Hideki Ohyama

Summary

Affiliation: Hyogo College of Medicine
Country: Japan

Publications

  1. pmc Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity
    H Ohyama
    Department of Allergy and Immunology, Saitama Medical School, Moroyama 350 0495, Japan
    J Clin Pathol 58:740-3. 2005
  2. ncbi request reprint An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Jpn J Infect Dis 62:381-3. 2009
  3. doi request reprint The involvement of IL-23 and the Th17 pathway in periodontitis
    H Ohyama
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    J Dent Res 88:633-8. 2009
  4. doi request reprint Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Interferon Cytokine Res 28:563-9. 2008
  5. ncbi request reprint Clinical and immunological assessment of periodontal disease in Japanese leprosy patients
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Jpn J Infect Dis 63:427-32. 2010
  6. doi request reprint Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int J Oncol 41:83-91. 2012
  7. doi request reprint Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Oncol Rep 28:1585-90. 2012
  8. doi request reprint Immunotherapy with interleukin-18 in combination with preoperative chemotherapy with ifosfamide effectively inhibits postoperative progression of pulmonary metastases in a mouse osteosarcoma model
    Naoko Yamada
    Department of Pathology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Tumour Biol 30:176-84. 2009
  9. doi request reprint Phenotypic characteristics and proliferative activity of hyperplastic ductule cells in cholangiofibrosis induced by thioacetamide in rats
    Masaki Hata
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501 Japan
    Exp Toxicol Pathol 65:351-6. 2013
  10. doi request reprint Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner
    Naoko Yamada
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int J Oncol 41:2005-12. 2012

Collaborators

Detail Information

Publications29

  1. pmc Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity
    H Ohyama
    Department of Allergy and Immunology, Saitama Medical School, Moroyama 350 0495, Japan
    J Clin Pathol 58:740-3. 2005
    ....
  2. ncbi request reprint An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Jpn J Infect Dis 62:381-3. 2009
    ..Thus, we demonstrate here that periodontal infection is a potential source of infection in the formation of PLA...
  3. doi request reprint The involvement of IL-23 and the Th17 pathway in periodontitis
    H Ohyama
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    J Dent Res 88:633-8. 2009
    ..Together, these results suggest that the IL-23-induced Th17 pathway is stimulated in inflammatory periodontal lesions...
  4. doi request reprint Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Interferon Cytokine Res 28:563-9. 2008
    ..These results suggest that these SNPs in IL12RB2 have differential effects on cellular activation of T cells and NK cells...
  5. ncbi request reprint Clinical and immunological assessment of periodontal disease in Japanese leprosy patients
    Hideki Ohyama
    Department of Pathology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Jpn J Infect Dis 63:427-32. 2010
    ..gingivalis might be one of the genetic factors determining periodontal disease susceptibility in leprosy patients...
  6. doi request reprint Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int J Oncol 41:83-91. 2012
    ..The present results suggest that combined administration of VPA and hydrazine is valuable for enhancing the therapeutic effects of immunotherapy for osteosarcomas...
  7. doi request reprint Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Oncol Rep 28:1585-90. 2012
    ..The present study therefore demonstrates that the downregulation of MMP-9 mRNA by VPA plays a role in the inhibitory action of VPA on the secretion of soluble MICA and MICB in osteosarcoma cells...
  8. doi request reprint Immunotherapy with interleukin-18 in combination with preoperative chemotherapy with ifosfamide effectively inhibits postoperative progression of pulmonary metastases in a mouse osteosarcoma model
    Naoko Yamada
    Department of Pathology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Tumour Biol 30:176-84. 2009
    ..These results suggest that immunotherapy in combination with preoperative chemotherapy is highly effective in suppressing postoperative progression of pulmonary metastasis...
  9. doi request reprint Phenotypic characteristics and proliferative activity of hyperplastic ductule cells in cholangiofibrosis induced by thioacetamide in rats
    Masaki Hata
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501 Japan
    Exp Toxicol Pathol 65:351-6. 2013
    ....
  10. doi request reprint Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner
    Naoko Yamada
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int J Oncol 41:2005-12. 2012
    ....
  11. ncbi request reprint Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity
    Koji Yamanegi
    Department of Pathology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Oncol Rep 24:1621-7. 2010
    ..The present results indicate that VPA sensitizes human osteosarcoma cells to cytotoxicity of NK cells...
  12. ncbi request reprint Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-18
    Shoji Nishio
    Department of Pathology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Cancer Sci 99:113-20. 2008
    ....
  13. doi request reprint The promotional effect of IL-22 on mineralization activity of periodontal ligament cells
    Nahoko Kato-Kogoe
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Cytokine 59:41-8. 2012
    ..This study investigated the biological effects of IL-22 on periodontal ligament (PDL) cells as part of studies to assess the involvement of IL-22 in periodontal disease...
  14. doi request reprint Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Cancer Res Clin Oncol 135:879-89. 2009
    ..Effects of valproic acid (VPA), a histone deacetylase inhibitor, on the susceptibility to cell death induced by agonistic anti-Fas antibody were examined using four human osteosarcoma cell lines...
  15. doi request reprint Fibroblasts stimulated via HLA-II molecules produce prostaglandin E₂ and regulate cytokine production from helper T cells
    Nahoko Kato-Kogoe
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 90:1747-56. 2010
    ....
  16. doi request reprint Expression of both hepatocellular carcinoma and cholangiocarcinoma phenotypes in hepatocellular carcinoma and cholangiocarcinoma components in combined hepatocellular and cholangiocarcinoma
    Mitsumaro Itoyama
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Med Mol Morphol 45:7-13. 2012
    ....
  17. doi request reprint Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen
    Hirofumi Watanabe
    Department of Pathology, Hyogo College of Medicine, Hyogo, Japan
    Pathology 40:272-6. 2008
    ..We examined whether hepatocytes are the origin of these biliary ductular cells...
  18. doi request reprint Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy
    Yasushi Uemura
    Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama 350 0495, Japan
    Int Immunol 20:405-12. 2008
    ..These findings may reflect one mechanism that is an essential component for the T(h)2 environment necessary for the maintenance of pregnancy...
  19. doi request reprint Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps
    Yoriko Yukitatsu
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Cell Tissue Res 352:647-57. 2013
    ..Thus, in nasal polyps, the barrier function of endothelial adherens and tight junctions is weakened, although glucocorticoid treatment improves this weakened barrier function...
  20. doi request reprint Immunohistochemical analyses of E-cadherin, beta-catenin, CD44s, and CD44v6 expressions, and Ki-67 labeling index in intraductal papillary mucinous neoplasms of the pancreas and associated invasive carcinomas
    Akira Okimura
    Department of Pathology, Hyogo College of Medicine, Hyogo, Japan
    Med Mol Morphol 42:222-9. 2009
    ..The present results indicate that carcinoma components are associated with a decrease in tumor cells expressing E-cadherin and beta-catenin and have the highest proliferative activity...
  21. ncbi request reprint Effect of interleukin-18 on metastasis of mouse osteosarcoma cells
    Yoshiteru Nakamura
    Department of Pathology, Hyogo College of Medicine, 663 8501 Nishinomiya, Hyogo, Japan
    Cancer Immunol Immunother 55:1151-8. 2006
    ..These results suggest that IL-18 inhibits metastasis of LM8 cells partly by inducing a factor(s) in the host which suppresses cell mobility...
  22. ncbi request reprint Epithelial-myoepithelial carcinoma arising in the nasal cavity
    Koji Yamanegi
    Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Auris Nasus Larynx 35:408-13. 2008
    ..Based on the histological and immunohistochemical findings, the tumor was diagnosed to be an EMC. The follow-up at 12 months after the operation showed no evidence of recurrence...
  23. doi request reprint Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells
    Tian Yi Liu
    Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan
    Eur J Immunol 38:1012-23. 2008
    ..These findings may provide an important insight into better understanding the contribution of iNKT-DC cross-talk governing the Th1/2 balance and the diverse influences of iNKT cells in various diseases...
  24. ncbi request reprint Down-regulation of osteoprotegerin production in bone marrow macrophages by macrophage colony-stimulating factor
    Naoko Yamada
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Cytokine 31:288-97. 2005
    ..The expression of RANK mRNA was not significantly affected by M-CSF. The results showed that M-CSF suppresses the OPG production in BMMs, which may increase the sensitivity of BMMs to RANKL...
  25. ncbi request reprint Fos plays no role in apoptosis of epithelia in the mouse male accessory sex organs and uterus
    Ayako Kuhara
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Endocr J 52:153-8. 2005
    ..This seems to be due to the retarded development of 50-day-castrated Fos-deficient mice, but not to a role of Fos in apoptosis...
  26. ncbi request reprint Oncocytic non-functioning endocrine tumor of the pancreas
    Ayako Sugihara
    Department of Pathology, Meiwa General Hospital, Nishinomiya, Hyogo 663 8186, Japan
    Pathol Int 56:755-9. 2006
    ....
  27. ncbi request reprint Monocytes of distinct clinical types of leprosy are differentially activated by cross-linking class II HLA molecules to secrete IL-12
    Hideki Ohyama
    Department of Allergy and Immunology, Saitama Medical School, Morohongo, Moroyama, Japan
    APMIS 112:271-4. 2004
    ....
  28. ncbi request reprint Combinatorial peptide library for the analysis of antigen recognition by T cells
    S Matsushita
    Department of Allergy and Immunology, Saitama Medical School, Moroyama, 350 0495, Japan
    Comb Chem High Throughput Screen 5:551-63. 2002
    ..For this purpose, use of reverse-phase hydrophobic interaction chromatography and mass spectrometry analysis was efficient. Detailed methods are described in the paper...
  29. ncbi request reprint Adaptive response in embryogenesis. III. Relationship to radiation-induced apoptosis and Trp53 gene status
    B Wang
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 154:277-82. 2000
    ..These findings indicate that induction of a radioadaptive response in embryogenesis is related to Trp53 gene status and the occurrence of radiation-induced apoptosis...