Tsutomu Tsuji

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. ncbi request reprint Characterization of mouse integrin alpha3 subunit gene
    T Tsuji
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Biochem 125:1183-8. 1999
  2. ncbi request reprint Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3)
    Tsutomu Tsuji
    Department of Microbiology, Hoshi University, Tokyo, Japan
    Clin Exp Metastasis 19:127-34. 2002
  3. ncbi request reprint Physiological and pathological roles of alpha3beta1 integrin
    Tsutomu Tsuji
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    J Membr Biol 200:115-32. 2004
  4. ncbi request reprint Changes in adhesive and migratory characteristics of hepatocellular carcinoma (HCC) cells induced by expression of alpha3beta1 integrin
    Hiromi Mizuno
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biochim Biophys Acta 1780:564-70. 2008
  5. ncbi request reprint Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5
    Yuta Saito
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, Japan
    Clin Exp Metastasis 27:197-205. 2010
  6. pmc Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain
    Saotomo Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    J Biol Chem 288:21569-80. 2013
  7. doi request reprint Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes
    Saotomo Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Nagoya 467 8603, Japan
    Biochem Biophys Res Commun 433:127-32. 2013
  8. doi request reprint Cytokine secretion from human monocytes potentiated by P-selectin-mediated cell adhesion
    Junsuke Suzuki
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 160:152-60. 2013
  9. doi request reprint Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix
    Go Kamoshida
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Cancer Lett 315:145-52. 2012
  10. ncbi request reprint Transforming growth factor-beta1 upregulates transcription of alpha3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region
    Kouji Katabami
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Clin Exp Metastasis 22:539-48. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Characterization of mouse integrin alpha3 subunit gene
    T Tsuji
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Biochem 125:1183-8. 1999
    ..This result is consistent with our previous finding that integrin alpha3 expression at both the protein and mRNA levels is enhanced upon oncogenic transformation of fibroblasts by tumor viruses...
  2. ncbi request reprint Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3)
    Tsutomu Tsuji
    Department of Microbiology, Hoshi University, Tokyo, Japan
    Clin Exp Metastasis 19:127-34. 2002
    ..These results strongly suggest that the interaction of laminin-5 produced in the epidermis with alpha3beta1 integrin on melanoma cells is involved in cell migration, invasion, and degradation of extracellular matrix proteins...
  3. ncbi request reprint Physiological and pathological roles of alpha3beta1 integrin
    Tsutomu Tsuji
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    J Membr Biol 200:115-32. 2004
    ....
  4. ncbi request reprint Changes in adhesive and migratory characteristics of hepatocellular carcinoma (HCC) cells induced by expression of alpha3beta1 integrin
    Hiromi Mizuno
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biochim Biophys Acta 1780:564-70. 2008
    ..These results strongly suggest that enhanced expression of alpha3beta1 integrin on HCC cells is directly involved in their malignant phenotypes such as invasion and metastasis...
  5. ncbi request reprint Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5
    Yuta Saito
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, Japan
    Clin Exp Metastasis 27:197-205. 2010
    ..These results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix...
  6. pmc Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain
    Saotomo Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    J Biol Chem 288:21569-80. 2013
    ..This is the first finding that the bacterial protein inhibits blood coagulation via targeting the Gla domain of coagulation factors...
  7. doi request reprint Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes
    Saotomo Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Nagoya 467 8603, Japan
    Biochem Biophys Res Commun 433:127-32. 2013
    ..The present study added a novel role of SSL family protein as an interrupting molecule against the function of extracellular matrix...
  8. doi request reprint Cytokine secretion from human monocytes potentiated by P-selectin-mediated cell adhesion
    Junsuke Suzuki
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 160:152-60. 2013
    ..We assessed how P-selectin-mediated cell adhesion affects cytokine secretion from monocytes...
  9. doi request reprint Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix
    Go Kamoshida
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Cancer Lett 315:145-52. 2012
    ..These results suggest that cell adhesion to the extracellular matrix plays a crucial role in monocyte differentiation into TAM-like cells...
  10. ncbi request reprint Transforming growth factor-beta1 upregulates transcription of alpha3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region
    Kouji Katabami
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Clin Exp Metastasis 22:539-48. 2005
    ..These results suggest that TGF-beta1 stimulates HepG2 cells to express a higher level of alpha3 integrin by transcriptional upregulation via Ets transcription factors and to exhibit a more invasive phenotype...
  11. pmc Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin
    Teruaki Oku
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    J Biol Chem 287:42910-20. 2012
    ..These results indicate that the constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin...
  12. doi request reprint Redistribution of P-selectin ligands on neutrophil cell membranes and the formation of platelet-neutrophil complex induced by hemodialysis membranes
    Saotomo Itoh
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biomaterials 29:3084-90. 2008
    ..The present study indicates the importance of synergistic exacerbation of complement activation and platelet-neutrophil microaggregate formation in developing hemodialysis-associated complications...
  13. ncbi request reprint Characterization of the promoter for the alpha3 integrin gene in various tumor cell lines: roles of the Ets- and Sp-family of transcription factors
    Kouji Katabami
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    J Cell Biochem 97:530-43. 2006
    ..These results suggest that the Sp3 and Ets transcription factors cooperatively regulate alpha3 integrin gene expression and that the contribution of each element depends on the type of tumor cells...
  14. pmc Staphylococcal superantigen-like protein 5 inhibits matrix metalloproteinase 9 from human neutrophils
    Saotomo Itoh
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Infect Immun 78:3298-305. 2010
    ..We discuss possible roles that SSL5 may play in immune evasion of staphylococci by inhibiting MMP and interfering with leukocyte trafficking...
  15. doi request reprint Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5)
    Go Kamoshida
    Department of Microbiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Clin Exp Metastasis 31:285-91. 2014
    ..These results indicate that the activity of laminin-332 for monocyte differentiation is dynamically regulated by the proteolytic processing of the γ2 chain...
  16. doi request reprint Involvement of transcription factor Ets-1 in the expression of the α3 integrin subunit gene
    Go Kamoshida
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    FEBS J 279:4535-46. 2012
    ..These results suggest that Ets-1 is involved in transcriptional activation of the α3 integrin gene through its binding to the Ets-consensus sequence at -133 bp...
  17. pmc Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages
    Ryosuke Yokoyama
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya, Japan
    Infect Immun 80:2816-25. 2012
    ..The present study provides a novel mechanism of SSL3 in immune evasion of S. aureus via interfering with its recognition by innate immune cells...
  18. ncbi request reprint Preventive effect of alpha-tocopherol and glycyrrhizin against platelet-neutrophil complex formation induced by hemodialysis membranes
    Kane Takeshita
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Int J Artif Organs 32:282-90. 2009
    ..This complex formation is mediated primarily by the interaction between P-selectin on activated platelets and its counter-ligands on leukocytes...
  19. doi request reprint Staphylococcal superantigen-like protein 10 binds to phosphatidylserine and apoptotic cells
    Saotomo Itoh
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1, Tanabe dori, Mizuho ku, Nagoya, Japan
    Microbiol Immunol 56:363-71. 2012
    ..These findings suggest SSL10 and its derived peptides may be a novel detection tool for apoptotic cells...
  20. ncbi request reprint Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains
    Saotomo Itoh
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    J Leukoc Biol 81:1414-21. 2007
    ....
  21. pmc Phorbol ester-dependent phosphorylation regulates the association of p57/coronin-1 with the actin cytoskeleton
    Teruaki Oku
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    J Biol Chem 283:28918-25. 2008
    ..These results strongly suggest that the phosphorylation of p57/coronin-1 down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton...
  22. doi request reprint Potentiation of tumor cell invasion by co-culture with monocytes accompanying enhanced production of matrix metalloproteinase and fibronectin
    Go Kamoshida
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Clin Exp Metastasis 30:289-97. 2013
    ..These results suggest that TNF-α secreted from monocytes is, at least in part, involved in the changes in invasive phenotype of tumor cells during co-culture with monocytes...
  23. ncbi request reprint Platelet activation through interaction with hemodialysis membranes induces neutrophils to produce reactive oxygen species
    Saotomo Itoh
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    J Biomed Mater Res A 77:294-303. 2006
    ....
  24. ncbi request reprint Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3)
    Hironori Takatsuki
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:6065-70. 2004
    ..These results strongly suggest that alpha3beta1 integrin plays an essential role in mediating the initial attachment of cancer cells to the peritoneum, leading to the formation of peritoneal metastasis...
  25. ncbi request reprint Characterization of the promoter for the mouse alpha 3 integrin gene
    Takumi Kato
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Eur J Biochem 269:4524-32. 2002
    ....
  26. doi request reprint Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway
    Saotomo Itoh
    Department of Microbiology, Hoshi University, School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    Mol Immunol 47:932-8. 2010
    ..These results suggest that SSL10 may play a role in the evasion of Staphylococcus aureus from the host immune system via interfering complement activation...
  27. pmc Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region
    Teruaki Oku
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biochem J 387:325-31. 2005
    ....
  28. ncbi request reprint On a salmon (Oncorhynchus [corrected] keta) liver RNase, belonging to RNase T2 family: primary structure and some properties
    Rie Suzuki
    Department of Applied Microbiology, Hoshi University, Tokyo, Japan
    Biosci Biotechnol Biochem 69:343-52. 2005
    ..Based on the results, the role of H104, which has been proposed to be a phosphate binding site with a substrate, was reconsidered, and we proposed a revised role of this His residue in the hydrolysis mechanism of RNase T2 family enzymes...
  29. ncbi request reprint Acetylcholine-induced translocation of RhoA in freshly isolated single smooth muscle cells of rat bronchi
    Yoshihiko Chiba
    Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo 142 8501, Japan
    J Pharmacol Sci 95:479-82. 2004
    ..Thus, the present study clearly demonstrated an acetylcholine-induced translocation of RhoA to the plasma membrane in single bronchial smooth muscle cells of the rat...
  30. ncbi request reprint Inhibition of P-selectin-mediated cell adhesion by a sulfated derivative of sialic acid
    Tomonori Shodai
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biochem Biophys Res Commun 312:787-93. 2003
    ..In conclusion, NMSO3 acts as a specific inhibitor for P-selectin-mediated cell adhesion and for adhesion-dependent leukocyte activation...
  31. ncbi request reprint Effect of replacing the aspartic acid/glutamic acid residues of bullfrog sialic acid binding lectin with asparagine/glutamine and arginine on the inhibition of cell proliferation in murine leukemia P388 cells
    Yuko Ogawa
    Department of Microbiology, Hoshi College of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 25:722-7. 2002
    ..The mutant was well-characterized as a pure cSBL derivative suitable for studying the mechanism of the anti-tumor action of cSBL...
  32. ncbi request reprint Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins
    Ryoko Nishiuchi
    Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University, Suita, Osaka, 565 0871, Japan
    Matrix Biol 25:189-97. 2006
    ....
  33. ncbi request reprint Cutaneous mixed tumors: an immunohistochemical study using two antibodies, G-81 and C8/144B
    Yoshimi Minami
    J Dermatol Sci 36:180-2. 2004
  34. ncbi request reprint Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella
    Tsuyoshi Hayashi
    Laboratory of Microbiology and Immunology and the Global COE Program, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Suruga ku, Shizuoka, Shizuoka 422 8526, Japan
    Biol Pharm Bull 31:861-5. 2008
    ..Taken together, these results suggest that the endocytic pathways of live Legionella species are distinct from general phagocytic pathways, which lead to lysosomal degradation...