Tadayuki Oshima

Summary

Affiliation: Hyogo College of Medicine
Country: Japan

Publications

  1. ncbi request reprint Successful endoscopic submucosal dissection of gastric carcinoid in a patient with autoimmune gastritis and systemic lupus erythematosus
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
    Intern Med 51:1211-3. 2012
  2. doi request reprint Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 92:22-31. 2012
  3. doi request reprint Genetic factors for functional dyspepsia
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol Hepatol 26:83-7. 2011
  4. doi request reprint Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Physiol Cell Physiol 295:C800-6. 2008
  5. ncbi request reprint Wip1 protects hydrogen peroxide-induced colonic epithelial barrier dysfunction
    T Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cell Mol Life Sci 64:3139-47. 2007
  6. doi request reprint Changes in the expression of claudins in active ulcerative colitis
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 23:S146-50. 2008
  7. doi request reprint The incidence of "silent" free air and aspiration pneumonia detected by CT after gastric endoscopic submucosal dissection
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Gastrointest Endosc 76:1116-23. 2012
  8. doi request reprint Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection
    Toshihiko Tomita
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    J Gastroenterol Hepatol 27:1441-6. 2012
  9. doi request reprint Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011
  10. ncbi request reprint Helicobacter pylori eradication decreases the expression of glycosylphosphatidylinositol-anchored complement regulators, decay-accelerating factor and homologous restriction factor 20, in human gastric epithelium
    Takashi Joh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Japan
    J Gastroenterol Hepatol 20:1344-51. 2005

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Successful endoscopic submucosal dissection of gastric carcinoid in a patient with autoimmune gastritis and systemic lupus erythematosus
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Japan
    Intern Med 51:1211-3. 2012
    ..Type I gastric carcinoid can occur at an earlier age with AIG and autoimmune diseases such as systemic lupus erythematosus (SLE). This is the first report of gastric carcinoid that was treated by ESD...
  2. doi request reprint Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 92:22-31. 2012
    ..In conclusion, TJs are located in the superficial layers of the esophagus, and acid stimulation disrupts barrier function, at least in part by modulating the amount and localization of claudin-4 in the superficial layers...
  3. doi request reprint Genetic factors for functional dyspepsia
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol Hepatol 26:83-7. 2011
    ..Several reports indicate the associations between FD and gene polymorphisms, however the data are inconsistent. This review summarized the evidence of genetics in FD based on genetic epidemiology...
  4. doi request reprint Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Physiol Cell Physiol 295:C800-6. 2008
    ..These results demonstrate, for the first time, that claudin-7 protein is important in aspirin-induced gastric barrier loss and that p38 MAPK activity mediates this epithelial barrier dysfunction...
  5. ncbi request reprint Wip1 protects hydrogen peroxide-induced colonic epithelial barrier dysfunction
    T Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cell Mol Life Sci 64:3139-47. 2007
    ..This is the first study to demonstrate that exogenous Wip1 functions to protect oxidative stress-mediated colonic mucosal permeability and that H2O2-induced claudin-4 dislocalization is abolished by Wip1...
  6. doi request reprint Changes in the expression of claudins in active ulcerative colitis
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 23:S146-50. 2008
    ..Because epithelial barrier function is primarily regulated by the most apical intercellular junction, referred to as the tight junction (TJ), we investigated the expression of TJ proteins on rectal epithelial mucosa in UC...
  7. doi request reprint The incidence of "silent" free air and aspiration pneumonia detected by CT after gastric endoscopic submucosal dissection
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Gastrointest Endosc 76:1116-23. 2012
    ....
  8. doi request reprint Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection
    Toshihiko Tomita
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    J Gastroenterol Hepatol 27:1441-6. 2012
    ..We prospectively compared the effects of omeprazole and famotidine in preventing delayed bleeding and promoting artificial ulcer healing after ESD...
  9. doi request reprint Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011
    ..In conclusion, acidic bile salts disrupted the squamous epithelial barrier function partly by modulating the amounts of claudin-1 and claudin-4. These results provide new insights for understanding the role of TJ proteins in esophagitis...
  10. ncbi request reprint Helicobacter pylori eradication decreases the expression of glycosylphosphatidylinositol-anchored complement regulators, decay-accelerating factor and homologous restriction factor 20, in human gastric epithelium
    Takashi Joh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Japan
    J Gastroenterol Hepatol 20:1344-51. 2005
    ..pylori stimulus. Furthermore, the expression of the complement fragment, C3c, was also investigated...
  11. doi request reprint Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin
    Yongmin Kim
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Gastroenterol 47:904-11. 2012
    ..We elucidated the endoscopic characteristics of gastric ulcers that occurred in the presence or absence of H. pylori infection and were associated with the use of these drugs...
  12. doi request reprint Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers
    Takuya Okugawa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Dig Dis Sci 57:1562-7. 2012
    ..Claudins are tight junction (TJ) proteins, and the relationship between the level of expression and localization of TJ protein, and tumor aggressiveness in early gastric cancer (GC) is still far from clear...
  13. doi request reprint Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects
    Takahisa Yamasaki
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Gastroenterol 48:360-5. 2013
    ..The aim of this study was to examine the impact of age on esophageal sensation, and to determine whether esophageal mechanosensitivity and chemosensitivity are correlated in healthy Japanese subjects...
  14. doi request reprint Oxidative stress induces gastric epithelial permeability through claudin-3
    Kayo Hashimoto
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Biochem Biophys Res Commun 376:154-7. 2008
    ..This is the first study to demonstrate that claudin-3 is involved in the barrier function of gastric epithelial cells and that rebamipide abolishes the H2O2-induced decrease in claudin-3 protein...
  15. pmc Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population
    Fumihiko Toyoshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    BMC Med Genet 12:88. 2011
    ..In the present study, the association between serotonin transporter (SERT) gene (SLC6A4) polymorphism and FD was explored...
  16. doi request reprint Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach
    Kanako Watanabe
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    J Gastroenterol 43:322-6. 2008
    ..The present study identified what types of NMDA receptor subunits are expressed in the rat stomach and examined whether vagotomy affects their expression...
  17. doi request reprint Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers
    Takashi Kondo
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G568-73. 2013
    ..80, P = 0.029). EP1 mRNA and protein expression were observed in the normal human esophageal mucosa. Esophageal PGE(2) expression is associated with mucosal acid exposure and heartburn...
  18. doi request reprint Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat
    Toshihiko Tomita
    Division of Upper Gastroenterology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol Hepatol 28:106-11. 2013
    ..Therefore, to clarify the usefulness of scintigraphy as a technique for assessing gastric accommodation, we compared scintigraphy with barostat, the gold standard modality...
  19. doi request reprint Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G199-208. 2012
    ..These results provide new insights into understanding the role of TJ proteins in esophagitis...
  20. pmc The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia
    Tadayuki Oshima
    Divisions of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, 663 8501, Japan
    BMC Med Genet 11:13. 2010
    ..In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up...
  21. doi request reprint Non-erosive reflux disease rather than cervical inlet patch involves globus
    Kazutoshi Hori
    Department of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol 45:1138-45. 2010
    ..This study aimed to reveal whether these two conditions were associated with globus...
  22. ncbi request reprint Bone morphogenetic protein 2 induced differentiation toward superficial epithelial cells in the gastric mucosa
    Keisuke Itoh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya, 467 8601, Japan
    J Gastroenterol 41:1064-75. 2006
    ..Moreover, diffusible factors from the underlying mesenchyme control the proliferation and differentiation of the epithelial cells. However, the details of the associated signaling remain unknown...
  23. ncbi request reprint Advantages of endoscopic submucosal dissection over conventional endoscopic mucosal resection
    Takaya Shimura
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Gastroenterol Hepatol 22:821-6. 2007
    ..The efficacy and problems associated with endoscopic submucosal dissection were evaluated by comparison with conventional endoscopic mucosal resection...
  24. doi request reprint Endoscopically treated Cronkhite-Canada syndrome associated with minute intramucosal gastric cancer: an analysis of molecular pathology
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Dig Endosc 23:319-23. 2011
    ..From the viewpoint of genetic alterations, patients with CCS polyps are considered to be at high risk for developing gastric cancer, and therefore careful follow-up examinations are necessary for the early detection of malignancies...
  25. doi request reprint Role of transient receptor potential ankyrin 1 in gastric accommodation in conscious guinea pigs
    Junichi Koseki
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    J Pharmacol Exp Ther 341:205-12. 2012
    ..We established a new model for measuring gastric tone and accommodation in conscious guinea pigs. TRPA1 activation suppresses gastric accommodation by increasing gastric tone through cholinergic neuronal pathways...
  26. doi request reprint Establishment of esophageal-like non-keratinized stratified epithelium using normal human bronchial epithelial cells
    Tadayuki Oshima
    Division of Upper Gastroenterology, Dept of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Am J Physiol Cell Physiol 300:C1422-9. 2011
    ..With respect to morphology, molecular markers, barrier properties, and acid resistance, this model presents a new way to investigate barrier properties and the possible effects of different agents on human esophagus-like epithelium...
  27. ncbi request reprint Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration
    Takashi Joh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G230-4. 2005
    ..Inhibited recovery of permeability on exposure to an ulcerogenic RX-77368 dose or on exposure to HCl plus a submaximal dose of RX-77368 may be crucial for the induction of gastric mucosal lesions by central RX-77368 administration...
  28. ncbi request reprint Oral vaccination against Helicobacter pylori with recombinant cholera toxin B-subunit
    Eiji Kubota
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Kawasumi Mizuho, Nagoya 467 8601, Japan
    Helicobacter 10:345-52. 2005
    ..The immunoadjuvanticity of rCTB against H. pylori was tested...
  29. doi request reprint Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model
    Jing Shan
    Division of Upper Gastroenterology, Dept of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G1105-12. 2012
    ..Under proton pump inhibitor therapy, refluxed trypsin may remain active and be a potential agent in the pathogenesis of refractory GERD...
  30. pmc Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of Helicobacter pylori eradication
    Jiro Watari
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Int J Cancer 130:2349-58. 2012
    ..MSI or Das-1 reactivity in IM strongly predicts the development of MGC. Patients in whom these biomarkers persist after eradication may therefore have a high risk of developing MGC...
  31. doi request reprint Abdominal ultrasonography as a new modality for the diagnosis of gastroesophageal reflux disease
    Toshihiko Tomita
    Department of Internal Medicine, Gastroenterology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol Hepatol 25:S45-8. 2010
    ....
  32. doi request reprint Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Gastroenterol 45:478-87. 2010
    ..A traditional Japanese medicine, rikkunshito, has been reported to relieve dyspepsia symptoms. We investigated the effect of rikkunshito on RE-induced abdominal dyspepsia, and performed experiments to elucidate the mechanism of that effect...
  33. doi request reprint Current understanding of pathogenesis of functional dyspepsia
    Hiroto Miwa
    Division of Upper, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol Hepatol 26:53-60. 2011
    ....
  34. doi request reprint Small gastrointestinal stromal tumor of the stomach showing rapid growth and early metastasis to the liver
    Junji Tanaka
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Dig Endosc 22:354-6. 2010
    ..Liver metastasis was found 6 months postoperatively, and molecular target therapy was carried out. However, the patient died 2 years after the finding of liver metastasis...
  35. ncbi request reprint Prevalence of gastric cancer decreases with age in long-living elderly in Japan, possibly due to changes in Helicobacter pylori infection status
    Masaya Kawade
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Japan
    J Gastroenterol Hepatol 20:1333-7. 2005
    ..However, no studies have investigated people older than 65 years in detail. In this study, we investigated the prevalence of Hp infection and gastric cancer in the elderly, and analyzed the influence of both factors on longevity...
  36. doi request reprint Outcomes of treatment of argon plasma coagulation therapy in elderly or high-risk patients with early gastric cancer: a comparison of outcomes among experienced and nonexperienced endoscopists
    Toshihiko Tomita
    Division of Upper Gastroenterology, Department of Internal Medicine, Gastroenterology, Hyogo College of Medicine, Nishinomiya, Japan
    J Clin Gastroenterol 45:e54-9. 2011
    ..The aim of this study was to assess the therapeutic outcomes of APC in aged and/or high-risk patients with early gastric neoplasm...
  37. ncbi request reprint Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer
    Yoshinori Mori
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Cancer 121:241-7. 2007
    ..These results indicate that ATBF1 in the nucleus negatively regulates the MUC5AC gene in gastric cancer by binding to an AT motif-like element in the MUC5AC promoter...
  38. pmc Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    PLoS ONE 8:e74757. 2013
    ..The relationship between the expression patterns of tight junction proteins and tumor proliferation in early gastric cancer is still far from clear...
  39. ncbi request reprint [Relationship between Helicobacter pylori status and the development of reflux esophagitis or Barrett's esophagus]
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
    Nihon Rinsho 71:1453-61. 2013
    ..pylori, the eradication should be recommended for patients with H. pylori infection irrespective of the presence of RE or BE even in terms of the prevention of gastric cancer...
  40. pmc Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study
    Jiro Watari
    Jiro Watari, Toshihiko Tomita, Fumihiko Toyoshima, Jun Sakurai, Takashi Kondo, Haruki Asano, Takahisa Yamasaki, Takuya Okugawa, Hisatomo Ikehara, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa, Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    World J Gastrointest Endosc 5:281-7. 2013
    ..To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study...
  41. ncbi request reprint [Therapeutic trends of diseases of the upper gastrointestinal tract in patients with negative H. pylori status]
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
    Nihon Rinsho 67:2378-86. 2009
    ..pylori infection. As for the treatment for gastric H. pylori-negative MALT lymphoma, radiation therapy (RT) should be selected first, and next chemotherapy will be given to the patients who failed to RT...
  42. doi request reprint Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model
    Jing Shan
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol Hepatol 28:823-8. 2013
    ..The effects of bile acids, which are major components of reflux fluid, on the production of IL-8 and related mechanisms remain unclear. This study aimed to address these questions using an esophageal stratified squamous epithelial model...
  43. pmc Association between obesity and Barrett's esophagus in a Japanese population: a hospital-based, cross-sectional study
    Jiro Watari
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    BMC Gastroenterol 13:143. 2013
    ..The association between obesity and Barrett's esophagus (BE) in the Japanese population remains unclear. The prevalence of BE and its associated risk factors was examined...
  44. ncbi request reprint IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells
    Yusuke Itoh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Cytokine 29:275-82. 2005
    ....
  45. doi request reprint Histology of symptomatic gastroesophageal reflux disease: is it predictive of response to proton pump inhibitors?
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol Hepatol 28:479-87. 2013
    ....
  46. ncbi request reprint Gastric gland heterotopic in muscularis mucosa treated by endoscopic polypectomy: a case report
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Gastrointest Endosc 60:664-7. 2004
  47. pmc A novel strategy in production of oligosaccharides in digestive tract: prevention of postprandial hyperglycemia and hyperinsulinemia
    Makoto Sasaki
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Clin Biochem Nutr 41:191-6. 2007
    ..05: 150 mg and 300 mg of TG vs control) and marginally decreased insulin concentrations (p = 0.099: 300 mg of TG vs control). These results suggest that TG may be useful for preventing the progression of type 2 diabetes mellitus...
  48. ncbi request reprint Role of prostaglandins in maintaining gastric mucus-cell permeability against acid exposure
    Yasuhide Takezono
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Lab Clin Med 143:52-8. 2004
    ..Prostaglandins play an important role in this protective response to acid exposure. COX inhibitors such as indomethacin may inhibit the regulation of epithelial permeability by reducing the concentration of PGE(2)...
  49. pmc Successful Self-Expandable Metallic Stent Placement for a Case of Distal Rectal Stenosis due to Gastric Cancer Metastasis
    Takuya Okugawa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Case Rep Gastroenterol 7:214-8. 2013
    ..This report demonstrates that rectal obstruction located less than 5 cm from the anal verge due to Schnitzler's metastasis could be treated by stenting without any symptomatic or technical complications...
  50. doi request reprint Role of transient receptor potential A1 in gastric nociception
    Takashi Kondo
    Division of Upper Gastroenterology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Digestion 82:150-5. 2010
    ..These data indicate that SP and CGRP may also be released by TRPA1 activation in primary afferent neurons to elicit neurogenic inflammation and promote visceral hyperalgesia...
  51. ncbi request reprint Endoscopic treatment for repeated arterial bleeding with ulcerative colitis
    Tadayuki Oshima
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya, Japan
    Dig Dis Sci 52:1434-7. 2007
  52. ncbi request reprint Contribution of capsaicin-sensitive afferent nerves to rapid recovery from ethanol-induced gastric epithelial damage in rats
    Masashi Sobue
    First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    J Gastroenterol Hepatol 18:1188-95. 2003
    ..The present study was therefore conducted focusing on recovery from gastric mucosal damage induced by ethanol in vivo...
  53. pmc Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    J Neurogastroenterol Motil 16:353-62. 2010
    ..This condition is known as silent gastroesophageal reflux disease. Although the pathogenesis of silent gastroesophageal reflux disease is still not known, hyposensitivity to reflux of acid may possibly explain the condition...
  54. ncbi request reprint [Pathogenesis and management of functional dyspepsia]
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
    Nihon Rinsho 68:1391-401. 2010
    ..Although usefulness of other drug options, such as H. pylori eradication, psychotropic drugs, and/or herbal medicine has been reported, more evidence and validation studies for their efficacy are necessary...
  55. ncbi request reprint Differential expression of decay-accelerating factor isoforms in the digestive tract of guinea pig
    Tsutomu Mizoshita
    First Department of Internal Medicine, Nagoya City University School of Medicine, Nagoya, Japan
    Life Sci 70:867-76. 2002
    ..In conclusion, DAF was found to be primarily expressed in the small intestinal epithelium with isoforms differing between the epithelium and stromal tissue, suggesting differential roles in the guinea pig digestive tract...
  56. ncbi request reprint Oxaliplatin in treatment of the cisplatin-resistant MKN45 cell line of gastric cancer
    Katsuyuki Tozawa
    Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Anticancer Res 28:2087-92. 2008
    ..Here, we studied oxaliplatin in vitro to reveal the mechanism of acquiring drug resistance and whether a cisplatin-resistant gastric cancer cell line has susceptibility to oxaliplatin...
  57. ncbi request reprint [Evidence based treatment strategy for dyspeptic symptoms]
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
    Nihon Shokakibyo Gakkai Zasshi 104:1594-600. 2007
  58. doi request reprint The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells
    Kanako Watanabe
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    Biochem Biophys Res Commun 367:487-90. 2008
    ....
  59. doi request reprint NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model
    T Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Neurogastroenterol Motil 22:579-84, e125. 2010
    ..In the present study, we investigated the role of NK-1 receptor (NK-1R) as a mediator of oesophagitis symptoms...
  60. doi request reprint Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease - a double-blind, placebo-controlled study
    H Miwa
    Hyogo College of Medicine, Nishinomiya, Japan
    Aliment Pharmacol Ther 33:323-32. 2011
    ..Proton pump inhibitors (PPIs) are less effective in non-erosive reflux disease (NERD) patients than in reflux oesophagitis patients. Whether the addition of prokinetics to PPIs improves NERD patients' symptoms remains unknown...
  61. doi request reprint Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: a validation study in a cohort of Japanese endoscopists
    H Miwa
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Dis Esophagus 21:355-63. 2008
    ..Further research is required to elucidate the pathophysiological basis of minimal change esophagitis...
  62. doi request reprint Experimental oesophagitis in the rat is associated with decreased voluntary movement
    H Miwa
    Division of Upper Gastroenteroelogy, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Neurogastroenterol Motil 21:296-303. 2009
    ..Decreases in voluntary movement of oesophagitis model rats may reflect visceral symptoms and be able to serve as an index of chronic abdominal symptoms...
  63. doi request reprint Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial
    Hiroto Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Am J Gastroenterol 104:2779-87. 2009
    ..The aim of this study was to examine the efficacy of tandospirone citrate, a new partial agonist of the 5-hydroxytryptamine 1A (5-HT1A) receptor, in improving the symptoms of patients with FD...
  64. doi request reprint An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment
    Atsushi Sakuraba
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Gastroenterol 104:2990-5. 2009
    ..The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC...
  65. ncbi request reprint Efficacy of famotidine and omeprazole in healing symptoms of non-erosive gastro-oesophageal reflux disease: randomized-controlled study of gastro-oesophageal reflux disease
    T Wada
    Department of Internal Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Aliment Pharmacol Ther 21:2-9. 2005
    ..There is a possibility that non-erosive gastro-oesophageal reflux disease treatment requires a different regimen/approach but it is not yet acknowledged...
  66. ncbi request reprint [Pathogenesis of gastro-esophageal reflux disease]
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
    Nihon Rinsho 65:797-801. 2007
    ..Esophageal visceral hypersensitivity, sustained esophageal contractions, and abnormal tissue resistance are thought to be the mechanisms of NERD. Further investigations for the pathogenesis of each classification are expected...
  67. ncbi request reprint Helicobacter pylori eradication decreases blood neutrophil and monocyte counts
    Y Kondo
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Aliment Pharmacol Ther 20:74-9. 2004
    ..The effect of Helicobacter pylori infection on systemic disorders is not well understood...
  68. ncbi request reprint The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells
    T Joh
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Aliment Pharmacol Ther 18:133-8. 2003
    ..Our previous study indicated that trans-epithelial resistance (TER) of rat gastric epithelial cells was rapidly increased when the cells were exposed to acid. This response to acid was diminished by indometacin...
  69. ncbi request reprint Tight junction peptide antagonists enhance neutrophil trans-endothelial chemotaxis
    Tadayuki Oshima
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Life Sci 73:1729-40. 2003
    ..The correlation between diminished occludin organization and increased neutrophil trans-endothelial chemotaxis provides additional support for occludin in the maintenance of the tight junctional barrier...
  70. ncbi request reprint [Phlebosclerotic enteritis]
    Yoshihiko Tomita
    Nihon Shokakibyo Gakkai Zasshi 105:583-4, 586. 2008
  71. ncbi request reprint Identification of an occludin cell adhesion recognition sequence
    Orest W Blaschuk
    Department of Surgery, Royal Victoria Hospital, Montreal, Quebec, Canada
    Inflammation 26:193-8. 2002
    ..This cyclic peptide also prevents the aggregation of fibroblasts stably transfected with cDNA encoding occludin. The data suggest that the LYHY motif is an occludin CAR sequence...