Hiroshi Yamazaki

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay
    Kei Takemoto
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Japan
    Mutat Res 519:199-204. 2002
  2. ncbi request reprint Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Life Sci 74:2739-47. 2004
  3. ncbi request reprint Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli
    Hiroshi Yamazaki
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Protein Expr Purif 24:329-37. 2002
  4. ncbi request reprint CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects
    Satoshi Yamaori
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo
    Drug Metab Pharmacokinet 19:120-9. 2004
  5. ncbi request reprint Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas
    Masafumi Miyazaki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 26:1947-55. 2005
  6. ncbi request reprint Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans
    Miyuki Kimura
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Drug Metab Dispos 33:1361-6. 2005
  7. ncbi request reprint Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)
    Kazuma Kiyotani
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 13:689-95. 2003
  8. ncbi request reprint Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers
    Miyuki Kimura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Drug Metab Lett 6:67-72. 2012
  9. ncbi request reprint Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
    Masaki Fujieda
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 25:2451-8. 2004
  10. ncbi request reprint High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana
    Maxwell Afari Gyamfi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Eur J Clin Pharmacol 60:855-7. 2005

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay
    Kei Takemoto
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Japan
    Mutat Res 519:199-204. 2002
    ..Until now, benzophenone has been investigated mainly in terms of estrogenic activity and cytotoxicity, however, the genotoxic activation of benzophenone by human cytochrome P450s should be examined in terms of the risks to humans...
  2. ncbi request reprint Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Life Sci 74:2739-47. 2004
    ..several weeks) than those observed for activated charcoal. The results suggest that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU...
  3. ncbi request reprint Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli
    Hiroshi Yamazaki
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Protein Expr Purif 24:329-37. 2002
    ..P450/NPR membrane systems containing b5 are useful models for prediction of the rates for liver microsomal P450-dependent drug oxidations...
  4. ncbi request reprint CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects
    Satoshi Yamaori
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo
    Drug Metab Pharmacokinet 19:120-9. 2004
    ....
  5. ncbi request reprint Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas
    Masafumi Miyazaki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 26:1947-55. 2005
    ..Based on these lines of evidence, we propose that 8-methoxypsoralen inhibits the CYP2A5-mediated metabolic activation of NNK in the mouse lung, leading to the prevention of NNK-induced adenoma...
  6. ncbi request reprint Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans
    Miyuki Kimura
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Drug Metab Dispos 33:1361-6. 2005
    ..Based on these data, we conclude that CYP2A6 is a main 17 X 8-hydroxylase and that the catalytic activities for the 17 X 8-hydroxylation are reduced by the genetic polymorphisms of the CYP2A6 gene...
  7. ncbi request reprint Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)
    Kazuma Kiyotani
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 13:689-95. 2003
    ..Individuals judged as CYP2A6*4/*9 were expected to be poor metabolizers, having extremely low activity of CYP2A6...
  8. ncbi request reprint Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers
    Miyuki Kimura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Drug Metab Lett 6:67-72. 2012
    ....
  9. ncbi request reprint Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
    Masaki Fujieda
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 25:2451-8. 2004
    ..10) were lower than that of adenocarcinoma (OR of 0.39) in group 4. These results suggest that the CYP2A6 is one of the principal determinants affecting not only smoking behavior but also susceptibility to tobacco-related lung cancer...
  10. ncbi request reprint High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana
    Maxwell Afari Gyamfi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Eur J Clin Pharmacol 60:855-7. 2005
    ..We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations...
  11. ncbi request reprint CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl
    Miki Nakajima
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa, Japan
    Int J Cancer 119:2520-6. 2006
    ..In conclusion, although the enzyme responsible for ABP N-hydroxylation in human bladder microsomes could not be determined, we found that CYP2A13 metabolically activates ABP...
  12. ncbi request reprint Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway
    Tomohisa Nakada
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Toxicol Sci 37:555-63. 2012
    ..We herein propose that cotinine induces tumor promotion by inhibiting apoptosis and enhancing cellular proliferation, thus underlining the importance of CYP2A6 in tobacco-related lung tumorigenesis...
  13. ncbi request reprint A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur
    Satoshi Daigo
    Laboratory of Drug Metabolism, Division of Pharmacobiodynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
    Pharmacogenetics 12:299-306. 2002
    ..From these results, we conclude that the poor metabolic phenotype of patient 1 was caused by the existence of the two mutant alleles, CYP2A6*4C and the new variant CYP2A6*11...
  14. ncbi request reprint Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens
    Yoshiyuki Yamazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mutat Res 562:151-62. 2004
    ..typhimurium TA1538 strains are applicable for detecting the activation of promutagens of which mutagenic activation is not or weakly detectable with N-nitrosamine-sensitive YG7108 strains expressing human P450s...
  15. ncbi request reprint Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
    Masafumi Miyazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Mutat Res 581:165-71. 2005
    ..Based on these data, we conclude that human CYP2A subfamily members play important roles in the mutagenic activation of essentially all betel quid-related N-nitrosamines tested in the present study...
  16. ncbi request reprint Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression sys
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    J Pharm Sci 91:952-63. 2002
    ..It was suggested that the RAF approach using recombinant CYPs from baculovirus-infected insect cells coexpressing OR (and b(5) if required) could be valuable for the prediction of the contribution of each CYP in drug metabolism...
  17. ncbi request reprint Identification of a novel polymorphic enhancer of the human CYP3A4 gene
    Keiko Matsumura
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Hokkaido, Japan
    Mol Pharmacol 65:326-34. 2004
    ..These results suggest that CLEM4 is a constitutive enhancer of the CYP3A4 gene in the liver and that -11,129_-11,128insTGT may at least partly contribute to the interindividual variability of CYP3A4 expression...
  18. doi request reprint Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene
    Tatsuki Fukami
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Chem Res Toxicol 21:720-5. 2008
    ....
  19. ncbi request reprint Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7
    Satoshi Yamaori
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, 060 0812 Sapporo, Japan
    Biochem Pharmacol 66:2333-40. 2003
    ..The effects of b(5) on kinetic parameters of CYP3A5 were similar to those of CYP3A4 but not CYP3A7. These results suggest that roles of b(5) in drug oxidation activities of CYP3A5 and CYP3A4 are different from those of CYP3A7...
  20. ncbi request reprint Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals
    Katsuhiko Tougou
    Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    Drug Metab Pharmacokinet 22:125-8. 2007
    ..405, 0.095, 0.500 and 0.000, respectively. On the other hand, the allelic frequency of the nonsynonymous SNP 602G>C was 0.194 in a Caucasian population...
  21. doi request reprint Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese
    Masayuki Matsunaga
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Drug Metab Dispos 37:699-701. 2009
    ..These results suggest that these two CYP2D6*10 haplotypes are possible causes of interindividual variation in the activities and the substrate specificity of CYP2D6...
  22. ncbi request reprint Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes
    Tomoko Komatsu
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Biochem Pharmacol 63:2081-90. 2002
    ..This is the first report that catalase in livers enhances drug oxidation activities catalyzed by P450 in human liver microsomes...
  23. ncbi request reprint [Genetic polymorphisms of drug metabolizing enzymes]
    Masaki Fujieda
    Division of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
    Gan To Kagaku Ryoho 29:663-8. 2002
    ..In this article, we describe recent findings that these polymorphic enzymes can abolish or quantitatively or qualitatively alter drug metabolism in humans...
  24. ncbi request reprint Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins
    Kenji Toide
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Cancer Epidemiol Biomarkers Prev 12:219-22. 2003
    ..05 and <0.01). These results suggest that CYP1B1 with polymorphic inducibility by dioxins is involved in aromatic hydrocarbon hydroxylase activities in human lymphocytes...
  25. ncbi request reprint CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka
    Zeki Topcu
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Department of Oral Patho biological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 23:595-8. 2002
    ..03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers...
  26. ncbi request reprint Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes
    Kenji Toide
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Pharmacol 67:1269-78. 2004
    ..The findings of this study clearly show that UGT2B specifically utilizes UDP-glucose but not UDP-glucuronic acid as a sugar donor for the conjugation of AS-3201 in human liver microsomes...
  27. ncbi request reprint Human cytochrome P450 1A1 is a novel target gene of liver X receptor α
    Norihito Shibahara
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Drug Metab Pharmacokinet 26:451-7. 2011
    ....
  28. ncbi request reprint [P450 and carcinogenesis]
    Hiroshi Yamazaki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6 Kita ku, Sapporo 060 0812, Japan
    Nihon Yakurigaku Zasshi 119:208-12. 2002
    ..This observation was clear in extrahepatic tissues that did not express mouse CYP3A enzymes. In conclusion, P450s are key factors involved in metabolic activation of environmental procarcinogens for their biological actions...
  29. ncbi request reprint Clinical evidence of pharmacokinetic changes in thalidomide therapy
    Katsunori Nakamura
    Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Pharmacokinet 28:38-43. 2013
    ..Here, we discuss clinical evidence of pharmacokinetic changes in thalidomide therapy...
  30. ncbi request reprint Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells
    Yui Yamamoto
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Drug Metab Dispos 30:155-60. 2002
    ..Since epoxides are generally regarded as the chemically reactive species, M-C may play a role in idiosyncrasy of troglitazone hepatotoxicity via individual differences either in the formation or degradation of this metabolite...
  31. pmc Transient trimethylaminuria related to menstruation
    Makiko Shimizu
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    BMC Med Genet 8:2. 2007
    ....
  32. ncbi request reprint Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes
    Norie Murayama
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
    Biochem Pharmacol 73:2020-6. 2007
    ....
  33. pmc Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese population
    Katsuyoshi Sugimoto
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Br J Clin Pharmacol 65:437-9. 2008
    ..Ethnic differences in the frequency of the variant allele have been reported. However, the frequency of the CYP2C19*17 allele has not been studied in the Japanese population...
  34. ncbi request reprint In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais
    Sompop Peamkrasatam
    Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Drug Metab Pharmacokinet 21:475-84. 2006
    ..Nicotine is a better probe according to its specificity, while coumarin is still valuable to be used for a routine CYP2A6 phenotyping since the test employs a non-invasive method...
  35. ncbi request reprint Mild trimethylaminuria observed in a Japanese cohort with liver damage
    Hiroshi Yamazaki
    Am J Med 118:803-5. 2005
  36. ncbi request reprint Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Curr Drug Metab 8:487-91. 2007
    ..The present article provides fundamental information for the importance of future investigations of the human FMO3 gene associated with trimethylaminuria (fish odor syndrome)...
  37. ncbi request reprint Activities of rat cytochrome P450 3A and 2C isoforms are increased in vivo by magnesium sulfate as evidenced by enhanced oxidation of bupivacaine and testosterone in liver microsomes
    Miwako Saito
    Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Drug Metab Pharmacokinet 21:201-7. 2006
    ....
  38. ncbi request reprint Three novel single nucleotide polymorphisms of the FMO3 gene in a Japanese population
    Makiko Shimizu
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan
    Drug Metab Pharmacokinet 21:245-7. 2006
    ..3) SNP, 060116Shimizu003; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-CCCATGCAGACAC/TGAGTGGTCGGGA-3'...
  39. ncbi request reprint Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo, Japan
    Drug Metab Dispos 34:1803-5. 2006
    ..Repeated administration of propofol could markedly decrease the biotransformation of propofol via P450 deactivation...
  40. ncbi request reprint Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice
    Hijiri Takeuchi
    Onco Pathology, Department of Pathology and Host Defense, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Cancer Res 63:7581-3. 2003
    ..97 to 0.23 (50 mg/kg) and 0.25 (12.5 mg/kg) tumors/mouse. These results clearly demonstrated that methoxsalen, a potent human CYP2A6 inhibitor, is a strong chemopreventive agent against NNK-induction of lung tumorigenesis...
  41. ncbi request reprint Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Mol Genet Metab 90:58-63. 2007
    ..The results suggest that individuals homozygous for either of the nonsense mutations, Arg500Stop and/or Cys197Stop alleles, in the FMO3 gene can possess abnormal TMA N-oxygenation...
  42. ncbi request reprint Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females
    Pailin Ujjin
    Department of Laboratory Medicine, Chulalongkorn University Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Pharmacogenetics 12:241-9. 2002
    ..Further investigations into the underlying factors that may lead to increased expression of CYP2A6 in association with abnormal body iron stores are currently in progress in our laboratory...
  43. ncbi request reprint A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test
    Junji Saruwatari
    Department of Pharmacology and Therapeutics, Graduate School of Clinical Pharmacy, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Clin Pharmacol Ther 72:200-8. 2002
    ..We assessed in vivo activities of cytochrome P450 1A2 (CYP1A2), N-acetyltransferase 2, and xanthine oxidase in Japanese residents of Kyushu, the southern island of Japan...
  44. pmc Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis
    Hiroshi Yamazaki
    Department of Biological Sciences, Faculty of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 101:14509-14. 2004
    ..CR cells thus strikingly change their cellular phenotypes during cortical development and play a pivotal role in both corticogenesis and cortical circuit maturation...
  45. ncbi request reprint Heterotropic cooperativity in oxidation mediated by cytochrome p450
    Toshiro Niwa
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8583, Japan
    Curr Drug Metab 9:453-62. 2008
    ..To understand causal factor(s) and mechanism(s) for such different reports summarized here is still one of the hot research topics to be solved in current activation reactions...
  46. ncbi request reprint Cytochrome P450 reconstitution systems
    Hiroshi Yamazaki
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Methods Mol Biol 320:61-71. 2006
    ..In this chapter, we describe optimal conditions that have been determined in our laboratories for the reconstitution of drug oxidation activities catalyzed by purified human CYP1A2, 2C9, 2E1, and 3A4...
  47. ncbi request reprint Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities
    Makiko Shimizu
    Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
    Drug Metab Dispos 35:328-30. 2007
    ..Genetic polymorphism in the human FMO3 gene might lead to unexpected changes of catalytic efficiency for N- and S-oxygenation of xenobiotics and endogenous materials...
  48. ncbi request reprint Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5
    Toshiro Niwa
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8583, Japan
    Curr Drug Metab 9:20-33. 2008
    ..To understand causal factor(s) and mechanism(s) for such different reports summarized here is still one of the hot research topics to be solved in current drug metabolism...
  49. doi request reprint Individual differences in toxicological response caused by a diversity of chemicals: observations in Japan
    Hiroshi Yamazaki
    Chem Res Toxicol 21:3-4. 2008
  50. doi request reprint Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects
    Yuki Usui
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390 8621, Japan
    Small 4:240-6. 2008
    ..These findings should encourage development of clinical treatment modalities involving CNTs...
  51. ncbi request reprint Missense and nonsense mutations of the flavin-containing monooxygenase 3 gene in a Japanese cohort
    Makiko Shimizu
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan
    Drug Metab Pharmacokinet 22:61-4. 2007
    ..3) SNP, 060825Shimizu006; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-TGTAGTCCCTACC/TAGTTTAGGCTGG-3'...
  52. ncbi request reprint Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors
    Tsutomu Shimada
    Department of Chemical Biology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Chem Res Toxicol 20:489-96. 2007
    ..These results suggest different mechanisms of inhibition of P450 1A1, 1A2, and 1B1 by PAHs and related chemicals and that interactions between P450 enzymes and PAH inhibitors are involved in differences in inhibition of the enzymes...
  53. ncbi request reprint [Clinical poisonings and genomics]
    Hiroshi Yamazaki
    Chudoku Kenkyu 19:359-64. 2006
  54. ncbi request reprint Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal region
    Makiko Shimizu
    Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Drug Metab Pharmacokinet 23:54-8. 2008
    ..These results suggest that the putative HNF-4 binding site and CCAAT box could be responsible cis-acting elements of the FMO3 gene in Japanese...