Hiroyasu Sakai


Affiliation: Hoshi University
Country: Japan


  1. Suto W, Ando Y, Hirabayashi T, Takenoya F, Shioda S, Kamei J, et al. Prostaglandin D₂ Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings suggest that PGD₂ causes RhoA/Rho-kinase-mediated Ca2+ sensitization of BSM contraction to augment its contractility. Increased PGD₂ level in the airways might be a cause of the AHR in asthma. ..
  2. Sakai H, Enzaka J, Sakai Oshita M, Chiba Y, Misawa M. Augmented venous responsiveness to leukotriene D(4) in nasal septal mucosae of repeatedly antigen-challenged rats. Eur J Pharmacol. 2010;644:215-9 pubmed publisher
    ..Therein, not only increased NO production but also enhanced NO responsiveness might be involved in the development of nasal hyperresponsiveness in allergic rhinitis. ..
  3. request reprint
    Sakai H, Fujita A, Watanabe A, Chiba Y, Kamei J, Misawa M. Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats. J Smooth Muscle Res. 2011;47:1-10 pubmed
    ..The increased expression of RhoA seems to have an important role in the augmented contractile responses of the airways in rats, a characteristic feature of early COPD. ..
  4. Sakai H, Kurihara Y, Hashimoto Y, Chiba Y, Misawa M. Phorbol 12,13-dibutyrate-mediated contraction of the stimulated bronchial smooth muscles of mice. Respir Physiol Neurobiol. 2010;173:120-4 pubmed publisher
    ..Thus, a certain level of intracellular Ca(2+) might be needed both for an activation of CPI-17 and an induction of contraction induced by PDBu in mouse BSMs. ..
  5. Sakai H, Sagara A, Matsumoto K, Hasegawa S, Sato K, Nishizaki M, et al. 5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines. PLoS ONE. 2013;8:e54788 pubmed publisher
    ..These decreases were not reversed by etanercept. These findings suggest TNF-? neutralization had no effect on the acutely 5-FU-induced diarrhea and impaired AQPs but reduced dramatically several inflammatory cytokines. ..
  6. Sakai H, Sato K, Sato F, Kai Y, Mandokoro K, Matsumoto K, et al. Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling. Inflamm Res. 2017;66:663-678 pubmed publisher
    ..Ear swelling induced by TNCB challenge might be mediated, in part, by the EPGN- and AREG-ERK proliferation pathway and was inhibited by curcumin. ..
  7. Sakai H, Nishizawa Y, Nishimura A, Chiba Y, Goto K, Hanazaki M, et al. Angiotensin II induces hyperresponsiveness of bronchial smooth muscle via an activation of p42/44 ERK in rats. Pflugers Arch. 2010;460:645-55 pubmed publisher
  8. Sakai H, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, et al. Mechanisms of cisplatin-induced muscle atrophy. Toxicol Appl Pharmacol. 2014;278:190-9 pubmed publisher
    ..This phenomenon could, at least in part, explain the mechanism of cisplatin-induced muscle fatigue. ..
  9. Sakai H, Hara T, Todoroki K, Igarashi Y, Misawa M, Narita M, et al. Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats. Microvasc Res. 2013;90:150-3 pubmed publisher
    ..The present findings suggest the idea that the promoted cGMP/PKG pathway may be involved in the enhanced NO-induced venodilatation in nasal mucosae of antigen-challenged rats. ..

More Information


  1. request reprint
    Sakai H, Chiba Y, Misawa M. Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle. Pulm Pharmacol Ther. 2007;20:734-9 pubmed
    ..Thus, RhoA/ROCK/CPI-17 pathway is considered to play an important role in the ET-1-induced Ca(2+) sensitisation of bronchial smooth muscle contraction. ..
  2. Sakai H, Kimura M, Isa Y, Yabe S, Maruyama A, Tsuruno Y, et al. Effect of acute treadmill exercise on cisplatin-induced muscle atrophy in the mouse. Pflugers Arch. 2017;469:1495-1505 pubmed publisher
    ..These findings suggest that treadmill exercise could attenuate cisplatin-induced muscle atrophy, at least partially, and could improve prognosis. ..
  3. Sakai H, Kai Y, Sato K, Ikebe M, Chiba Y. Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction. Eur J Pharmacol. 2018;818:74-83 pubmed publisher
    ..These results suggest that Rac1, activated by G protein-coupled receptor agonists, such as CCh and ET-1, may induce myosin light chain and MYPT phosphorylation and modulate the contraction of bronchial smooth muscle. ..