N Hirono

Summary

Affiliation: Hyogo Institute for Aging Brain and Cognitive Disorders
Country: Japan

Publications

  1. ncbi request reprint Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia
    N Hirono
    Divisions of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:1263-8. 2000
  2. ncbi request reprint Left frontotemporal hypoperfusion is associated with aggression in patients with dementia
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji 670 0981, Japan
    Arch Neurol 57:861-6. 2000
  3. ncbi request reprint Impact of white matter changes on clinical manifestation of Alzheimer's disease: A quantitative study
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:2182-8. 2000
  4. ncbi request reprint Distinctive neurobehavioral features among neurodegenerative dementias
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:498-503. 1999
  5. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
  6. ncbi request reprint Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
  7. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
  8. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
  9. ncbi request reprint Regional hypometabolism related to language disturbance in Alzheimer's disease
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 9:68-73. 1998
  10. ncbi request reprint The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002

Detail Information

Publications28

  1. ncbi request reprint Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia
    N Hirono
    Divisions of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:1263-8. 2000
    ..We studied the association between the apoE epsilon4 allele and white matter hyperintensities (WMHs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia...
  2. ncbi request reprint Left frontotemporal hypoperfusion is associated with aggression in patients with dementia
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji 670 0981, Japan
    Arch Neurol 57:861-6. 2000
    ..Temporolimbic and prefrontal cortical lesions can produce pathological aggression; however, involvement of these structures has not been established in aggressive patients with dementia...
  3. ncbi request reprint Impact of white matter changes on clinical manifestation of Alzheimer's disease: A quantitative study
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:2182-8. 2000
    ..We studied the association between the volume of white matter hyperintensities (WMHs) on T2-weighted images and cognitive, neurological, and neuropsychiatric symptoms...
  4. ncbi request reprint Distinctive neurobehavioral features among neurodegenerative dementias
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:498-503. 1999
    ..The findings clearly demonstrate that AD, DLB, and FTD have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias...
  5. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
    ..Our results suggested that the left inferior temporal lobe contributes to verbal semantic memory...
  6. ncbi request reprint Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
    ..The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele...
  7. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
    ..However, the region most responsible for dyscalculia in Alzheimer's disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer's disease was therefore examined...
  8. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
    ..The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer's disease...
  9. ncbi request reprint Regional hypometabolism related to language disturbance in Alzheimer's disease
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 9:68-73. 1998
    ..These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions...
  10. ncbi request reprint The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002
    ..One possible reason for this controversy is that previous studies did not consider the effect of patient age at symptom onset...
  11. ncbi request reprint Amygdalar volume and emotional memory in Alzheimer's disease
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Am J Psychiatry 156:216-22. 1999
    ..e., memory of events arousing strong emotions. The aim of this study was to elucidate the relationship between medial temporal damage and impaired memory of real-life emotional events in patients with Alzheimer's disease...
  12. ncbi request reprint Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:139-46. 2000
    ..These features of regional glucose metabolic abnormality in CBD may correspond to neurological and cognitive disturbances peculiar to CBD...
  13. ncbi request reprint Age at onset and language disturbances in Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neuropsychologia 36:945-9. 1998
    ..The different patterns of language deficits between early- and late-onset patients may correspond to the genetic heterogeneity of AD...
  14. ncbi request reprint Clinical diagnosis of dementia with Lewy bodies in a Japanese dementia registry
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 10:210-6. 1999
    ..Patients with DLB have a unique dementia syndrome even in the stage of mild to moderate cognitive impairments. Further studies are recommended to establish diagnosis, treatment and management...
  15. ncbi request reprint Occipital glucose metabolism in dementia with lewy bodies with and without Parkinsonism: a study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:194-7. 2001
    ..The neurobiological bases of occipital hypometabolism in DLB may be pathological processes in the brainstem or basal forebrain structures other than the nigrostriatal system...
  16. ncbi request reprint Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease
    E Mori
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 154:18-24. 1997
    ....
  17. ncbi request reprint Visuoperceptual impairment in dementia with Lewy bodies
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 57:489-93. 2000
    ..In dementia with Lewy bodies (DLB), vision-related cognitive and behavioral symptoms are common, and involvement of the occipital visual cortices has been demonstrated in functional neuroimaging studies...
  18. ncbi request reprint Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging, Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 235:49-52. 1997
    ..These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases...
  19. ncbi request reprint Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease
    M Yasuda
    Division of Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan
    Am J Psychiatry 155:779-84. 1998
    ..The aim of this study was to examine the relationship between the APOE epsilon 4 allele and whole brain atrophy...
  20. ncbi request reprint A study of remote memory impairment in Alzheimer's disease by using the family line test
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:53-8. 2000
    ..A prominent temporal gradient in remote memory impairment was documented in the patients with AD. The total FLT score and duration of remote memory impairment correlated with recent memory and general cognitive dysfunctions...
  21. ncbi request reprint Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Br J Psychiatry 177:343-7. 2000
    ..In an earlier study we showed that a powerful emotional experience (the Kobe earthquake) reinforced memory retention in patients with Alzheimer's disease, but we could not control factors other than the emotional impact of the earthquake...
  22. ncbi request reprint Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
    M Hashimoto
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 57:1461-6. 2001
    ..Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial...
  23. ncbi request reprint Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer's disease
    M Fujimori
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, 670 0981, Japan
    Neuropsychologia 38:1356-61. 2000
    ..The present study showed that visuospatial disturbance was related to bilateral parietal metabolism, and that visuoperceptual disturbance was related to right temporo-parietal metabolism in patients with mild-to-moderate AD...
  24. ncbi request reprint Fall-related injuries in dementia with Lewy bodies (DLB) and Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Ageing Brain and Cognitive Disorders, Hyogo Institute Hospital for Ageing Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 7:77-9. 2000
    ..An appropriate clinical discrimination between DLB and AD is recommended to manage and prevent fall-related injuries...
  25. ncbi request reprint A diagnostic method for suspected Alzheimer's disease using H(2)15O positron emission tomography perfusion Z score
    K Ishii
    Division of Imaging Research, Hyogo Institute for Ageing Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    Neuroradiology 42:787-94. 2000
    ..946 and 0.584, respectively). These results indicate that a Z map obtained in this way is superior to conventional PET for diagnosing AD...
  26. ncbi request reprint Striatal infarcts mimicking frontotemporal dementia: a case report
    Y Nishio
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 10:457-60. 2003
    ..A disruption of the fronto-subcortical circuits at the level of the striatum or the anterior thalamic peduncle is attributable to the FTD-like behavioral and cognitive syndrome...
  27. pmc Case-control study of presenilin-1 intronic polymorphism in sporadic early and late onset Alzheimer's disease
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji
    J Neurol Neurosurg Psychiatry 66:722-6. 1999
    ..The purpose of this study is to determine whether Alzheimer's disease is associated with presenilin-1 gene polymorphism and the apolipoprotein E genotype in an extended case-control study...
  28. ncbi request reprint Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images
    H Kitagaki
    Neuroimaging Research Radiology Service, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Radiology 216:31-8. 2000
    ..To determine the characteristics of cortical atrophy in corticobasal degeneration and Alzheimer disease by using a hemispheric surface display generated with magnetic resonance (MR) images...