M Morishita

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. ncbi request reprint The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA
    M Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa ku, 142 8501, Tokyo, Japan
    Int J Pharm 201:175-85. 2000
  2. ncbi request reprint Is the oral route possible for peptide and protein drug delivery?
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Drug Discov Today 11:905-10. 2006
  3. ncbi request reprint A novel approach using functional peptides for efficient intestinal absorption of insulin
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa Tokyo 142 8501, Japan
    J Control Release 118:177-84. 2007
  4. pmc Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara, Shinagawa, Tokyo, Japan
    J Control Release 110:587-94. 2006
  5. ncbi request reprint Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 97:115-24. 2004
  6. ncbi request reprint In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Pharm Res 21:309-16. 2004
  7. doi request reprint Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Tokyo, Japan
    J Control Release 132:99-104. 2008
  8. ncbi request reprint Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin
    M Morishita
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501, Tokyo, Japan
    Int J Pharm 212:289-93. 2001
  9. pmc Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501, Tokyo, Japan
    J Control Release 81:25-32. 2002
  10. ncbi request reprint Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid
    M Kajita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    J Pharm Sci 89:1243-52. 2000

Collaborators

  • NIKOLAOS A PEPPAS
  • Yoshinori Onuki
  • Kozo Takayama
  • Ayako Ueno
  • F Yanagawa
  • A Suzuki
  • A Kato
  • Yasuko Obata
  • M Sakagami
  • Hideaki Okabe
  • Noriyasu Kamei
  • El Sayed Khafagy
  • Koji Nakamura
  • Takahiro Goto
  • Tetsuo Yamagata
  • Yoshinobu Aoki
  • Nikhil J Kavimandan
  • Ken Nishimura
  • Kazunori Asai
  • Koichi Isowa
  • Reiji Nishio
  • Nobuo Ida
  • Yoshimi Eda
  • Anthony Tuesca
  • Jumpei Ehara
  • Mahito Nakanishi
  • Anthony M Lowman
  • Aaron C Foss
  • Silvia Surini
  • Tsuneji Nagai
  • Yousuke Kanayama
  • Emi Hayashinaka
  • Mie Nishimura
  • Koki Hasegawa
  • M Kajita
  • Yasuyoshi Watanabe
  • Yasuhiro Wada
  • Hitomi Chiba
  • Jun Imai
  • Yohei Ikeno
  • Kozo Takayma
  • Jeffrey Joseph
  • Junpei Ehara
  • Anthony Lowman
  • Yuichi Sugiyama
  • Tetsuya Yoshida
  • Hassan Benameur
  • Hiroaki Segawa
  • Kunitada Shimotono
  • Masahiro Asada
  • Akinori Masago
  • Hiroyuki Kusuhara
  • Hitoshi Takahashi
  • Yoshihiro Ohmiya
  • Toru Imamura
  • Takemasa Sakaguchi
  • Yu Fukuoka
  • Bunshiro Akikusa
  • Shuji Hosoda
  • Jeffrey I Joseph
  • Robert J Murray
  • Hidero Akiyama
  • Masahiro Noro
  • Hideo Katsuta
  • Shoji Hosoda
  • Katsuhiko Shinomiya
  • S Tokiwa
  • T Nagai
  • Y Chiba

Detail Information

Publications44

  1. ncbi request reprint The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA
    M Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa ku, 142 8501, Tokyo, Japan
    Int J Pharm 201:175-85. 2000
    ..Our results indicate that emulsion incorporating highly purified long-chain polyunsaturated fatty acid, especially DHA, has the potential of becoming the formulation for enteral delivery of insulin...
  2. ncbi request reprint Is the oral route possible for peptide and protein drug delivery?
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Drug Discov Today 11:905-10. 2006
    ..Clearly, it is essential that these approaches maintain the biological activity of the proteins...
  3. ncbi request reprint A novel approach using functional peptides for efficient intestinal absorption of insulin
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa Tokyo 142 8501, Japan
    J Control Release 118:177-84. 2007
    ..We conclude that oligoarginines are likely to become powerful tools for overcoming the low permeability of insulin through the epithelial cell membrane, the major barrier to oral insulin delivery...
  4. pmc Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara, Shinagawa, Tokyo, Japan
    J Control Release 110:587-94. 2006
    ..These results indicate that the blood glucose levels of diabetic rats can be effectively controlled by oral SS-ILP administration, and thus SS-ILP would be a promising delivery carrier of insulin via the oral route...
  5. ncbi request reprint Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 97:115-24. 2004
    ..These results imply that the particle size and delivery site are very important factors for ILP with respect to increasing the bioavailability of insulin following oral administration...
  6. ncbi request reprint In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Pharm Res 21:309-16. 2004
    ..To test the hypothesis that the ileal mucous/glycocalyx layers can be removed by hyaluronidase and that their significant roles in insulin absorption can thereby be identified...
  7. doi request reprint Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Tokyo, Japan
    J Control Release 132:99-104. 2008
    ..These data suggested that the colon-specific delivery of DHA, EPA, and possibly EPA-E would be a novel antidiabetic treatment by the stimulation of intrinsic GLP-1 secretion...
  8. ncbi request reprint Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin
    M Morishita
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501, Tokyo, Japan
    Int J Pharm 212:289-93. 2001
    ..9+/-7.9%). Our finding demonstrate that 20% PF-127 gels containing unsaturated fatty acids are potential formulations for the buccal delivery of insulin...
  9. pmc Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501, Tokyo, Japan
    J Control Release 81:25-32. 2002
    ..These data suggest that gels containing equimolar amounts of MAA:EG have the potential to be used as an oral carrier of peptide drugs, especially for insulin...
  10. ncbi request reprint Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid
    M Kajita
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    J Pharm Sci 89:1243-52. 2000
    ....
  11. ncbi request reprint [Application of pH-responsive polymers to oral dosage forms for insulin]
    M Morishita
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hoshi University
    Nippon Rinsho 59:2255-60. 2001
    ..Thus, the polymer has the potential to be used as a carrier for oral dosage forms of insulin to enhance its mucosal absorption...
  12. ncbi request reprint [The design of oral insulin delivery systems based on smart hydrogels]
    Mariko Morishita
    Department of Pharmaceutics, Hoshi University
    Nihon Rinsho 60:516-21. 2002
  13. ncbi request reprint Role of the mucous/glycocalyx layers in insulin permeation across the rat ileal membrane
    Yoshinobu Aoki
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 297:98-109. 2005
    ....
  14. ncbi request reprint Prediction of permeability of FD-4 through porous poly (2-hydroxyethyl methacrylate) membrane by multiple linear regression and artificial neural network
    F Yanagawa
    Department of Pharmaceutics, Hoshi University, Tokyo, Japan
    Pharmazie 64:311-5. 2009
    ....
  15. doi request reprint Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins
    El Sayed Khafagy
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan
    Int J Pharm 381:49-55. 2009
    ..17% for nasal and intestinal administration, respectively. From these findings, penetratin is a promising carrier for transmucosal delivery of therapeutic peptides and macromolecules as an alternative to conventional parenteral routes...
  16. pmc Key functions in polymer carriers for intestinal absorption of insulin
    Koji Nakamura
    Department of Pharmaceutics, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 354:135-42. 2008
    ..These results supported that MVS can be an effective tool with which to approximate the relationship between the function of a dosage form and its absorption, and to explore the optimized preparative conditions...
  17. doi request reprint Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery
    Noriyasu Kamei
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa Tokyo 142 8501, Japan
    J Control Release 131:94-9. 2008
    ....
  18. doi request reprint Effect of cell-penetrating peptides on the nasal absorption of insulin
    El Sayed Khafagy
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan
    J Control Release 133:103-8. 2009
    ..In conclusion, these data demonstrate that L-penetratin markedly increased the permeability of insulin across the nasal membrane without causing detectable damage to the integrity of cells in the nasal respiratory mucosa...
  19. ncbi request reprint Novel mucosal insulin delivery systems based on fusogenic liposomes
    Takahiro Goto
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Pharm Res 23:384-91. 2006
    ..The objective of this study was to evaluate the potential of FL to improve the mucosal absorption of insulin from rat intestinal membranes...
  20. ncbi request reprint Current challenges in non-invasive insulin delivery systems: a comparative review
    El Sayed Khafagy
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Adv Drug Deliv Rev 59:1521-46. 2007
    ..In addition, this article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes...
  21. ncbi request reprint Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: involvement of formulation factors in physical properties and pharmacological effects
    Yoshinori Onuki
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 349:47-52. 2008
    ..Because we can freely control the physical properties of the hydrogel and anticipate the significant pharmacological effects, photocrosslinked polyacrylic acid hydrogel is an attractive candidate adhesive for dermatological patches...
  22. doi request reprint Usefulness of cell-penetrating peptides to improve intestinal insulin absorption
    Noriyasu Kamei
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan
    J Control Release 132:21-5. 2008
    ..Thus, among CPPs used in this study, L-penetratin had the strongest ability to improve insulin intestinal absorption...
  23. ncbi request reprint Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane
    Yoshinori Onuki
    Department of Pharmaceutics, Hoshi University, Ebara, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 54:68-71. 2006
    ....
  24. ncbi request reprint Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats
    Takahiro Goto
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan
    J Pharm Sci 95:462-9. 2006
    ..These findings indicated that the hydrogels may be a promising tool for improving oral bioavailability of various drugs, which are poorly absorbed from the GI tract...
  25. ncbi request reprint Involvement of fractal geometry on solute permeation through porous poly (2-hydroxyethyl methacrylate) membranes
    Fumiki Yanagawa
    Department of Pharmaceutics, Hoshi University, 2 4 41, Ebara, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 110:395-9. 2006
    ....
  26. doi request reprint Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography
    Noriyasu Kamei
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 146:16-22. 2010
    ..This imaging methodology is likely to be useful for developing effective drug delivery systems targeted to specific organs...
  27. ncbi request reprint Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch
    Yoshinori Onuki
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 108:331-40. 2005
    ..A high functional photocrosslinked PAA modified with HEMA hydrogel as an adhesive for a dermatological patch was successfully created using the simultaneous optimization technique incorporating MSI...
  28. ncbi request reprint Neural network based optimization of drug formulations
    Kozo Takayama
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Adv Drug Deliv Rev 55:1217-31. 2003
    ..Superior function of the ANN approach was demonstrated by the optimization for typical numerical examples...
  29. ncbi request reprint Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane
    Yoshinobu Aoki
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Pharm Res 22:1854-62. 2005
    ..Furthermore, the variation of the enzymatic activities in the mucous/glycocalyx layers and in the brush-border membrane would be one factor that accounts for the regional differences in the transport of insulin...
  30. doi request reprint Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
    Noriyasu Kamei
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 136:179-86. 2009
    ..Thus, this study suggests that intermolecular binding between drug and CPP is an important factor governing the enhancing effect of the CPP on the intestinal absorption of therapeutic peptides and proteins...
  31. pmc Complexation hydrogels for intestinal delivery of interferon beta and calcitonin
    Noriyasu Kamei
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan
    J Control Release 134:98-102. 2009
    ..These findings indicate that P(MAA-g-EG) hydrogels are promising carriers for administration of various peptides and proteins via an oral route...
  32. ncbi request reprint Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery
    Yoshinori Onuki
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 97:91-9. 2004
    ....
  33. doi request reprint Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices
    F Yanagawa
    Department of Pharmaceutics, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Colloids Surf B Biointerfaces 63:146-52. 2008
    ..It is likely that the release rate of DIL from pHEMA matrices is mainly controlled by epsilon and Df, but eta matrix was less effective...
  34. ncbi request reprint Multivariate spline interpolation as a novel method to optimize pharmaceutical formulations
    K Takayama
    Department of Pharmaceutics, Hoshi University, Ebara, Shinagawa, Tokyo, Japan
    Pharmazie 59:392-5. 2004
    ..The method was applied to the optimization problem of a transdermal hydrogel formulation for ketoprofen containing several chemical enhancers. Results suggested a superior function of the MSI approach...
  35. ncbi request reprint Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate
    Silvia Surini
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, 142 8501 Tokyo, Japan
    J Control Release 90:291-301. 2003
    ..Although both the ANN and HSI successfully represented a non-linear relationship between the formulation factors and the release rate constant, HSI methodology gave a better estimation than that of the ANN...
  36. ncbi request reprint Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids
    Tetsuo Yamagata
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo, 142 8501, Japan
    J Control Release 112:343-9. 2006
    ....
  37. ncbi request reprint Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients
    Tetsuo Yamagata
    Department of Pharmaceutics, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Drug Metab Dispos 35:1142-8. 2007
    ..Taken together, these results suggest that Pluronic P85 and Tween 20 can improve the oral bioavailability of BCRP substrates by inhibiting BCRP function in the small intestine...
  38. doi request reprint The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides
    El Sayed Khafagy
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 388:209-12. 2010
    ..This difference in the enhancing effect of CPPs on nasal drug absorption is attributed to the degree of binding with the therapeutic macromolecule...
  39. doi request reprint Structural requirements of penetratin absorption enhancement efficiency for insulin delivery
    El Sayed Khafagy
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Control Release 143:302-10. 2010
    ..In conclusion, modulation of amino acid sequences by fixing the cationic residue positions can augment penetratin-enhanced nasal absorption and may lead to improvements in nasal insulin absorption...
  40. ncbi request reprint Complexation hydrogels for oral insulin delivery: effects of polymer dosing on in vivo efficacy
    Anthony Tuesca
    Chemical and Biological Engineering, Drexel University, Philadelphia, PA 19104, USA
    J Pharm Sci 97:2607-18. 2008
    ..The total insulin absorption was dependent on both the amount of the polymer present and the concentration of insulin within an ILP sample, with a maximum relative bioavailability of 8.0%...
  41. ncbi request reprint Development of acrylic-based copolymers for oral insulin delivery
    Aaron C Foss
    Biomaterials, Drug Delivery and Molecular Recognition Laboratories, Department of Chemical Engineering, Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712 0231, USA
    Eur J Pharm Biopharm 57:163-9. 2004
    ..The insulin loaded copolymer nanospheres caused a significant reduction of serum glucose with respect to that of a control animal...
  42. ncbi request reprint Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
    Koji Nakamura
    Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
    J Control Release 95:589-99. 2004
    ..In these studies, bioavailabilities ranged from 4.6% to 7.2% and were dependent on reaction solvent content...
  43. ncbi request reprint Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus
    Ken Nishimura
    Biotherapeutic Research Laboratory, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8562, Japan
    J Biol Chem 282:27383-91. 2007
    ..This stable RNA replicon is a potentially valuable genetic platform for various biological applications...
  44. ncbi request reprint The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa
    Kazunori Asai
    Department or Pharmacy, Matsudo City Hospital, Kamihongo 4005, Chiba 271 8511, Japan
    Int J Pharm 246:25-35. 2002
    ..These results suggest that at least, less than 10% w/v CD solutions do not induce gross tissue damage and can keep the histological integrity of the nasal mucosa...