J Kamei

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. pmc Fentanyl enhances the excitability of rapidly adapting receptors to cause cough via the enhancement of histamine release in the airways
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa, Tokyo 142 8501, Japan
    Cough 9:3. 2013
  2. ncbi request reprint Effect of mexiletine on vincristine-induced painful neuropathy in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 536:123-7. 2006
  3. ncbi request reprint Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 528:158-61. 2005
  4. doi request reprint Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan (Yi-gan san)
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1431-7. 2009
  5. ncbi request reprint Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 547:160-4. 2006
  6. ncbi request reprint Modification of the fenvalerate-induced nociceptive response in mice by diabetes
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 948:17-23. 2002
  7. doi request reprint Effect of chronic pain on morphine-induced respiratory depression in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 174:224-33. 2011
  8. doi request reprint Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Eur J Pharmacol 652:117-20. 2011
  9. ncbi request reprint Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Pulm Pharmacol Ther 15:235-40. 2002
  10. pmc The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Tokyo 142 8501, Japan
    Mol Pain 7:85. 2011

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. pmc Fentanyl enhances the excitability of rapidly adapting receptors to cause cough via the enhancement of histamine release in the airways
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa, Tokyo 142 8501, Japan
    Cough 9:3. 2013
    ..abstract:..
  2. ncbi request reprint Effect of mexiletine on vincristine-induced painful neuropathy in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 536:123-7. 2006
    ....
  3. ncbi request reprint Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 528:158-61. 2005
    ..Furthermore, stimulation of P2X receptors, especially P2X4 receptors, on rapidly adapting receptors may be required for the ATP-induced enhancement of the cough reflex sensitivity...
  4. doi request reprint Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan (Yi-gan san)
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1431-7. 2009
    ..Chotoko is an effective component of YKS for producing an anxiolytic-like effect. The effective compound(s) should be contained, at least in part, in the water-soluble fraction of YKS...
  5. ncbi request reprint Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 547:160-4. 2006
    ..Furthermore, ATP might act not only on P2X receptors to directly activate rapidly adapting receptors, but also on P2Y receptors to increase histamine release, indirectly increasing the cough reflex sensitivity...
  6. ncbi request reprint Modification of the fenvalerate-induced nociceptive response in mice by diabetes
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 948:17-23. 2002
    ....
  7. doi request reprint Effect of chronic pain on morphine-induced respiratory depression in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 174:224-33. 2011
    ..These results suggest that the decrease in morphine-induced respiratory depression under chronic pain is mediated by the enhancement of 5-HT4a receptor systems in the brainstem...
  8. doi request reprint Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Eur J Pharmacol 652:117-20. 2011
    ..The present findings indicate that TTX-resistant sodium channels may play an important role in the enhancement of C-fiber-mediated cough pathways. Furthermore, ambroxol may prove to be a useful cough suppressant...
  9. ncbi request reprint Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Pulm Pharmacol Ther 15:235-40. 2002
    ..In this review, we study the possibility of the delta-opioid receptor antagonist as a new concept for central acting antitussive drugs...
  10. pmc The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Tokyo 142 8501, Japan
    Mol Pain 7:85. 2011
    ..In this study, we studied a small synthetic dipeptide related to SP1-7 and endomorphin-2, i.e. Phe-Phe amide, using the tail-flick test and von Frey filament test in diabetic and non-diabetic mice...
  11. ncbi request reprint Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Pharmacol Biochem Behav 75:247-54. 2003
    ..Furthermore, in diabetic mice, SSRIs and selective NA reuptake inhibitors did not affect immobility time even though the prolonged duration of immobility was suppressed by pretreatment with diazepam...
  12. ncbi request reprint Therapeutic potential of PKC inhibitors in painful diabetic neuropathy
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    Expert Opin Investig Drugs 10:1653-64. 2001
    ..Thus, activation of PKC may underlie the neuronal sensitisation that produces hyperalgesia in diabetic neuropathy...
  13. ncbi request reprint Potentiation of the antidepressant-like effect of fluoxetine by aripiprazole in the mouse tail suspension test
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    J Pharmacol Sci 108:381-4. 2008
    ..We suggest that aripiprazole augments the antidepressant-like effect of fluoxetine without affecting glucose metabolism...
  14. ncbi request reprint The antitussive effects of endomorphin-1 and endomorphin-2 in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 467:219-22. 2003
    ....
  15. doi request reprint Effects of cytidine 5'-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    Eur J Pharmacol 598:32-6. 2008
    ..Moreover, these effects of CDP-choline may result from the normalization of Na(+)-K(+)-ATPase activity...
  16. ncbi request reprint Effects of methylphenidate on the hyperemotional behavior in olfactory bulbectomized mice by using the hole-board test
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41 Ebara 2 chome, Shinagawaku, Tokyo 142 8501, Japan
    J Pharmacol Sci 103:175-80. 2007
    ..In addition, we proposed that the improvement in the noradrenergic abnormalities in the frontal cortex due to methylphenidate treatment may play a key role in the improvement of impulsive-like behaviors observed in OBX mice...
  17. doi request reprint Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 600:83-6. 2008
    ..Moreover, L-carnosine combined with zinc shows more potent amelioration of abnormal sensory perception in diabetic mice than by itself...
  18. ncbi request reprint Role of cyclin-dependent kinase 5 in capsaicin-induced cough
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 566:181-4. 2007
    ..These results suggest that Cdk5-dependent factors are involved in C-fiber-mediated cough signaling...
  19. ncbi request reprint Effects of first- and second-generation histamine-H1-receptor antagonists on the pentobarbital-induced loss of the righting reflex in streptozotocin-induced diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    J Pharmacol Sci 97:266-72. 2005
    ..Our results suggest that the systemic administration of second-generation histamine-H(1)-receptor antagonists may produce a central nervous system depressant effect in diabetes...
  20. ncbi request reprint Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang)
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 507:163-8. 2005
    ....
  21. ncbi request reprint Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    J Pharmacol Sci 96:280-5. 2004
    ..This effect may be, at least in part, mediated by the inhibition of TTX-R sodium channel-mediated nociceptive transmission in the spinal cord...
  22. ncbi request reprint Antitussive effect of NS-398, a selective cyclooxygenase-2 inhibitor, in guinea pigs
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 497:233-9. 2004
    ..These results suggest that cyclooxygenase-2 inhibitors may have a therapeutic benefit in reducing coughs...
  23. ncbi request reprint Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    Pulm Pharmacol Ther 21:356-9. 2008
    ..restrictus by itself, that is without subsequent allergen challenge, enhances the excitability of cough receptors to tussive stimuli, and the physiologic features of this animal model are consistent with those of atopic cough...
  24. ncbi request reprint Effects of nociceptin on the exploratory behavior of mice in the hole-board test
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebra 2 chrome, Shinagawa, Tokyo 142 8501, Japan
    Eur J Pharmacol 489:77-87. 2004
    ....
  25. ncbi request reprint Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang)
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa, Tokyo 142 8501, Japan
    Eur J Pharmacol 469:159-63. 2003
    ..These results suggest that G. radix contains a potent antitussive compound, liquilitin apioside, whose antitussive effect may depend on both peripheral and central mechanisms...
  26. ncbi request reprint [Sensitization of cough sensitivity through activation of C-and/or Adelta fibers]
    Junzo Kamei
    Nihon Yakurigaku Zasshi 131:429-33. 2008
  27. ncbi request reprint Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Jpn J Pharmacol 86:336-41. 2001
    ....
  28. ncbi request reprint Effects of epinastine on the antitussive and rewarding effects of dihydrocodeine in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 21:663-8. 1999
    ..p.) and epinastine (1 mg/kg s.c.). These results suggest that epinastine may be a useful constituent opioid-containing antitussive preparation that would not enhance the potential for psychological dependence...
  29. ncbi request reprint Involvement of spinal delta 1-opioid receptors in forced walking stress-induced antinociception in the tail-flick test in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 21:595-8. 1999
    ..These results suggest that forced walking stress-induced antinociception is mediated by spinal delta 1-opioid receptors in mice...
  30. ncbi request reprint The modulatory effect of (+)-TAN-67 on the antinociceptive effects of the nociceptin/orphanin FQ in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 383:241-7. 1999
    ..TAN-67 (0.3-3.0 microg, i.t.), by itself, did not facilitate the tail-flick response or produce apparent behavioral changes. It is possible that (+)-TAN-67 has an antagonistic effect on nociceptin/orphanin FQ-induced antinociception...
  31. ncbi request reprint Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 370:109-16. 1999
    ..Furthermore, the results of this study suggest that the reduction of substance P-mediated nociceptive transmission in the spinal cord may be responsible for the antinociceptive effect of nociceptin/orphanin FQ...
  32. ncbi request reprint Algogenic mediator-induced nociceptive response in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 369:319-23. 1999
    ....
  33. ncbi request reprint Antitussive effect of moguisteine on allergic coughs in the guinea pig
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 347:253-5. 1998
    ..Dihydrocodeine at doses of 30 and 56 mg/kg, p.o., dose-dependently but not significantly reduced the number of allergic coughs. These results suggest that moguisteine may be of a therapeutic benefit in reducing allergic coughs...
  34. ncbi request reprint Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 322:27-30. 1997
    ..In conclusion, (-)-TAN-67, but not its enantiomer (+)-TAN-67, produced an antinociceptive effect through the activation of delta 1-opioid receptors...
  35. ncbi request reprint Evidence for the modulation of spontaneous locomotor activity by higher serum glucose levels and/or spleen-derived factor(s) in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, Japan
    Life Sci 60:1699-708. 1997
    ..Furthermore, factor(s) derived from spleen cells of diabetic mice during the incipient stages of diabetes may play a role in the enhancement of dopaminergic neurotransmission...
  36. ncbi request reprint The role of spinal delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 326:31-6. 1997
    ..These results suggest that a spinal delta1-opioid receptor-mediated endogenous antinociceptive system may inhibit the formalin-induced second phase of the nociceptive response in diabetic mice...
  37. ncbi request reprint Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Life Sci 60:PL 333-7. 1997
    ..These results support our previous hypothesis that mu1- rather than mu2-, delta- or kappa-opioid receptors are involved in the antinociceptive effects of buprenorphine...
  38. ncbi request reprint Antinociceptive effects of (+)-matrine in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 337:223-6. 1997
    ..In conclusion, (+)-matrine produced an antinociceptive effect mainly through the activation of kappa-opioid receptors and partially through mu-opioid receptors...
  39. ncbi request reprint Effect of diabetes on bradykinin-induced thermal hyperalgesia in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 390:113-8. 2000
    ..These results suggest that the change in bradykinin-induced thermal hyperalgesia in diabetic mice may be due, at least in part, to the modification of nociceptive transmission in the spinal cord by the activation of protein kinase C...
  40. ncbi request reprint The antinociceptive effects of endomorphin-1 and endomorphin-2 in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 391:91-6. 2000
    ....
  41. ncbi request reprint Modification of the effects of benzodiazepines on the exploratory behaviors of mice on a hole-board by diabetes
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Jpn J Pharmacol 86:47-54. 2001
    ..The heightened anxiety in diabetic mice may be due to the dysfunction of the benzodiazepine receptor and/or of central inhibitory systems...
  42. ncbi request reprint Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Tokyo 142 8501, Shinagawa, Japan
    Eur J Pharmacol 418:141-5. 2001
    ..Furthermore, the scratching behavior produced by norbinaltorphimine may be due in part to the release of histamine followed by antagonism of kappa-opioid receptors...
  43. ncbi request reprint Role of cholecystokinin in the reduction of endomorphin-2-induced antinociception in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa, 142 8501, Tokyo, Japan
    Eur J Pharmacol 416:95-9. 2001
    ..The results indicated that the reduction of endomorphin-2-induced antinociception in diabetic mice might be due, at least in part, to the activation of CCK(2) receptors...
  44. ncbi request reprint The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41 Ebara 2 chome, Shinagawa ku, 142 8501, Tokyo, Japan
    Brain Res 892:370-5. 2001
    ..These results indicate that the thermal allodynia and hyperalgesia in diabetic mice may be due, at least in part, to the activation of CCK(B) receptors followed by the activation of PKC in the spinal cord...
  45. ncbi request reprint Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa, Tokyo 142 8501, Japan
    Eur J Pharmacol 422:83-6. 2001
    ..Thus, it seems likely that thermal allodynia and hyperalgesia in diabetic mice may be due to the sensitization of vanilloid VR1 receptors in primary sensory neurons in the spinal cord...
  46. ncbi request reprint Intraventricular insulin reduces the antinociceptive effect of [D-Ala2, NMePhe4, Gly-ol5]enkephalin in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Science, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 345:171-4. 1998
    ..Furthermore, the attenuation of DAMGO-induced antinociception in C57BL/KsJ-db/db diabetic mice may be due in part to increased tyrosine kinase activity as a result of hyperinsulinemia...
  47. ncbi request reprint Socio-psychological stress-induced antinociception in diabetic mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Psychopharmacology (Berl) 149:397-400. 2000
    ..Although it is well established that different forms of stress produce a pronounced antinociception, the effect of diabetes on psychological stress-induced antinociception is not yet clear...
  48. ncbi request reprint Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of intracellular calcium
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, Japan
    Brain Res 862:257-61. 2000
    ..These results suggest that the change in the formalin-induced nociceptive response in diabetic mice may be due, at least in part, to the modification of nociceptive transmission in the spinal cord by intracellular calcium...
  49. ncbi request reprint Involvement of haloperidol-sensitive sigma-sites in antitussive effects
    J Kamei
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 224:39-43. 1992
    ..Pretreatment with haloperidol also markedly reduced the antitussive effects of (+/-)-pentazocine and dextromethorphan. These results suggest that haloperidol-sensitive sigma-sites may be involved in the regulation of coughs...
  50. ncbi request reprint Supersensitivity of 5,7-dihydroxytryptamine-treated rats to the respiratory depressant and antitussive effects of dihydrocodeine
    J Kamei
    Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
    Eur J Pharmacol 153:305-8. 1988
    ..The increased sensitivity to dihydrocodeine in terms of the depression of frequency of respiration and the cough reflex in 5,7-DHT-treated rats could possibly have been due to changes in the sensitivity of serotonergic receptors...
  51. ncbi request reprint Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice
    Chihiro Nozaki
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 552:99-104. 2006
    ..c. fluvoxamine or i.t. 5-HT in the chronic state of sciatic nerve ligation-induced neuropathic pain may be related to opioidergic activity, mainly through the activation of spinal mu- and delta-opioid receptors...
  52. ncbi request reprint Characterization of the antinociceptive effects of oxycodone in diabetic mice
    Chihiro Nozaki
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 535:145-51. 2006
    ....
  53. ncbi request reprint Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice
    Shoko Hirano
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Pharmacol Biochem Behav 86:27-31. 2007
    ..In conclusion, we suggest that leptin exerts the antidepressant-like effect in diabetic mice mediated by, at least in part, 5-HT2 receptors...
  54. ncbi request reprint The hypoglycemic effect of (7R*,9aS*)-7-phenyl-octahydroquinolizin-2-one in mice
    H Kubo
    Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Biol Pharm Bull 23:1114-7. 2000
    ..This result indicates that compounds possessing the quinolizidin-2-one ring system as the basic structure may be possible lead compounds for a new type of diabetes drug...
  55. ncbi request reprint Effects of serotonergic anxiolytics on the freezing behavior in the elevated open-platform test in mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    J Pharmacol Sci 105:272-8. 2007
    ..In addition, this test is convenient for assaying anxiolytic drugs that affect serotonergic neurotransmission...
  56. doi request reprint Inhibitory effect of hydrocortisone on cerebral salt wasting after subarachnoid hemorrhage in rats
    M Yoneko
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 32:727-31. 2010
    ..We conclude that hydrocortisone is a useful drug for the treatment of CSW after SAH...
  57. ncbi request reprint Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    J Pharmacol Sci 95:374-80. 2004
    ..Furthermore, it is possible that delta-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects...
  58. ncbi request reprint Abnormal benzodiazepine receptor function in the depressive-like behavior of diabetic mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, Japan
    Pharmacol Biochem Behav 82:615-20. 2005
    ....
  59. ncbi request reprint Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants
    Kou Takahashi
    Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Pharmacol Sci 108:320-34. 2008
    ..Defining the roles of candidate neuronal systems in antidepressant-induced neural changes are likely to transform the course of research on the biological basis of mood disorders...
  60. ncbi request reprint Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 186:1-6. 2006
    ..We previously reported that the head-twitch responses induced by the 5-HT2 receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI) (DOI-HTRs) were decreased in streptozotocin-induced diabetic mice...
  61. ncbi request reprint Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Neuropsychopharmacology 29:461-9. 2004
    ..Plasma corticosterone levels in diabetic mice were significantly higher than that in nondiabetic mice. These results suggest that the antidepressant-like effect mediated by 5-HT(1A) receptors may be attenuated by diabetes...
  62. ncbi request reprint Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function
    J Kamei
    Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
    Pharmacol Biochem Behav 34:595-8. 1989
    ..It is possible that the decreased sensitivity to both opioid and nonopioid antitussive drugs, in terms of the depression of the cough reflex, in morphine-dependent rats may be due to changes in the number of serotonin receptors...
  63. ncbi request reprint Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs
    Kayo Morita
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Jpn J Pharmacol 89:171-5. 2002
    ..Furthermore, it is possible that ATP-sensitive K+ channels may be involved in the antitussive effects of peripherally acting non-narcotic antitussive drugs...
  64. ncbi request reprint ROCK inhibition produces anxiety-related behaviors in mice
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 188:1-11. 2006
    ..The role of Rho/Rho-associated kinase (ROCK) in regulating dendritic and axonal morphology during development has gained much attention. Very little is known, however, about the role of the Rho/ROCK pathway in emotional behavior...
  65. ncbi request reprint Effect of diabetes on pinacidil-induced antinociception in mice
    Ko Zushida
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Tokyo 142 8501, Shinagawa, Japan
    Eur J Pharmacol 453:209-15. 2002
    ....
  66. ncbi request reprint Antinociceptive effect of oxycodone in diabetic mice
    Chihiro Nozaki
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 524:75-9. 2005
    ..These results suggest that the antinociceptive effects of oxycodone may be mediated by mu- and kappa-opioid receptors in diabetic mice, whereas it may interact primarily with mu-opioid receptors in non-diabetic mice...
  67. ncbi request reprint Inhibitory modulation of the reflex tracheal constriction induced by afferent vagal stimulation
    M Misawa
    Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
    Jpn J Pharmacol 53:506-9. 1990
    ..These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition...
  68. doi request reprint Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Eur J Pharmacol 588:213-6. 2008
    ..These results provide evidence of the prophylactic and therapeutic potential of ALC on the progressive diabetic neuropathy...
  69. ncbi request reprint Involvement of dopamine D1 receptors and alpha1-adrenoceptors in the antidepressant-like effect of chlorpheniramine in the mouse tail suspension test
    Shoko Hirano
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 562:72-6. 2007
    ..In addition, the antidepressant-like effect of chlorpheniramine may be induced by several mechanisms that are different from those involved in the antidepressant-like effect of imipramine...
  70. ncbi request reprint Diabetes attenuates psychological stress-elicited 5-HT secretion in the prefrontal cortex but not in the amygdala of mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 1147:233-9. 2007
    ..In addition, we suggest the possibility that the dysfunction of stress-elicited 5-HT release, but not basal 5-HT release, causes the increased expression of fear-related behavior in diabetic mice...
  71. ncbi request reprint Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice
    Chihiro Nozaki
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 560:160-2. 2007
    ..These results suggest that although primarily interacts with mu(1)-opioid receptor, kappa-opioid receptors are also strongly involved in oxycodone-induced antinociception...
  72. ncbi request reprint Antipruritic activity of the kappa-opioid receptor agonist, TRK-820
    Yuko Togashi
    Pharmaceutical Research Laboratories, Toray Industries, Inc, 1111 Tebiro Kamakura, Kanagawa 248 8555, Japan
    Eur J Pharmacol 435:259-64. 2002
    ..These results suggest that TRK-820 has antipruritic activity which is mediated by kappa-opioid receptors, and is effective in both antihistamine-sensitive and -resistant pruritus...
  73. doi request reprint Olanzapine increases hepatic glucose production through the activation of hypothalamic adenosine 5'-monophosphate-activated protein kinase
    M Ikegami
    Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Diabetes Obes Metab 15:1128-35. 2013
    ....
  74. ncbi request reprint Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    J Pharmacol Sci 102:377-86. 2006
    ..In addition, we suggest that the hyperemotional behavior characterized by head-dipping behavior in OBX mice was selectively reversed by benzodiazepine and non-benzodiazepine anxiolytics...
  75. ncbi request reprint Hypoglycemic effects of multiflorine derivatives in normal mice
    Hajime Kubo
    Institute of Medicinal Chemistry, Hoshi University, Ebara, Tokyo, Japan
    Biol Pharm Bull 29:2046-50. 2006
    ..No hypoglycemic effect of a 4-piperidone-type compound was observed. These results indicate that compounds possessing double bond(s) in the A ring of multiflorine may be lead compounds for a new type of diabetes drug...
  76. doi request reprint Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41 Ebara 2 chome, Shinagawa ku, Tokyo 142 8501, Japan
    Brain Res 1208:160-9. 2008
    ..In conclusion, we demonstrated that subchronic SNC80 treatment could completely reverse OBX-induced behavioral abnormalities and defects in serotonergic function...
  77. ncbi request reprint [Effect of streptozotocin-induced diabetes on the function of the central nervous system in rodents]
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:83-7. 2006
    ..In this review, we summarized the effect of STZ-induced diabetes on the function of the central nervous system in rodents and the similarity to the clinical features of several psychiatric disorders such as depression...
  78. ncbi request reprint Effect of MK-801 on the antinociceptive effect of [D-Ala(2),N-MePhe(4), Gly-ol(5)]enkephalin in diabetic mice
    Ko Zushida
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinsgawa, Tokyo 142 8501, Japan
    Eur J Pharmacol 448:39-44. 2002
    ....
  79. ncbi request reprint [The approaches in the discovery of antidepressants using affective disorder models]
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41, Ebara, Shinagawa ku, Tokyo, 142 8501 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:75-82. 2003
    ..In this report, we provide an overview of the approaches in the discovery of new antidepressants using these affective disorder models...
  80. ncbi request reprint Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 191:857-65. 2007
    ..It has been reported that many of the behavioral and serotonergic neuronal changes observed in olfactory bulbectomy (OBX) were improved by subchronic administration of a variety of antidepressants...
  81. ncbi request reprint Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects
    Kimio Higashiyama
    Institute of Medicinal Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
    Biol Pharm Bull 28:845-8. 2005
    ..c.v. may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord, and this phenomenon in turn produces the antinociception in mice...
  82. ncbi request reprint Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    J Pharmacol Sci 98:25-32. 2005
    ..The dysfunction of kappa-opioid receptor subtypes in diabetic mice may underlie this CNS region-specific variation in the effects of these kappa-opioid receptor agonists...
  83. ncbi request reprint Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 182:327-34. 2005
    ..Recent studies have shown that endogenous opioid systems are associated with the regulation of emotional responses. In particular, it has been reported that delta-opioid receptors act naturally to inhibit stress and anxiety...
  84. ncbi request reprint Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Pain 117:112-20. 2005
    ..These results indicate that dysfunction of the L-arginine/NO/cGMP cascade in the spinal cord may trigger vincristine-induced thermal hyperalgesia in mice...
  85. ncbi request reprint Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats
    Yoshihiko Chiba
    Department of Pharmacology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Respir Cell Mol Biol 33:574-81. 2005
    ....
  86. ncbi request reprint Effects of histamine H(1) receptor antagonists on depressive-like behavior in diabetic mice
    Shoko Hirano
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    Pharmacol Biochem Behav 83:214-20. 2006
    ..In conclusion, we suggest that the altered neuronal system mediated by the activation of histamine H(1) receptors is involved, at least in part, in the depressive-like behavior seen in diabetic mice...
  87. doi request reprint Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents
    Satoshi Sakami
    Pharmaceutical Research Laboratories, Toray Industries, Inc, 6 10 1 Tebiro, Kamakura, Kanagawa 248 8555, Japan
    J Med Chem 51:4404-11. 2008
    ..40 microg/kg)...
  88. ncbi request reprint New approach for chronic renal failure model by direct kidney injection of doxorubicin in rats
    M Yoneko
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 29:389-94. 2007
    ..A light microscopic image showed glomerular decrement, tubular dilation and atrophy and vacuolation of parenchyma. In conclusion, the results of this study demonstrate that the DXR model using Method C develops CRF within 4 weeks...
  89. doi request reprint Characterization of cerebral salt wasting after subarachnoid hemorrhage model induced by endovascular puncture
    M Yoneko
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 32:475-80. 2010
    ..Although the BI model rats exhibited SAH of grade 4, the volume of urine and Na excretion did not change. Therefore, our conclusion is that the spread of bleeding in the subarachnoid space may not cause CSW...
  90. ncbi request reprint Antitussive effect of WIN 55212-2, a cannabinoid receptor agonist
    Kayo Morita
    School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41 Ebara 2 chome, Shinagawa ku, 142 8501 Tokyo, Japan
    Eur J Pharmacol 474:269-72. 2003
    ....
  91. ncbi request reprint Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa ku, 142 8501, Tokyo, Japan
    Psychopharmacology (Berl) 166:176-80. 2003
    ..Little information is available about the interaction between dihydrocodeine and second-generation antihistamine drugs such as cetirizine and ebastine, with particular reference to the rewarding effect of dihydrocodeine...
  92. ncbi request reprint [Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptors in the mouse tail suspension test]
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 41, Ebara, Shinagawa ku, Tokyo, 142 8501 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:159-63. 2004
    ..These results suggest a possibility that the antidepressant-like effect mediated by the activation of 5-HT1A receptors may be attenuated by diabetes...
  93. ncbi request reprint Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat
    Hirotoshi Utsunomiya
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    Biomed Res 26:193-200. 2005
    ..Plum treatment significantly increased plasma adiponectin concentrations and PPARgamma mRNA expression in adipose tissue from Wistar fatty rats. Plum thus may increase insulin sensitivity in these rats via adiponectin-related mechanisms...
  94. ncbi request reprint Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway
    Tadashi Yamakawa
    Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohoma, Japan
    Biomed Res 29:1-8. 2008
    ..These results suggest that in rat VSMCs lysoPC regulates COX-2 expression and PG production and also modulates cell proliferation through p38MAPK-mediated signaling pathways...
  95. ncbi request reprint Toxicological study of a new maintenance fluid, Veen 3G, in rats
    J Kamei
    Department of Pathophysiology and Therapeutics Faculty of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 24:493-6. 2002
    ..Since this rate is about 27-80 times higher than that used clinically in maintenance treatment, Veen 3G is suggested to be safe, with the exception of polyuria, in clinical situations at the standard infusion rate (5-15 ml/kg/h)...
  96. doi request reprint Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, Japan
    Eur J Pharmacol 641:49-53. 2010
    ..This attenuation may be, in part, due to the normalization of increased peripheral NO contents in the hindpaw of diabetic mice...
  97. doi request reprint RhoA/Rho kinase signaling in the spinal cord and diabetic painful neuropathy
    Masahiro Ohsawa
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 644:1-4. 2010
    ..Findings on the association between the spinal RhoA/ROCK pathway and diabetic painful neuropathy may lead to new strategies for its treatment...
  98. ncbi request reprint Prazosin inhibits spontaneous locomotor activity in diabetic mice
    Akiyoshi Saitoh
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Pharmacol Biochem Behav 72:365-9. 2002
    ..Furthermore, alpha1-adrenoceptor antagonism might have an inhibitory effect on presynaptic dopaminergic neurotransmission in the limbic forebrain in diabetic mice...
  99. ncbi request reprint Diabetes inhibits the DOI-induced head-twitch response in mice
    Shigeo Miyata
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo, 142 8501, Japan
    Psychopharmacology (Berl) 177:224-9. 2004
    ..It has been reported that central serotonin(2A) (5-HT(2A)) receptors may be involved in the pathogenesis and treatment of psychiatric disorders...
  100. ncbi request reprint Involvement of delta1-opioid receptors in the spatial learning impairment in streptozotocin-induced diabetic mice
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2 4 16 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:221-5. 2005
    ..Based on these results, we suggest that the enhanced response to central delta1-opioid receptors in diabetic mice is involved, at least in part, in the spatial learning impairment in the Morris water maze test...
  101. ncbi request reprint Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain
    Kazuo Isoma
    Central Research Laboratories, SSP Co, Ltd, Narita, Japan
    Jpn J Pharmacol 88:206-12. 2002
    ....