E Mori

Summary

Affiliation: Hyogo Institute for Aging Brain and Cognitive Disorders
Country: Japan

Publications

  1. ncbi request reprint Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease
    E Mori
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 154:18-24. 1997
  2. ncbi request reprint Amygdalar volume and emotional memory in Alzheimer's disease
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Am J Psychiatry 156:216-22. 1999
  3. ncbi request reprint Visuoperceptual impairment in dementia with Lewy bodies
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 57:489-93. 2000
  4. ncbi request reprint Impact of subcortical ischemic lesions on behavior and cognition
    Etsuro Mori
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji 670 0981, Japan
    Ann N Y Acad Sci 977:141-8. 2002
  5. ncbi request reprint Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele
    Etsuro Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Ann Neurol 51:209-14. 2002
  6. ncbi request reprint Functional brain imaging as a surrogate marker in vascular cognitive impairment
    Etsuro Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Int Psychogeriatr 15:267-72. 2003
  7. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
  8. ncbi request reprint Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:139-46. 2000
  9. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
  10. ncbi request reprint Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease
    M Yasuda
    Division of Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 155:779-84. 1998

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease
    E Mori
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 154:18-24. 1997
    ....
  2. ncbi request reprint Amygdalar volume and emotional memory in Alzheimer's disease
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Am J Psychiatry 156:216-22. 1999
    ..e., memory of events arousing strong emotions. The aim of this study was to elucidate the relationship between medial temporal damage and impaired memory of real-life emotional events in patients with Alzheimer's disease...
  3. ncbi request reprint Visuoperceptual impairment in dementia with Lewy bodies
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 57:489-93. 2000
    ..In dementia with Lewy bodies (DLB), vision-related cognitive and behavioral symptoms are common, and involvement of the occipital visual cortices has been demonstrated in functional neuroimaging studies...
  4. ncbi request reprint Impact of subcortical ischemic lesions on behavior and cognition
    Etsuro Mori
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji 670 0981, Japan
    Ann N Y Acad Sci 977:141-8. 2002
    ....
  5. ncbi request reprint Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele
    Etsuro Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Ann Neurol 51:209-14. 2002
    ....
  6. ncbi request reprint Functional brain imaging as a surrogate marker in vascular cognitive impairment
    Etsuro Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Int Psychogeriatr 15:267-72. 2003
    ..Also mentioned is an ongoing clinical trial of extracranial-intracranial artery bypass surgery for hemispheric hemodynamic misery perfusion where single-photon emission tomography is used as a surrogate measure...
  7. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
    ..However, the region most responsible for dyscalculia in Alzheimer's disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer's disease was therefore examined...
  8. ncbi request reprint Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:139-46. 2000
    ..These features of regional glucose metabolic abnormality in CBD may correspond to neurological and cognitive disturbances peculiar to CBD...
  9. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
    ..Our results suggested that the left inferior temporal lobe contributes to verbal semantic memory...
  10. ncbi request reprint Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease
    M Yasuda
    Division of Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 155:779-84. 1998
    ..The aim of this study was to examine the relationship between the APOE epsilon 4 allele and whole brain atrophy...
  11. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
    ..The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer's disease...
  12. ncbi request reprint Clinical diagnosis of dementia with Lewy bodies in a Japanese dementia registry
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 10:210-6. 1999
    ..Patients with DLB have a unique dementia syndrome even in the stage of mild to moderate cognitive impairments. Further studies are recommended to establish diagnosis, treatment and management...
  13. ncbi request reprint Occipital glucose metabolism in dementia with lewy bodies with and without Parkinsonism: a study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:194-7. 2001
    ..The neurobiological bases of occipital hypometabolism in DLB may be pathological processes in the brainstem or basal forebrain structures other than the nigrostriatal system...
  14. ncbi request reprint Regional hypometabolism related to language disturbance in Alzheimer's disease
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 9:68-73. 1998
    ..These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions...
  15. ncbi request reprint Age at onset and language disturbances in Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neuropsychologia 36:945-9. 1998
    ..The different patterns of language deficits between early- and late-onset patients may correspond to the genetic heterogeneity of AD...
  16. ncbi request reprint Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging, Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 235:49-52. 1997
    ..These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases...
  17. ncbi request reprint Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
    ..The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele...
  18. ncbi request reprint A study of remote memory impairment in Alzheimer's disease by using the family line test
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:53-8. 2000
    ..A prominent temporal gradient in remote memory impairment was documented in the patients with AD. The total FLT score and duration of remote memory impairment correlated with recent memory and general cognitive dysfunctions...
  19. ncbi request reprint Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia
    N Hirono
    Divisions of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:1263-8. 2000
    ..We studied the association between the apoE epsilon4 allele and white matter hyperintensities (WMHs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia...
  20. ncbi request reprint Distinctive neurobehavioral features among neurodegenerative dementias
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:498-503. 1999
    ..The findings clearly demonstrate that AD, DLB, and FTD have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias...
  21. ncbi request reprint Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Br J Psychiatry 177:343-7. 2000
    ..In an earlier study we showed that a powerful emotional experience (the Kobe earthquake) reinforced memory retention in patients with Alzheimer's disease, but we could not control factors other than the emotional impact of the earthquake...
  22. ncbi request reprint Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer's disease
    M Fujimori
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, 670 0981, Japan
    Neuropsychologia 38:1356-61. 2000
    ..The present study showed that visuospatial disturbance was related to bilateral parietal metabolism, and that visuoperceptual disturbance was related to right temporo-parietal metabolism in patients with mild-to-moderate AD...
  23. ncbi request reprint Relatively preserved hippocampal glucose metabolism in mild Alzheimer's disease
    K Ishii
    Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders HI ABCD, Himeji, Japan
    Dement Geriatr Cogn Disord 9:317-22. 1998
    ....
  24. ncbi request reprint Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
    M Hashimoto
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 57:1461-6. 2001
    ..Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial...
  25. ncbi request reprint Tc-99m ethyl cysteinate dimer SPECT and 2-[F-18]fluoro-2-deoxy-D-glucose PET in Alzheimer's disease. Comparison of perfusion and metabolic patterns
    K Ishii
    Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Clin Nucl Med 24:572-5. 1999
    ..This study compared Tc-99m ethyl cysteinate dimer (ECD) SPECT images with 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) PET images in the same patients with Alzheimer's disease and determined whether ECD SPECT is as useful as FDG PET clinically...
  26. ncbi request reprint Fall-related injuries in dementia with Lewy bodies (DLB) and Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Ageing Brain and Cognitive Disorders, Hyogo Institute Hospital for Ageing Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 7:77-9. 2000
    ..An appropriate clinical discrimination between DLB and AD is recommended to manage and prevent fall-related injuries...
  27. pmc Case-control study of presenilin-1 intronic polymorphism in sporadic early and late onset Alzheimer's disease
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji
    J Neurol Neurosurg Psychiatry 66:722-6. 1999
    ..The purpose of this study is to determine whether Alzheimer's disease is associated with presenilin-1 gene polymorphism and the apolipoprotein E genotype in an extended case-control study...
  28. ncbi request reprint The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002
    ..One possible reason for this controversy is that previous studies did not consider the effect of patient age at symptom onset...
  29. ncbi request reprint Impact of white matter changes on clinical manifestation of Alzheimer's disease: A quantitative study
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:2182-8. 2000
    ..We studied the association between the volume of white matter hyperintensities (WMHs) on T2-weighted images and cognitive, neurological, and neuropsychiatric symptoms...
  30. ncbi request reprint A diagnostic method for suspected Alzheimer's disease using H(2)15O positron emission tomography perfusion Z score
    K Ishii
    Division of Imaging Research, Hyogo Institute for Ageing Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    Neuroradiology 42:787-94. 2000
    ..946 and 0.584, respectively). These results indicate that a Z map obtained in this way is superior to conventional PET for diagnosing AD...
  31. ncbi request reprint Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images
    H Kitagaki
    Neuroimaging Research Radiology Service, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Radiology 216:31-8. 2000
    ..To determine the characteristics of cortical atrophy in corticobasal degeneration and Alzheimer disease by using a hemispheric surface display generated with magnetic resonance (MR) images...
  32. ncbi request reprint Cortical activation during retrieval of arithmetical facts and actual calculation: a functional magnetic resonance imaging study
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute forAging Brain and Cognitive Disorders, Himeji, Japan
    Psychiatry Clin Neurosci 54:479-85. 2000
    ..These processes include proper alignment of digits, which may have caused the right parietal activation, and maintaining digits needed for the mental serial subtractions, which may have caused the bilateral prefrontal activation...
  33. ncbi request reprint Transient global amnesia: increased signal intensity in the right hippocampus on diffusion-weighted magnetic resonance imaging
    M Matsui
    Division of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Neuroradiology 44:235-8. 2002
    ..DWI was sensitive and useful for evaluating the early stage of TGA and might help to explain the pathophysiology of TGA...
  34. pmc Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease
    Y Yamamoto
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Himeji, Japan
    J Neurol Neurosurg Psychiatry 67:94-6. 1999
    ..In the Japanese population studied here, there was no association between BChE-K and Alzheimer's disease, nor an interaction between BChE-K and APOE epsilon4 allele...
  35. ncbi request reprint Striatal infarcts mimicking frontotemporal dementia: a case report
    Y Nishio
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 10:457-60. 2003
    ..A disruption of the fronto-subcortical circuits at the level of the striatum or the anterior thalamic peduncle is attributable to the FTD-like behavioral and cognitive syndrome...
  36. ncbi request reprint Referral and care for acute ischemic stroke in a Japanese tertiary emergency hospital
    Y Yoneda
    Neurology Service, Hyogo Brain and Heart Center at Himeji, 520 Saisho Ko, Himeji, 670 0981, Japan
    Eur J Neurol 8:483-8. 2001
    ..Although our in-hospital stroke management is functioning relatively well, further efforts are necessary in reducing the diagnostic delay...
  37. ncbi request reprint MR angiographic evaluation of carotid and intracranial arteries in Japanese patients scheduled for coronary artery bypass grafting
    T Uehara
    Neurology Service, Hyogo Brain and Heart Center at Himeji, Himeji, Japan
    Cerebrovasc Dis 11:341-5. 2001
    ....
  38. ncbi request reprint Risk factors for occlusive lesions of intracranial arteries in stroke-free Japanese
    T Uehara
    Neurology Service, Hyogo Brain and Heart Center, Himeji, Japan
    Eur J Neurol 12:218-22. 2005
    ....
  39. ncbi request reprint Comparison of regional brain volume and glucose metabolism between patients with mild dementia with lewy bodies and those with mild Alzheimer's disease
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan
    J Nucl Med 48:704-11. 2007
    ..The aim of this study was to investigate regional differences between morphologic and functional changes in patients with mild dementia with Lewy bodies (DLB) compared with those with Alzheimer's disease (AD)...
  40. ncbi request reprint Everyday memory impairment of patients with mild cognitive impairment
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord 19:331-7. 2005
    ..7% of NC, thus demonstrating the usefulness of the RBMT for diagnosing MCI patients. Prospective memory tasks were not useful for detecting the patients with MCI...
  41. ncbi request reprint Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
    Mamoru Hashimoto
    Hyogo Institute for Aging Brain and Cognitive Disorders, Hyogo, Japan
    Am J Psychiatry 162:676-82. 2005
    ..The purpose of the present study was to determine whether donepezil has a neuroprotective effect in Alzheimer's disease by using the rate of hippocampal atrophy as a surrogate marker of disease progression...
  42. ncbi request reprint Comparison of gray matter and metabolic reduction in mild Alzheimer's disease using FDG-PET and voxel-based morphometric MR studies
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo, 670 0981, Japan
    Eur J Nucl Med Mol Imaging 32:959-63. 2005
    ..The aim of this study was to investigate regional differences between morphologic and functional changes in the same patients with mild Alzheimer's disease (AD) using statistical parametric mapping (SPM) and voxel-based morphometry (VBM)...
  43. ncbi request reprint Detectability of hypometabolic regions in mild Alzheimer disease: function of time after the injection of 2-[fluorine 18]-fluoro-2-deoxy-D-glucose
    Setsu Sakamoto
    Department of Radiology, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan
    AJNR Am J Neuroradiol 26:843-7. 2005
    ..The aim of this study was to evaluate the sensitivity of the early scanning (ES) compared with late scanning (LS) for demonstrating decreased regional glucose metabolism in patients with Alzheimer disease (AD)...
  44. ncbi request reprint Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: a case-control study
    Wenxiang Quan
    Department of Psychiatry and Neurology, Kobe Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, and Hyogo Institute of Aging Brain and Cognitive Disorders, Himeji Brain and Heart Center, Japan
    J Neurol Sci 240:71-5. 2006
    ..The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin-2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study...
  45. ncbi request reprint [Hippocampal atrophy and memory disturbance]
    Etsuro Mori
    Department of Neuropsychology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    No To Shinkei 57:1067-78. 2005
  46. ncbi request reprint Fully automatic diagnostic system for early- and late-onset mild Alzheimer's disease using FDG PET and 3D-SSP
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo, 670 0981, Japan
    Eur J Nucl Med Mol Imaging 33:575-83. 2006
    ..The purpose of this study was to design a fully automatic computer-assisted diagnostic system for early- and late-onset mild Alzheimer's disease (AD)...
  47. ncbi request reprint Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease
    Takashi Kawachi
    Division of Neuroimaging Research, HIABCD, Himeji, Hyogo, Japan
    Eur J Nucl Med Mol Imaging 33:801-9. 2006
    ....
  48. ncbi request reprint A randomized controlled trial of the group reminiscence approach in patients with vascular dementia
    Tomoko Ito
    Division of Behavioral Neurology and Cognitive Neuroscience, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dement Geriatr Cogn Disord 24:48-54. 2007
    ..To evaluate the beneficial effect of the group reminiscence approach (GRA) in patients with vascular dementia on the aspect of cognitive and observed behavioral parameters...
  49. ncbi request reprint Insight into management of dementias from neuroimaging
    Etsuro Mori
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School ofMedicine, Sendai, Japan
    Acta Neurol Taiwan 15:52-5. 2006
    ....
  50. ncbi request reprint What constitutes clinical evidence for neuroprotection in Alzheimer disease: support for the cholinesterase inhibitors?
    Etsuro Mori
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
    Alzheimer Dis Assoc Disord 20:S19-26. 2006
    ..Among the clinical data suggesting a possible neuroprotective effect of ChEIs, the most rigorous published evidence comes from magnetic resonance imaging (MRI) hippocampal volumetric studies with donepezil...
  51. ncbi request reprint Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer's disease using FDG-PET and 3D-SSP
    Atsushi K Kono
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo, 670 0981, Japan
    Eur J Nucl Med Mol Imaging 34:1490-7. 2007
    ..To evaluate a fully automatic computer-assisted diagnostic system for mild dementia with Lewy bodies (DLB), permitting distinction from mild Alzheimer's disease (AD)...
  52. ncbi request reprint Non-verbal learning is impaired in very mild Alzheimer's disease (CDR 0.5): normative data from the learning version of the Rey-Osterrieth Complex Figure Test
    Mari Kasai
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
    Psychiatry Clin Neurosci 60:139-46. 2006
    ..These results suggest that the CDR 0 participants maintained intact learning abilities of encoding and retrieval, while the CDR 0.5 participants did not do so; but further studies will be needed to clarify these findings...
  53. ncbi request reprint Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele
    Nobutsugu Hirono
    Department of Clinical Neurosciences and Basic Neurosciences, Faculty of Health Sciences, Ehime University School of Medicine, Japan
    J Neuropsychiatry Clin Neurosci 15:354-8. 2003
    ..Findings revealed that APOE epsilon4 allele is related to an accelerated memory decline in AD...
  54. ncbi request reprint Neuropsychosocial features of very mild Alzheimer's disease (CDR 0.5) and progression to dementia in a community: the Tajiri project
    Kenichi Meguro
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 9808575, Japan
    J Geriatr Psychiatry Neurol 17:183-9. 2004
    ..The neuropsychological data showed CDR 0.5 to be similar to very mild Alzheimer's disease. It would be better if subjective complaints were excluded from the criteria of the borderline condition...
  55. ncbi request reprint Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Japan
    Ann Nucl Med 18:447-51. 2004
    ....
  56. ncbi request reprint One-year change in cerebral glucose metabolism in patients with Alzheimer's disease
    Nobutsugu Hirono
    Department of Psychology, Kobegakuin University, 518 Arise, Ikawadani, Nishi ku, Kobe, 651 2180, Japan
    J Neuropsychiatry Clin Neurosci 16:488-92. 2004
    ..Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials...
  57. ncbi request reprint Confabulations in episodic memory are associated with delusions in Alzheimer's disease
    EunJoo Lee
    Department of Behavioral Neurology and Cognitive Neuro science, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Geriatr Psychiatry Neurol 20:34-40. 2007
    ..There was a correlation between cognitive impairment and confabulations in semantic memory. These findings suggest that different mechanisms are involved in confabulations between semantic and episodic memories...
  58. ncbi request reprint Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease
    Setsu Sakamoto
    Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    J Neurol Sci 200:27-32. 2002
    ..The purpose of this study was to delineate the specific patterns of cerebral glucose metabolism with regard to the time of onset of Alzheimer's disease (AD)...
  59. ncbi request reprint Deceiving others: distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions
    Nobuhito Abe
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Cogn Neurosci 19:287-95. 2007
    ..Our results provide clear evidence of functionally dissociable roles of the prefrontal subregions and amygdala for human deception...
  60. ncbi request reprint Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information: A positron emission tomography study
    Aya Ueno
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Neuroimage 34:1292-8. 2007
    ....
  61. ncbi request reprint [Writing Kanji without semantics in a case with probable Alzheimer's disease]
    Atsuko Hayashi
    Section of Neuropsychology, Division of Disability Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    No To Shinkei 54:481-8. 2002
    ..Furthermore, she would not necessarily use the semantics (word meanings) of kanji words during dictation...
  62. ncbi request reprint Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration
    Kayo Hosaka
    Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    J Neurol Sci 199:67-71. 2002
    ..The purpose of this study was to elucidate cerebral metabolic differences of these two diseases with cognitive impairments by [18F] fluorodeoxyglucose (FDG) and positron emission tomography (PET)...
  63. ncbi request reprint Nature of personal semantic memory: evidence from Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Himeji, Japan
    Neuropsychologia 41:981-8. 2003
    ..This result supports the hypotheses that personal semantic memory has features of both episodic and semantic memory, and that semantic memory is transformed from episodic memory...
  64. ncbi request reprint [Early ischemic lesion demonstrated by ictal diffusion-weighted MRI during prior TIA in a patient with cerebral infarction]
    Hirotaka Shimizu
    Neurology Service, Hyogo Brain and Heart Center at Himeji, Japan
    No To Shinkei 54:247-53. 2002
    ..In addition to recurrent embolism, we would like to point out that the reperfusion injury, secondary delayed neuronal death, and other factors may be involved in the second exacerbation evolving to the completed stroke...
  65. ncbi request reprint Selective impairment in the retrieval of family relationships in person identification: a case study of delusional misidentification
    Nobuhito Abe
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Neuropsychologia 45:2902-9. 2007
    ..We speculate that this specific type of misidentification can be elicited by failure to update semantic memory through the encoding of new episodic memory due to right-hemisphere-dominant fronto-temporal dysfunction...
  66. ncbi request reprint Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan
    Akira Ogawa
    Iwate Medical University School of Medicine, Morioka, Japan
    Stroke 38:2633-9. 2007
    ..The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan was organized to determine the safety and clinical efficacy of intraarterial infusion of urokinase (UK) in patients with stroke within 6 hours of onset...
  67. ncbi request reprint Left hippocampal volume inversely correlates with enhanced emotional memory in healthy middle-aged women
    Yutaka Matsuoka
    Division of Adult Mental Health, NIMH, National Center of Neurology and Psychiatry, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8553, Japan
    J Neuropsychiatry Clin Neurosci 19:335-8. 2007
    ..Irrespective of age, education, intracranial volume, cognitive function, delayed recall, and neuroticism, left hippocampal volume showed a significant negative correlation with enhanced emotional memory...
  68. doi request reprint Frontal behavioral syndromes in Prader-Willi syndrome
    Kaeko Ogura
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Japan
    Brain Dev 30:469-76. 2008
    ..This combination of behavioral problems is likely to be caused by damage to the orbitofrontal cortices and anterior temporal lobes or to circuits involving them...
  69. doi request reprint Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Japan
    Dement Geriatr Cogn Disord 25:329-35. 2008
    ..To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry...
  70. ncbi request reprint Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT)
    Takenori Yamaguchi
    National Cardiovascular Center, Suita, Osaka, Japan
    Stroke 37:1810-5. 2006
    ..6 mg/kg, which is lower than the internationally approved dosage of 0.9 mg/kg, aiming to assess the efficacy and safety of alteplase in acute ischemic stroke for the Japanese...
  71. ncbi request reprint [Validity of the Japanese version of Rivermead Behavioural Memory Test for evaluation of everyday memory function in patients with mild Alzheimer's disease]
    Akemi Matsuda
    Divisions of Neurorehabilitation, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, 670 0981 Hyogo, Japan
    No To Shinkei 54:673-8. 2002
    ..To validate the Japanese version of Rivermead Behavioural Memory Test (RBMT) in evaluating everyday memory function in patients with mild Alzheimer's disease (AD)...
  72. ncbi request reprint Evaluation of cortical atrophy between progressive supranuclear palsy and corticobasal degeneration by hemispheric surface display of MR images
    Masato Taki
    Hyogo Brain and Heart Center, Department of Radiology and Nuclear Medicine, Saisho Ko 520, Himeji, Hyogo 670 0981, Japan
    AJNR Am J Neuroradiol 25:1709-14. 2004
    ..Our purpose was to determine the features of cortical atrophy in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) by means of a hemispheric surface display generated with MR images...
  73. ncbi request reprint Voxel-based morphometric comparison between early- and late-onset mild Alzheimer's disease and assessment of diagnostic performance of z score images
    Kazunari Ishii
    Department of Radiology, Hyogo Brain and Heart Center, Saisho Ko 520, Himeji 670 0981, Hyogo, Japan
    AJNR Am J Neuroradiol 26:333-40. 2005
    ..We sought to delineate the specific patterns of cerebral gray matter loss with regard to onset of Alzheimer's disease (AD) by using MR imaging and VBM and to evaluate the diagnostic performance of VBM with Z score images...
  74. ncbi request reprint [Visual search training for a case of homonymous field defect with multiple visual dysfunctions]
    Kazumi Hirayama
    Division of Neuropsychology, Department of Disability Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    No To Shinkei 56:403-13. 2004
    ..In conclusion, it was suggested that disordered visual search after a homonymous field defect can be treated effectively, even if multiple visual dysfunctions were associated...
  75. ncbi request reprint [Manual tracing guideline for volumetry of hippocampus and amygdala with high-resolution MRI]
    Yutaka Matsuoka
    Psycho Oncology Division, National Cancer Center Research Institute East, 6 5 1 Kashinoha, Kashiwa shi, Chiba 277 8577, Japan
    No To Shinkei 55:690-7. 2003
    ..Both intra- and inter-rater reliability (intraclass correlation coefficients) yielded 0.99 for the hippocampus and 0.98 for the amygdala. It was confirmed that this segmentation protocol was highly reliable...
  76. ncbi request reprint [Amnesia following left medial frontal subcortical hemorrhage: a case report]
    Osamu Iizuka
    Devision of Behavioral Neurology and Cognitive Neuroscience, Department of Functional Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    No To Shinkei 57:227-31. 2005
    ..It seems that Papez's circuite participated in the development of these symptoms...
  77. ncbi request reprint Different MRI findings for normal elderly and very mild Alzheimer's disease in a community: implications for clinical practice the Tajiri Project
    Hiroshi Ishii
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Arch Gerontol Geriatr 42:59-71. 2006
    ..For CDR 0.5, amygdala atrophy was the only finding indicating CDR effect but no age effect. The amygdala or anterior entorhinal atrophy is important for discriminating very mild dementia from normal elderly...
  78. ncbi request reprint Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Hyogo, Japan
    J Neuropsychiatry Clin Neurosci 15:221-6. 2003
    ....
  79. ncbi request reprint [Thrombolytic therapy in acute ischemic stroke: present and future]
    Etsuro Mori
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji 670 0981, Japan
    No Shinkei Geka 31:249-60. 2003
  80. ncbi request reprint Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
    J Geriatr Psychiatry Neurol 19:3-12. 2006
    ..Thus, existing treatments for memory impairment and delusions may be beneficial for increasing the awareness of mild AD patients of their cognitive impairment...
  81. ncbi request reprint Hospital-based study of the care and cost of acute ischemic stroke in Japan
    Yukihiro Yoneda
    Neurology Service, Hyogo Brain and Heart Center at Himeji, 520 Saisho Ko, Himeji 670 0981, Japan
    Stroke 34:718-24. 2003
    ..To evaluate the current status of care and cost of acute ischemic stroke in Japan, we performed a hospital-based analysis at a tertiary emergency hospital with a 24-hour neurology-neurosurgery team and care unit...
  82. ncbi request reprint [Predictors of long-term institutionalization in patients with Alzheimer's disease: role of caregiver burden]
    Nobutsugu Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging, Brain and Cognitive Disorders, Japan
    No To Shinkei 54:812-8. 2002
    ..However, no studies have been carried out in Japan. In order to address this issue, we studied outcome of patients with AD...
  83. ncbi request reprint Efficacy and safety of donepezil in patients with dementia with Lewy bodies: preliminary findings from an open-label study
    Satoru Mori
    Department of Neurology, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan
    Psychiatry Clin Neurosci 60:190-5. 2006
    ....
  84. ncbi request reprint Guidelines for management of idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Kitano Hospital, Japan
    Neurol Med Chir (Tokyo) 48:S1-23. 2008
    ..The use of programmable valves at shunt surgeries is recommended. Flowcharts for diagnosis, preoperative assessment, and prevention for complications of shunt surgery are made to promote a wide use of them...