Seiichi Hirota

Summary

Affiliation: Hyogo College of Medicine
Country: Japan

Publications

  1. ncbi request reprint Pathology of gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Pathol Int 56:1-9. 2006
  2. pmc Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    World J Surg Oncol 10:231. 2012
  3. doi request reprint Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503
    Ning Ning Liu
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 93:502-7. 2013
  4. doi request reprint Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis
    Hirokuni Akahori
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Eur Heart J 32:888-96. 2011
  5. doi request reprint Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors
    Mayumi Nakai
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 92:451-7. 2012
  6. doi request reprint In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice
    Takashi Ishikawa
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 89:1161-8. 2009
  7. ncbi request reprint Influence of body mass index on clinicopathological factors including estrogen receptor, progesterone receptor, and Ki67 expression levels in breast cancers
    Ayako Yanai
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Int J Clin Oncol 19:467-72. 2014
  8. ncbi request reprint Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: report of a very rare case
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 209:124-7. 2013
  9. doi request reprint Small gastrointestinal stromal tumor of the stomach showing rapid growth and early metastasis to the liver
    Junji Tanaka
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Dig Endosc 22:354-6. 2010
  10. ncbi request reprint [Small-molecule inhibitors against KIT and PDGFRs especially in GISTs]
    Kazuhiro Shiba
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Gan To Kagaku Ryoho 36:1080-5. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Pathology of gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Pathol Int 56:1-9. 2006
    ..Mutational analyses of c-kit and PDGFRA genes are also significant for prediction of effectiveness of drugs including newly developed agents...
  2. pmc Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    World J Surg Oncol 10:231. 2012
    ..In some cases, the interval between the primary breast cancer and metastatic colorectal lesions is so long that the critical records for diagnosis including history might be lost or missed...
  3. doi request reprint Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503
    Ning Ning Liu
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 93:502-7. 2013
    ..Although mutation sites of KIT-Dup-Ser501Ala502 and KIT-Dup-Ala502Tyr503 are closely located, imatinib- and nilotinib-sensitive KIT-Dup-Ser501Ala502 are distinguishable from KIT-Dup-Ala502Tyr503...
  4. doi request reprint Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis
    Hirokuni Akahori
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Eur Heart J 32:888-96. 2011
    ..The purpose of this study is to clarify whether the haemorrhage in the aortic valve leaflet (intraleaflet haemorrhage) accelerates the progression of aortic valve stenosis (AS)...
  5. doi request reprint Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors
    Mayumi Nakai
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 92:451-7. 2012
    ....
  6. doi request reprint In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice
    Takashi Ishikawa
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 89:1161-8. 2009
    ....
  7. ncbi request reprint Influence of body mass index on clinicopathological factors including estrogen receptor, progesterone receptor, and Ki67 expression levels in breast cancers
    Ayako Yanai
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Int J Clin Oncol 19:467-72. 2014
    ..It is speculated that both enhanced production of estrogens and other factors associated with obesity are involved in these associations, but the biological characteristics associated with high BMI have yet to be thoroughly identified...
  8. ncbi request reprint Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: report of a very rare case
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 209:124-7. 2013
    ..Genetic analysis elucidated that the tumor had a chromosomal translocation, type 3 DDIT3-FUS chimeric gene. The tumor was definitely diagnosed as myxoid/round cell liposarcoma of the paratesticular region...
  9. doi request reprint Small gastrointestinal stromal tumor of the stomach showing rapid growth and early metastasis to the liver
    Junji Tanaka
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Dig Endosc 22:354-6. 2010
    ..Liver metastasis was found 6 months postoperatively, and molecular target therapy was carried out. However, the patient died 2 years after the finding of liver metastasis...
  10. ncbi request reprint [Small-molecule inhibitors against KIT and PDGFRs especially in GISTs]
    Kazuhiro Shiba
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Gan To Kagaku Ryoho 36:1080-5. 2009
    ..Secondary mutations of the c-kit gene in addition to primary c-kit gene mutation are a major cause of secondary resistance to imatinib. Now, we can use sunitinib for patients with imatinib-resistant GIST...
  11. ncbi request reprint Distribution of myofibroblast and tenascin-C in cystic adventitial disease: comparison with ganglion
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Pathol Int 63:591-8. 2013
    ..These results suggest that CAD may arise as capsular synovial structures, similar to ganglion cysts. ..
  12. ncbi request reprint Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 206:372-5. 2010
    ..Nuclear accumulation of beta-catenin protein and a point mutation of the beta-catenin gene by genomic DNA sequencing confirmed that the tumor was SPN. This is a very rare case of pancreatic SPN with massive calcification in an old man...
  13. doi request reprint Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats
    Yoshiro Naito
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Biochem Biophys Res Commun 436:145-51. 2013
    ..Iron restriction attenuated the development of monocrotaline-induced pulmonary vascular remodeling and RV failure. Cellular iron transport might be involved in the pathophysiology of PH and PH induced RV failure. ..
  14. doi request reprint Primary carcinoid tumor of the urinary bladder with prominent subnuclear eosinophilic granules
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 208:109-12. 2012
    ..The lower part of the mass showed the findings of glandular cystitis, as its coexistence with carcinoid tumors of the bladder has often been described in previous reports...
  15. doi request reprint New double embedding technique for specimens of endoscopic submucosal dissection using agarose: comparison with other media
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Clin Pathol 63:904-9. 2010
    ..Therefore, easy and reliable tissue-processing method for multiple cut specimens is needed. The authors report here a new double embedding technique for specimens of ESD...
  16. doi request reprint Increase in tissue and circulating pentraxin3 levels in patients with aortic valve stenosis
    Yoshiro Naito
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am Heart J 160:685-91. 2010
    ..Inflammation is involved in the pathogenesis of nonrheumatic aortic valve stenosis (AS). Pentraxin3 (PTX3) is produced at the inflammatory site; however, tissue and circulating PTX3 levels in patients with AS remain largely unknown...
  17. ncbi request reprint Drug-eluting stent: importance of clinico-pathological correlations
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Circ J 75:1548-58. 2011
    ..Ex vivo imaging using angioscopy, intravascular ultrasound, and optical coherency tomography of SES implantation is presented and the images are compared with the corresponding pathological section...
  18. doi request reprint Correlation of thin fibrous cap possessing adipophilin-positive macrophages and intraplaque hemorrhage with high clinical risk for carotid endarterectomy
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Neurosurg 114:1080-7. 2011
    ..Furthermore, the authors examined whether the plaque with high embolic potential after CA intervention, particularly CAS, could be predicted based on clinical risks for CEA...
  19. ncbi request reprint Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate
    Takeyoshi Itsukuma
    Division of Hematology Oncology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol 42:402-5. 2007
    ..Eighteen months later, however, the polyps were enlarged. In this patient, imatinib administration led to the remission of CML and might also have been responsible for the temporary regression of adenomatous polyps of FAP...
  20. doi request reprint Combined small cell carcinoma of the hypopharynx
    Nobuhiro Uwa
    Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Auris Nasus Larynx 40:106-9. 2013
    ..Combined SmCC is a disease with a poor prognosis. Although biopsy sometimes fails to detect the SmCC component, intensive diagnosis and treatment are necessary...
  21. ncbi request reprint Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation
    Nami Nakagomi
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 87:365-71. 2007
    ....
  22. ncbi request reprint Spontaneous regression of pulmonary involvement after smoking reduction and removal of and radiation therapy for Langerhans cell histiocytosis of the sphenoid bone: which comes first, the chicken or the egg?
    Hiroya Tamaki
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Japan
    Intern Med 51:497-501. 2012
    ..Here, we present a 37-year-old man with spontaneous regression of pulmonary lesions in multisystem LCH, achieved solely by smoking reduction following local treatment of bone lesions...
  23. ncbi request reprint Distinct global DNA methylation status in B-cell lymphomas : immunohistochemical study of 5-methylcytosine and 5-hydroxymethylcytosine
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine
    J Clin Exp Hematop 54:67-73. 2014
    ..J Clin Exp Hematop 54(1): 67-73, 2014]. ..
  24. pmc Diffuse alveolar damage in a patient with Epstein Barr virus (EBV)-positive diffuse large B-cell lymphoma,severely low serum folate, and megaloblastic anemia: a case report of autopsy
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 7:1742-7. 2014
    ..We considered that low serum folate in this case was not by the low intake but by increased consumption of folate by rapid progression of the lymphoma. ..
  25. doi request reprint ¹⁸F-Fluorodeoxyglucose uptake and clinicopathological features of recurrent or metastatic endometrial stromal sarcoma
    Kayo Inoue
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Department of Obstetrics and Gynecology, Meiwa General Hospital, Nishinomiya, Hyogo, Japan
    J Obstet Gynaecol Res 40:576-82. 2014
    ..Maximum standardized uptake value on (18) F-fluorodeoxyglucose positron emission tomography was evaluated as a predictive surrogate marker in developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma...
  26. pmc A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    BMC Pulm Med 13:25. 2013
    ..On the other hand, echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene in a subset of lung adenocarcinoma is related to mucinous cribriform histology...
  27. doi request reprint Upregulation of interleukin-33 in the epidermis of two Japanese patients with Netherton syndrome
    Tomoko Konishi
    Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan
    J Dermatol 41:258-61. 2014
    ..The upregulation of interleukin-33 (IL-33) was evident in basal and thickened lower spinous layers of the epidermis in those cases. This suggests that IL-33 may be involved in the pathophysiology of NS as well as in atopic dermatitis. ..
  28. ncbi request reprint STAT6-positive intraorbital papillary tumor: a rare variant of solitary fibrous tumor?
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Pathol Res Pract 210:450-3. 2014
    ....
  29. doi request reprint Biological characteristics of luminal subtypes in pre- and postmenopausal estrogen receptor-positive and HER2-negative breast cancers
    Keiko Murase
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 21:52-7. 2014
    ..However, the biological differences in ER and progesterone receptor (PR) expression levels between these luminal subtypes are not clear...
  30. doi request reprint A rare case of clear cell sarcoma with 4 types of EWSR1-ATF1 fusions detected not in primary site but in metastatic site
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Pathol Res Pract 209:803-7. 2013
    ..In our case, increased splicing activity in the EWSR1-ATF1 fusion might be acquired at the metastatic site. There is another possibility that metastasis might develop through the increased splicing activity in the fusion...
  31. ncbi request reprint Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa
    Emi Segawa
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Oral Oncol 44:664-71. 2008
    ..The patients with high expression of both COX-2 and DNA-Topo II alpha showed poor prognosis. Our results suggested that COX-2 expression become a possible indicator in oral carcinogenesis and may reflect the outcome of the patients...
  32. doi request reprint Global histone modification profiles are well conserved between normal B lymphocytes and neoplastic counterparts
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Pathol Oncol Res 16:447-51. 2010
    ....
  33. doi request reprint Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Pathol Int 60:528-32. 2010
    ..Furthermore, diffuse distribution of estrogen and progesterone receptors, lack of human gastric mucin and low proliferative activity were distinct features for endocervicosis compared to well-differentiated mucinous adenocarcinoma...
  34. pmc Primary squamous cell carcinoma of the liver: an uncommon finding in contrast-enhanced ultrasonography imaging
    Yuji Iimuro
    Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Case Rep Gastroenterol 5:628-35. 2011
    ..From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver...
  35. doi request reprint Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib
    Hiroya Tamaki
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int J Hematol 92:655-8. 2010
    ....