Affiliation: Hokkaido University
Kato S, Tobe H, Matsubara H, Sawada M, Sasaki Y, Fukiya S, et al
. The membrane phospholipid cardiolipin plays a pivotal role in bile acid adaptation by Lactobacillus gasseri JCM1131T. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;: pubmed publisher
..Therefore, CL plays important roles in bile acid resistance and maintenance of the membrane lipid composition in L. gasseri. ..
Kurdi P, Kawanishi K, Mizutani K, Yokota A. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol. 2006;188:1979-86 pubmed
Yanase M, Aikoh T, Sawada K, Ogura K, Hagiwara T, Imai K, et al
. Pyruvate kinase deletion as an effective phenotype to enhance lysine production in Corynebacterium glutamicum ATCC13032: Redirecting the carbon flow to a precursor metabolite. J Biosci Bioeng. 2016;122:160-7 pubmed publisher
..Overall, these results provide valuable knowledge for engineering the anaplerotic reaction to increase lysine yield in C. glutamicum. ..
Yokota A, Sawada K, Wada M. Boosting Anaplerotic Reactions by Pyruvate Kinase Gene Deletion and Phosphoenolpyruvate Carboxylase Desensitization for Glutamic Acid and Lysine Production in Corynebacterium glutamicum. Adv Biochem Eng Biotechnol. 2017;159:181-198 pubmed publisher
..These findings may facilitate the rational use of C. glutamicum in fermentation industries. ..
Maeda S, Shimizu K, Kihira C, Iwabu Y, Kato R, Sugimoto M, et al
. Pyruvate dehydrogenase complex regulator (PdhR) gene deletion boosts glucose metabolism in Escherichia coli under oxygen-limited culture conditions. J Biosci Bioeng. 2017;123:437-443 pubmed publisher
..coli. The overall results demonstrate the biotechnological advantages of pdhR deletion in boosting glucose metabolism and also improve our understanding of the role of PdhR in bacterial physiology. ..
Wada M, Sawada K, Ogura K, Shimono Y, Hagiwara T, Sugimoto M, et al
. Effects of phosphoenolpyruvate carboxylase desensitization on glutamic acid production in Corynebacterium glutamicum ATCC 13032. J Biosci Bioeng. 2016;121:172-7 pubmed publisher
..9Â g/L, which was 1.42-fold higher than ATCC13032 and significantly higher than the other three strains. The results showed a synergistic effect of these two mutations on glutamic acid production in C.Â glutamicum. ..
Watanabe M, Fukiya S, Yokota A. Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. J Lipid Res. 2017;58:1143-1152 pubmed publisher
..These findings will help us to determine the fundamental properties of FBAs and better understand the role of FBAs in the regulation of gut microbiota composition. ..
Tawthep S, Fukiya S, Lee J, Hagio M, Ogura Y, Hayashi T, et al
. Isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents. J Biosci Bioeng. 2017;124:514-522 pubmed publisher
..These findings will contribute to elucidation of SBA formation in the gut. ..