Research Topics
Species | Hiroshi YamazakiSummaryAffiliation: Hokkaido University Country: Japan Publications
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Detail Information
Publications
Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assayKei Takemoto
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Japan
Mutat Res 519:199-204. 2002..Until now, benzophenone has been investigated mainly in terms of estrogenic activity and cytotoxicity, however, the genotoxic activation of benzophenone by human cytochrome P450s should be examined in terms of the risks to humans...- Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patientsHiroshi Yamazaki
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
Life Sci 74:2739-47. 2004..several weeks) than those observed for activated charcoal. The results suggest that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU... - Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coliHiroshi Yamazaki
Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
Protein Expr Purif 24:329-37. 2002..P450/NPR membrane systems containing b5 are useful models for prediction of the rates for liver microsomal P450-dependent drug oxidations... - CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjectsSatoshi Yamaori
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo
Drug Metab Pharmacokinet 19:120-9. 2004.... - Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomasMasafumi Miyazaki
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
Carcinogenesis 26:1947-55. 2005..Based on these lines of evidence, we propose that 8-methoxypsoralen inhibits the CYP2A5-mediated metabolic activation of NNK in the mouse lung, leading to the prevention of NNK-induced adenoma... - Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humansMiyuki Kimura
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
Drug Metab Dispos 33:1361-6. 2005..Based on these data, we conclude that CYP2A6 is a main 17 X 8-hydroxylase and that the catalytic activities for the 17 X 8-hydroxylation are reduced by the genetic polymorphisms of the CYP2A6 gene... - Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)Kazuma Kiyotani
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Pharmacogenetics 13:689-95. 2003..Individuals judged as CYP2A6*4/*9 were expected to be poor metabolizers, having extremely low activity of CYP2A6... - Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokersMasaki Fujieda
Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Carcinogenesis 25:2451-8. 2004..10) were lower than that of adenocarcinoma (OR of 0.39) in group 4. These results suggest that the CYP2A6 is one of the principal determinants affecting not only smoking behavior but also susceptibility to tobacco-related lung cancer... - High prevalence of cytochrome P450 2A6*1A alleles in a black African population of GhanaMaxwell Afari Gyamfi
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
Eur J Clin Pharmacol 60:855-7. 2005..We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations... - CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenylMiki Nakajima
Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma-machi, Kanazawa, Japan
Int J Cancer 119:2520-6. 2006..In conclusion, although the enzyme responsible for ABP N-hydroxylation in human bladder microsomes could not be determined, we found that CYP2A13 metabolically activates ABP... - Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathwayTomohisa Nakada
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
J Toxicol Sci 37:555-63. 2012..We herein propose that cotinine induces tumor promotion by inhibiting apoptosis and enhancing cellular proliferation, thus underlining the importance of CYP2A6 in tobacco-related lung tumorigenesis... - Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagensYoshiyuki Yamazaki
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
Mutat Res 562:151-62. 2004..typhimurium TA1538 strains are applicable for detecting the activation of promutagens of which mutagenic activation is not or weakly detectable with N-nitrosamine-sensitive YG7108 strains expressing human P450s... - Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108Masafumi Miyazaki
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita-ku, Sapporo 060-0812, Japan
Mutat Res 581:165-71. 2005..Based on these data, we conclude that human CYP2A subfamily members play important roles in the mutagenic activation of essentially all betel quid-related N-nitrosamines tested in the present study... - Identification of a novel polymorphic enhancer of the human CYP3A4 geneKeiko Matsumura
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Hokkaido, Japan
Mol Pharmacol 65:326-34. 2004..These results suggest that CLEM4 is a constitutive enhancer of the CYP3A4 gene in the liver and that -11,129_-11,128insTGT may at least partly contribute to the interindividual variability of CYP3A4 expression... - Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression sysMiki Nakajima
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
J Pharm Sci 91:952-63. 2002..It was suggested that the RAF approach using recombinant CYPs from baculovirus-infected insect cells coexpressing OR (and b(5) if required) could be valuable for the prediction of the contribution of each CYP in drug metabolism... 
Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and tolueneTatsuki Fukami
Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Chem Res Toxicol 21:720-5. 2008....- A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafurSatoshi Daigo
Laboratory of Drug Metabolism, Division of Pharmacobiodynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
Pharmacogenetics 12:299-306. 2002..From these results, we conclude that the poor metabolic phenotype of patient 1 was caused by the existence of the two mutant alleles, CYP2A6*4C and the new variant CYP2A6*11... - Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7Satoshi Yamaori
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, 060-0812 Sapporo, Japan
Biochem Pharmacol 66:2333-40. 2003..The effects of b(5) on kinetic parameters of CYP3A5 were similar to those of CYP3A4 but not CYP3A7. These results suggest that roles of b(5) in drug oxidation activities of CYP3A5 and CYP3A4 are different from those of CYP3A7... - Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individualsKatsuhiko Tougou
Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Drug Metab Pharmacokinet 22:125-8. 2007..405, 0.095, 0.500 and 0.000, respectively. On the other hand, the allelic frequency of the nonsynonymous SNP 602G>C was 0.194 in a Caucasian population... - Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in JapaneseMasayuki Matsunaga
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Drug Metab Dispos 37:699-701. 2009..These results suggest that these two CYP2D6*10 haplotypes are possible causes of interindividual variation in the activities and the substrate specificity of CYP2D6... - [Genetic polymorphisms of drug metabolizing enzymes]Masaki Fujieda
Division of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
Gan To Kagaku Ryoho 29:663-8. 2002..In this article, we describe recent findings that these polymorphic enzymes can abolish or quantitatively or qualitatively alter drug metabolism in humans... - Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomesTomoko Komatsu
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
Biochem Pharmacol 63:2081-90. 2002..This is the first report that catalase in livers enhances drug oxidation activities catalyzed by P450 in human liver microsomes... - Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxinsKenji Toide
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
Cancer Epidemiol Biomarkers Prev 12:219-22. 2003..05 and <0.01). These results suggest that CYP1B1 with polymorphic inducibility by dioxins is involved in aromatic hydrocarbon hydroxylase activities in human lymphocytes... - Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokersMiyuki Kimura
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Drug Metab Lett 6:67-72. 2012.... - CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri LankaZeki Topcu
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Department of Oral Patho biological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 0812, Japan
Carcinogenesis 23:595-8. 2002..03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers... - Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomesKenji Toide
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Biochem Pharmacol 67:1269-78. 2004..The findings of this study clearly show that UGT2B specifically utilizes UDP-glucose but not UDP-glucuronic acid as a sugar donor for the conjugation of AS-3201 in human liver microsomes... - Human cytochrome P450 1A1 is a novel target gene of liver X receptor αNorihito Shibahara
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Drug Metab Pharmacokinet 26:451-7. 2011.... - [P450 and carcinogenesis]Hiroshi Yamazaki
Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6 Kita-ku, Sapporo 060-0812, Japan
Nippon Yakurigaku Zasshi 119:208-12. 2002..This observation was clear in extrahepatic tissues that did not express mouse CYP3A enzymes. In conclusion, P450s are key factors involved in metabolic activation of environmental procarcinogens for their biological actions... - Clinical evidence of pharmacokinetic changes in thalidomide therapyKatsunori Nakamura
Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Drug Metab Pharmacokinet 28:38-43. 2013..Here, we discuss clinical evidence of pharmacokinetic changes in thalidomide therapy... - Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cellsYui Yamamoto
Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
Drug Metab Dispos 30:155-60. 2002..Since epoxides are generally regarded as the chemically reactive species, M-C may play a role in idiosyncrasy of troglitazone hepatotoxicity via individual differences either in the formation or degradation of this metabolite... 
Transient trimethylaminuria related to menstruationMakiko Shimizu
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
BMC Med Genet 8:2. 2007....- Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomesNorie Murayama
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
Biochem Pharmacol 73:2020-6. 2007.... - Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese populationKatsuyoshi Sugimoto
Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
Br J Clin Pharmacol 65:437-9. 2008..Ethnic differences in the frequency of the variant allele have been reported. However, the frequency of the CYP2C19*17 allele has not been studied in the Japanese population... - In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in ThaisSompop Peamkrasatam
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand
Drug Metab Pharmacokinet 21:475-84. 2006..Nicotine is a better probe according to its specificity, while coumarin is still valuable to be used for a routine CYP2A6 phenotyping since the test employs a non-invasive method... - Mild trimethylaminuria observed in a Japanese cohort with liver damageHiroshi Yamazaki
Am J Med 118:803-5. 2005 - Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patientsHiroshi Yamazaki
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
Curr Drug Metab 8:487-91. 2007..The present article provides fundamental information for the importance of future investigations of the human FMO3 gene associated with trimethylaminuria (fish odor syndrome)... - Activities of rat cytochrome P450 3A and 2C isoforms are increased in vivo by magnesium sulfate as evidenced by enhanced oxidation of bupivacaine and testosterone in liver microsomesMiwako Saito
Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
Drug Metab Pharmacokinet 21:201-7. 2006.... - Three novel single nucleotide polymorphisms of the FMO3 gene in a Japanese populationMakiko Shimizu
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan
Drug Metab Pharmacokinet 21:245-7. 2006..3) SNP, 060116Shimizu003; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-CCCATGCAGACAC/TGAGTGGTCGGGA-3'... - Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofolHiroshi Yamazaki
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo, Japan
Drug Metab Dispos 34:1803-5. 2006..Repeated administration of propofol could markedly decrease the biotransformation of propofol via P450 deactivation... - Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J miceHijiri Takeuchi
Onco-Pathology, Department of Pathology and Host-Defense, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Cancer Res 63:7581-3. 2003..97 to 0.23 (50 mg/kg) and 0.25 (12.5 mg/kg) tumors/mouse. These results clearly demonstrated that methoxsalen, a potent human CYP2A6 inhibitor, is a strong chemopreventive agent against NNK-induction of lung tumorigenesis... - Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese populationHiroshi Yamazaki
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
Mol Genet Metab 90:58-63. 2007..The results suggest that individuals homozygous for either of the nonsense mutations, Arg500Stop and/or Cys197Stop alleles, in the FMO3 gene can possess abnormal TMA N-oxygenation... - Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and femalesPailin Ujjin
Department of Laboratory Medicine, Chulalongkorn University Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Pharmacogenetics 12:241-9. 2002..Further investigations into the underlying factors that may lead to increased expression of CYP2A6 in association with abnormal body iron stores are currently in progress in our laboratory... - A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine testJunji Saruwatari
Department of Pharmacology and Therapeutics, Graduate School of Clinical Pharmacy, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan
Clin Pharmacol Ther 72:200-8. 2002.... - Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesisHiroshi Yamazaki
Department of Biological Sciences, Faculty of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Proc Natl Acad Sci U S A 101:14509-14. 2004..CR cells thus strikingly change their cellular phenotypes during cortical development and play a pivotal role in both corticogenesis and cortical circuit maturation... - Heterotropic cooperativity in oxidation mediated by cytochrome p450Toshiro Niwa
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8583, Japan
Curr Drug Metab 9:453-62. 2008..To understand causal factor(s) and mechanism(s) for such different reports summarized here is still one of the hot research topics to be solved in current activation reactions... - Cytochrome P450 reconstitution systemsHiroshi Yamazaki
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
Methods Mol Biol 320:61-71. 2006..In this chapter, we describe optimal conditions that have been determined in our laboratories for the reconstitution of drug oxidation activities catalyzed by purified human CYP1A2, 2C9, 2E1, and 3A4... - Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activitiesMakiko Shimizu
Showa Pharmaceutical University, 3 3165 Higashi tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
Drug Metab Dispos 35:328-30. 2007..Genetic polymorphism in the human FMO3 gene might lead to unexpected changes of catalytic efficiency for N- and S-oxygenation of xenobiotics and endogenous materials... - Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5Toshiro Niwa
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194 8583, Japan
Curr Drug Metab 9:20-33. 2008..To understand causal factor(s) and mechanism(s) for such different reports summarized here is still one of the hot research topics to be solved in current drug metabolism... - Individual differences in toxicological response caused by a diversity of chemicals: observations in JapanHiroshi Yamazaki
Chem Res Toxicol 21:3-4. 2008 - Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effectsYuki Usui
Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390 8621, Japan
Small 4:240-6. 2008..These findings should encourage development of clinical treatment modalities involving CNTs... - Missense and nonsense mutations of the flavin-containing monooxygenase 3 gene in a Japanese cohortMakiko Shimizu
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan
Drug Metab Pharmacokinet 22:61-4. 2007..3) SNP, 060825Shimizu006; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-TGTAGTCCCTACC/TAGTTTAGGCTGG-3'... - Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitorsTsutomu Shimada
Department of Chemical Biology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
Chem Res Toxicol 20:489-96. 2007..These results suggest different mechanisms of inhibition of P450 1A1, 1A2, and 1B1 by PAHs and related chemicals and that interactions between P450 enzymes and PAH inhibitors are involved in differences in inhibition of the enzymes... - [Clinical poisonings and genomics]Hiroshi Yamazaki
Chudoku Kenkyu 19:359-64. 2006 - Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal regionMakiko Shimizu
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
Drug Metab Pharmacokinet 23:54-8. 2008..These results suggest that the putative HNF-4 binding site and CCAAT box could be responsible cis-acting elements of the FMO3 gene in Japanese...