M Hashimoto

Summary

Affiliation: Hyogo Institute for Aging Brain and Cognitive Disorders
Country: Japan

Publications

  1. ncbi request reprint Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
    M Hashimoto
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 57:1461-6. 2001
  2. ncbi request reprint Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:139-46. 2000
  3. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
  4. ncbi request reprint Clinical diagnosis of dementia with Lewy bodies in a Japanese dementia registry
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 10:210-6. 1999
  5. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
  6. ncbi request reprint Age at onset and language disturbances in Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neuropsychologia 36:945-9. 1998
  7. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
  8. ncbi request reprint Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging, Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 235:49-52. 1997
  9. ncbi request reprint Distinctive neurobehavioral features among neurodegenerative dementias
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:498-503. 1999
  10. ncbi request reprint Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Br J Psychiatry 177:343-7. 2000

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease
    M Hashimoto
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 57:1461-6. 2001
    ..Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial...
  2. ncbi request reprint Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:139-46. 2000
    ..These features of regional glucose metabolic abnormality in CBD may correspond to neurological and cognitive disturbances peculiar to CBD...
  3. pmc Regional metabolism: associations with dyscalculia in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 65:913-6. 1998
    ..However, the region most responsible for dyscalculia in Alzheimer's disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer's disease was therefore examined...
  4. ncbi request reprint Clinical diagnosis of dementia with Lewy bodies in a Japanese dementia registry
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 10:210-6. 1999
    ..Patients with DLB have a unique dementia syndrome even in the stage of mild to moderate cognitive impairments. Further studies are recommended to establish diagnosis, treatment and management...
  5. pmc Factors associated with psychotic symptoms in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neurol Neurosurg Psychiatry 64:648-52. 1998
    ..The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer's disease...
  6. ncbi request reprint Age at onset and language disturbances in Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neuropsychologia 36:945-9. 1998
    ..The different patterns of language deficits between early- and late-onset patients may correspond to the genetic heterogeneity of AD...
  7. ncbi request reprint Neuronal substrates for semantic memory: a positron emission tomography study in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:15-21. 2001
    ..Our results suggested that the left inferior temporal lobe contributes to verbal semantic memory...
  8. ncbi request reprint Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging, Brain and Cognitive Disorders, Himeji, Japan
    Neurosci Lett 235:49-52. 1997
    ..These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases...
  9. ncbi request reprint Distinctive neurobehavioral features among neurodegenerative dementias
    N Hirono
    Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:498-503. 1999
    ..The findings clearly demonstrate that AD, DLB, and FTD have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias...
  10. ncbi request reprint Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Br J Psychiatry 177:343-7. 2000
    ..In an earlier study we showed that a powerful emotional experience (the Kobe earthquake) reinforced memory retention in patients with Alzheimer's disease, but we could not control factors other than the emotional impact of the earthquake...
  11. ncbi request reprint Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    J Neuropsychiatry Clin Neurosci 11:66-70. 1999
    ..The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele...
  12. ncbi request reprint Visuoperceptual impairment in dementia with Lewy bodies
    E Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 57:489-93. 2000
    ..In dementia with Lewy bodies (DLB), vision-related cognitive and behavioral symptoms are common, and involvement of the occipital visual cortices has been demonstrated in functional neuroimaging studies...
  13. ncbi request reprint A study of remote memory impairment in Alzheimer's disease by using the family line test
    H Kazui
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 11:53-8. 2000
    ..A prominent temporal gradient in remote memory impairment was documented in the patients with AD. The total FLT score and duration of remote memory impairment correlated with recent memory and general cognitive dysfunctions...
  14. ncbi request reprint A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 56:65-9. 1999
    ..To disclose a novel mutation of the presenilin 1 (PS1) gene responsible for early-onset Alzheimer disease and to clarify genotype-phenotype correlation that should help to establish the function of this protein...
  15. ncbi request reprint Occipital glucose metabolism in dementia with lewy bodies with and without Parkinsonism: a study using positron emission tomography
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Dement Geriatr Cogn Disord 12:194-7. 2001
    ..The neurobiological bases of occipital hypometabolism in DLB may be pathological processes in the brainstem or basal forebrain structures other than the nigrostriatal system...
  16. ncbi request reprint Fall-related injuries in dementia with Lewy bodies (DLB) and Alzheimer's disease
    T Imamura
    Division of Clinical Neurosciences, Hyogo Institute for Ageing Brain and Cognitive Disorders, Hyogo Institute Hospital for Ageing Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 7:77-9. 2000
    ..An appropriate clinical discrimination between DLB and AD is recommended to manage and prevent fall-related injuries...
  17. ncbi request reprint The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset
    N Hirono
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Neurology 58:743-50. 2002
    ..One possible reason for this controversy is that previous studies did not consider the effect of patient age at symptom onset...
  18. ncbi request reprint Impact of white matter changes on clinical manifestation of Alzheimer's disease: A quantitative study
    N Hirono
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Stroke 31:2182-8. 2000
    ..We studied the association between the volume of white matter hyperintensities (WMHs) on T2-weighted images and cognitive, neurological, and neuropsychiatric symptoms...
  19. ncbi request reprint Striatal infarcts mimicking frontotemporal dementia: a case report
    Y Nishio
    Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Eur J Neurol 10:457-60. 2003
    ..A disruption of the fronto-subcortical circuits at the level of the striatum or the anterior thalamic peduncle is attributable to the FTD-like behavioral and cognitive syndrome...
  20. ncbi request reprint Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats
    S Gamoh
    Department of Physiology, Shimane Medical University, Izumo, Japan
    Clin Exp Pharmacol Physiol 28:266-70. 2001
    ..Moreover, chronic administration of DHA was effective in decreasing the level of hippocampal LPO, then improving learning ability...
  21. ncbi request reprint Collagen degradation by host-derived enzymes during aging
    D H Pashley
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    J Dent Res 83:216-21. 2004
    ..2% chlorhexidine. We hypothesize that collagen degradation occurred over time, via host-derived matrix metalloproteinases that are released slowly over time...
  22. ncbi request reprint Effects of exercise on platelet and aortic functions in aged rats
    Y Tanaka
    Department of Neurosurgery, San in Rosai Hospital, Yonago, Tottori, Japan
    Acta Physiol Scand 179:155-65. 2003
    ....
  23. pmc State-dependent regulation of cortical blood flow and respiration in hamsters: response to hypercapnia during arousal from hibernation
    P G Osborne
    Department of Physiology, Asahikawa Medical University School of Medicine, Asahikawa 078 8510, Japan
    J Physiol 547:963-70. 2003
    ....
  24. ncbi request reprint A new model to evaluate the diet-induced prothrombotic state, using He-Ne laser-induced thrombogenesis in the carotid artery of apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    Y Ijiri
    Laboratory of Physiology, Faculty of Nutrition, and High Technology Research Center, Kobe Gakuin University, Japan
    Blood Coagul Fibrinolysis 13:497-504. 2002
    ..These diets were on the basis of AIN93G and were given to mice for 4 or 8 weeks. The high fat diet significantly enhanced both the thrombotic reaction and the development of atherosclerosis as compared with the low fat diet...
  25. ncbi request reprint Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD
    J M Woulfe
    Department of Pathology, The University of Ottawa, Hamilton, Ontario, Canada
    Neurology 58:1435-6. 2002
  26. pmc Comparative studies of AJG049, a novel Ca2+ channel antagonist, on voltage-dependent L-type Ca2+ currents in intestinal and vascular smooth muscle
    M Hashimoto
    Pharmaceutical Research Laboratories, Ajinomoto Co Inc, Kawasaki, Japan
    Br J Pharmacol 149:155-62. 2006
    ....
  27. ncbi request reprint Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis
    T Kaneshige
    Shionogi Biomedical Laboratories, Osaka, Japan
    Tissue Antigens 44:204-7. 1994
  28. pmc beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    E Masliah
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 98:12245-50. 2001
    ..Therefore, treatments that block the production or accumulation of beta-amyloid peptides could benefit a broader spectrum of disorders than previously anticipated...
  29. ncbi request reprint Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling
    M Hashimoto
    Department of Biology and Biochemistry, University of Bath, Claverton Down, UK
    Carbohydr Res 331:119-27. 2001
    ..Studies on the erythrocyte glucose transporter (GLUT1) and the insulin-stimulated adipose cell transporter (GLUT4) have revealed the biotinylated photoreactive bis-glucose compounds are effective labelling reagents...
  30. ncbi request reprint Hemagglutinin genotype profiles of canine distemper virus from domestic dogs in Japan
    M Hashimoto
    Laboratory of Clinical Microbiology, Kyoritsu Shoji Corporation, Tokyo, Japan
    Arch Virol 146:149-55. 2001
    ..One is the native and numerically predominant KDK-1 genotype, while the other is the 98-002 genotype that may have evolved in the Far East beyond the border between Japan and the Republic of Korea...
  31. ncbi request reprint Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus
    M Hashimoto
    The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Hum Genet 105:197-9. 1999
    ..However, this association is not independent of TNFa polymorphisms...
  32. ncbi request reprint Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development
    L J Hsu
    Department of Neuroscience, University of California San Diego, La Jolla 92093 0624, USA
    J Neurochem 71:338-44. 1998
    ....
  33. ncbi request reprint Brain-derived neurotrophic factor gene expression in the developing zebrafish
    M Hashimoto
    Evans Department of Clinical Research and Medicine, Boston University Medical Center Hospital, MA 02118, USA
    Int J Dev Neurosci 15:983-97. 1997
    ..The early onset and cellular sites of expression suggest that BDNF functions in nervous system and fin development in the zebrafish...
  34. ncbi request reprint A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences
    S Saito
    Nagano Red Cross Blood Center, Japan
    Tissue Antigens 48:580-5. 1996
    ..The HLA molecule encoded by the allele is not defined by serology. This new allele was officially recognized and named DQB1*0306 by the WHO Nomenclature Committee in November 1995...
  35. ncbi request reprint Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18
    S Sugama
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
    Neuroscience 146:1388-99. 2007
    ..The present study reports evidence that physical/emotional stress may induce morphological microglial activation in the brain and this activation is in part mediated by interleukin-18...