mRNA in variety of rabbit tissues, especially abundantly in liver, vas deferens, brain, and aorta, but not in heart... - Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptorF Suzuki
Department of Pharmacology, Fukui Medical School, Japan
Biochim Biophys Acta 1323:6-11. 1997..Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex... - Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's diseaseH Matsushima
Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan
J Neurochem 67:317-23. 1996.... - A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genesT Yamagata
Third Department of Internal Medicine, Tokyo University, Japan
Mol Cell Biol 16:1283-94. 1996..These results suggest that a novel mechanism of gene regulation by "differential repression" is used by multiple members of repressor proteins with different repressive effects on the IFN-responsive genes... - Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionK Yamaguchi
Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
Science 270:2008-11. 1995..Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members... - Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2H Harada
Institute for Molecular and Cellular Biology, Osaka University, Japan
Science 259:971-4. 1993..This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors... - The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transductionT Miyazaki
Institute for Molecular and Cellular Biology, Osaka University, Japan
EMBO J 10:3191-7. 1991..Our results indicate the critical role of the two Trp residues in the proper folding of the IL-2R beta extracellular domain and point to the general functional importance of the WS motif in the new cytokine receptor family...