Minoru Narita

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. ncbi request reprint [The implication of protein kinase C in the cell-cell interaction during the development of dependence on morphine]
    Minoru Narita
    Nihon Yakurigaku Zasshi 127:32-5. 2006
  2. pmc Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells
    N Kuzumaki
    Department of Physiology, Keio University, School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Br J Cancer 106:1148-52. 2012
  3. pmc Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
    Addict Biol 18:614-22. 2013
  4. doi request reprint Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain
    Satoshi Imai
    Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Brain 136:828-43. 2013
  5. ncbi request reprint [Global understanding of pain]
    Minoru Narita
    Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:63-72. 2012
  6. ncbi request reprint Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    J Neurosci 26:398-405. 2006
  7. ncbi request reprint Role of Src family kinase in the rewarding effect and hyperlocomotion induced by morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Neuroreport 17:115-9. 2006
  8. ncbi request reprint Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Neuropsychopharmacology 31:2476-88. 2006
  9. ncbi request reprint Neuronal protein kinase C gamma-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Neurosci 19:479-84. 2004
  10. ncbi request reprint Increased phosphorylated-mu-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 354:148-52. 2004

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint [The implication of protein kinase C in the cell-cell interaction during the development of dependence on morphine]
    Minoru Narita
    Nihon Yakurigaku Zasshi 127:32-5. 2006
  2. pmc Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells
    N Kuzumaki
    Department of Physiology, Keio University, School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Br J Cancer 106:1148-52. 2012
    ..It is becoming increasingly recognised that opioids are responsible for tumour growth. However, the effects of opioids on tumour growth have been controversial...
  3. pmc Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
    Addict Biol 18:614-22. 2013
    ..The present findings indicate that released β-endorphin within the spinal cord may be implicated in the rapid development of tolerance to fentanyl under a neuropathic pain-like state. ..
  4. doi request reprint Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain
    Satoshi Imai
    Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Brain 136:828-43. 2013
    ....
  5. ncbi request reprint [Global understanding of pain]
    Minoru Narita
    Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:63-72. 2012
    ..For a global understanding of the pain, it is necessary to analyze the correlation between these temporal parameters and phenomics...
  6. ncbi request reprint Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    J Neurosci 26:398-405. 2006
    ..These findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents...
  7. ncbi request reprint Role of Src family kinase in the rewarding effect and hyperlocomotion induced by morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Neuroreport 17:115-9. 2006
    ..These findings suggest that Src family kinases in the nucleus accumbens are involved in the rewarding effect and hyperlocomotion induced by morphine...
  8. ncbi request reprint Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Neuropsychopharmacology 31:2476-88. 2006
    ..The present study provides direct evidence that astrocytes may, at least in part, contribute to the synaptic plasticity induced by drugs of abuse during the development of rewarding effects induced by psychostimulants and opioids...
  9. ncbi request reprint Neuronal protein kinase C gamma-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Neurosci 19:479-84. 2004
    ..This neuron-glia communication may lead to the development of tolerance to morphine-induced antinociception...
  10. ncbi request reprint Increased phosphorylated-mu-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 354:148-52. 2004
    ....
  11. ncbi request reprint mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 138:609-19. 2006
    ..These findings raise the possibility that the increased astroglia response produced by chronic morphine could be associated with the lack of mu-opioid receptor internalization...
  12. ncbi request reprint Change in the expression of c-fos in the rat brain following sciatic nerve ligation
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 352:231-3. 2003
    ..These results provide direct evidence that the neuropathic pain-like state causes a substantial change in the expression of c-fos in the rat brain...
  13. ncbi request reprint Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    J Neurochem 97:1337-48. 2006
    ....
  14. ncbi request reprint [Role of astrocytes in rewarding effects of drugs of abuse]
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:33-9. 2006
    ....
  15. ncbi request reprint Molecular mechanism of changes in the morphine-induced pharmacological actions under chronic pain-like state: suppression of dopaminergic transmission in the brain
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Life Sci 74:2655-73. 2004
    ..Conclusively, our recent findings provide novel evidences for the mechanism underlying the less sensitivity to opioids under a neuropathic pain-like state...
  16. ncbi request reprint Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 125:545-51. 2004
    ....
  17. ncbi request reprint [Implication of glial function in the development of drug dependence associated with synaptic plasticity]
    Minoru Narita
    Nihon Yakurigaku Zasshi 126:43-8. 2005
  18. ncbi request reprint Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Life Sci 77:2207-20. 2005
    ..The following review provides a summary of recent our findings regarding the role of NMDA receptor and its associated protein kinase in the development of psychological dependence on morphine...
  19. ncbi request reprint Implication of cyclin-dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    J Neurochem 93:1463-8. 2005
    ..These findings suggest that the induction and/or activation of cdk5 are implicated in the development of psychological dependence on morphine...
  20. ncbi request reprint Long-lasting change in brain dynamics induced by methamphetamine: enhancement of protein kinase C-dependent astrocytic response and behavioral sensitization
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Ebara, Tokyo, Japan
    J Neurochem 93:1383-92. 2005
    ..This information can break through the definition of drugs of abuse and the misleading of concept that morphine produces a long-lasting neurotoxicity...
  21. ncbi request reprint Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 132:553-60. 2005
    ..The present data provide evidence for the change in the translation rate, which can be regulated by S6K phosphorylation, in the N.Acc. during the development of sensitization to METH-induced rewarding effects in rats...
  22. ncbi request reprint Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 127:941-8. 2004
    ....
  23. ncbi request reprint Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Ebara, Shinagawa ku, Tokyo, Japan
    Neuropsychopharmacology 30:111-8. 2005
    ..Acc., resulting in suppression of the morphine-induced rewarding effect in rats. The present study provides further evidence of the clinical usefulness of morphine in patients suffering from severe pain...
  24. ncbi request reprint Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Brain Res 1015:189-93. 2004
    ..These findings suggest that the stimulation of spinal PKC results in an enhancement of neuronal activity in the PF, amygdala and CG associated with hyperalgesia...
  25. ncbi request reprint Role of the calcium/calmodulin-dependent protein kinase ii (CaMKII) in the morphine-induced pharmacological effects in the mouse
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 126:415-21. 2004
    ..pretreatment with KN-93. These results provide evidence that the increase in CaMKII activity in the mouse limbic forebrain may contribute to the rewarding effect, but not the antinociception and the hyperlocomotion, induced by morphine...
  26. ncbi request reprint Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Tokyo 142 8501, Japan
    J Neurosci 25:10000-9. 2005
    ..These data provide novel evidence that PAR-1 and PDGF-A-mediated signaling pathway within spinal cord neurons may be directly implicated in neuropathic pain after nerve injury in mice...
  27. ncbi request reprint Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Neuropsychopharmacology 31:739-50. 2006
    ..Collectively, the present data constitute the first evidence that chronic pain has an anxiogenic effect in mice. This phenomenon may be associated with changes in opioidergic function in the amygdala...
  28. ncbi request reprint Prenatal and neonatal exposure to low-dose of bisphenol-A enhance the morphine-induced hyperlocomotion and rewarding effect
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawaku, Tokyo 142 8501, Japan
    Neurosci Lett 402:249-52. 2006
    ....
  29. ncbi request reprint Chronic pain-induced emotional dysfunction is associated with astrogliosis due to cortical delta-opioid receptor dysfunction
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    J Neurochem 97:1369-78. 2006
    ..This phenomenon may lead to emotional disorders including aggravated anxiety under chronic pain-like state...
  30. doi request reprint Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 152:477-86. 2008
    ....
  31. doi request reprint Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Ann N Y Acad Sci 1141:96-104. 2008
    ..These findings provide direct evidence that astrocytes may, at least in part, contribute to the development of the rewarding effects induced by drugs of abuse in the nucleus accumbens and cingulate cortex...
  32. doi request reprint Suppression of dopamine-related side effects of morphine by aripiprazole, a dopamine system stabilizer
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Eur J Pharmacol 600:105-9. 2008
    ..These results suggest that the co-administration of aripiprazole may be useful for reducing the severity of morphine-induced dopamine-related side effects...
  33. doi request reprint Implication of dopaminergic projection from the ventral tegmental area to the anterior cingulate cortex in μ-opioid-induced place preference
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Addict Biol 15:434-47. 2010
    ..The activation of DARPP32 and CREB through dopamine D1 receptors in the ACG could be implicated in the maintenance of μ-opioid-induced place preference...
  34. doi request reprint Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex
    Minoru Narita
    Department of Toxicology, Hoshi University, School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Pain 152:1358-72. 2011
    ..Neuropathic pain-like stimuli suppress the GABAergic transmission with increased GABA (γ-aminobutyric acid) transporters located on activated astrocytes in the cingulate cortex related to sleep disturbance...
  35. ncbi request reprint Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 137:1359-67. 2006
    ..This phenomenon may lead to emotional disorders including aggravated anxiety during normal aging...
  36. doi request reprint Post-synaptic action of morphine on glutamatergic neuronal transmission related to the descending antinociceptive pathway in the rat thalamus
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Ebara, Shinagawa ku, Tokyo, Japan
    J Neurochem 104:469-78. 2008
    ..The present data suggest that the stimulation of MOR in the Hb may be involved in activation of the descending antinociceptive pathway through glutamatergic neurotransmission via the NMDA receptor...
  37. ncbi request reprint [Evaluation method for a pain-like action]
    Minoru Narita
    Nihon Yakurigaku Zasshi 130:124-7. 2007
  38. ncbi request reprint Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Neuropsychopharmacology 33:1097-112. 2008
    ..Furthermore, the reduction in G-protein activation induced by M-6-G may, at least in part, contribute to the suppression of the antinociceptive effect produced by morphine under a neuropathic pain-like state...
  39. ncbi request reprint Changes in central dopaminergic systems and morphine reward by prenatal and neonatal exposure to bisphenol-A in mice: evidence for the importance of exposure period
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawaku, Tokyo, Japan
    Addict Biol 12:167-72. 2007
    ..In conclusion, the present data suggest that the organogenesis and lactation are the most important period to cause the alternation of dopaminergic system by bisphenol-A exposure in the mouse...
  40. ncbi request reprint Role of delta-opioid receptor function in neurogenesis and neuroprotection
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    J Neurochem 97:1494-505. 2006
    ..These findings raise the possibility that delta-opioid receptors play a crucial role in neurogenesis and neuroprotection, mainly through the activation of Trk-dependent tyrosine kinase, which could be linked to PI3K, PKC, CaMKII and MEK...
  41. ncbi request reprint Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Life Sci 80:852-9. 2007
    ..These findings suggest that spinal p-Ser1303-NR2B plays a significant role in the development of the ethanol-dependent neuropathic pain-like state in rats...
  42. ncbi request reprint Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 144:777-82. 2007
    ....
  43. ncbi request reprint Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 414:21-5. 2007
    ..These findings support the idea that the activation and hypertrophy of microglia in the spinal cord may be, at least in part, associated with in the induction of ethanol-dependent neuropathic pain-like state...
  44. ncbi request reprint [Differences in neuronal toxicity and its molecular mechanisms between methamphetamine and methylphenidate]
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacological Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:115-20. 2009
    ..Taken together, the present findings suggest that the psychostimulus effects of METH and MPH occur through different mechanisms...
  45. ncbi request reprint Implication of protein kinase C in the orexin-induced elevation of extracellular dopamine levels and its rewarding effect
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Neurosci 25:1537-45. 2007
    ....
  46. ncbi request reprint Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Life Sci 80:2015-24. 2007
    ..Furthermore, the present data provide evidence that the neuropathic pain may be effectively controlled by repeated treatment with GBP at the early stage...
  47. doi request reprint Direct evidence for the involvement of endogenous beta-endorphin in the suppression of the morphine-induced rewarding effect under a neuropathic pain-like state
    Keiichi Niikura
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 435:257-62. 2008
    ..This phenomenon could explain the mechanism that underlies the suppression of opioid reward under a neuropathic pain-like state...
  48. ncbi request reprint Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice
    Naoko Kuzumaki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 415:22-7. 2007
    ..The astrocyte activation in the CG may, at least in part, contribute to the development of a chronic pain-like state following sciatic nerve ligation in mice...
  49. doi request reprint Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain
    Kazuhiro Torigoe
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Anesthesiology 116:159-69. 2012
    ..However, chronic pain can induce sleep disturbance. The authors investigated the effects of the atypical antipsychotic olanzapine on morphine-induced emesis and the sleep dysregulation associated with chronic pain...
  50. doi request reprint Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis
    Keiichi Niikura
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 433:6-10. 2008
    ..These results suggest that the activation of spinal PKCgamma associated with the activation of ascending pain transmission may be an important factor in chronic pain-like hyperalgesia with changes in emotionality...
  51. ncbi request reprint Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence
    Mayumi Miyatake
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawaku, Tokyo 142 8501, Japan
    Eur J Neurosci 22:1476-88. 2005
    ..These findings provide evidence that the changes in PKC-dependent neuronal and astrocytic glutamatergic transmission induced by METH may, at least in part, contribute to the development of psychological dependence on METH...
  52. doi request reprint Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice
    Atsushi Nakamura
    Department of Toxicology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Psychopharmacology (Berl) 200:307-16. 2008
    ..The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state...
  53. doi request reprint Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli
    Yasuko Taketa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Anesthesiology 112:418-31. 2010
    ..In this study, the authors investigated the role of spinal dynorphinergic transmission in ongoing brain activation under noxious stimuli in mice...
  54. ncbi request reprint Lack of development of behavioral sensitization to methylphenidate in mice: correlation with reversible astrocytic activation
    Tsutomu Suzuki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    Eur J Pharmacol 574:39-48. 2007
    ..These findings suggest that, unlike methamphetamine, methylphenidate shows a lack of development of behavioral sensitization to its hyperlocomotion and induces reversible astrocytic activation...
  55. ncbi request reprint Role of extracellular signal-regulated kinase in the ventral tegmental area in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation
    Satoru Ozaki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    J Neurochem 88:1389-97. 2004
    ..These results suggest that a sustained reduction in the ERK-dependent signalling pathway in dopamine cells of the VTA may be implicated in the suppression of the morphine-induced rewarding effect under neuropathic pain...
  56. ncbi request reprint Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    J Neurochem 94:1297-305. 2005
    ....
  57. ncbi request reprint Heterologous mu-opioid receptor adaptation by repeated stimulation of kappa-opioid receptor: up-regulation of G-protein activation and antinociception
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    J Neurochem 85:1171-9. 2003
    ....
  58. doi request reprint Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice
    Keiichi Niikura
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 433:54-8. 2008
    ..These results suggest that the activation of PKC in the spinal cord may play an essential role in the suppression of the morphine-induced rewarding effect in mice with neuropathic pain through the constant release of beta-endorphin...
  59. ncbi request reprint Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    J Neurosci 23:1006-12. 2003
    ....
  60. ncbi request reprint Effect of a selective GABA(B) receptor agonist baclofen on the mu-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects
    Tsutomu Suzuki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuropharmacology 49:1121-31. 2005
    ..Taken together, these results suggest that co-administration of baclofen with mu-opioid receptor agonist produced a potentiation of antinociceptive effect, whereas an untoward effect was completely blocked...
  61. ncbi request reprint Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice
    Yoshinori Yajima
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 992:288-93. 2003
    ..These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice...
  62. ncbi request reprint Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine
    Hideaki Kato
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:119-24. 2006
    ..These findings suggest that Tyr-1472 phosphorylation of NR2B subunit-containing NMDA receptor associated with activation of Src family kinase in the limbic forebrain may be involved in the morphine-induced rewarding effect...
  63. ncbi request reprint Effect of repeated administration of morphine on the activity of extracellular signal regulated kinase in the mouse brain
    Minoru Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 324:97-100. 2002
    ..These data suggest that the sustained activation of ERK activity be associated with the development of antinociceptive tolerance to morphine in mice...
  64. ncbi request reprint Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes
    Hideaki Kato
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Synapse 59:10-7. 2006
    ..Thus, glutamate-mediated pathway via NR2B subunit-containing NMDA receptor may, at least in part, contribute to neuron-to-astrocyte signaling...
  65. ncbi request reprint Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice
    Takeshi Aoki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Neurosci 20:1633-8. 2004
    ..The present data provide direct evidence that the activation of mGlu5 receptor linked to the increased PKCgamma isoform in the mouse limbic forebrain is implicated in the development of rewarding effect of morphine...
  66. ncbi request reprint Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area
    Satoru Ozaki
    Department of Toxicology, School of Pharmacy, Hoshi University, Tokyo, Japan
    J Neurochem 82:1192-8. 2002
    ..Acc with reduction in the mu-opioid receptor-mediated G-protein activation in the VTA...
  67. ncbi request reprint Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain
    Satoshi Imai
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:183-92. 2006
    ..The present data provide the first evidence for the mechanism underlying the development of tolerance to fentanyl-induced anti-hyperalgesic effect under chronic pain...
  68. ncbi request reprint Suppression of the morphine-induced rewarding effect and G-protein activation in the lower midbrain following nerve injury in the mouse: involvement of G-protein-coupled receptor kinase 2
    S Ozaki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    Neuroscience 116:89-97. 2003
    ....
  69. ncbi request reprint mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption
    Kan Miyoshi
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 562:208-11. 2007
    ..These findings constitute direct evidence that spinal mGlu5 receptor and PKC play substantial roles in the development and maintenance of an ethanol-dependent neuropathic pain-like state in rats...
  70. ncbi request reprint Changes in G-protein activity mediated through the stimulation of dopamine and GABA(B) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Addict Biol 8:319-25. 2003
    ..The present data provide evidence that these G-protein activation changes may lead to behavioural sensitization to morphine-induced hyperlocomotion in mice...
  71. ncbi request reprint Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats
    Minoru Narita
    Department of Toxicology, School of Pharmacy and Pharmaceutical Science, Hoshi University, Shinagawa ku, Tokyo, Japan
    J Neurochem 86:273-82. 2003
    ..In contrast, this pathway is not essential for the increased level of dopamine in this region induced by morphine, providing further evidence for the different mechanisms of dopamine release by methamphetamine and morphine in rats...
  72. ncbi request reprint [Implication of neuron-glia interaction in the molecular mechanism of drug dependence]
    Minoru Narita
    Department of Toxicology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 43:13-8. 2008
  73. doi request reprint Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission
    Keiichi Niikura
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Trends Pharmacol Sci 31:299-305. 2010
    ..We also review data on particular gene polymorphisms (e.g. in the mu-receptor gene) that could also influence the relative abuse potential of mu-agonists in clinical pain populations...
  74. ncbi request reprint Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A
    Kazuya Miyagawa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawaku, Tokyo 142 8501, Japan
    Neurosci Lett 418:236-41. 2007
    ..These results suggest that chronic exposures to bisphenol-A could induce the memory impairment associated with the reduction in ACh production in the hippocampus...
  75. ncbi request reprint Oxidative stress in methamphetamine-induced self-injurious behavior in mice
    Tomohisa Mori
    Department of Legal Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Behav Pharmacol 18:239-49. 2007
    ..These findings may help us to better understand the clinical phenomenon of self-injurious behavior...
  76. ncbi request reprint Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites
    Minoru Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, Tokyo, Japan
    Life Sci 70:2341-54. 2002
    ..t.-administered fentanyl-induced antinociception were 73.7, 18.5 and 1.2-fold lower than that of morphine, respectively. The present data clearly suggest the usefulness of peripheral treatment with fentanyl for the control of pain...
  77. ncbi request reprint Prenatal and neonatal exposure to bisphenol-A affects the morphine-induced rewarding effect and hyperlocomotion in mice
    Keisuke Mizuo
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 356:95-8. 2004
    ..The present data provide further evidence that prenatal and neonatal exposure to BPA can directly influence the development of the central dopaminergic system...
  78. ncbi request reprint Increased level of neuronal phosphoinositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception
    M Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Neuroscience 124:515-21. 2004
    ..This effect may, at least in part, result in the expression of morphine-induced pharmacological actions including antinociception in mice...
  79. ncbi request reprint Dynamic changes in dopaminergic neurotransmission induced by a low concentration of bisphenol-A in neurones and astrocytes
    M Miyatake
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    J Neuroendocrinol 18:434-44. 2006
    ..These findings provide evidence that BPA alters dopamine responsiveness in neurones and astrocytes and that, at least in part, it may contribute to potentiate the development of psychological dependence on drugs of abuse...
  80. doi request reprint Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats
    S Furuta
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Neuroscience 164:1252-62. 2009
    ..Furthermore, this chronic muscle pain may result from nociceptive neuroplasticity of the spinal cord dorsal horn...
  81. ncbi request reprint Up-regulation of mu-opioid receptor-mediated G-protein activation in protein kinase Cgamma knockout mice following repeated naloxone treatment
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, 142 8501, Tokyo, Japan
    Neurosci Lett 338:103-6. 2003
    ..The present data provide direct evidence that protein kinase Cgamma is not involved in the development of the up-regulation of mu-opioid receptor functions to activate G-proteins in the mouse spinal cord by repeated naloxone treatment...
  82. ncbi request reprint Intensification of the development of ethanol dependence in mice lacking dopamine D(3) receptor
    Minoru Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, 2 4 41 Ebara Shinagawa Ku, Tokyo 142 8501, Japan
    Neurosci Lett 324:129-32. 2002
    ..The present data suggest that the lack of dopamine D3 receptor genes in the mouse brain leads to the aggravation of the development of physical dependence on ethanol...
  83. ncbi request reprint Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis
    Mitsuru Shiokawa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 570:108-10. 2007
    ..These results suggest that the co-administration of aripiprazole may be useful for reducing the severity of morphine-induced emesis...
  84. ncbi request reprint Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol-A in mice
    Keisuke Mizuo
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Addict Biol 9:19-25. 2004
    ..The present data provide further evidence that prenatal and neonatal exposure to BPA leads to the reduction of functional dopamine D3 receptors without affecting the new synthesis of dopamine D3 receptors in the mouse limbic forebrain...
  85. ncbi request reprint Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mice
    Kousei Oe
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 177:55-60. 2004
    ..However, little direct evidence is available for the involvement of activated PKC in the spinal cord in reduction of rewarding effects induced by morphine under chronic pain-like state...
  86. ncbi request reprint Chronic morphine treatment increases the expression of vesicular glutamate transporter 1 in the mouse spinal cord
    Masami Suzuki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, 142 8501, Japan
    Eur J Pharmacol 535:166-8. 2006
    ..These findings suggest that repeated treatment with morphine enhances excitatory synaptic transmission in the spinal cord, and in turn suppresses the morphine-induced antinociception...
  87. doi request reprint Cell-dependent physiological synaptic action of morphine in the rat habenular nucleus: morphine both inhibits and facilitates excitatory synaptic transmission
    Keisuke Hashimoto
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    Neurosci Lett 451:270-3. 2009
    ..These results suggest that morphine may induce cell-dependent dual modulation of glutamatergic synaptic transmission in the Hb...
  88. ncbi request reprint [Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state]
    Imai Satoshi
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:169-76. 2008
    ..This phenomenon may explain the high degree of tolerance to fentanyl that develops with hyperalgesia caused by a chronic pain-like state...
  89. doi request reprint Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice
    Naoko Kuzumaki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Synapse 64:721-8. 2010
    ..These findings suggest that aging may decrease hippocampal neurogenesis via epigenetic modifications accompanied by the activation of microglia and astrocytes with the increased expression of IL-1beta in the hippocampus...
  90. doi request reprint Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine
    Daigo Ikegami
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Addict Biol 15:358-61. 2010
    ....
  91. ncbi request reprint mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons
    Keisuke Hashimoto
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neurosci Lett 453:62-7. 2009
    ..These results suggest that morphine, fentanyl and oxycodone each produce the MOR-independent suppression of sodium currents by distinct mechanisms in thalamic neurons...
  92. ncbi request reprint Role of gap junction in the expression of morphine-induced antinociception
    Masami Suzuki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 535:169-71. 2006
    ..These findings suggest that gap-junctional-dependent communication in the mouse spinal cord may play, at least in part, a role in the expression of morphine-induced antinociception...
  93. ncbi request reprint Up-regulation of spinal mu-opioid receptor function to activate G-protein by chronic naloxone treatment
    M Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, Shinagawa, 142-8501, Tokyo, Japan
    Brain Res 913:170-3. 2001
    ....
  94. ncbi request reprint Up-regulation of the G(q/11alpha) protein and protein kinase C during the development of sensitization to morphine-induced hyperlocomotion
    M Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 111:127-32. 2002
    ..These findings suggest that the up-regulation of G(q/11alpha)-dependent PKC activity in membranes of the limbic forebrain is implicated in the development of sensitization to morphine-induced hyperlocomotion in mice...
  95. ncbi request reprint Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin
    M Narita
    Department of Toxicology, Hoshi University, School of Pharmacy, Tokyo, 142-8501, Japan
    J Neurosci 21:3715-20. 2001
    ..These findings indicate that repeated intrathecal administration of DAMGO may activate the PKCgamma isoform and in turn cause a desensitization of mu-receptor-mediated G-protein activation in the mouse spinal cord...
  96. ncbi request reprint [Effects of fasudil on neuropathic pain-like state in mice]
    Mitsuru Shiokawa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:153-9. 2007
    ..The present data raise the fascinating possibility that i.t. or epidural administration with fasudil may be useful for the treatment of neuropathic pain...
  97. ncbi request reprint Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice
    Yoshinori Yajima
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 958:338-46. 2002
    ..These findings suggest the possibility that the binding of BDNF to full-length TrkB and subsequent its activation may play a critical role in the development of neuropathic pain-like thermal hyperalgesia induced by nerve injury in mice...
  98. ncbi request reprint Direct evidence for the up-regulation of spinal micro-opioid receptor function after repeated stimulation of kappa-opioid receptors in the mouse
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    Eur J Neurosci 18:2498-504. 2003
    ....
  99. ncbi request reprint Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord
    Masami Suzuki
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Tokyo 142 8501, Japan
    Neurosci Lett 399:202-5. 2006
    ..This phenomenon leads to the enhanced excitatory synaptic transmission in the dorsal horn of the spinal cord, and in turn suppresses the morphine-induced antinociception...
  100. ncbi request reprint Changes in Ca2+-dependent protein kinase C isoforms induced by chronic ethanol treatment in mice
    M Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, 2-4-41 Ebara Shinagawa-Ku, 142-8501, Tokyo, Japan
    Neurosci Lett 307:85-8. 2001
    ..These findings suggest that the change in membrane-bound cPKC in the limbic forebrain and frontal cortex may play substantial roles for the development of ethanol dependence...
  101. ncbi request reprint Involvement of protein kinase Cgamma isoform in morphine-induced reinforcing effects
    M Narita
    Department of Toxicology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, 142 8501, Tokyo, Japan
    Neuroscience 103:309-14. 2001
    ..These findings suggest that activated PKCgamma in the limbic forebrain following the treatment with morphine may be critical for the development and/or maintenance of reinforcing effects induced by morphine in mice...