Junichi Azuma

Summary

Affiliation: Hyogo University of Health Sciences
Country: Japan

Publications

  1. pmc Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice
    Takashi Ito
    Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
    J Biomed Sci 17:S20. 2010
  2. pmc NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: a randomized controlled trial for pharmacogenetics-based therapy
    Junichi Azuma
    Clinical Pharmacology and Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Eur J Clin Pharmacol 69:1091-101. 2013
  3. pmc The potential usefulness of taurine on diabetes mellitus and its complications
    Takashi Ito
    Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1 3 6 Minatojima, Chuo Ku, Kobe, Hyogo, 650 8530, Japan
    Amino Acids 42:1529-39. 2012
  4. pmc Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
  5. pmc Physiological roles of taurine in heart and muscle
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S2. 2010
  6. pmc The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine
    Junichi Azuma
    Clinical Pharmacology and Pharmacogenomics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1 3 6, Minatojima, Chuo Ku, Kobe, 650 8530, Japan
    Eur J Clin Pharmacol 68:29-37. 2012
  7. doi request reprint The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II
    Takashi Ito
    Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Amino Acids 46:111-9. 2014
  8. doi request reprint Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients
    Masako Ohno
    Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Eur J Clin Pharmacol 65:1097-103. 2009
  9. ncbi request reprint Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity
    Etsuko Uejima
    Department of Pharmacy, Osaka University Hospital, Suita, Osaka, Japan
    J Clin Pharmacol 42:1374-9. 2002
  10. ncbi request reprint [Genetic analysis for nicotine dependence]
    Makiko Maeda
    Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences
    Nihon Rinsho 69:1887-90. 2011

Collaborators

Detail Information

Publications11

  1. pmc Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice
    Takashi Ito
    Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
    J Biomed Sci 17:S20. 2010
    ..In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice...
  2. pmc NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: a randomized controlled trial for pharmacogenetics-based therapy
    Junichi Azuma
    Clinical Pharmacology and Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Eur J Clin Pharmacol 69:1091-101. 2013
    ....
  3. pmc The potential usefulness of taurine on diabetes mellitus and its complications
    Takashi Ito
    Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1 3 6 Minatojima, Chuo Ku, Kobe, Hyogo, 650 8530, Japan
    Amino Acids 42:1529-39. 2012
    ..This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness...
  4. pmc Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
    ..The present study examines the effect of taurine deficiency on the first step of mitochondrial protein synthesis regulation by taurine, namely, the formation of taurinomethyluridine containing tRNA...
  5. pmc Physiological roles of taurine in heart and muscle
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S2. 2010
    ..The mechanism of this action has not been studied. Taurine is a chemically simple compound, but it has profound effects on cells. This has led to the suggestion that taurine is an essential or semi-essential nutrient for many mammals...
  6. pmc The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine
    Junichi Azuma
    Clinical Pharmacology and Pharmacogenomics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, 1 3 6, Minatojima, Chuo Ku, Kobe, 650 8530, Japan
    Eur J Clin Pharmacol 68:29-37. 2012
    ..To investigate the effects of coadministration of paroxetine or fluvoxamine on the pharmacokinetics of aripiprazole in healthy adult Japanese with different CYP2D6 genotypes...
  7. doi request reprint The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II
    Takashi Ito
    Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Amino Acids 46:111-9. 2014
    ..In this review, we summarize the beneficial actions of taurine in CHF, focusing on its antagonism of the catecholamines and angiotensin II. ..
  8. doi request reprint Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients
    Masako Ohno
    Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Eur J Clin Pharmacol 65:1097-103. 2009
    ..The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population...
  9. ncbi request reprint Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity
    Etsuko Uejima
    Department of Pharmacy, Osaka University Hospital, Suita, Osaka, Japan
    J Clin Pharmacol 42:1374-9. 2002
    ..This is the first report of evaluating the urinary 6beta-hydroxycortisol/cortisol ratio in a case of porphyria...
  10. ncbi request reprint [Genetic analysis for nicotine dependence]
    Makiko Maeda
    Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences
    Nihon Rinsho 69:1887-90. 2011
    ..Referring to the genome association studies, better understanding the molecular mechanisms of nicotine dependence would help to design targeted, more effective therapies for the tobacco-related diseases and smoking cessation program...
  11. doi request reprint Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers
    Seong Ryul Kim
    Department of Clinical Research and Development, Otsuka Pharmaceutical Co, Ltd, 3 2 27 Otedori, Chuo Ku, Osaka, 540 0021, Japan
    Cardiovasc Drugs Ther 25:S5-17. 2011
    ..Single- and multiple-dose studies were conducted to assess the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Japanese subjects...